Sharath Babu

• bhaskara

Background: Avoralstat is a potent small-molecule oral plasma kallikrein inhibitor under development for treatment of hereditary angioedema. This first-in-human study evaluated the safety, tolerability, pharmacokinetics, and pharmacodynamics of avoralstat. Methods: This double-blind, placebo-controlled, ascending-dose cohort trial evaluated avor...

Foodborne Listeria monocytogenes (LM) causes serious illness & death every year in the US. Ingestion of LM can lead to septicemia, meningitis, & abortion. IL17 is secreted by T cells and regulates the production of CXC chemokines for monocyte and neutrophil recruitment to infected tissue. Foodborne LM infection occurs through the oral route, but mi...

The bacteriocidal effects of silver mixtures are well characterized and as a consequence they are used worldwide in many food contact substances. However, the long-term effect of silver ion exposure on the developing immune system has not been well studied. In this study, 50 d old male and female rats were exposed to 0.4, 4 or 40 mg/Kg body weight...

Scrub typhus and leptospirosis are both zoonosis and systemic febrile illnesses with diverse clinical manifestations and they may present with similar signs and symptoms. We present a case of co-infection of scrub typhus and leptospirosis from Himachal Pradesh in the Himalayan region of India.

We present a new class of unified SO(10) models where the GUT symmetry breaking down to the standard model gauge group involves just one scale, in contrast to the conventional SO(10) models which require two scales. Further, the models we discuss possess a natural doublet-triplet splitting via the missing partner mechanism without fine tuning. Such...

Scrub typhus, a zoonosis, is a systemic febrile illness with diverse clinical manifestations. It may also present with signs and symptoms of acute abdomen. We present two serologically confirmed cases of scrub typhus presenting with acute abdomen that were managed conservatively with antibiotics.

With the continued threat of morbidity and mortality from influenza and the development of resistance to influenza antiviral drugs, there is increasing interest in new treatments, such as the investigational intravenous drug peramivir, and in combination treatments. In this study, we determined the impact of oseltamivir carboxylate on the binding a...

New and emerging influenza virus strains, such as the pandemic influenza A (H1N1) virus require constant vigilance for antiviral drug sensitivity and resistance. Efficacy of intramuscularly (IM) administered neuraminidase (NA) inhibitor, peramivir, was evaluated in mice infected with recently isolated pandemic A/California/04/2009 (H1N1, swine orig...

Efficacy of combination of the intramuscularly administered neuraminidase (NA) inhibitor, peramivir, and the orally administered M2 ion channel blocker, rimantadine was evaluated in mouse influenza A/Victoria/3/75 (H3N2) model. Mice were challenged with a sub-lethal virus dose (0-40% mortality in placebo group) and changes in body weights were anal...

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

We present a class of realistic unified models based on supersymmetric SO(10) wherein issues related to natural doublet-triplet (DT) splitting are fully resolved. Using a minimal set of low dimensional Higgs fields which includes a single adjoint, we show that the Dimopoulos-Wilzcek mechanism for DT splitting can be made stable in the presence of a...

This study was conducted to compare growth performance, gut morphometry, and parameters of local and systemic immunity in broiler chickens fed for 22 consecutive days with a diet supplemented with Bacillus spp. as direct-fed microbials (DFM), a commercial product incorporating 3 DFM, or a nonsupplemented diet. Direct-fed microbials did not signific...

We show that in supersymmetric models with gauged B−L symmetry, there is a new source for cosmological lepton asymmetry. The Higgs bosons responsible for B−L gauge symmetry breaking decay dominantly into right-handed sneutrinos and producing an asymmetry in over . This can be fully converted into ordinary lepton asymmetry in the decays of . In simp...

We propose a new mechanism for generating small neutrino masses which predicts the relation m_\nu ~ v^4/M^3, where v is the electroweak scale, rather than the conventional seesaw formula m_\nu ~ v^2/M. Such a mass relation is obtained via effective dimension seven operators LLHH(H*H)/M^3, which arise when an isospin 3/2 Higgs multiplet \Phi is intr...

We investigate flavor violation mediated by Higgs bosons and supersymmetric particles in a predictive class of models based on the non-Abelian flavor symmetry Q_6. These models, which aim to reduce the number of parameters of the fermion sector and to solve the flavor changing problems of generic SUSY setup, assume three families of Higgs bosons an...

