Shawn Tan

Shawn Tan
EMBL-EBI | EBI

PhD

About

30
Publications
7,013
Reads
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175
Citations
Additional affiliations
September 2016 - present
The University of Hong Kong
Position
  • PhD Student
November 2014 - May 2016
Temasek Life Sciences Laboratory
Position
  • Assistant Research Officer
July 2012 - July 2014
The Florey Institute of Neuroscience and Mental Health
Position
  • Master's Student
Education
September 2016 - September 2020
The University of Hong Kong
Field of study
  • Neuroscience
July 2012 - July 2014
University of Melbourne
Field of study
  • Neuroscience
July 2011 - July 2012
University of Melbourne
Field of study
  • Neuroscience

Publications

Publications (30)
Article
Full-text available
We examined the role of hippocampal metabotropic glutamate receptor 5 (mGlu5) in spatial learning and memory. Although it has been shown that mGlu5 signalling is required for certain forms of learning and memory, its role in spatial learning is unclear since studies using pharmacological or knockout mice models provide inconsistent findings. Additi...
Article
Full-text available
Saffold virus (SAFV) is an emerging human cardiovirus that has been shown to be ubiquitous. Initial studies of SAFV focused on respiratory and gastrointestinal infection; however, it has also recently been associated with diverse clinical symptoms including the endocrine, cardiovascular, and neurological systems. Given the systemic nature of SAFV,...
Article
Full-text available
Saffold Virus (SAFV) is a human cardiovirus that has been suggested to cause severe infection of the central nervous system (CNS). Compared to a similar virus, Theiler's murine encephalomyelitis virus (TMEV), SAFV has a truncated Leader (L) protein, a protein essential in the establishment of persistent CNS infections. In this study, we generated a...
Article
Full-text available
Tetratricopeptide repeat domain 9A (TTC9A) expression is abundantly expressed in the brain. Previous studies in TTC9A knockout (TTC9A−/−) mice have indicated that TTC9A negatively regulates the action of estrogen. In this study we investigated the role of TTC9A on anxiety-like behavior through its functional interaction with estrogen using the TTC9...
Article
Full-text available
Objectives: The involvement of Tetratricopeptide repeat domain 9A (TTC9A) in anxiety-like behaviors through estrogen action has been reported in female mice, this study further investigated its effects on social anxiety and aggressive behaviors. Materials and Methods: Using female Ttc9a knockout (Ttc9a-/-) mice, the role of TTC9A in anxiety was inv...
Article
Full-text available
Background: Given that visual impairment is bi-directionally associated with depression, we decided to examine whether transcorneal electrical stimulation (TES), a non-invasive treatment for visual disorders, can ameliorate depressive symptoms. Objective: The putative antidepressant-like effects of TES and the underlying mechanisms were investiga...
Article
Neuroscience has long sought to develop methods that can "edit" or even "erase" memories , with the aim to provide treatments for memory-related neurological and psychiatric diseases such as anxiety and addiction. Current efforts are heavily focused on modifying cognitive behavio-ral therapy protocols or pharmacological treatments, but the efficacy...
Article
Full-text available
A deficiency in GM3-derived gangliosides, resulting from a lack of lactosylceramide-alpha-2,3-sialyltransferase (ST3GAL5), leads to severe neuropathology, including epilepsy and metabolic abnormalities. Disruption of ganglioside production by this enzyme may also have a role in the development of neuropsychiatric disorders. ST3Gal5 knock-out (St3ga...
Preprint
Full-text available
Large scale single cell omics profiling is revolutionising our understanding of cell types, especially in complex organs like the brain. This presents both an opportunity and a challenge for cell ontologies. Annotation of cell types in single cell 'omics data typically uses unstructured free text, making comparison and mapping of annotation between...
Article
Background and purpose: Anxiety disorders pose one of the biggest threats to mental health worldwide, yet current therapeutics have been mostly ineffective due to issues with relapse, efficacy and toxicity of the medications. Deep brain stimulation (DBS) is a promising therapy for treatment-resistant psychiatric disorders including anxiety, but ve...
Article
Full-text available
The pressures of the ethos of “publish or perish” in academia has led to a multitude of issues for science and scientists. In this paper, we argue that the existentialist philosophy concept of authenticity would be useful for scientists to prevent issues of reproducibility, data manipulation, fraud, and mentorship. We highlight some major caveats a...
Article
Full-text available
An ever-increasing ageing population has elevated Alzheimer's disease to be one of the biggest challenges in modern medicine. Alzheimer's disease is highly complex, and we are still no closer to understanding the causes, let alone an effective treatment. The lack of good experimental models and lack of critical understanding has led to high failure...
Article
Full-text available
Aversive memories underlie many types of anxiety disorders. One area of research to more effectively treat anxiety disorders has therefore been identifying pharmacological targets to affect memory processes. Among these targets, the metabotropic glutamate 5 receptor (mGlu 5) has received attention due to the availability of drugs to utilize its rol...
Preprint
Full-text available
