Shen-Ing Liu

Shen-Ing Liu
Mackay Memorial Hospital · Department of Psychiatry

About

80
Publications
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Publications

Publications (80)
Article
Full-text available
Few studies have investigated the contagion effects of exposure to others’ confided suicidal thoughts among adolescents. The aim of this study was to investigate whether recent real-world exposure to confided suicidal thoughts was associated with adolescent self-harm and suicidality within one month, and if so, to determine the related risk and pro...
Article
Suicidal risk has been a significant mental health problem. However, the predictive ability for repeated self-harm (SH) has not improved over the past decades. This study thus aimed to explore a potential tool with theoretical accommodation and clinical application by employing traditional logistic regression (LR) and newly developed machine learni...
Article
Suicidal risk has been a significant mental health problem. However, the predictive ability for repeated self-harm (SH) has not improved over the past decades. This study thus aimed to explore a potential tool with theoretical accommodation and clinical application by employing traditional logistic regression (LR) and newly developed machine learni...
Article
Introduction Dialectical behavior therapy (DBT) is the most commonly used treatment for patients suffering from borderline personality disorder (BPD). However, data on its applications in Asian countries remain lacking. This pilot study aims to evaluate the feasibility and effectiveness of applying Mandarin‐translated DBT among suicidal Chinese pat...
Article
Introduction Delirium is a common neuropsychiatric condition in the general hospital population. Thus, the goal of the present study is to extend the use of diagnostic tools for delirium by developing and validating a Mandarin version of the Memorial Delirium Assessment Scale (MDAS). Methods Participants were sampled from two general Mackay Memori...
Article
Introduction: Dialectical behavior therapy (DBT) is the most commonly used treatment for patients suffering from borderline personality disorder (BPD). However, data on its applications in Asian countries remain lacking. This pilot study aims to evaluate the feasibility and effectiveness of applying Mandarin-translated DBT among suicidal Chinese pa...
Article
Adjunctive psychosocial interventions are part of the preferred method to treat bipolar disorder (BD). This study aimed to conduct a randomized control and protocol-guided trial, in order to evaluate the feasibility and effectiveness of adjunctive group-based treatments for Chinese outpatients with BD. A single-blind trial in which 68 outpatients w...
Article
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Background Cigarette smoking and alcohol drinking are the most common types of substance use and misuse (SUM) among adolescents. This study aimed to estimate the prevalence and psychosocial factors associated with current cigarette smoking and hazardous alcohol drinking among adolescents in Taiwan. Methods Data were collected via self-administered...
Article
Objective: We examined the effectiveness of brief cognitive-based psychotherapy plus standard case management in the prevention of further suicide attempts, clinical severity, and treatment adherence in a randomized clinical trial compared with standard case management. Method: Among five hundred and ninety-seven patients presenting with suicide...
Article
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Stigma of major depressive disorder (MDD) is an important public health problem. This study aimed to examine the level of perceived stigma and its associated factors in MDD patients in five Asian countries, including China, Korea, Malaysia, Singapore, and Thailand. A total of 547 outpatients with MDD were included from Asian countries. We used the...
Article
Objectives The association between older‐age bipolar disorder and cognitive impairments may be mediated by vascular burden. The aim of the study was to examine the difference of cognitive function between older people with late‐onset bipolar disorder (LOBD) and early‐onset bipolar disorder (EOBD) by considering rigorous vascular risk burden evaluat...
Article
Developing an automatic model to precisely and quickly classify medical data is a challenging work due to lack of medical knowledge. This paper presented a transformed fuzzy neural network (TFNN) to enhance medical data classification accuracy by learning knowledge from the available medical databases. We developed a novel reward/penalty fuzzy rule...
Article
This study examines the reliability, factor structure, convergent, and construct validities of the Mandarin Chinese version of the Reasons For Living Inventory (RFL) among Taiwanese psychiatric patients. Demographical characteristics of patients who hold these adaptive cognitions and differences on the level of endorsement between suicidal and non-...
