Shaival K Rao

Shaival K Rao

PhD

About

34
Publications
9,390
Reads
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940
Citations
Additional affiliations
July 2007 - June 2015
C. U. Shah College of Pharmacy & Research
Position
  • Professor

Publications

Publications (34)
Article
The study was aimed to evaluate antitumor activity of methanolic extract of Crotalaria burhia Buch.-Ham. roots (MECB) in Swiss Albino mice against Ehrlich’s Ascites Carcinoma (EAC). The mice were divided into seven groups (n=20) in which Group I was treated with Sterile Physiological Saline (SPS) (Normal mice), Group II served as EAC control and Gr...
Article
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Plant Cassia tora also known as Chakra Marda or Puvad was found in most part of India and it was previously used in treatment of common skin ailments by Indian tribes. However, there are no scientific evidences justifying use of Cassia tora in wound healing. Therefore, the present study was performed to evaluate wound healing activity of Cassia tor...
Article
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Diabetes Mellitus is a syndrome of disordered metabolism, due to a combination of hereditary and environmental causes, resulting in abnormally high blood sugar levels (hyperglycemia), caused by defects in either insulin secretion or its action in the body. A diabetes epidemic is underway and currently available therapeutic options for non-insulin-d...
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The passage of ionizing radiations through aqueous medium of biological material leads into the generation of a burst of free radicals owing to radiolysis of water. These free radicals are extremely reactive and interact with important macromolecules of cells resulting in the cytotoxicity. It is well known that ionizing radiation induce damage to t...
Article
Aim: The study was aimed to investigate the effect of voglibose or acarbose as an add-on treatment in overweight/obese type 2 diabetes (T2DM) patients who are uncontrolled with metformin and sulfonylureas (SUs) in Western part of India. Participants and methods: A retrospective study included 77 participants (BMI≥25kg/m(2); HbA1c level>8% and<9....
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Environmental science is moving through a dreaded and drastic crisis. Tinospora cordifolia or giloe is used in Ayurvedic system of medicine for the treatment of many diseases. Our earlier studies have shown that giloe exerts cytotoxic effect in vitro and in vivo, which stimulated us to understand the mechanism of cell death is HeLa cells receving v...
Article
Diabetes mellitus (DM) is a metabolic disorder of the endocrine system. This frightful disease is found in all parts of the world and is becoming a serious threat to healthcare providers. Nowadays DM is a most spreading disease in the world. In rapidly growing world a number of treatment options are available for treatment of DM. Long term use of a...
Article
Corchorus depressus (L.) Stocks syn. C. depressus (L.) C. Chr. (Tiliaceae), commonly known as Baphuli, traditionally used in pain, fever, sexual dysfunction and to treat gonorrhea. In the present investigation, various pharmacognostical standards for C. depressus have been established. Collection of plant material was carried out and its morphologi...
Article
Ethnopharmacological relevance: Corchorus depressus Linn. has been used as an aphrodisiac in traditional Indian medicine to treat male sexual dysfunction and impotency. Aim of the study: The petroleum ether, chloroform, ethyl acetate, n-butanol and aqueous fractions of 95% methanol extract of Corchorus depressus were screened initially for their...
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Objective: To investigate the hepatoprotective and in vivo antioxidant effects of Corchorus depressus in carbon tetrachloride (CCl 4)-induced hepatotoxicity in rats. Methods: Group allotment in this study included vehicle, CCl 4 , Methanol extract of Corchorus depressus 100, 200, and 400 mg/kg + CCl 4 and silymarin 50 mg/kg + CCl 4 , and treatment...
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The present study was carried out in an attempt to study the pharmacognostical characteristics of the leaves of Elaeocarpus ganitrus, Family: Elaeocarpaceae, commonly called as "Rudraksh". Rudraksh beads have been used since ancient times as an adornment to ward off evil spirits and omens.
Article
Objective: To investigate the hepatoprotective and in vivo antioxidant effects of Corchorus depressus in carbon tetrachloride (CCl4)-induced hepatotoxicity in rats. Methods: Group allotment in this study included vehicle, CCl4, Methanol extract of Corchorus depressus 100, 200, and 400 mg/kg + CCl4 and silymarin 50 mg/kg + CCl4, and treatment was ca...
Article
