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Citations since 2017
3 Research Items
We have engineered the substrate specificity of chymotrypsin to cleave after Asn by high-throughput screening of large libraries created by comprehensive remodeling of the substrate binding pocket. The engineered variant (chymotrypsiN, ChyB-Asn) demonstrated an altered substrate specificity with an expanded preference for Asn containing substrates....
Objective To obtain the comprehensive transcriptome profile of human citrulline‐specific B cells from patients diagnosed with rheumatoid arthritis (RA). Methods Citrulline and hemagglutinin (HA) specific B cells were flow‐sorted using peptide‐streptavidin conjugates from peripheral blood of RA patients and healthy individuals respectively. Transcr...
Although the contribution of B-cell derived autoreactive antibodies to rheumatoid arthritis (RA) has been studied extensively, the autoantibody-independent roles of B cells in the progression of the disease is not well-defined. Here we present the first comprehensive transcriptome profile of human autoreactive B cells in an autoimmune disease by pe...