Article
This study aimed to develop a psychometrically valid touch screen tablet-based cognitive test battery to identify early cognitive impairment due to dementia in older adults. The battery includes eight tests with 13 subscores, evaluating visual attention, auditory attention, information processing speed, visual memory, motor control, and visuospatia...
Article
Full-text available
Objectives The aim of this study was to investigate differences and similarities in risk factors for deliberate self-harm (DSH) and suicidal attempt (SA), and the role of impulsivity among a group of community adolescents. Setting This is a cross-sectional study conducted at high schools in Northern Taiwan. Data and participants We recruited grad...
Article
Objective: To investigate whether the Culturally Sensitive Collaborative Treatment (CSCT) would improve outcomes for patients with major depression who were managed in family medicine clinics in Taiwan. Method: A single-blinded randomized trial was conducted in 26 family medicine clinics. Patients with major depressive disorder were consecutivel...
Article
OBJECTIVE: To investigate whether the Culturally Sensitive Collaborative Treatment (CSCT) would improve outcomes for patients with major depression who were managed in family medicine clinics in Taiwan. METHOD: A single-blinded randomized trial was conducted in 26 family medicine clinics. Patients with major depressive disorder were consecutively...
Article
Suicide is a major social and clinical problem in Asia. Although studies have suggested that personality traits are possible risk factors for suicide, no study has been conducted among Chinese to compare the temperament traits of suicidal and non-suicidal mood disorder patients with those of healthy controls. This study compared temperament traits...
Article
Full-text available
The goal of this study is to investigate associations between subjective memory complaint and objective cognitive performance in older people with previous major depression–a high-risk sample for cognitive impairment and later dementia. A cross-sectional study was carried out in people aged 60 or over with previous major depression but not fulfilli...
Article
BACKGROUND/PURPOSE: Self-harm (SH) is a risk factor for suicide. We aimed to determine whether internet addiction and internet exposure to confided suicidal ideation are associated with SH in adolescents. METHODS: This study was a cross-sectional survey of students who self-completed a series of online questionnaires including a sociodemographic in...
Article
Full-text available
Background: Informal caregivers for dementia are vulnerable to psychological distress. Researches have shown the inconsistent results in the efficacy of various psychosocial interventions for burden of informal caregivers for patients with dementia. The aim of this study was to provide further understanding for the relative efficacy of psychosocial...
Article
Purpose: Data on the incidence of deliberate self-harm (DSH) and suicide attempts (SAs) are lacking in non-Western adolescents, and no studies have investigated differences in incident DSH and SA worldwide. This study aimed to investigate the incidence rates and relationships between predictors in DSH and SA. Methods: The Taiwanese Adolescent Se...
Article
Impairments in interpersonal relationships are a core feature of borderline personality disorder (BPD). Social cognition dysfunction, like false recognition of others' emotions and intentions, may lead to emotional disturbances, self-injury, and impulsive aggression behaviors in patients with BPD. This study explored the extent to which social cogn...
Article
Background This study aimed to assess the reliability, validity, and factor structure of the Patient Health Questionnaire-9 (PHQ-9) and its two subscales (PHQ-2, PHQ-1) for screening major depression disorder (MDD) in primary care elderly patients in Taiwan. Method A total of 634 participants aged ≥60 years were enrolled from the primary care sett...
Article
Full-text available
Background: This study aimed to assess the reliability, validity, and factor structure of the Patient Health Questionnaire-9 (PHQ-9) and its two subscales (PHQ-2, PHQ-1) for screening major depression disorder (MDD) in primary care elderly patients in Taiwan. Method: A total of 634 participants aged ≥60 years were enrolled from the primary care set...
Article
Full-text available
Background/purpose: Self-harm (SH) is a risk factor for suicide. We aimed to determine whether internet addiction and internet exposure to confided suicidal ideation are associated with SH in adolescents. Methods: This study was a cross-sectional survey of students who self-completed a series of online questionnaires including a sociodemographic...
