
Sharath Burugina NagarajaESIC Medical College and PGIMSR, Rajajinagar, Bangalore · Community Medicine
Sharath Burugina Nagaraja
MBBS, MD
About
254
Publications
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Introduction
Sharath BN is deeply committed to advancing public health research, with a primary emphasis on tuberculosis, HIV, and diabetes. His research endeavors are centered on addressing programmatic challenges and devising practical solutions to enhance the quality of care services through operational research. He advocates for the empowerment of professionals through mentorship programs, fostering the capacity to conduct and disseminate impactful research.
Publications
Publications (254)
The global health crisis triggered by the SARS-CoV-2 in 2019, known as the COVID-19 pandemic, prompted vaccination drives worldwide, including in India, to address the crisis. However, vaccine hesitancy remains a significant challenge to achieving vaccination goals. Hence, we conducted a systematic review and meta-analysis during 2021-2023 to estim...
Background: Air pollution has been a global environmental concern, and its effects on human health in the past have played an important role. Thus, this study investigated the concentrations of particulate matter (PM10, PM2.5), nitrogen dioxide (NO2), sulfur dioxide (SO2), and carbon monoxide (CO) in four distinct areas of Bengaluru over one year....
Introduction
The WHO has now declared COVID-19 as endemic and it may be prudent to identify high-risk patients requiring reverse transcriptase-polymerase chain reaction (RT-PCR). During the pandemic, RT-PCR testing and reporting were running around-the-clock. We attempted to validate this scoring system and predict high probable in the obstetric su...
Background: Tuberculosis (TB) patients often experience depressive and anxiety symptoms, which can significantly impact their quality of life, treatment adherence, and outcomes. Understanding the magnitude of these mental health issues is crucial for improving TB programs and achieving successful treatment outcomes. Materials and Methods: We conduc...
Tuberculosis remains a significant global health challenge, with millions of new cases reported annually. Recent studies suggest that expanding the accessibility of TB intervention programs can lead to a substantial decrease in both TB incidence and prevalence. This paper initiates by examining a deterministic mathematical model for TB transmission...
Background: India introduced fractional-dose inactivated poliovirus vaccine (fIPV) into its routine immunization
program as part of the polio eradication and endgame strategic plan. The study aimed to assess the uptake of the 3rd
dose of fIPV among eligible beneficiaries and explore the implementation challenges perceived by auxiliary nurse
midw...
Background
Estimates of demographic metrics are crucial to assess levels and trends of population health outcomes. The profound impact of the COVID-19 pandemic on populations worldwide has underscored the need for timely estimates to understand this unprecedented event within the context of long-term population health trends. The Global Burden of D...
[This corrects the article DOI: 10.1371/journal.pone.0234651.].
This study aimed to investigate the rate of occurrence of pyrazinamide (PZA) resistance among patients with MDR-TB from the clinical specimens submitted to a referral centre in Bengaluru, Karnataka. PZA has been used for almost 50 years as first line drug for short course chemotherapy against MTB and its inclusion has significantly shortened the tr...
The WHO’s “End TB” initiative aims to reduce catastrophic expenses, incidence, and mortality by 90%, 80%, and 0%,
respectively by 2030 and Government of India has committed to reaching these goals by 2025. Despite tremendous
progress, tuberculosis (TB) remains one of the main public health issues. To limit TB transmission and expedite
reduction in...
Socioeconomic status (SES) is evaluated by considering a family's income, level of education, and occupation of head of household. SES serves as significant indicator of the family's overall health and their access to resources. Modified Kuppuswamy scale is among the most used tools to assess SES of urban residents, but it necessitates regular upda...
Background: The study aimed to evaluate the implementation status of the National Tuberculosis Elimination Program (NTEP) at medical colleges in Karnataka, India, and identify the challenges encountered by the medical college core committee members. Methods: A cross-sectional study was conducted among 14 medical colleges in 2019-20, using a pre-tes...
Introduction: The study aimed to evaluate the effectiveness of screening pediatric household contacts (under the age of 15 years) for tuberculosis (TB) in India through verbal screening, tuberculin skin testing, and chest radiography at intervals of 0, 3, 6, 9, and 12 months. The study also aimed to determine the proportion of contacts who tested p...
Introduction
The study aimed to evaluate the effectiveness of screening pediatric household contacts (under the age of 15 years) for tuberculosis (TB) in India through verbal screening, tuberculin skin testing, and chest radiography at intervals of 0, 3, 6, 9, and 12 months. The study also aimed to determine the proportion of contacts who tested po...