The use of immersive interactive mixed reality (IMR) technologies has been of interest to educators due to the rapid advancement of technology, lowered cost, and increased engagement of the senses. This is particularly attractive in special needs education (SNE) as it can provide a safe space in which students can learn and practice skills needed i...
Article
Full-text available
Background: Recent advancements in neuroscientific techniques have allowed us to make huge progress in our understanding of memories, and in turn has paved the way for new memory modification technologies (MMTs) that can modulate memories with a degree of precision, which was not previously possible. With advancements in such techniques, new and cr...
Article
Full-text available
Electrical stimulation of the dorsolateral periaqueductal gray (dlPAG) in rats has been shown to elicit panic-like behaviour and can be a useful tool for modelling anticipatory fear and agoraphobia. In this study, we further analysed our previous data on the effects of escitalopram (a selective serotonin reuptake inhibitor, SSRI) and buspirone (a 5...
Article
Full-text available
Neuromodulation techniques such as Deep Brain Stimulation (DBS) are a promising treatment for memory-related disorders including anxiety, addiction, and dementia. However, the outcomes of such treatments appears to be somewhat paradoxical, in that these techniques can both disrupt and enhance memory even when applied to the same brain target. In th...
Article
Dementia poses major health challenges worldwide, yet current treatments are faced with issues of efficacy and toxicity. Deep brain stimulation (DBS) is a promising non-pharmacological treatment for dementia, but most DBS studies use young healthy animals, which may not be aetiologically relevant. In this study, we used an aged rat model in which c...
Preprint
Full-text available
Neuromodulation techniques such as Deep Brain Stimulation (DBS) are a promising treatment for memory-related disorders including anxiety, addiction, and dementia. However, the outcome of these treatments appears to be paradoxical, as the use of these techniques can both disrupt and enhance memory even when applied to the same brain target. In this...
Article
Full-text available
Deep brain stimulation (DBS) is a promising treatment for many memory-related disorders including dementia, anxiety, and addiction. However, the use of DBS can be a paradoxical conundrum-dementia treatments aim to improve memory, whereas anxiety or addiction treatments aim to suppress maladaptive memory. In this review, the key hypotheses on how DB...
Preprint
Full-text available
Background Electrical stimulation of the dorsolateral periaqueductal gray (dlPAG) in rats has been shown to elicit panic-like behaviour and can be a useful tool for modelling anticipatory fear and agoraphobia. Methods In this study, we further analysed our previous data on the effects of escitalopram (a selective serotonin reuptake inhibitor, SSRI...
Preprint
Full-text available
Anxiety disorders pose one of the biggest threats to mental health worldwide, yet current therapeutics have been mostly ineffective due to issues with relapse, efficacy, and toxicity. Deep brain stimulation (DBS) is a promising therapy for treatment-resistant psychiatric disorders including anxiety, but very little is known about the effects of DBS...
Article
Anxiety disorders pose one of the greatest threats to mental health. Modern treatment methods exist but are hindered by relapse, toxicity, and low efficacy. The use of neuromodulation to treat anxiety disorders has shown promising results, yet its underpinning mechanisms remain poorly understood. In this review, we make the case for further develop...
Article
It is well accepted that it is part of a scientist’s duty to communicate science, yet most practicing scientists lack the training and opportunity to do so. In this article, we use the framework of science talks in bars to highlight the importance of locality and environment. We propose that science communication programs should be developed around...
Article
Full-text available
Background Saffold Virus (SAFV) is a human cardiovirus that is suspected of causing infection of the central nervous system (CNS) in children. While recent animal studies have started to elucidate the pathogenesis of SAFV, very little is known about the mechanisms behind it. Method In this study, we attempted to elucidate some of the mechanisms of...
Article
Full-text available
The metabotropic glutamate receptor 5 (mGlu5) and N-methyl-d-aspartate (NMDA) receptor are critical for processes underlying synaptic plasticity, such as long-term potentiation. mGlu5 signaling increases neuronal excitability and potentiates NMDA receptor currents in the amygdala and the hippocampus. The present study examined the involvement of mG...
Article
Osmoregulated periplasmic glucans (OPGs) are major periplasmic constituents of Gram-negative bacteria. The role of OPGs has been postulated in symbiotic as well as pathogenic host-microorganism interactions. Here, we report the role of OPGs from Salmonella enterica serovar Typhimurium during growth and biofilm formation in leafy-green vegetable was...

Questions

Questions (2)
Question
So I'm interested in how my treatment affects downstream activation of neurons in the hippocampus and am thinking of running co-localisation of c-fos with a marker for excitatory neurons and inhibitory neurons. Was wondering if there are "gold standard" markers? Have been thinking of using vGluT1 for excitatory, and Parvalbumin for inhibitory - is this actually representative?
Question
Our lab just obtained some 5XFAD Het mice that we plan to use. Our plan is to use WT, Hets, and Homozygous animals and was wondering if anyone had a better way to genotype them besides using real-time PCR (which is really expensive). Anyone has any primers suggestions that we can use for normal PCR?

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