Shailendra Saraf

Shailendra Saraf
Pandit Ravishankar Shukla University · UniversityInstitute of Pharmacy

M. Pharm., Ph.D.

About

167
Publications
88,597
Reads
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7,392
Citations
Introduction
Prof. Dr. Shailendra Saraf, M. Pharm., Ph.D. Professor, Pt. Ravishankar Shukla University, Raipur, CG Former Vice-President, Pharmacy Council of India Former Vice-Chancellor, Hemchand Yadav University, Durg, CG
Additional affiliations
October 1995 - November 2002
B. R. Nahata College of Pharmacy
Position
  • Head of Faculty
November 2002 - February 2015
Pandit Ravishankar Shukla University
Position
  • Professor (Full)
November 2002 - present
Pandit Ravishankar Shukla University
Position
  • Professor (Full)

Publications

Publications (167)
Patent
The invention aimed to develop a microemulsion loaded with atenolol for improving permeability using glycerol monostearate and oleic acid effective against Hypertension. The invention used the phase titration method to formulate an atenolol microemulsion containing various proportions of glycerol monostearate and oleic acid. All the formulations wi...
Preprint
Full-text available
Pollutants or novel entities are the atoms, molecules, and particles that come up with as pollution. This paper discusses the several ways that pollutants can enter the environment, both naturally and via human activity. There exist several kinds of pollutant which includes primary pollutant, secondary pollutant, water pollutants, anthropogenic con...
Article
In this modern era, medicinal plants and their phytoconstituents have received keen attention from researchers due to the various therapeutic implication found in different pharmacological investigations. Among millions of medicinal plants, Gloriosa superba is one of the therapeutically important ornamental climbers that has been traditionally used...
Article
As per the WHO, every year around 2.1 million women are detected with breast cancer. It is one of the most invasive cancer in women and second most among all, contributing around 15% of death worldwide. The available anticancer therapies including chemo, radio, and hormone therapy are associated with a high load of reversible and irreversible adver...
Article
Herbal antioxidant like curcumin holds great potential to treat neurodegenerative disease like Alzheimer's disease. However, its therapeutic potency is obstructed due to rapid metabolism, poor solubility, GI susceptibility, enzymatic degradation and lower bioavailability. Thus, the present work aimed to design and optimize curcumin-loaded NLC (CNL)...
Article
Development of natural mosquito repellants is essential considering their safety profile unlike synthetic insecticides. Herein, novel liquid vaporizable preparations of the essential oils obtained from the leaves of weeds Lantana camara Linn (L. Camara) family Verbenaceae, and Ocimum gratissimum Linn (O. gratissimum) family Lamiaceae were developed...
Article
Present work focuses on the development and optimization (Box-Behnken design) of calcipotriol (CP) loaded nanostructured lipid carrier (NLC) enriched nanogel for topical treatment of psoriasis. In this regard, CP-NLCs were prepared, optimized, and investigated in vitro for various physical parameters. Further, the optimized batch of CP-NLCs was loa...
Article
In December 2019, when the whole world is waiting for Christmas and New Year, the physicians of Wuhan, China, are astounded by clusters of patients suffering from pneumonia from unknown causes. The pathogen isolated from the respiratory epithelium of the patients is similar to previously known coronaviruses with some distinct features. The disease...
Article
The diagnosis and treatment of neurological ailments always remain an utmost challenge for research fraternity due to the presence of BBB. The intranasal route appeared as an attractive and alternative route for brain targeting of therapeutics without the intrusion of BBB and GI exposure. This route directly and effectively delivers the therapeutic...
Article
In last two decades, the lipid nanocarriers have been extensively investigated for their drug targeting efficiency towards the critical areas of the human body like CNS, cardiac region, tumor cells, etc. Owing to the flexibility and biocompatibility, the lipid-based nanocarriers, including nanoemulsion, liposomes, SLN, NLC etc. have gained much att...
Article
Alzheimer's disease, a progressive neurodegenerative disorder, is one of the leading causes of death in the USA, along with cancer and cardiac disorders. AD is characterized by various neurological factors like amyloid plaques, tau hyperphosphorylation, mitochondrial dysfunction, acetylcholine deficiency, etc. Together, impaired insulin signaling i...
Chapter
Polymers are one of the most researched materials in different fields of study like engineering, chemistry, biomedicine, etc. Interpenetrating polymer network-based gels are highly versatile as they possess the properties of two or even more type of polymers from which they are formulated. The 3D structure of IPN hydrogels possesses the ability of...
Article