Background: Thyroid dysfunction (TD) is considered a common cause of secondary hypertension (HT). Therefore, correcting TD may help in quicker and sustained achievement of desired blood pressure goals. However, there is a paucity of literature from India which estimates the relationship of HT with TD.
Objectives: The objective of the study was to...
Background: Extra-pulmonary tuberculosis (EPTB) remains a major problem in developing countries, which acquire diagnostic and management challenges. The study was conducted to characterize the diagnosed EPTB cases, and to understand the perspectives of clinicians on diagnosis and challenges in its management. Methods: A total of 150 EPTB patients'...
Background: The mid-day meal scheme (MDMS) in India is the world’s largest free school lunch program. In 2021, the scheme was renamed as PM-POSHAN (Pradhan Mantri Poshan Shakthi Nirman). We conducted a study to quantify the routine daily dietary intake of school children with reference to calorie and protein intake and assess the proportion of calo...
Pediatric tuberculosis is a major cause of mortality and morbidity in children due to high transmission, poor diagnostic tools, and various respiratory diseases mimicking TB. Identifying risk factors will provide evidence for clinicians to strongly relate their diagnosis to the associated pathology. Studies were retrieved from PubMed, Embase, and G...
Background
Government of India is committed to eliminate tuberculosis by 2025 under National Tuberculosis Elimination Program which provides free investigations and treatment as well as incentives for nutritional support during their treatment course.Many tuberculosis patients prefer to seek treatment fromthe private sector which sometimes leads to...
Background
Universal access to safe drinking water and sanitation facilities is an essential human right, recognised in the Sustainable Development Goals as crucial for preventing disease and improving human wellbeing. Comprehensive, high-resolution estimates are important to inform progress towards achieving this goal. We aimed to produce high-res...
Background:
Hypertension in women of reproductive age group is of special concern because of the vulnerability of women to pregnancy-induced hypertension apart from socio-cultural vulnerability.
Aim:
The objective of the study was to identify the predictors for hypertension among Indian women and to develop a risk score which would provide an op...
Background
More than 3 billion people do not have access to clean energy and primarily use solid fuels to cook. Use of solid fuels generates household air pollution, which was associated with more than 2 million deaths in 2019. Although local patterns in cooking vary systematically, subnational trends in use of solid fuels have yet to be comprehens...
(1) Background: Rational use of medicines (RUM) and their assessment are important to ensure optimal use of resources and patient care in hospitals. These assessments are essential to identifying practice gaps for quality improvement. (2) Methods: Assessment of adherence to WHO/International Network for Rational Use of Drugs core prescribing indica...
Background: Rational use of medicines (RUM) and their assessment are important to ensure optimal use of resources and patient care in hospitals. These assessments are essential to identifying practice gaps for quality improvement.
Methods: Assessment of adherence to WHO/International Network for Rational Use of Drugs core prescribing indicators amo...
(1) Background: Rational use of medicines (RUM) and their assessment is important to ensure optimal use of resources and patient care in hospitals. These assessments are essential to identifying practice gaps for quality improvement. (2) Methods: Assessment of adherence to WHO/ International Network for Rational Use of Drugs core prescribing indica...
Background:
Monitoring of antibiotic prescription practices in hospitals is essential to assess and facilitate appropriate use. This is relevant to halt the progression of antimicrobial resistance.
Methods:
Assessment of antibiotic prescribing patterns and completeness of antibiotic prescriptions among out-patients in 2021 was conducted at the U...
Due to the coronavirus disease (COVID-19) pandemic and its associated response, TB deaths increased for the first time in a decade. In any potentially fatal illness, an assessment of severity is essential. This is not systematically done for adults with TB, mostly due to a lack of policy and/or limited availability of diagnostic and clinical capaci...
Problem considered
Directly Observed Treatment (DOT) has been the cornerstone for favourable outcomes in Tuberculosis treatment. Hitherto, the role of Diabetic DOT for TB-DM patients has not been explored in the present times when TB-DM dual epidemic has grown by significant proportions. The study aims to know the treatment outcomes in TB-DM patien...
Objectives
We verified subnational (state/union territory (UT)/district) claims of achievements in reducing tuberculosis (TB) incidence in 2020 compared with 2015, in India.
Design
A community-based survey, analysis of programme data and anti-TB drug sales and utilisation data.
Setting
National TB Elimination Program and private TB treatment sett...