Article
Backgrounds: Apolipoprotein E epsilon-4 (APOE ε4) allele, methylenetetrahydrofolate reductase (MTHFR C677T), and methionine synthase (MTR A2756G) were tested their associations with cognitive impairment in people with late-life depression (LLD). Methods: People with LLD were assessed by mini-mental state examination and were examined the distrib...
Article
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Objective: Despite high mortality associated with serious mental illness, risk of acute myocardial infarction (AMI) remains unclear, especially for patients with bipolar disorder. The main objective was to investigate the relative risk of AMI associated with schizophrenia and bipolar disorders in a national sample. Method: Using nationwide admin...
Article
Previous studies have identified the significant role of stressful life events in the onset of depressive episodes. However, there is a paucity of cross-national studies on stressful life events that precede depression. We aimed to compare types of stressful life events associated with the onset of depressive episodes in patients with major depress...
Article
Our aims were (1) to measure respiratory sinus arrhythmia (RSA), a high-frequency spectrum component of heart rate variability (HRV) in mood-disordered suicide attempters and (2) to investigate the relationship of RSA to symptoms and length of hospitalization. Forty-nine female repetitive-suicide attempters with depressive disorder or bipolar disor...
Article
Full-text available
Children with attention-deficit/hyperactivity disorder (ADHD) often have problems in social interactions. We investigated the social and behavioral effects of providing both social skill training and parent training to school-aged children with ADHD in Taiwan. Seven consecutive 8-week behavioral-based social skill training (SST) group sessions were...
Article
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Suicide is a serious public health problem worldwide. The emergency department (ED) is often the first place of contact with medical and mental health care for suicidal patients. This study aimed to determine the characteristics, management, and aftercare of patients who attempted suicide and then were taken to the ED of a general hospital in Taipe...
Article
The aim of this study was to compare the symptomatic and clinical features of depression among five groups of patients with major depressive disorder (MDD) living in China, Korea, Malaysia/Singapore, Taiwan, and Thailand. Consecutive consenting adults (aged 18-65) who met DSM-IV criteria for non-psychotic MDD – based on the Mini International Neuro...
Article
Full-text available
Past and repeated self-harm are long-term risks to completed suicide. A brief rating scale to assess repetition risk of self-harm is important for high-risk identification and early interventions in suicide prevention. The study aimed to examine the validity of the Chinese version SAD PERSONS Scale (CSPS) and to evaluate its feasibility in clinical...
Article
The Short Form version of the Quality of Life Enjoyment and Satisfaction Questionnaire (Q-LES-Q-SF) was designed to measure patients' subjective experience of enjoyment and satisfaction. However, it had not yet been validated for Chinese societies. This paper reports on the validation of the Chinese version of the Q-LES-Q-SF among primary care pati...
Article
This is a single-blind, parallel, flexible-dose study to compare the efficacy and tolerability of escitalopram and paroxetine in the treatment of patients with major depressive disorder. We recruited 399 patients from the outpatient clinics of five hospitals in northern Taiwan. Patients were administered either escitalopram (10-30 mg) or paroxetine...
Article
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Aim: The liver CYP1A2 enzyme may metabolize antidepressant escitalopram (S-CIT) to S-desmethylcitalopram (S-DCIT) and S-didesmethylcitalopram (S-DDCIT). This study tested whether genetic polymorphisms in the CYP1A2 gene are associated with the treatment responses to S-CIT. Materials & methods: Ten SNPs in CYP1A2 were selected and genotyped in 15...
Article
Full-text available
Background Although suicide has been postulated as a result of social breakdown, relatively little attention has been paid to the association between social relationships and non-fatal self-harm. We sought to investigate the extent to which social factors correlate with self-harm in this case–control study. Methods The primary outcome was self-har...
Article
Full-text available
Purpose: Mental health promotion campaign requires a good understanding of public attitudes and mental health literacy. Few studies have investigated changes in these two aspects over time. We aimed to examine such changes and their associations with help-seeking preference in Taiwan. Methods: Data were extracted from the Taiwan Social Change Surve...
