Shakti Prasad Pattanayak

Central University of South Bihar | CUB · School of Medicine

The hemi-parasitic plant Dendrophthoe falcata (L.f) Ettingsh (Loranthaceae) of the order Santalales, is used ethnomedicinally for treating ulcers, asthma, impotence, paralysis, skin diseases, and wounds. The aerial parts are also used in menstrual troubles, psychic disorders, pulmonary tuberculosis, consumption and mania by the tribal of India. In...

Dendrophthoe falcata (L.f) Ettingsh (Loranthaceae) is a medicinally active, bushy parasitic plant growing on a variety of host plants in the dense forests of India. The present study was conducted to evaluate the hepatoprotective effect of ethanol and aqueous extracts using carbon tetrachloride induced liver damage in wistar albino rats. The study...

Plasma cells (PCs) are responsible for the secretion of antibodies. Development of fully functional PCs relies on the activation of the IRE1/XBP-1 arm of the unfolded protein response (UPR). XBP-1-deficient PCs poorly secrete antibodies and exhibit distensions of the endoplasmic reticulum (ER). The kinase mTOR promotes anabolic activities and is ne...

Dendrophthoe falcata (L.f) Ettingsh (Loranthaceae) of the order Santalales, is used ethnomedicinally for treating ulcers, asthma, impotence, paralysis, skin diseases, and wounds. In this context, validations of the ethnotherapeutic claims of the plant in wound healing activity was studied, besides anti-microbial activity and antioxidant activity we...

Investigations on bioactive phytoconstituents, especially bioflavonoids and their role in the mitigation of breast cancer have directed our interest to 2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-4H-chromen-4-one or taxifolin (TX) which possesses potent chemotherapeutic potential in murine breast cancer model. However, it has been observed to possess...

Background: Mammary carcinogenesis possesses great challenges due to the lack of effectiveness of the multiple therapeutic options available. Gene therapy-based cancer treatment strategy provides more targeting accuracy, fewer side effects, and higher therapeutic efficiency. Downregulation of the oncogene mTOR by mTOR-siRNA is an encouraging appro...

This experimental work was focused to study the anti-oxidant and antimicrobial potential of Vaishvanara Churna– a polyherbal traditional ayurvedic formulation generally recommended for rheumatism (amavata), flatulence with gurgling sound (adhmana), abdominal lumps (gulma), duodenal ulcer (parinamasula), heart disease (hardya roga), etc. In order to...

The possibility of increasing the cropping intensity in Khordha district was assessed by block-wise characterisation of rainfall, soil texture, available water holding capacity of soil and district level temperature during the rice fallow period as well as deciding the appropriate sowing window for both kharif and rabi crops. More than 50% chances...

COVID-19, a type of viral pneumonia caused by severe acute respiratory syndrome coronavirus 2 has challenged the world as global pandemic. It has marked the identification of third generation of extremely pathogenic zoonotic coronaviruses of twenty-first century posing threat to humans and mainly targeting the lower respiratory tract. In this revie...

Breast cancer has become one of the most common dreadful diseases that target women across the globe. The most obvious reasons we associate with it are either genetic mutations or dysregulation of pathways. However, there is yet another domain that has a significant role in influencing the genetic mutations and pathways. Epigenetic mechanisms influ...

Ethnopharmacological relevance Zanthoxylum armatum DC (Rutaceae) containing flavonoids, alkaloids, coumarins, lignans, amides and terpenoid is well-known for its curative properties against various ailments including cancer. In the current research, phytochemicals present in the methanolic extract of Zanthoxylum armatum bark (MeZb) were characteriz...

Novel plasmonic (>800 nm) pentagonal QRC-FA-AgNPs synthesized through simple chemical technique induces light activated combined chemo-photothermal efficacy against breast cancer.

Breast cancer is a serious health issue and a major concern in biomedical research. Alteration in major signaling (viz. PI3K-AKT-mTOR, Ras-Raf-MEK-Erk, NF-kB, cyclin D1, JAK-STAT, Wnt, Notch, Hedgehog signaling and apoptotic pathway) contributes to the development of major subtypes of mammary carcinoma such as HER2 positive, TNBC, luminal A and B a...