We investigate flavor violation mediated by Higgs bosons and supersymmetric particles in a predictive class of models based on the non-Abelian flavor symmetry Q_6. These models, which aim to reduce the number of parameters of the fermion sector and to solve the flavor changing problems of generic SUSY setup, assume three families of Higgs bosons an...

LM is a gram positive foodborne pathogen that causes a flu-like illness in immunocompetent patients, but immunocompromised patients can develop septicemia and meningitis resulting in a high mortality rate. The primate model of LM infection is being used to investigate both innate and adaptive components of immunity in an animal model that is more r...

Salmonella typhimurium SR11 (ST) induced apoptosis of chicken macrophage cell line (HD11 cells) was assessed with or without caspase inhibitors. Apoptosis was measured upon the uptake of green fluorescent protein-labeled bacteria using flow cytometry. Dual staining of HD11 cells with annexin V PE and 7-amino-actinomycin-D (7-AAD) allowed differenti...

We suggest predictive scenarios for neutrino masses which provide a common origin for CP violation in early universe cosmology and in neutrino oscillations. Our setup is the seesaw mechanism in the context of MSSM with two quasi-degenerate right-handed neutrinos, with baryon asymmetry generated via resonant leptogenesis. Three different models are...

We investigate the impact of TeV-scale matter belonging to complete vectorlike multiplets of unified groups on the lightest Higgs boson in the MSSM. We find that consistent with perturbative unification and electroweak precision data the mass ${m}_{h}$ can be as large as 160 GeV. These extended MSSM models can also render the little hierarchy probl...

This work is aimed at optimizing the production of a new heteropolysaccharide (HePS) of Leuconostoc sp. CFR-2181 by standardizing the fermentation conditions in a low cost semi-synthetic medium. Both nutritional and cultural parameters, such as carbon source and its concentration, initial pH of the exopolysaccharide (EPS) medium, fermentation tempe...

We present a new realization of inverted neutrino mass hierarchy based on $S_3 \times {\mathcal U}(1)$ flavor symmetry. In this scenario, the deviation of the solar oscillation angle from π/4 is correlated with the value of θ13, as they are both induced by a common mixing angle in the charged lepton sector. We find several interesting predictions:...

century has observed the rapid development of mobile phone technology and increase in the number of users. Thi s rapid development has direct/indirect impact mainly on 3 parameters s uch as societal, environmental and economical. This paper is an attempt to show an anthropological review of mobile phone and its vari ous evolutionary impacts. This p...

Unification based on the group SO3(10)×S3 is studied. Each family has its own SO(10) group, and the S3 permutes the three families and SO(10) factors. This is the maximal local symmetry for the known fermions. Family unification is achieved in the sense that all known fermions are in a single irreducible multiplet of the symmetry. The symmetry supp...

Factor VIIa (FVIIa) is a trypsin-like serine protease in the coagulation cascade. Its complex with tissue factor (TF) triggers the extrinsic pathway of the coagulation cascade, generating a blood clot. Research programs at several centers now recognize the important roles played by TF and FVIIa in both the thrombotic and inflammatory processes asso...

Uncontrolled kallikrein activation is involved in diseases such as hereditary angioedema, bacterial septic shock and procedures such as cardiopulmonary bypass. Here we report a series of small molecule compounds that potently inhibit kallikrein activity in vitro. Kinetic studies indicate that some of these compounds are slow binding inhibitors of k...

An analysis of generating fermion masses via cubic couplings in SO(10) grand unification with a unified Higgs sector is given. The new framework utilizes a single pair of vector--spinor representation $144+\bar{144}$ to break the gauge symmetry all the way to $SU(3)_C \times U(1)_{em}$. Typically the matter--Higgs couplings in this framework are qu...

The Extended Supersymmetric Standard Model (ESSM), motivated on several grounds, introduces two vectorlike families [${\bf 16} + {\overline{\bf 16}}$ of SO(10)] with masses of order 1 TeV. In an earlier work, a successful pattern for fermion masses and mixings (to be called pattern I) has been proposed within a unified SO(10)-framework, based on MS...

Macrophages are major effectors against Salmonella infection, and also transport bacteria between host tissues and provide a protected site for intracellular bacterial replication. We hypothesized that differences in chicken macrophage responses to Salmonella enterica serovar Enteritidis (SE) and serovar Typhimurium (ST) played a role in preferenti...