Background: Monitoring of antibiotic prescription practices in hospitals is essential to assess and facilitate appropriate use. This is relevant to halt the progression of antimicrobial resistance. Methods: Assessment of antibiotic prescribing patterns and completeness of antibiotic prescriptions among out-patients in 2021 was conducted at the Univ...
Objectives: We verified subnational (state/union territory (UT)/district) claims of achievements in reducing tuberculosis (TB) incidence in 2020 compared with 2015, in India.
Design: A community-based survey, analysis of programme data and anti-TB drug sales and utilisation data.
Setting: National TB Elimination Program and private TB treatment se...
Objectives
To use data from the Global Burden of Diseases, Injuries, and Risk Factors Study 2019 (GBD 2019) to estimate mortality and disability trends for the population aged ≥70 and evaluate patterns in causes of death, disability, and risk factors.
Design
Systematic analysis.
Setting
Participants were aged ≥70 from 204 countries and terri...
India launched a national community-based active TB case finding (ACF) campaign in 2017 as part of the strategic plan of the National Tuberculosis Elimination Programme (NTEP). This review evaluated the outcomes for the components of the ACF campaign against the NTEP’s minimum indicators and elicited the challenges faced in implementation. We suppl...
Setting:
Patan Hospital, Lalitpur, Nepal.
Objectives:
To describe 1) the prevalence of methicillin-resistant Staphylococcus aureus (MRSA) and its antibiotic sensitivity pattern; 2) the demographic and clinical characteristics associated with MRSA infections; and 3) the treatment outcomes of in-patients with MRSA infection among patients with S....
BACKGROUND: Documentation of patterns and long-term trends in mortality in young people, which reflect huge changes in demographic and social determinants of adolescent health, enables identification of global investment priorities for this age group. We aimed to analyse data on the number of deaths, years of life lost, and mortality rates by sex a...
Anemia is a globally widespread condition in women and is associated with reduced economic productivity and increased mortality worldwide. Here we map annual 2000–2018 geospatial estimates of anemia prevalence in women of reproductive age (15–49 years) across 82 low- and middle-income countries (LMICs), stratify anemia by severity and aggregate res...
Background
Documentation of patterns and long-term trends in mortality in young people, which reflect huge changes in demographic and social determinants of adolescent health, enables identification of global investment priorities for this age group. We aimed to analyse data on the number of deaths, years of life lost, and mortality rates by sex an...
Background
Tuberculosis is a major contributor to the global burden of disease, causing more than a million deaths annually. Given an emphasis on equity in access to diagnosis and treatment of tuberculosis in global health targets, evaluations of differences in tuberculosis burden by sex are crucial. We aimed to assess the levels and trends of the...
Background: In India, challenges in pediatric TB contact screening and chemoprophylaxis
initiation are still underexplored. Elucidating these challenges will help in better implementation of the programme at the grass-roots level thereby helping in early detection of pediatric cases and timely initiation of preventive therapy. This study aimed at e...
Background: In India, challenges in pediatric TB contact screening and chemoprophylaxis
initiation are still underexplored. Elucidating these challenges will help in better implementation of the programme at the grass-roots level thereby helping in early detection of pediatric cases and timely initiation of preventive therapy. This study aimed at e...
Background
Sustainable Development Goal 3.2 has targeted elimination of preventable child mortality, reduction of neonatal death to less than 12 per 1000 livebirths, and reduction of death of children younger than 5 years to less than 25 per 1000 livebirths, for each country by 2030. To understand current rates, recent trends, and potential traject...
This study aims to assess private and public sector contributions to Tuberculosis (TB) notification in Bengaluru city (2011 to 2016) and identify challenges of program personnel in their interaction with private practitioners and procedural barriers for TB notification from the private sector as perceived by them. A mixed methods study was carried...
The policy documents at workplace of any organization or an industry, provides a framework and specific guidelines to protect
the health and safety of the human resources associated in it either through fixed term period or on temporary basis. These
documents help to reduce the risk of the workplace accidents or diseases (preventive measures). In o...
Background
Data sparsity is a major limitation to estimating national and global dementia burden. Surveys with full diagnostic evaluations of dementia prevalence are prohibitively resource-intensive in many settings. However, validation samples from nationally representative surveys allow for the development of algorithms for the prediction of deme...
Introduction:
Dementia is currently one of the leading causes of mortality globally, and mortality due to dementia will likely increase in the future along with corresponding increases in population growth and population aging. However, large inconsistencies in coding practices in vital registration systems over time and between countries complica...