Article
Objective To investigate inpatient mortality and the use of invasive diagnostic and revascularization procedures after acute myocardial infarction (AMI) in people with schizophrenia and bipolar disorder.MethodsA case-control study was nested within the first AMI episodes between 1996 and 2007 using nationwide data. Participants with schizophrenia o...
Article
To assess whether non-psychiatric physicians would benefit from a national depression training program and explore associated factors. Attending physicians were asked to complete survey questionnaires of confidence, attitude, knowledge, and their willingness to implement new strategies to improve care, before and after training. Paired t-test and m...
Article
Full-text available
Help-seeking behavior may protect people from harming themselves. However, few studies have discussed how and why people access lay or professional help prior to self-harm. This study explored the subjective experiences of individuals with deliberate self-harm in terms of help-seeking behavior and medical care pathways. Researchers performed qualit...
Article
Lower concentrations of n-3 PUFAs have been reported to be associated with cognitive impairment and dementia, but also with depression-itself a potential risk factor for cognitive decline. The aims of this study were to investigate associations between n-3 PUFA concentrations in erythrocyte membrane or plasma and cognitive function in an at-risk sa...
Article
This paper aims to explore characteristics of demoralization syndrome as well as the relationship between demoralization syndrome and psychosocial issues as seen through examinations of cancer outpatients in Taiwan. Outpatients with different cancer types were enrolled in this study. The Demoralization Scale Mandarin Version (DS-MV), Patient Health...
Article
Depression in late life often follows a chronic course with residual depressive and anxiety symptoms. Levels of omega-3 polyunsaturated fatty acids (PUFAs) have been found to be depleted in people with major depression in the acute stage. Additionally, lower omega-3 PUFA levels have been suggested to be associated with anxiety. The aim of this stud...
Article
This study aimed to understand the current inclinations toward depression and compulsion for members of four different religious groups, and to predict religious beliefs along the suicide path through analyzing the lifetime prevalence of suicidal ideation and suicide attempts for members of these religious groups. Participants in this cross-section...
Conference Paper
Antidepressant paroxetine is a serotonin reuptake inhibitor used in treatment of major depressive disorder. Its metabolism is through liver cytochrome P450 (CYP) 3A4, which is regulated by nuclear receptor pregnane X receptor (PXR; also known as nuclear receptor subfamily 1, group I, member 2; NR1I2) in its expression and activities. In this study,...
Article
AIMS: To evaluate the effectiveness of a brief intervention in hospitalized Taiwanese men to reduce unhealthy alcohol consumption. DESIGN: Randomized controlled trial. SETTING: Medical/surgical wards of a medical centre in Taipei, Taiwan. PARTICIPANTS: Of 3669 consecutive adult male in-patients, 616 were identified as unhealthy alcohol users (>14 d...
Article
Full-text available
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (ABCB1) is a drug transporter protein expressed on the epithelial cells of the intestine and the endothelial cells of the blood-brain barrier. Intestinal ABCB1 actively transports drugs from the cell membrane and prevents them from entering the blood stream whereas the blood-brain barrier ABCB1...
Article
The aim of this study was to determine the reliability and validity of a Chinese version of the Patient Health Questionnaire (PHQ-9) for the purpose of screening major depressive disorder (MDD) among primary care patients in Taiwan. A total of 1954 primary care patients completed the PHQ-9. Patients (n = 1532) were interviewed using the Schedule fo...
Article
To evaluate the effectiveness of a brief intervention in hospitalized Taiwanese men to reduce unhealthy alcohol consumption. Randomized controlled trial. Medical/surgical wards of a medical centre in Taipei, Taiwan. Of 3669 consecutive adult male in-patients, 616 were identified as unhealthy alcohol users (>14 drinks/week) and assigned randomly to...