Integrated nutrient management (INM) is a strategy for judicious and balanced use of plant nutrients for sustainable crop production under varied agro-climatic conditions. Results from on-farm and farmer’s fields of Jharkhand and Odisha (Eastern Plateau and Hill Region) states of India reveal the imperative need to use organic manures, biofertilize...

Background: Cancer is the most dreadful disease since last few decades. Besides all causative reasons, it is observed that one in every five cancers globally is linked with infectious diseases. Among all the infectious oncogenic viruses, 35% of the human cancers have been caused by Human Papilloma Viruses (HPVs). One such type is Epidermodysplasia...

Breast cancer is one of the biggest global dilemmas and its current therapy is to target the hormone receptors by the use of partial agonists/antagonists. Potent drugs for breast cancer treatment are Tamoxifen, Trastuzumab, Paclitaxel, etc. which show adverse effects and resistance in patients. The aim of the study has been on certain phytochemical...

Cytochrome P450 1B1, considered as one of the novel chemotherapeutic targets involved in cancer prevention and therapy is also associated with the conversion of procarcinogens into their active metabolites. The aryl hydrocarbon receptor (AhR) is responsible for mediating different biological responses to a wide variety of environmental pollutants a...

mTORC1 is a key regulator of cell metabolism and lymphocyte proliferation. mTORC1 is inhibited by the tuberous sclerosis complex (TSC), a heterodimer of TSC1 and TSC2. Deletion of either genes results in robust activation of mTORC1. Mature B cells reside in the spleen at two major anatomical locations, the marginal zone (MZ) and follicles. MZ const...

Aim: 7,12-dimethylbenz(a)anthracene(DMBA), a PAH derivative initializes cascades of signaling events that alters a variety of enzymes responsible for lipid and glucose homeostasis resulting in enhanced availability and consumption of energy producing molecules for the development of carcinogenesis. 3-hydroxy-3-methylglutaryl-coenzyme A reductase (...

Breast cancer (BC) is a persistent and impulsive metabolic disorder with the highest prevalence in women, worldwide. 7,12-Dimethylbenz(a)anthracene (DMBA) is a potent polyaromatic hydrocarbon (PAH)-based carcinogen producing mammary carcinomas in rats resembling the human hormone-dependent BC. 7,8-Dihydroxycoumarin (78DC) is a coumarin derivative t...

Background Breast cancer (BC), because of its invasive characteristics, is one of the most common and deadliest cancers among the female population around the world. Research has demonstrated that AhR signaling also plays a vital role in BC initiation and development as well. Therefore, blocking this pathway to natural interferences paves a new cha...

Background: Silibinin is a semi-purified fraction of silymarin contained in milk thistle (Silybum marianum Asteraceae). Primarily known for its hepatoprotective actions, silymarin may also stimulate epithelialization and reduce inflammation in excision wound. Previous studies show antioxidant, anti-inflammatory, and antimicrobial actions of silibi...

Cancer is a faction of disorders that conjugated primarily with oxidative imbalance. In mammary carcinoma, oxidative stress secondarily changes various gene expressions and signalling pathways that bring genomic instability and mutagenic alterations that fascinating carcinogenesis. Several coumarin compounds are active against various malignancies....

Coumarins, identified as plant secondary metabolites possess diverse biological activities including anti-angiogenic properties. Daphnetin (DAP), a plant derived dihydroxylated derivative of coumarin has shown significant pharmacological properties such as anticancer, anti-arthritic, anti-inflammatory, etc. The present study was performed to invest...

Objective: Mammary carcinoma is one of the most common and prominent cause of cancer-related death in women worldwide. The role of fatty acid synthesis and altered lipid metabolism in cancer progression was well established. Cancer cells undergo enhanced de-novo lipogenesis and liver uptake. The magnitudes of bioflavonoids in lipid management again...

