Sheetal Ullal

Sheetal Ullal
Manipal Academy of Higher Education | MAHE · Pharmacology, Kasturba Medical College, Mangalore

MBBS, MD

About

67
Publications
9,110
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
573
Citations

Publications

Publications (67)
Article
Full-text available
Malaria is a major global public health problem mainly in the tropics and subtropics. Malaria control and elimination strategies mainly rely on efficacious antimalarial drugs. At present the major hurdle faced by malaria control programs is the drug resistance to antimalarials. Molecular surveillance using genetic markers associated with resistance...
Article
Full-text available
Tocilizumab (TCZ) is used to treat rheumatoid arthritis and other systemic inflammatory disorders. There is some evidence suggesting the occurrence of pancreatitis following TCZ use. We aimed to determine the reporting of pancreatitis following TCZ use in comparison with other drugs using the United States Food and Drug Administration Adverse Event...
Article
Drug use during pregnancy is not common. Drug-induced liver injury (DILI) is a potential complication that is rare but can adversely affect both the mother and the fetus. Although many drugs can directly cause hepatotoxicity, idiosyncratic liver injury is common in pregnancy. Underreporting of adverse drug reactions, lack of adequate literature reg...
Article
Objectives: Levetiracetam (LEV) is an antiepileptic recommended during pregnancy. Bacopa monneri is a medicinal herb used in Ayurveda for improvement of cognition. Data on effects of LEV and Bacopa on cognition is inadequate. The study evaluated the cognitive effects of LEV on rat offspring of dams exposed to LEV and whether pretreatment with Baco...
Article
Full-text available
The aim of this study was to determine the malondialdehyde (MDA) level and superoxide dismutase ( SOD) activity in colchicine induced Alzheimer’s disease ( AD), resveratrol ( RS) treated and RS + donepezil (DPZ) treated rat models. The objective was to compare the MDA level and SOD activity among these rat models. The present study included 3 month...
Article
Alzheimer's disease (AD) is a neurodegenerative disorder, which is commonly seen in older individuals. This is characterized by cognitive dysfunction, which leads to dementia. Pharmacological treatments for AD are mainly targeted on its symptoms like memory loss and cognitive impairment. The pathophysiology involved in AD is intra-neuronal accumula...
Article
Full-text available
AIMS: To determine the learning approach of second-year undergraduate medical students and whether a surface or deep approach to learning had any correlation with the pharmacology sessional and university examination marks obtained.METHODS: A cross-sectional study was conducted among second-year medical students in their fifth semester. To determin...
Article
Objective: The objective of this study is to evaluate the antihypertensive drug usage and dosage differences between geriatric and non-geriatric diabetics with reference to the duration of hypertension and creatinine clearance (Crcl).Methods: In this observational study, patients with type 2 diabetes mellitus were grouped into geriatric (age ≥60 ye...
Article
Background: Malaria continues to be a devastating disease in India and Mangaluru is endemic to malaria. The success of malaria control programmes has been directly proportional to the awareness in the community; hence this study has been conducted to assess patients’ knowledge, attitude and practices towards the disease and its prevention. Methodol...
Article
Background & Objective: Bacopa Monnieri (BM) is known to have general anxiolytic properties. However, its possible anxiolytic effect in ethanol withdrawal induced anxiety is not yet identified. This study was done to evaluate the effect of BM on ethanol-induced anxiolysis and withdrawal anxiety in Wistar rats. Methods: A total of 126 rats were incl...
Article
Full-text available
This study aimed to assess the health literacy (HL) of patients having diabetes mellitus, their understanding of prescription instructions (PI), and the correlation between HL and understanding of PI. A cross-sectional survey was conducted in 263 adult diabetic patients who were assessed for their understanding of route of intake of the prescribed...
Article
Aim: To evaluate the clinical and microbiological profile of diabetic foot ulcer patients admitted to a tertiary care hospital. Methodology: This study recruited 120 diabetic foot ulcer patients of all grade. Their medical records were evaluated retrospectively. Results: We found that median age of patient was 60(52, 67.75) years. 68.3% of pat...
Article
Aim: To develop and validate Health Related Quality of Life Questionnaire in Diabetic Foot Ulcer Patients (HRQLQDFU) for Indian scenario. Materials and methods: This study was conducted in two phases. First phase was Development of HRQLQDFU which included literature search and expert interview. Second phase was validation of HRQLQDFL which inclu...
Article