A new SO(10) unified model is proposed based on a one step breaking of SO(10) to the Standard Model gauge group $SU(3)\times SU(2)\times U(1)_Y$ using a single 144 of Higgs. The symmetry breaking occurs when the SU(5) 24-plet component of 144 develops a vacuum expectation value. Further, it is possible to obtain from the same 144 a light Higgs doub...

Lepton flavor violation (LFV) is studied within a realistic unified framework, based on supersymmetric SO(10) or an effective G(224)=SUL(2)×SUR(2)×SUc(4) symmetry, that successfully describes (i) fermion masses and mixings, (ii) neutrino oscillations, as well as (iii) CP violation. LFV emerges as an important prediction of this framework, bringing...

The kinetics of cerium(IV) oxidation of D-fructose in aqueous H2SO 4 medium has been studied spectrophotometrically. The reaction is first order in [Ce(IV)] in the presence of excess [D-fructose]. The effect of H2SO4 on the UV-vis. spectrum of cerium(IV) is discussed. The overall process shows first order dependence on [D-fructose] whereas that in...

Supersymmetric extensions of the Standard Model generally give a theoretical upper limit on the lightest Higgs boson mass which may be uncomfortably close to the current experimental lower bound of $m_h$ > 114 GeV. Here we show ways in which this upper limit on $m_h$ can be relaxed substantially in the perturbative regime, while maintaining the suc...

In this paper we explore the possibility that (a) fermion masses, (b) neutrino oscillations, (c) CP non-conservation and (d) flavor violations get intimately linked to each other within supersymmetric grand unification based on SO(10) or an effective G(224) = SU(2)_L\times SU(2)_R\times SU(4)^c symmetry. We extend the framework proposed previously...

Two experimental approaches were used to investigate the immunological responses of chickens to a commercial killed Salmonella enteritidis (SE) vaccine. In the first, the effects of host age on antigen-specific proliferative responses and cytokine production were examined. Compared with non-vaccinated controls, 4-wk-old vaccinated chickens showed h...

The kinetics of reduction of Cr(VI) by thiourea has been studied spectrophotometrically in an HClO4 medium. The reaction follows overall third order kinetics, first order each in Cr(VI), thiourea and HClO 4. The reaction is HClO4 catalyzed. Addition of Mn(II) and Ce(IV) ions largely decrease the reaction rate. The reaction rate is increased by addi...

The oxidative degradation of D-fructose by vanadium(V) in the presence of H(2)SO(4) has an induction period followed by autoacceleration. The kinetics and mechanism of the induction period have been studied at constant ionic strength. The reaction was followed spectrophotometrically by measuring the changes in absorbance at 350 nm. Evidence of indu...

Addressing multicast group integrity management with particular regard to policy specification, this paper discusses our approach referred to as MGMS/GML - a tailored multicast group management system complemented by our group management language. We classify and compare existing policy specification approaches and find that none is sufficiently su...

The extended supersymmetric standard model (ESSM), motivated on several grounds, introduces two vectorlike families (16+16̅ ) of SO(10) with masses of the order of one TeV. It is noted that the successful predictions of prior work on fermion masses and mixings, based on the MSSM embedded in SO(10), can be retained rather simply within the ESSM exte...

Flaxseed, a rich source of reportedly beneficial n-3 fatty acid and phytoestrogens, has not been thoroughly tested for reproductive effects. High levels of flaxseed (FS, 20 or 40%) or defatted flaxseed meal (FLM, 13 or 26%) added to AIN-93 diet were evaluated in a two-phase study: dosed during gestation only or during gestation and maturation in a...

Gestation day 9.5 rat embryos were cultured for 45 h in serum obtained from pregnant rats that had been fed throughout gestation with either a control diet (based on the AIN-93 formulation), a diet supplemented with flaxseed (20% or 40%, w/w), or a diet supplemented with de-fatted flaxseed ("flaxseed meal", 13 or 26%, w/w). The embryos were fixed i...

The effects of dietary flaxseed (FS), and defatted flaxseed meal (FLM) on serum and tissue fatty acid profiles were investigated. Pregnant Sprague-Dawley rats were fed AIN-93 based diets balanced in calories, fat, nitrogen, and fiber. Diets contained 0, 20%, 40% FS or 13% or 26% FLM by weight. The control, FS and FLM diets differed in linoleic acid...