Objective: To examine the antiangiogenic effect of some flavonoids (taxifolin and phloretin) against various In vivo and In vitro experimental models such as Chick Chorio Allantoic Membrane (CAM) assay, Dorsal Skinfold Chamber (DSFC) and Tube formation assay. Methods: Three different concentrations of drug solution (40μM, 80 μM, 120 μM) and (50 μM,...

Small bowel injuries in general are uncommon after blunt abdominal trauma and are usually due to high-energy deceleration injuries, often in relation to motor vehicle accidents and affect fixed segments such as duodenum, duodeno-jejunal (DJ) flexure, proximal jejunum and terminal ileum. High morbidity and mortality are associated with this type of...

Lipid, lipoproteins, and lipid-metabolizing enzymes are associated with breast cancer risk. In this study, the potential of hydroalcoholic extract (HEDF) of Dendrophthoe falcata (L.f) Ettingsh (Loranthaceae) for the management of lipid metabolism on 7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary carcinoma was investigated in Wistar female ra...

The methanolic (Fr-Me) and ethyl acetate fraction (Fr-Et) obtained from the aerial parts of Cressa cretica L. (Convolvulaceae) exhibited inhibitory effect against acute and chronic models of inflammation, namely, carrageenan-induced paw edema, cotton pellet granuloma, carrageenan air pouch inflammation, vascular permeability, freuds complete adjuva...

The present study assessed heavy metal contents in the soil with special reference to Cr, Ni, Cd and investi- gated the soil physico-chemical properties in the neighborhood of a sponge iron plant (open forest and crop fields). Standard laboratory procedures were adopted in analyzing the soils and the data obtained were subjected to analysis of vari...

To evaluate the effect of ethylacetate fraction (Fr-Et) and methanolic fraction (Fr-Me) obtained from Cressa cretica L.(C. cretica) L. on experimental models for bronchodilatory activity and mast cell stabilising activity. The effect of Fr-Et and Fr-Me were studied on acetylcholine and histamine aerosol-induced broncospasm using guinea pigs as expe...

The total phenolic content(TPC) and total flavonoid content(TFC) of chloroform(CEDF), methanol(MEDF) and hydroalcoholic(HEDF) extracts of an Indian ayurvedic plant Dendrophthoe falcata (L.f) Ettingsh were measured using Folin-Ciocalteau and aluminum chloride colorimetric methods, respectively. The in vitro antioxidant activities were also investiga...

In the present investigation different fractions (hexane, ethylacetate and methanol) of the whole methanolic extract of Cressa cretica L.(Convolulaceae), a widely grown halophytic plant were studied against wide ranges of bacteria (both positive and negative strain) and five fungi Candida albicans, Candida tropicalis – dimorphic fungi, Aspergillus...

This review brings up regarding the plant derived compounds with estrogenic activity. The authors correctly emphasize the need of foods containing phyto-oestrogens in view of its significant pharmacokinetic profile. This is particularly essential in the light of the current wave of enthusiasm for vegetarian food in general and phyto-oestrogens in p...

In the present study, an attempt was made to screen immunomodulatory activity of the hydroalcoholic extract (HEDF) of Dendrophthoe falcata (L.f.) Ettingsh (Loranthaceae), an Indian Ayurvedic plant, on different arms of the immune system. HEDF was evaluated for immunological function by studying delayed type hypersensitivity (DTH) to sheep RBCs, nit...

This review discusses plant-derived compounds with estrogenic activity. The authors rightly emphasize the need for the intake of foods containing phytoestrogens in view of their positive effects on postmenopausal indications. This is particularly significant in the light of the current wave of enthusiasm for vegetarian food, in general, and phytoes...

Cressa cretica is halophytic plant belongs to family Convolvulaceae, growing extensively all over India. The entire plant is medicinally important and used extensively in traditional system of medicine. The present work attempted to summarize the macroscopic characters of the plant Cressa cretica. The microscopic characters, physical constant value...

The total phenolic content (TPC) and total flavonoid content (TFC) of ethylacetate fraction (Fr-Et) and methanol fraction (Fr-Me) of an Indian ayurvedic plant Cressa cretica Linn were measured using Folin-Ciocalteau and aluminum chloride colorimetric methods, respectively. The in vitro antioxidant activities were also investigated by using in vitro...