Introduction: India is a rich source of medicinal plants used therapeutically to treat various disorders including depression. This study was undertaken to evaluate the antidepressant effect of acute and chronic administration of Punica granatum (pomegranate) whole fruit in mice. Methods: We used the aqueous extract of Punica granatum (250 and 500...
Article
Objectives: The present study was undertaken to evaluate anxiolytic effect of Camellia sinensis (CS) and possible mechanism on acute and chronic administration in rats. Materials and Methods: Eight groups of rats with six in each group were used. Group I served as control. Group II received diazepam (1 mg/kg). Groups III, IV, and V received CS in d...
Article
Full-text available
Introduction: Despite theavailability of numerous antidepressant drugs the therapy of depression is far from satisfactory. Two of the many reasons for this are the delay in onset of effect and the adverse effects associated with most of the antidepressants. Costus speciosus rhizome has shown adaptogenic activity. Objective: To evaluate the antidepr...
Article
Objective: To evaluate anti-inflammatory activity of bioenhanced turmeric formulation (BCM-95) compared to commercial Curcumin formulation (Curcuminoids 95%) in Carrageenan-induced acute inflammatory model. Materials and Methods: Thirty six Wistar rats were divided into six groups-Normal control (2 ml of vehicle), Standard control (Indomethacin 10...
Article
Topical honey has been used for the treatment of wound since ancient time. But the medical evidence proving it is limited. Hence a systematic review was planned. An exhaustive literature search was done in PUBMED, COCHRANE, GOOGLE using 'topical honey', 'diabetic foot ulcer', 'chronic wounds' as key words. Literature search showed total of five cli...
Article
Full-text available
Objective: This study is planned to examine the possible beneficial effect of chronic administration of melatonin on ethanol drinking in rat models chronic voluntary ethanol consumption. Methods: Intermittent access 10% ethanol two-bottle-choice drinking paradigm was employed in 4 groups of rats where the rats had access to ethanol on alternate day...
Article
T. terrestris commonly known as Gokshura, Gokharu or Puncture vine belongs to the family Zygophyllaceae, widely distributed throughout India and traditionally it is used for treatment of many infectious diseases. Present study was designed to evaluate the effect of T. terrestris dry fruit extract in diabetes induced cognitive dysfunction. Diabetes...
Article
Background: Studies have shown the prevalence of micronutrient insufficiency in HIV patients. Decreased plasma levels of pyridoxine, Vitamins B12, A, and E, and zinc have been correlated with significant alterations in immune response and cognitive functions. Serum pyridoxine levels in different subgroup of HIV patients are not well studied. Object...
Article
Full-text available
Introduction: Hypertension is a major public health problem in India and worldwide. Since hypertension is often asymptomatic, it commonly remains undetected, leading to serious complications if untreated. Hypertension is one of the leading causes of end stage renal disease. It doubles the risk of developing coronary artery disease, increases the ri...
Article
The objective of this study is to compare and evaluate the clinical profile of geriatric and nongeriatric diabetic patients. This is a cross-sectional study conducted in a tertiary care teaching hospital. Patients with type 2 diabetes mellitus were grouped into geriatric (age ≥ 60 years) and nongeriatric (age P = 0.0001). There was a significant di...
Article
Full-text available
This study was conducted to estimate the cost of medications and polypharmacy in elderly with cardiovascular disorders. A retrospective cross-sectional study was conducted for six months in the outpatient department of a tertiary care hospital. The medical records of patients ≥ 60 years with cardiovascular diseases were reviewed. Demographic data a...
Article
Haloperidol, an antipsychotic drug, leads to the development of a behavioural state called catalepsy, in which the animal is not able to correct an externally imposed posture. In the present study we have attempted to evaluate the anticataleptic effect of Tribulus terrestris on haloperidol-induced catalepsy in albino mice. Mice were allocated to fo...
Article
Background: Hypertension is more common in diabetics than in non-diabetic patients. An aggressive approach to the diagnosis and treatment of hypertension in patients with diabetes is required in order to substantially reduce the incidence of both macro-vascular and micro-vascular complications. The role of diuretics in the treatment of hypertension...
Article
While there are several tools to study learning styles of students, the visual-aural-read/write-kinesthetic (VARK) questionnaire is a simple, freely available, easy to administer tool that encourages students to describe their behavior in a manner they can identify with and accept. The aim is to understand the preferred sensory modality (or modalit...
Article
Objectives: The present study was designed to evaluate the effect of aqueous extract of fruits of Tribulus terrestris on learning and memory in rodents. Materials and Methods: Thirty wistar rats were divided in 5 groups of 6 rats each. Baseline values for the time taken to reach reward chamber (TRC) in the Hebb William Maze and transfer latency (TL...