Flaxseed (FS) being rich in alpha-linolenic acid may alter the immune parameters. Therefore, we assessed the impact of FS and defatted flaxseed meal (FLM) on fatty acid composition, cell subsets, proliferation and IL-2 production by splenic lymphocytes. Pregnant female Sprague-Dawley rats were fed diets containing 0% FS and FLM, 20 or 40% FS, 13 or...

We show that the Standard Model Lagrangian, including small neutrino masses, has an anomaly-free discrete Z6 symmetry. This symmetry can emerge naturally from (I3R+Li+Lj−2Lk) gauge symmetry (Li is the ith lepton number) and ensure the stability of the nucleon even when the threshold of new physics Λ is low. All ΔB=1 and ΔB=2 (B is the baryon number...

Observing that the ever-increasing availability of WiFi-enabled gadgets is forming a technological basis for networked ad-hoc communities, and noting that such communities are actually user groups calling for group management schemes, we propose in this position paper a new group integrity management approach in support of mobile ad-hoc communities...

The axion solution to the strong CP problem makes use of a global Peccei-Quinn U(1) symmetry which is susceptible to violations from quantum gravitational effects. We show how discrete gauge symmetries can protect the axion from such violations. PQ symmetry emerges as an approximate global symmetry from discrete gauge symmetries. Simple models base...

In the minimal supersymmetric Standard Model with seesaw neutrino masses we show how R-parity can emerge naturally as a discrete gauge symmetry. The same discrete symmetry explains the smallness of the \mu-term (the Higgsino mass parameter) via the Giudice--Masiero mechanism. The discrete gauge anomalies are cancelled by a discrete version of the G...

Recent observations of neutrino oscillations imply nonzero neutrino masses and lepton flavor violation (LFV), most economically explained by the seesaw mechanism. Within the context of supersymmetry, LFV among the neutrinos can be communicated to the sleptons and from there to the charged leptons. We show that LFV can appear in the couplings of the...

Recent observations of neutrino oscillations imply nonzero neutrino masses and lepton flavor violation (LFV), most economically explained by the seesaw mechanism. Within the context of supersymmetry, LFV among the neutrinos can be communicated to the sleptons and from there to the charged leptons. We show that LFV can appear in the couplings of the...

A variant of MSSM - the so-called Extended Supersymmetric Standard Model (ESSM) - has been motivated sometime ago on several grounds. Briefly speaking, in addition to the three chiral families, ESSM introduces two vectorlike families of quarks and leptons (together with their superpartners) that transform as 16+16 of SO(10), and possess an SO(10)-i...

A general analysis is made of the question of whether the d=5 proton-decay operators coming from the exchange of colored Higgsinos can be completely eliminated in a natural way in supersymmetric (SUSY) grand unified models. It is shown that they can indeed be in SO(10) while at the same time naturally solving the doublet-triplet splitting problem,...

The Extended Supersymmetric Standard Model (ESSM), motivated on several grounds, introduces two vector-like families [16+ 16-bar of SO(10)] with masses of order one TeV. In an earlier work, a successful pattern for fermion masses and mixings (to be called pattern I) has been proposed within a unified SO(10)-framework, based on MSSM, which makes sev...

In family unification models, all three families of quarks and leptons are grouped together into an irreducible representation of a simple gauge group, thus unifying the Standard Model gauge symmetries and a gauged family symmetry. Large orthogonal groups, and the exceptional groups $E_7$ and $E_8$ have been much studied for family unification. The...

The design and synthesis of novel, orally active, potent, and selective inhibitors of influenza neuraminidase differing structurally from existing neuraminidase inhibitors are described. X-ray crystal structures of complexes of neuraminidase with known five- and six-membered ring inhibitors revealed that potent inhibition of the enzyme is determine...

Current solar and atmospheric neutrino oscillation data seem to favor a bimaximal pattern for neutrino mixings where the matrix elements Ue2 and Uμ3 are of order one, while Ue3 is much smaller. We show that such a pattern can be obtained quite easily in theories with “lopsided” mass matrices for the charged leptons and the down type quarks. A relat...

DNA sequence analysis of a chicken interleukin (IL)-15 cDNA identified a 187 amino acid open reading frame encoding a protein with a predicted molecular weight of 21,964Da, two potential N-linked glycosylation sites, four highly conserved Cys residues, two out-of-frame AUG initiation codons in the 5' untranslated region, and an unusually long (66 a...