In this study, the therapeutic potential of the hydroalcoholic extract of Dendrophthoe falcata (L.f) Ettingsh (Loranthaceae; HEDF) on 7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary carcinoma was investigated in Wistar female rats at 55days of age. Thirty female rats were divided into five groups with six animals in each group: control, DMBA...

Herbal medicine is used by up to 80% of the population in developing countries. Cressa cretica L. is a popular holophytic plant and is used in folklore medicine for ailments including diabetes, ulcers, asthma, anthelmintic, stomachic, tonic and aphrodisiac purposes, enriches the blood, and is useful in constipation, leprosy, and urinary discharges....

The hydroalcoholic extract (HEDF) from the aerial parts of the hemiparasitic plant D. falcata, was evaluated for acute and subacute toxicity with the hope that the results would provide information on the safety of this extract prior to the evaluation of its efficacy in humans. In rats, single intraperitoneal injections of HEDF (1.0 – 2.5 g/kg) ind...

In respect of the traditional uses of medicinal plants in the treatment of various ulcerative lesions; it was revealed that the flowers of Pterospermum acerifolium (L) Willd. were extensively used in folklore medicine to treat ulcerative lesions, tumors, diabetes and inflammation. So far our knowledge is concerned; the flowers were not yet scientif...

This study was designed to assess the effect of one traditionally used antifertility plant, Dendrophthoe falcata (L.f.) Ettingsh (Loranthaceae), on female reproductive system, fertility and safety, by oral administration to adult female Wistar rats. After the oral acute toxicity study, the hydroalcoholic extract of the aerial parts was administered...

Coccinia grandis (Cucurbitaceae) has extensively used to get relief from asthma and cough by the indigenous people of India. The antitussive effect of aerosols of two different concentrations (2.5%, 5%w/v) of methanol extract of C. grandis fruits were tested by counting the numbers of coughs produced due to aerosols of citric acid, 10 min after exp...

Cressa cretica Linn. Voigt. (Convolulaceae), has also been extensively used to get relief from asthma and cough by the indigenous people of India. In the present study the antitussive effect of the plant was evaluated in two different experimental models. The antitussive effect of aerosols of two different concentrations (2.5%w/v, 5%w/v)of methanol...

This study was designed to assess the potential anti-tumor effect of the administration of the hydroalcoholic extract of Hygrophila spinosa (HEHS), on 7,12 - Dimethylbenz(a)anthracene (DMBA) - induced mammary tumors in female rats and its sub-acute toxicity evaluation. In the sub-acute toxicity exposure of 28 days, BEHS showed no significant change...

The plant Dendrophthoe falcata (L.f) Ettingsh (Loranthaceae) of the order Santalales, is used in folklore medicine for ailments including ulcers, asthma, importence, menstrual troubles, asthma, psychic disorders, paralysis, skin diseases, and wounds. Dendrophthoe falcata bark is considered to be astrngent and narcotic. The present study was underta...

A methanol extract of the shade dried flowers of Pterospermum acerifolium (MEPA) was investigated for anti-inflammatory and antinociceptive activities at the doses (p.o.) of 200 and 400 mg/kg body weight. In acute oral toxicity studies (OECD-425 guidelines), no mortality was observed up to the highest dose of MEPA (2000 mg/kg, p.o). The extract pro...

Condensation of substituted benzaldehydes with primary aryl amines gave a series of Schiff bases(1a₁ -e₁ ,a₂ ,b₂ ,d₂ ,b₃ -e₃ ) which, on reaction with thioglycolic acid, resulted in the formation of the corresponding 4-thiazolidinones(2a₁ -e₁...

This paper brings up regarding the plant derived compounds with estrogenic activity. The authors correctly emphasize the need for control of estrogenicity of foods containing phyto-oestrogens in view of the significant health effects of various estrogenic derivatives. This is particularly essential in the light of the current wave of enthusiasm for...