Article
Full-text available
Mucuna pruriens commonly known as cowhage plant has been claimed to possess various beneficial effects like anti-parkinsonian, anti-tumor, neuroprotective, antioxidant, anti-diabetic and antidepressant activities. Previous studies have reported that Mucuna pruriens contains L-DOPA and 5-hydroxy tryptophan (5-HT) as a major constituent with higher c...
Article
Alocasia macrorrhizos (AM) belongs to the family Araceae, different parts of this plant have shown hepatoprotective, anti-oxidant and anti-inflammatory action. Though it is traditionally used as a diuretic it needs substantial experimental evidence to support this. Hence we aimed to evaluate the diuretic activity of hydroalcoholic extract of leaves...
Article
Costus speciosus is a medicinal herb with various proven pharmacological actions. Traditionally it has been reported to possess diuretic activities which have not yet been scientifically explored. This study attempts to explore the diuretic activity of aqueous-ethanolic extract of the leaves of Costus speciosusin healthy Wistar albino rats. The stu...
Article
Objective: To assess the hepatoprotective and hepatoregenerative activity of Phyllanthusniruri in liver damage caused by long term administration of high doses of thioacetamide. Methods: Sixty, albino wistar male rats weighing 150 - 200g were divided into six groups of ten rats each. The study was conducted in two phases of twelve weeks each. Group...
Article
Objective: To evaluate the antidiabetic drug dosage differences between geriatric and nongeriatric diabetics with reference to duration of disease and creatinine clearance (Crcl). Materials and methods: Prospective study conducted for 6 months in a tertiary care hospital. Patients with type 2 diabetes mellitus were grouped into geriatric (age ≥6...
Article
Full-text available
1. To evaluate and compare the pattern and rationality of prophylactic antimicrobial therapy in elective surgeries. 2. To evaluate and compare the adherence of hospitals to the standard guidelines on prophylactic antimicrobial therapy. A total of 150 patients each from a government hospital (group I), medical college teaching hospital (group II), a...
Article
Full-text available
Objectives: 1. To evaluate and compare the pattern and rationality of prophylactic antimicrobial therapy in elective surgeries. 2. To evaluate and compare the adherence of hospitals to the standard guidelines on prophylactic antimicrobial therapy.
Article
To evaluate the effect of vanillin on the lipid profile of high fat diet induced hyperlipidemia in rats, the hyperlipidemia was induced by feeding cholesterol-rich high fat diet for 45 days in wistar rats of either sex. The reduction in the triglycerides and VLDL-C was significant at 200 & 400 mg/kg dose of vanillin compared to atorvastatin group....
Article
Objectives: To evaluate the acute oral toxicity of VTH pills in wistar rats Methods: The study was conducted in two phases: initial and continuation phase. In the initial phase there were two groups: control and test, with ten rats (5 male and 5 female) in each group. The control group received 2% gum acacia (vehicle) 10mg/kg; the test group receiv...
Article
Full-text available
Objectives: To evaluate the acute oral toxicity of VTH pills in wistar rats Methods: The study was conducted in two phases: initial and continuation phase. In the initial phase there were two groups: control and test, with ten rats (5 male and 5 female) in each group. The control group received 2% gum acacia (vehicle) 10mg/kg; the test group receiv...
Article
Lycium barbarum L. Solanaceae a traditional medicinal plant of China has been accorded a very high safety value. It has been known to possess various benefi cial effects like reducti on of blood glucose and serum lipids in alloxan-induced diabetes models, anti-ageing, immuno-modulating, anti-cancer, anti-fatigue, and male fertility-facilitatory act...
Article
Introduction: Vanillin is one of the primary chemical components of the vanilla bean (Vanilla planifolia). An aphrodisiac is defined as any food or drug that arouses the sexual instinct, induces venereal desire and increases sexual pleasure and performance. Unpublished data claim that vanillin, taken under proper guidance, can help relieve problems...
Article
Full-text available
Objective: To compare the estimated GFR (eGFR) calculated by CG and MDRD formulae and to study the correlation between body mass index (BMI) and eGFR in healthy South Indian men. Material & Methods: Healthy male volunteers were enrolled. eGFR was estimated by CG and MDRD equation and categorized as normal, mild, moderate, severe renal impairment a...
Article
Full-text available
There is growing evidence that statins play a role in many of the central nervous disorders. Though there are studies reporting statins modulate functions of neurotransmitters and receptors involved in mood disorders, little research has been made to evaluate its potential in anxiety disorder where alteration of neurotransmitters is an established...
Article
