Shaum ShiyanUniversitas Sriwijaya | UNSRI · Pharmacy
Shaum Shiyan
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23
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Publications
Publications (23)
Clindamycin HCl has anti-acne properties because it can inhibit the growth of Propionibacterium acnes (P. acnes) bacteria. However, the bioavailability of clindamycin HCl is less than 13% of the given dose, so it needs to be developed in the form of ethosomes to increase its bioavailability. This study aimed to create a clindamycin HCl ethosomal ge...
Gaya hidup kurang gerak dikombinasikan dengan asupan kalori yang berlebihan menghasilkan penyimpanan energi ekstra sebagai lemak. Prevalensi sindrom metabolik diperkirakan akan berkembang secara substansial dalam skala global. Pasien dengan sindrom metabolik memiliki resiko terkena stroke 3-4x lebih besar. Sebanyak 34% penduduk di Ulak Kerbau Baru...
Clindamycin HCl is a drug for the treatment of acne. Clindamycin can act as an anti-acne by interfering with bacterial protein synthesis. The concentration of clindamycin used in the treatment of acne is 1%. Still, the bioavailability of the drug in the serum only reaches 0.7 – 12.4% of the total active substance in the preparation, so it is necess...
Gambir leaf (Uncaria gambir Roxb) has potential as an antidiabetic through the inhibition of α-glucosidase and amylase enzymes. However, natural extracts have disadvantages such as solubility, stability, and bioavailability. Therefore, gambir leaf extract was formulated to be self-nano emulsifying (GE-SNE) with several different concentrations of c...
The use of immunomodulators is one strategy in maintaining the immune system during the Covid-19 pandemic. Sungkai leaf extract from Peronema canecens keeps the immune system in good shape. Therefore, in this study, we formulated a self-emulsifying loaded sungkai leaves extract (SE-SLE) with oleic acid and virgin coconut oil (VCO) oil phases, span...
PULAU SEMAMBU VILLAGE COVID 19 PREVENTION TRAINING ON LOCAL AGRICULTURAL HEALTH DRINK. The growing epidemic of COVID-19 poses a significant problem for the government and the population. Among the several measures used to avoid infection is the consumption of nutritious meals and beverages that boost the body’s immunity. Based on the results of the...
Introduction : Phyllanthus niruri L. (PnL) is a herbaceous plant containing flavonoid quercetin and can be used as an immunomodulator to prevent Covid-19. However, the flavonoid content and yield of herbs extract were not maximized. Therefore, PnL herbs were planted in various harvest periods and application of NPK-chitosan nanopolymer fertilizer t...
Latar Belakang: Jeruk lemon banyak digunakan sebagai bahan makanan atau mimuan, obat-obatan, kosmetik, deterjen dan aromaterapi. Lemon kaya dengan kandungan senyawa yang berpotensi dapat digunakan sebagai alternatif pengobatan, diantaranya adalah glikosida flavonoid, kumarin, β dan ɤ-sitosterol, dan senyawa volatil. Tujuan: Untuk membahas profil fi...
The optimization approach using the simplex lattice design (SCD) has many advantages, including a minimized number of experiments and a good description of the interactions between components. However, modeling with the SCD approach has not evaluated between responses. Therefore, this study aims to apply chemometric analysis to evaluate the respons...
In this study, self-emulsifying method was applied to formulate the Centella asiatica L. urban extract (CeCa). The presence of groups in the extract was established on the basis of FTIR-ATR spectra using a chemometric approach. Further, the super saturable-CeCa-self micro emulsifying (SS-CeCa-SME) extracts were formulated using an oleic acid carrie...
Quercetin is formulated in a super saturable - self-nano emulsifying (SS-SNE) to increase its stability and bioavailability. This study focuses on the screening design for SS-SNE components with a fractional factorial design (FrFD) approach and chemometric analysis. The FrFD method was chosen because it provides comprehensive benefits. The oil comp...
Latar Belakang: Akar tunjuk langit (Helminthostachys Zeylanica (L) Hook) merupakan salah satu obat tradisional yang banyak di gunakan oleh masyarakat di berbagai wilayah di Indonesia, senyawa yang terkandung dalam Akar Tunjung Langit di antara lain salah satunya flavonoid, memiliki potensi sebagai obat anti inflamasi, anti hiperurisemia dan anti ka...
Objective: This study aims to increase the solubility of simvastatin (SIM), a hydrophobic drug, by incorporating it into PCL-PEG-PCL triblock copolymer micelles and validating the assay method used, namely Uv-Vis spectrophotometric. Methods: The shake flask method was used to determine the increase in solubility experienced by SIM after being incor...
Catechins are isolated from tea leaves and shown to have pharmacological activities. However, the permeability and absorption capacity of the digestive tract is low, thus affecting the value of bioavailability. Self-nano emulsifying drug delivery system (SNEDDS) is formulated as a breakthrough in nano delivery to increase the value of bioavailabili...
Ibuprofen is a non-steroidal anti-inflammatory drug that has a disadvantage in its oral use, such as gastrointestinal disorders, nausea, vomiting and gastric ulcers. Transdermal patch dosage forms are an alternative in overcoming this weakness. The transdermal patch is formulated using a special membrane that can control drug release in a matrix sy...
Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) class of drugs, and oral use can cause side effects. Transdermal patch dosage forms are useful for minimizing side effects on oral administration. Transdermal patches are formulated using a special membrane that can control drug release in the matrix system. This study was intended to dete...
Objective: This research aimed to find modeling and optimization of a novel kinetic-assisted infundation for rich-epigallocatechin gallate (EGCG) and polyphenols extraction from white tea leaf (Camellia sinensis L.).Methods: The optimal conditions for the best extraction of kinetic-assisted infundation were determined using central composite design...
Objective: Red cabbage (Brassica oleracea L. var. Capitata f. rubra) has a fairly high anthocyanin content and is a source of powerful antioxidants. This study is basic for the development of a nutraceutical, which has nephroprotective activity.Methods: Red cabbage was extracted using ethanol and water with a mixture of citric acid with a variation...
Daun kopi robusta (Coffea canephora) memiliki potensi sebagai agen antioksidan dan antidiabetes karena kandungan senyawa fenolik yang melimpah. Penelitian ini bertujuan untuk mengetahui potensi ekstrak etanolik daun kopi robusta (EEDK) terhadap penurunan kadar glukosa darah. Hewan uji dibagi menjadi kelompok normal, kontrol negatif (NaCMC 0,5%), ko...