The influenza virus neuraminidase inhibitor RWJ-270201 (cyclopentane carboxylic acid, 3-[cis-1-(acetylamino)-2-ethylbutyl]-4[(aminoiminomethyl)amino]-2-hydroxy-[cis, 2S, 3R, 4R]) was significantly inhibitory to an infection in mice induced by influenza A/NWS/33 (H1N1) virus when oral gavage (p.o.) treatment with 10 mg/kg per day was delayed at leas...

The dipole moments of the leptons and quarks are matrices in flavor space, which can potentially reveal as much about the flavor structure of the theory as do the mass matrices. The off-diagonal elements of the dipole matrices lead to flavor-changing decays such as \mu -> e \gamma, while the imaginary parts of the diagonal elements give rise to ele...

We have recently reported an influenza virus neuraminidase inhibitor, RWJ-270201 (BCX-1812), a novel cyclopentane derivative discovered through structure-based drug design. In this paper, we compare the potency of three compounds, RWJ-270201, oseltamivir, and zanamivir, against neuraminidase enzymes from various subtypes of influenza. RWJ-270201 ef...

The cyclopentane influenza virus neuraminidase inhibitor RWJ-270201 was evaluated against influenza A/NWS/33 (H1N1), A/Shangdong/09/93 (H3N2), A/Victoria/3/75 (H3N2), and B/Hong Kong/05/72 virus infections in mice. Treatment was by oral gavage twice daily for 5 days beginning 4 h pre-virus exposure. The influenza virus inhibitor oseltamivir was run...

As a first step in determining the mechanism of action of specific fatty acids on immunological function of macrophages, a comparative study of the effect of long-chain polyunsaturated fatty acids (PUFA) in the medium was conducted in two macrophage cell lines, J774A.1 and WEHI-3. The baseline fatty-acid profiles of the two cell lines differed in t...

Quantitative information was collected on male reproductive effects of maternal and postnatal dietary exposure to flaxseed (20 or 40%), flaxmeal (13 or 26%) or standard NIH AIN-93 feed (0% flaxseed control). Measurements were made on the testes of F1 generation males rats (1) whose mothers were exposed to the diets designated above, and (2) who, af...

Pregnant Sprague-Dawley rats were exposed to a flaxseed (20 or 40%), flaxmeal (13 or 26%) or standard NIH AIN-93 (0% flaxseed control) diet throughout gestation and until their offspring were weaned. After weaning, F(1) generation males were placed in the same diet treatment groups as their mothers for 70 days. Statistically significant differences...

A generalization of the well-known Georgi-Jarlskog relation m_{\mu}/m_{\tau} = 3 (m_s/m_b) to neutrinos is found in the context of SO(10). This new relation is m_{\nu_\mu}/m_{\nu_\tau} = 16 (m_c/m_t), which is consistent with present data, assuming the small-angle MSW solution to the solar neutrino problem.

An 8-week study was conducted to determine the impact of dietary ground flaxseed (FS) or defatted flaxseed meal (FLM) on plasma lipids, minerals, hematological parameters and vitamin E status of weanling female Sprague-Dawley rats. These rats were fed isocaloric modified AIN-76 diets supplemented with 0.0, 5.0, 10.0% (w/w) FS or 6.2% (w/w) FLM for...

We induced reverse passive Arthus (RPA) reactions in the skin of rodents and found that the contribution of complement to immune complex-mediated inflammation is species specific. Complement was found to be necessary in rats and guinea pigs but not in C57BL/6J mice. In rats, within 4 h after initiation of an RPA reaction, serum alternative pathway...

We demonstrate a new source for flavor-changing neutral currents within the minimal supersymmetric standard model. At moderate to large tanβ, it is no longer possible to diagonalize the masses of the quarks in the same basis as their Yukawa couplings. This generates flavor-violating couplings of the form b̅ RdLφ and b̅ RsLφ where φ is any of the th...

Neuraminidase (NA) plays a critical role in the life cycle of influenza virus and is a target for new therapeutic agents. A new benzoic acid inhibitor (11) containing a lipophilic side chain at C-3 and a guanidine at C-5 was synthesized. The X-ray structure of 4-(N-acetylamino)-5-guanidino-3-(3-pentyloxy)benzoic acid in complex with NA revealed tha...