Background: the nation-wide lockdown due global pandemic has disrupted a vital strategic intervention resulting in overall 60% decrease in presumptive and diagnostic TB cases during the lockdown period.Methods: A discrete choice experimental (DCE) exploratory operational research conducted during March to May 2020.Results: Health care services were...
Globally, cancer is emerging as a major public health problem. Monoclonal antibodies are extensively used for cancerous conditions at tertiary hospitals. Many of these are not easily available for patients seeking treatment from public sector. It is difficult for poor patients to afford these drugs on individual basis.
The aim of our study is to ca...
Background. Informal (unqualified) health care providers are an important source of medical care for persons with presumptive TB (PPTB) in India. A project (titled RIPEND) was implemented to engage informal providers for the identification of PPTBs and TB patients in 4 districts of Telangana State, India, during October 2018-December 2019 project p...
Due to limited availability of diagnostics and capacity, people with tuberculosis do not always undergo systematic assessment for severe illness (requiring inpatient care). In Karnataka (south India), para-medical programme staff used a screening tool to identify people at ‘high risk of severe illness’, defined using indicators of very severe under...
Background
High-resolution estimates of HIV burden across space and time provide an important tool for tracking and monitoring the progress of prevention and control efforts and assist with improving the precision and efficiency of targeting efforts. We aimed to assess HIV incidence and HIV mortality for all second-level administrative units across...
This is a supplementary material for the article entitled "Measuring universal health coverage based on an index of effective coverage of health services in 204 countries and territories, 1990–2019"
COVID-19 is an emerging viral disease affecting more than 200 countries worldwide and it present with varied clinical profile throughout the world. Without effective drugs to cure COVID-19, early identification and control of risk factors are important measures to combat COVID-19. This study was conducted to determine the clinical profile and risk...
Background:
India implements universal drug susceptibility testing (UDST) using rapid genotypic tests (cartridge-based nucleic acid amplification test CBNAAT - and line probe assay - LPA). to bridge the gap of diagnosis of multidrug/rifampicin-resistant TB. There is limited evidence assessing the implementation of UDST in India. We assessed the im...
Setting
Five select districts of Karnataka, India, providing anti-tubercular and antiretroviral therapy (ATT and ART) to people with Human Immunodeficiency Virus (HIV) - associated Tuberculosis (TB) through a single window care approach at the ART centres (seven ART centres and 16 link ART centres).
Objectives
To determine the factors associated w...
Introduction
The mycobacterium tuberculosis complex (MTBC) has highly clonal population structure which made the organism spread globally mirroring human migration out of Africa and resulted in the formation of seven lineages. We conducted this study to determine the proportion of spoligotype lineages and drug susceptibility profile of Mycobacteriu...
Background
Early and accurate diagnosis followed by timely treatment are the key prerequisites to fight tuberculosis (TB) and reduce its global burden. Despite scientific advances, the rapid and correct diagnosis of both pulmonary and extrapulmonary tuberculosis remains a challenge due to traditional reliance on detection of the elusive bacilli. My...
Summary
Background Many causes of vision impairment can be prevented or treated. With an ageing global population, the demands for eye health services are increasing. We estimated the prevalence and relative contribution of avoidable causes of blindness and vision impairment globally from 1990 to 2020. We aimed to compare the results with the World...
The safe, highly effective measles vaccine has been recommended globally since 1974,
yet in 2017 there were more than 17 million cases of measles and 83,400 deaths in
children under 5 years old, and more than 99% of both occurred in low- and
middle-income countries (LMICs)1–4. Globally comparable, annual, local estimates of
routine first-dose measl...
Objectives
The Medical Council of India has introduced competency based medical education (CBME) for all the undergraduate medical students across the country. We conducted this study to assess the impact of new curriculum on students’ performance and the differential time utilization of the teaching faculty.
Materials and Methods
It is a cross-se...
Background: A large proportion of people with hypertension do not take medications regularly. There is little understanding of this complex behaviour in India.
Methods: A descriptive qualitative study was conducted in two districts of Andhra Pradesh, India, to explore the reasons for irregular intake of anti-hypertensive drugs from patient’s and he...
Background
Achieving universal health coverage (UHC) involves all people receiving the health services they need, of high quality, without experiencing financial hardship. Making progress towards UHC is a policy priority for both countries and global institutions, as highlighted by the agenda of the UN Sustainable Development Goals (SDGs) and WHO's...