Exposure of HeLa cells to TCE (dichloromethane extract of Tinospora cordifolia) for 4 hours before exposure to 2-Gy γ-radiation caused a significant decrease in the cell viability (approximately 50%). The surviving fraction (SF) was reduced to 0.52 after 4 hours of TCE treatment; thereafter, clonogenecity of HeLa cells declined negligibly with trea...
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Pimenta dioica commonly known as Allspice was used by early Central American civilizations as a flavoring for chocolate and found to have good anti-microbial action. The current study was therefore carried out to provide requisite pharmacognostic details about the plant. The results of the study could be useful in setting some diagnostic indices fo...
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The radiosensitizing activity of dichloromethane extract of guduchi [Tinospora cordifolia (WILLD.) MIERS ex HOOK. F. & THOMS. Family: Menispermaceae (TCE)] in the mice transplanted with Ehrlich ascites carcinoma (EAC) was investigated. The EAC mice received 0, 25, 30, 40, 50 or 100 mg/kg b.wt. TCE 1 h before exposure to 6 Gy hemi-body γ-radiation a...
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Extracts of Tinospora cordifolia (TCE) have been shown to possess anti-tumor properties, but the mechanism of the anti-tumor function of TCE is poorly understood. This investigation elucidates the possible mechanism underlying the cytotoxic effects of dichlormethane extracts of TCE, after selecting optimal duration and concentration for treatment....
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Full-text available
Extracts of Tinospora cordifolia (TCE) have been shown to possess anti-tumor properties, but the mechanism of the anti-tumor function of TCE is poorly understood. This investigation elucidates the possible mechanism underlying the cytotoxic effects of dichlormethane extracts of TCE, after selecting optimal duration and concentration for treatment....
Article
Full-text available
The anticancer activity of dichloromethane extract of guduchi [Tinospora cordifolia (Willd.) Miers ex Hook. F. & Thoms. Family: Menispermaceae (TCE)] in the mice transplanted with Ehrlich ascites carcinoma (EAC) was investigated. The EAC mice receiving 25, 30, 40, 50 and 100 mg/kg, TCE showed a dose dependent elevation in tumor-free survival and a...
Article
The nitric oxide (NO) scavenging activities of traditional polyherbal drugs like abana, chyavanaprasha, geriforte, septilin, mentat and triphala were examined using sodium nitroprusside as a NO donor in vitro. All the drugs tested demonstrated direct scavenging of NO and were superior to Gingko biloba, which was used as a positive control. The extr...
Article
The effect of various doses (0, 25, 50, 75, 100, 125, 150, 300, 600 and 900 mg kg(-1)) of the alcoholic extract of the plant Ageratum conyzoides Linn. (ACE), on the alteration of radiation-induced mortality in mice exposed to 10 Gy of gamma radiation was studied. The acute toxicity studies showed that the drug was non-toxic up to a dose of 3000 mg...
Article
The plant extracts of some commonly used spices were examined for their possible regulatory effect on nitric oxide (NO) levels using sodium nitroprusside as a NO donor in vitro. Most of the extracts tested demonstrated direct scavenging of NO and exhibited significant activity and the potency of scavenging activity was in the following order: Foeni...
Article
In spite of the immense therapeutic gains produced by the fractionated irradiation (IR) regimen, radiation burden on the skin increases significantly. Protection of skin might enable use of higher radiation doses for better therapeutic gains. Ascorbic acid (AA), an essential ingredient of the human diet, is known to be a free radical scavenger and...
Article
Alteration of the radiation-induced changes in wound contraction, collagen synthesis and wound histology by ascorbic acid was studied in mice exposed to 10, 16 and 20 Gy of fractionated (2 Gy/fraction) gamma radiation. The animals were given double-distilled water or ascorbic acid daily before exposure to 2 Gy/day of fractionated irradiation. A ful...
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Full-text available
glutathione, glutathione peroxidase, superoxide dismutase and lipid peroxidation by ascorbic acid in the skin of mice exposed to fractionated g radiation $ Abstract Background: In spite of the immense therapeutic gains produced by the fractionated irradiation (IR) regimen, radiation burden on the skin increases significantly. Protection of skin mig...
Article
Full-text available
The essential oil obtained by steam distillation, from the leaf of Pimenta dioica, showed a strong antibacterial activity against Coagulase negative Staphylococci and Pseudomonas spp and a strong antifungal activity against Aspergillus niger.

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Project (1)
Project
In vitro & In vivo Evaluation of Indian Traditional Medicinal Plant for skin ailments . Formulation Development from herbal extract.