Shant Rising

Cedars-Sinai Medical Center · Department of Physical Medicine and Rehabilitation

Background Growing need exists to link volumetric brain analysis to functional cognitive performance in early prediction of Alzheimer’s disease. Method In cognitively healthy older adults ( N = 40; M age = 71.7±7.7 years), we established amyloid/tau ratios from cerebrospinal fluid, thus finding a small group with pathological amyloid/tau ratios (P...

Background The CSF amyloid to tau ratio can isolate c ognitively h ealthy participants into n ormal A β 42 / t au (CH‐NAT) or a p athological A β 42 / t au (CH‐PAT) with a low or high risk of cognitive decline, respectively. We aim to determine if plasma A β 42 / t au ratios can differentiate CH‐NAT from CH‐PAT participants. Method Study participa...

Background Disrupted brain connectivity precedes cognitive impairment in Alzheimer’s disease (AD), affects self‐regulation and executive functions, and can be revealed by quantitative electroencephalography (qEEG). Neuroimaging research on AD progression has demonstrated structural and functional abnormalities in specific brain regions and connecti...

Background Non‐invasive molecules related to AD imaging biomarkers can reveal disease mechanisms and may help in the mass screening of an aging population. Our study aims to determine if urine dicarboxylic acids (DCA) that changed in AD are coupled with brain volume changes. Method Study participants (> 65 years) were recruited in an ongoing HMRI...

Background Alzheimer’s Disease (AD) impacts brain regions associated with memory and executive function in early stages. The Stroop task is used to evaluate inhibition, a common factor for executive functioning. Alpha Event‐Related Desynchronization (ERD) from electroencephalogram (EEG) analysis evaluates brain activation during a task. Also of int...

Objective Early cognitive signs of Alzheimer's disease are often subtle and go unnoticed until they become more prominent and debilitating. Thus, symptoms begin long before an actual Alzheimer's diagnosis is given. However, it is known that cognitively healthy older individuals with lower amyloid/tau ratios (PAT) are more likely to develop Alzheime...

IntroductionResting heart rate (HR) and heart rate variability (HRV) have been linked with cognition in the general population and in older individuals. The knowledge of this aspect of heart-brain relationship is relatively absent in older individuals with early Alzheimer's disease (AD) pathology. This study explores relationships of the HR, HRV, a...

Both resting heart rate variability (HRV) and resting heart rate (HR) are regulated by the central autonomic network linking prefrontal cortex with cardiac regulation. To better understand the interactions between the heart and cognition we determined the relationships between resting HR/HRV and cognitive function. We compared and correlated restin...

Framingham, or cardiovascular (CVD) risk score, as a composite score can accurately predict long‐term CVD risk in the general population. General lipid profiles contribute to CVD risk and Alzheimer’s disease (AD) with inconsistent reports: both high and low triglyceride or body mass index (BMI) have been linked with AD risk. However, the knowledge...

Age related atrophy occurs in Alzheimer’s disease and related dementia (ADRD). Although atrophy was reported in early stage as mild cognitive impairment (MCI), the knowledge about earlier changes is limited. To fill this knowledge, we explored the age‐related atrophy in our pilot MRI database when participants at different stages of ADRD. MRI data...

Framingham, or cardiovascular (CVD) risk score, as a composite score can accurately predict long-term CVD risk in the general population. General lipid profiles contribute to CVD risk and Alzheimer’s disease (AD) with inconsistent reports: both high and low triglyceride or body mass index (BMI) have been linked with AD risk. However, the knowledge...

Age-related atrophy occurs in Alzheimer’s disease and related dementia (ADRD). Although atrophy was reported in the early stage as mild cognitive impairment (MCI), the knowledge about earlier changes is limited. To fill this knowledge, we explored the age-related atrophy in our pilot MRI database when participants were at different stages of ADRD.

Heart rate variability (HRV) measures the variation of difference in the inter-beat intervals of successive heartbeats and allows non-invasive evaluation of the autonomic nervous system. Both resting heart rate variability (HRV) and resting heart rate (HR) are regulated by the central autonomic network linking the prefrontal cortex with cardiac reg...

The authors applied machine learning (ML) to the item responses of 44,846 MMPI-2 (Butcher et al., 1989) profiles to identify important predictors of gender identity, utilizing ML algorithms' capacity to learn and recognize structural relationships in the data without being explicitly programmed or hypothesized (Samuel, 1959). Several ML algorithms,...

Sports fulfill a number of important functions in the psychosocial development of youth. For one, researchers find that sport involvement increases self esteem, decreases stress, contributes to better academic performance. However, fear of failure in the athletic context may lead youth to disengage and avoid participation altogether. Researchers fo...