Article
Full-text available
Little is known about use of formal or informal help-seeking resources prior to deliberate self-harm (DSH) outside Western settings. The aim of the study was to investigate help-seeking behavior and correlates of this prior to self-harm in an East Asian setting. Over a year period, consecutive attendees at a general hospital emergency room in Taiwa...
Article
Full-text available
Microelectronic engineers are considered valuable human capital contributing significantly toward economic development, but they may encounter stressful work conditions in the context of a globalized industry. The study aims at identifying risk factors of depressive disorders primarily based on job stress models, the Demand-Control-Support and Effo...
Article
Benzodiazepines cause a high proportion of adverse effects while non-benzodiazepine compounds have demonstrated high efficacy and less adverse effects in patients with insomnia. The objective of this study was to compare the effectiveness and safety of non-BZ zaleplon and zolpidem in primary insomnia. This was a randomized, double-blind, active-con...
Article
Full-text available
Deficits in understanding others’ minds, evident in most individuals with autism spectrum disorders, have been suggested as a core deficit of autism. However, nonverbal ability has gone untested because most theory of mind measurement has involved verbal materials such as reading tasks. This raises the possibility that children with high function a...
Article
Antipsychotic drugs may cause prolongation of the heart rate-corrected QT interval (QTc). Amisulpride, a relatively new atypical antipsychotic drug, has been considered to have few cardiac adverse effects, except in cases of overdose. We report 2 schizophrenic patients with no history of cardiac disease who developed significant QTc prolongation af...
Article
Research in the West has shown that persons with severe mental illness are easy targets of criminals. The aim of the present study was to investigate the types, incidence, and prevalence of crime victimization and its demographic and clinical correlates among persons with severe mental illness in Taiwan. Participants diagnosed with schizophrenia or...
Article
Full-text available
Depression is a major health concern, often treated by non-psychiatrists. This study assessed self-reported knowledge, attitudes and treatment practices of non-psychiatric physicians in the recognition and management of depression. Survey questionnaires were given to non-psychiatric physicians who attended a depression training program. We asked ph...
Article
AIM: The aim of this study was to validate the Mandarin Chinese version of different screening instruments and compare their performances for identifying hazardous drinkers in Taiwan. METHODS: We compared the performance of the Mandarin Chinese versions of AUDIT, AUDIT-C (AUDIT items 1, 2 and 3), AUDIT-4 (AUDIT items 1, 2, 3 and 10), AUDIT-3 (AUDIT...
Article
The prevalence of dementia is expected to increase in Chinese society in the next 40 years. Family members remain the primary caregivers and bear a heavy burden. The present study aims to examine the reliability and validity of the Chinese version of the Zarit Burden Interview (CZBI). One hundred eighty-one patient-caregiver dyads were recruited. C...
Article
Full-text available
The aim of this study was to validate the Mandarin Chinese version of different screening instruments and compare their performances for identifying hazardous drinkers in Taiwan. We compared the performance of the Mandarin Chinese versions of AUDIT, AUDIT-C (AUDIT items 1, 2 and 3), AUDIT-4 (AUDIT items 1, 2, 3 and 10), AUDIT-3 (AUDIT item 3), TWEA...
Article
Full-text available
Delirium is a common syndrome in terminal cancer patients. However, its detection and treatment by palliative care teams are not well documented. This survey aimed to determine the prevalence, detection and treatment of delirium in terminal cancer inpatients. The survey was conducted in Mackay Hospice and Palliative Care Center, Taiwan, from August...
Article
OBJECTIVE: Common mental disorders (CMD) are prevalent high-impact illnesses seen in general medical settings worldwide. There has been no investigation on the efficacy of enhanced care in Chinese societies. The aim of this study was to compare the outcome of three interventions for treating CMD: usual care (UC), problem-solving therapy plus UC (PS...
Article
Common mental disorders (CMD) are prevalent high-impact illnesses seen in general medical settings worldwide. There has been no investigation on the efficacy of enhanced care in Chinese societies. The aim of this study was to compare the outcome of three interventions for treating CMD: usual care (UC), problem-solving therapy plus UC (PST-UC), and...