Recent studies have indicated that angiotensin II [ANG II] might influence platelet activation & coagulation process suggesting prothrombotic activity. Experimental studies have indicated that ANG II is involved in arterial thrombus formation which is considered as a risk factor for adverse cardiovascular events such as MI & stroke. Very limited da...
Article
Full-text available
Men with diabetes mellitus have a significantly higher prevalence of erectile dysfunction than the general population. This study is planned to assess the various aspects of sexual functions like libido, erectile function and ejaculatory function in male with type 2 diabetes mellitus. Fifty male type 2 diabetic patients were included. All the patie...
Article
Background and objectives: Vanilla (Vanilla planifolia), a monocotyledonous orchid, native of Central America, grown for the attractive aroma produced by its fruit is reported to have been used by the Aztec people in Mexico to promote diuresis and purify blood. However a search of literature revealed no scientific data to prove this claim and hence...
Article
Introduction: Currently, there is considerable interest in the development of lipid-lowering agents from natural products. The purpose of this study was to evaluate the hypolipidemic activity of hydroalcoholic extract of leaves of Alocasia macrorrhizos (AM), which is known to have anti-oxidant activity. Materials and Methods: Cholesterol-rich high-...
Article
Full-text available
Dapagliflozin is a promising new drug that targets the so far untapped renal glucose reabsorption. By inhibiting sodium glucose co-transporter-2 (SGLT2) which is mainly localized in the S1 segment of the proximal tubule, Dapagliflozin promotes renal glucose excretion and reduces hyperglycemia in an insulin-independent manner. Dapagliflozin also pro...
Article
Full-text available
Septicemia is a leading cause of mortality in hospitalized patients. The septic response is now a contributing factor in more than 1,00,000 deaths per year in the United States. Incidence of sepsis is increasing due to increase in the risk factors such as comorbid conditions like diabetes mellitus, immunocompromised status of patients etc. Objectiv...
Article
Neuroleptic drugs used in the treatment of schizophrenia and other affective disorders are known to produce extrapyramidal side effects. Catalepsy induced by these drugs in animals has been used as a model for the extrapyramidal side effects associated with antipsychotic agents in human beings. In the present study, we have attempted to evaluate th...
Article
Full-text available
Background: Lecturing to a large group is the usual mode of teaching in most of the dental colleges in India. Only little research has been done to examine the effectiveness of the different teaching styles. Effective teaching is required to produce more efficient dentists and hence an effort was made to compare two different teaching styles among...
Article
Geriatric population in India is on the rise. Cost of pharmacological treatment and drug interactions due to polypharmacy is a concern in elderly population. The study of prescribing pattern helps to make medical care rational and cost effective. Objective of the study was to describe and analyze the profile of prescriptions among geriatric patient...
Article
Diabetes mellitus [DM] is a chronic metabolic disorder that continues to present a major world wide health problem. Many herbal products have been used in an attempt to cure or control DM, since ages. Numerous herbal drugs like Momordica charantia, Tinospora cordifolia, Terminalia cattapa, Melia azadirachta and Syzygium cumini have been used by peo...
Article
Full-text available
Background: Treatment of osteoarthritis aims at reducing pain and improving mobility. NSAIDs are widely prescribed for symptomatic relief despite well-known adverse effects. Paracetamol with its better safety profile is recommended as the initial analgesic of choice. SYSADOA is a generic term used for symptomatic slow acting drugs for osteoarthitis...
Article
Full-text available
Background: Non steroidal anti-inflammatory drugs (NSAIDs) are the most common drugs prescribed the world over. However, they have many adverse effects, especially gastrointestinal toxicity, which is the reason for their frequent co-prescription with gastroprotective agents. Misoprostol has been specifically approved for prevention of NSAID-induced...
Article
Oropharynx is an important site of cancer in India. Global comparison indicates higher incidences in India. Radiotherapy remains an important treatment modality. Efforts to improve loco-regional treatment and prolong survival are areas of focus. Radiosensitizers in hypoxic tumors have shown promise. To study the safety and radiosensitizing efficacy...
Article
Full-text available
The world is facing an explosive increase in the incidence of diabetes mellitus and cost-effective complementary therapies are needed. The effects of Eugenia jambolana, a household remedy for diabetes, were studied. Streptozotocin diabetic female albino Wistar rats weighing 150-200 g (N = 6) were fed E. jambolana seed powder (250, 500 or 1000 mg/kg...

Network

Cited By

Projects

Project (1)
Archived project