Shamik Hazra

Shamik Hazra
Indian Institute of Technology Madras | IIT Madras · Department of Mechanical Engineering

Researcher

About

21
Publications
1,786
Reads
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40
Citations
Introduction
Droplet Microfluidics || Viscoelastic Microfluidics || Rheology || Soft matter || Lab-on-Chip

Publications

Publications (21)
Article
Label free sorting of circulating tumor cells (CTCs) often remains a challenge due to their rarity in peripheral blood and identical morphology with white blood cells. We present a novel label-free passive microfluidic technique for isolation of cancer cells (EpCAM+ and CD45–) from peripheral blood mononuclear cells (PBMCs) (CD45+ and EpCAM–) in aq...
Article
Cross-stream motion of viscoelastic droplets in viscoelastic fluids has received little attention since the classical study of migration of drops in a second order fluid. In this work, going beyond the existing classical theory, we experimentally elucidate the role of drop-to-medium viscosity ratio k and elasticity ratio ξ on wall and center migrat...
Article
Full-text available
Shear-thinning viscoelastic (STVE) flows exhibit intriguing phenomena owing to their complex rheology and the coupling of various forces involved. Here, we present an understanding of the cross-stream migration of droplets in a confined STVE flow and unravel the role of a shear-thinning induced lift force (FSM) in their dynamical behavior. We perfo...
Conference Paper
Full-text available
We experimentally elucidate the cross-stream migration behavior of viscoelastic Polydimethylsiloxane (PDMS) droplets in the non-inertial Poiseuille flow of constant viscosity aqueous viscoelastic solution of Polyvinylpyrrolidone (PVP) in straight rectangular microchannels. We investigate the complex interaction among deformability induced non-inert...
Conference Paper
Despite growing interest of microparticle manipulation in non-Newtonian fluids, combined effect of viscoelasticity and shear thinning on particle's lateral position is not well understood. We performed experiments with rigid microparticles of 15 m diamater in popular Shear thinning viscoelastic (STVE) liquid poyethylene oxide (PEO) of different mol...
Article
Interfacial migration of droplets in microfluidic confinements has significant relevance in cell biology and biochemical assays. So far, studies on passive interfacial migration of droplets are limited to co-flow interfaces having small interfacial tension (IFT ∼ 1 mN/m). Here, we elucidate the migration and spreading of droplets (SiO-1000, SiO-100...
Conference Paper
Interfacial instability in the presence of objects in microfluidic co-flow configuration has been rarely investigated. We investigate droplet induced instability at the interface of PEG and immiscible oil phases. For droplets with higher confinement ratio, periodic waviness is generated. Simulations revealed that differential pressure across the in...
Chapter
Disease detection, single-cell analysis, biochemical reactions, etc. are of profound interest in several biomedical and bioengineering applications. These important processes require several profound aspects, e.g., lower consumption of reagent, rapid reactions, rapid detection, high throughput, etc. needs to be satiated. Droplet microfluidics has a...
Conference Paper
Full-text available
Passive manipulation of droplets across a laminar fluid-fluid interface is often achieved either by hydrodynamic lift 1 or interfacial energy gradient 2. Herein, we investigate the interaction of oil droplets in the microfluidic co-flow of aqueous polyethylene glycol and immiscible oil phases. In the absence of hydrodynamic lift or favorable spread...
Conference Paper
Full-text available
We discover lateral migration dynamics of droplets in non-Newtonian matrix in microflidic confinement is underpinned by several forces. Any deformable object would be acted upon by center directed deformability induced and matrix viscoelasticity induced force,. By comparing cross-stream migration behaviour of Newtonian castor drops and viscoelastic...
Article
Full-text available
Despite a growing interest in the focusing and manipulation of particles in non-Newtonian fluids in confined flows, the combined effect of viscoelastic and shear-thinning effects on particle dynamics is not well understood. Herein, we report the dynamics of rigid microparticles in confined flows of strongly shear-thinning viscoelastic (STVE) fluids...
Conference Paper
Full-text available
Cross-stream motion of viscoelastic droplets in viscoelastic and Shear-thinning viscoelastic (STVE) fluids has received little or no attention since the work of Chan and Leal (1979). Going beyond the existing theory, we experimentally elucidate the role of drop-to-medium viscosity ratio and elasticity ratio on wall and center migration of viscoelas...
Conference Paper
Full-text available
Cross-stream motion of viscoelastic droplets in viscoelastic and Shear-thinning viscoelastic (STVE) fluids has received little attention in recent past. Going beyond the existing theory, we experimentally elucidate the role of drop-to-medium viscosity ratio and elasticity ratio on wall and center migration of viscoelastic polydimethylsiloxane (PDMS...
Conference Paper
Full-text available
Cross-stream motion of viscoelastic droplets in viscoelastic fluids has received little or no attention since the work of Chan and Leal (1979). In this work, going beyond the existing theory of Chan and Leal, we experimentally elucidate the role of drop-to-medium viscosity ratio and elasticity ratio on wall and center migration of viscoelastic drop...
Conference Paper
Despite growing interest of microparticle manipulation in non-Newtonian fluids, combined effect of viscoelasticity and shear thinning on particle lateral position is not well understood. We performed experiments with rigid microparticles of 15 um diamater in popular Shear thinning viscoelastic (STVE) liquid poyethylene oxide (PEO) of different mole...
Conference Paper
Full-text available
POSTER) Understanding cross-stream migration behaviour of micro-scale objects in Newtonian and non-Newtonian fluids in microfluidic confinement has profound importance in chemical and biological applications. In confined microfluidic systems, we often deal with emulsions and particulate flows wherein both discrete and continuous phases can be rheol...
Conference Paper
Full-text available
We report non-inertial lift induced sorting of metastatic breast cancer cells from Peripheral Blood Mononuclear Cells (PBMCs) across liquid-liquid interface. The interplay between lift force and interfacial tension (IFT) force governs cell migration phenomena. We demonstrated isolation of two different types of cancer cells, namely, MCF-7 and MDA-M...
Conference Paper
Full-text available
We experimentally elucidate the effect of drop-to-medium viscosity ratio k and elasticity ratio ξ on wall and center migration of viscoelastic droplets in a Poiseuille flow of a viscoelastic medium (PVP) at low Reynolds numbers (Re 1). We observed a contrasting migration behavior of Newtonian and viscoelastic droplets having the same viscosity rati...
Conference Paper
Full-text available
Current understanding of migration dynamics of microparticles in Shear-thinning viscoelastic (STVE) medium at low Reynolds numbers (Re) is very much limited owing to the complex rheology. We performed experiments with rigid microparticles of 15 um diamater in popular STVE liquids polyacrylamide (PAM)) and polyacrylic acid (PAA) and of different mol...
Conference Paper
Full-text available
We present a novel label-free passive microfluidic technique to isolate CTC (EpCAM+ CD45−) from PBMC (CD45+ EpCAM−) using co-flowing Aqueous Two-Phase System (ATPS), i.e, aqueous Dextran and Poly-ethylene glycol. We report non-inertial lift induced lateral cell migration across the fluid-fluid interface and use this principle for sorting cells of d...

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