A 2-pyrrolidinone ring containing a single hydroxymethyl side chain effectively replaces the N-acetylamino group of 4-(N-acetylamino)-3-guanidinobenzoic acid, a low micromolar inhibitor of influenza neuraminidase. This novel structural template affords new opportunities to evolve more potent benzoic acid inhibitors.

On the basis of the lead compound 4-(N-acetylamino)-3-guanidinobenzoic acid (BANA 113), which inhibits influenza A sialidase with a Ki of 2.5 microM, several novel aromatic inhibitors of influenza sialidases were designed. In this study the N-acetyl group of BANA 113 was replaced with a 2-pyrrolidinone ring, which was designed in part to offer oppo...

We suggest a novel approach towards resolving the fermion mass hierarchy problem within the framework of the Standard Model. It is shown that the observed masses and mixings can be explained with order one couplings using successive higher dimensional operators involving the SM Higgs doublet field. This scenario predicts flavor-dependent enhancemen...

The impact of rosemary extract on splenic mononuclear cell proliferation was determined. Weanling male Sprague-Dawley rats were fed diets containing 0, 100, 200 or 400 ppm rosemary extract or 400 ppm butylated hydroxytoluene (BHT) in combination with 10 or 20% casein enriched diets for 8 weeks. Splenic mononuclear cells were isolated from these ani...

We show that the branching ratio ) of the Higgs boson h0 may usefully differentiate between the Higgs sectors of the Minimal Supersymmetric Standard Model (MSSM) and non-supersymmetric models such as the Standard Model or its two Higgs doublet extensions. Although at tree level Rb/τ is the same in all these models, only in the MSSM can it receive a...

Within the framework of unified gauge models, interactions responsible for neutrino masses can also provide mechanisms for nucleon instability. We discuss their implications concretely in the light of recent results on neutrino oscillation from the SuperKamiokande collaboration. We construct a predictive SO(10)-based framework that describes the ma...

Within the framework of unified gauge models, interactions responsible for neutrino masses can also provide mechanisms for nucleon instability. We discuss their implications concretely in the light of recent results on neutrino oscillation from the SuperKamiokande collaboration. We construct a predictive SO(10)-based framework that describes the ma...

We show that the branching ratio R_{b/tau}=BR(h^0->bb)/BR(h^0->tau tau) of the Higgs boson h^0 may usefully differentiate between the Higgs sectors of the Minimal Supersymmetric Standard Model (MSSM) and non-supersymmetric models such as the Standard Model or its two Higgs doublet extensions. Although at tree level R_{b/tau} is the same in all thes...

Factor D is a serine protease essential for the activation of the alternative pathway of complement. The structures of native factor D and a complex formed with isatoic anhydride inhibitor were determined at resolution of 2.3 and 1.5 Å, respectively, in an isomorphous monoclinic crystal form containing one molecule per asymmetric unit. The native s...

Factor D (D) is a serine protease essential in the activation of the alternative complement pathway. Only a few of the common serine protease inhibitors inhibit D, binding covalently to the serine hydroxyl of the catalytic triad. 3,4-Dichloroisocoumarin (DCI) is a mechanism-based inhibitor which inhibits most serine proteases and many esterases, in...

A structure is proposed for the mass matrices of the quarks and leptons that arises in a natural way from the assumption that the breaking of SO(10) gauge symmetry is achieved by the smallest possible set of vacuum expectation values. This structure explains well many features of the observed spectrum of quarks and leptons. It reproduces the Georgi...

A minimal SO(10) Higgs structure involving a single adjoint field along with spinors, vectors and singlets has been shown to break the SO(10) gauge symmetry to the standard model while stabilizing the F-flat directions and solving the doublet-triplet splitting problem naturally. With this minimal set of Higgs fields, we show how to construct quark...

Influenza neuraminidase (NA) plays an important role in viral replication, and characterization of viruses resistant to NA inhibitors will help elucidate the role of active-site residues. This information will assist in designing better inhibitors targeted to essential active-site residues that cannot generate drug-resistant mutations. In the prese...

Supersymmetric extensions of the standard model generically contain additional sources of CP violation. We discuss how at one loop a potentially large CP violating coupling of the lightest Higgs, h^0, to leptons is induced in the minimal supersymmetric standard model (MSSM). The CP violating couplings of h^0 in extensions of the MSSM, such as the n...