NLC is a next-generation lipid nanocarrier which holds many advantages over other colloidal lipid carrier system like higher drug loading, better and controlled release and enhanced stability. Owing to the unique structural composition, i.e. crystallized solid and liquid lipid blend it offers excellent biocompatibility and higher permeation across...
Article
Background Diabetes is one of the most common chronic metabolic disorder which affect the quality of human life worldwide. As per the WHO report, between 1980 to 2014, the number of diabetes patient increases from 108 million to 422 million, with a global prevalence rate of 8.5% per year. Diabetes is the prime reason behind various other diseases l...
Article
Dendrimers are emerging class of nanoparticles used in targeted drug delivery systems. These are radially symmetric molecules with well-defined, homogeneous, and monodisperse structures. Due to the nano size, they can easily cross the biological membrane and increase bioavailability. The surface functionalization facilitates targeting of the partic...
Chapter
Contents 1. Introduction 1 2. Properties of supercritical CO2 2 3. Applications of SCO2 in polymer production and processing 3 3.1 Purification of polymers 3 3.2 Impregnation and supercritical dyeing 4 3.3 Particle production 4 3.4 Polymer modification 4 4. Polymer production 5 4.1 Step-growth polymerization 5 4.2 Chain growth polymerization 7 5. P...
Chapter
Contents 1. Introduction 2 2. Green solvent 3 3. Carbon dioxide as a green solvent 4 4. Green tea composition and bioactives 4 4.1 Decaffeination of green tea leaves 5 4.2 Catechin 6 4.3 Physical properties of catechin 8 4.4 Chemical properties of catechin 8 4.5 Biological potential of catechin 8 5. Extraction techniques 10 5.1 Conventional extract...
Article
Full-text available
Globally, the central nervous system (CNS) disorders appear as the most critical pathological threat with no proper cure. Alzheimer’s disease (AD) is one such condition frequently observed with the aged population and sometimes in youth too. Most of the research utilizes different animal models for in vivo study of AD pathophysiology and to investi...
Article
Full-text available
Microemulsions are thermodynamically stable, transparent, colloidal drug carrier system extensively used by the scientists for effective drug delivery across the skin. It is a spontaneous isotropic mixture of lipophilic and hydrophilic substances stabilized by suitable surfactant and co-surfactant. The easy fabrication, long-term stability, enhance...
Article
Diabetes and its complications are a significant health concern throughout the globe. There are physiological differences in the mechanism of type-I and type-II diabetes and the conventional drug therapy as well as insulin administration seem insufficient to address the problem at large successfully. Hypoglycemic swings, frequent dose adjustments a...
Article
The unique self-renewal and differentiation ability of stem cells drag the attention of many scientists and researchers towards the clinical application of stem cells. Stem cells are basically the normal living cells of multicellular organisms with some special ability to proliferate and transform into any kind of the body cells with their characte...
Article
In last few years, the stem cell therapy gets much popularity among researchers and scientists of biomedical field. It became an effective and alternative approach for the treatment of various physiological conditions (like accidental injuries, burn damage, organ failure, bone marrow transfusion, etc.) and chronic disorders (diabetes, cancer, neuro...
Article
Utilizing the diverse features of biocompatible polymers to target drugs into the tumor/s has been a research hotspot since last decade. Such polymeric conjugates of anti-cancer drugs have proven their potential in providing sustained release of drugs with reduced systemic toxicity and improved tumor retention. Polymers like polyethylene glycol (PE...
Article
According to the Alzheimer Association Report (2017), Alzheimer's disease (AD) is the 6th primary cause of death in the USA, which affects nearly 5.5 million people. In the year 2017 itself, the cost of AD treatment in the USA has been reported to rise to $259 billion. This statistic shows the severity of the disease in the USA which is very much s...
Article
Introduction: Brain is supposed to be the most complicated part of the body which is very far from the reach of drug moieties. The drug entry in to the brain region depends upon various factors, and among those, the blood-brain-barrier remains the most prominent one. This barrier restricts the entry of almost all the drug and most of the essential...
Article
Tissue engineering is a multi-disciplinary field such as material science, life science, and bioengineering that are necessary to make artificial tissue or rejuvenate damaged tissue. Numerous tissue repair techniques and substitute now exist even though it has several shortcomings; these shortcomings give a good reason for the continuous research f...
Article
Transdermal delivery serves as non-invasive and effortless terminable means for systemic as well as topical drug delivery and finds itself as an option to conventional delivery route. Significant impervious nature of skin is the greatest hurdle for successful delivery of drug molecules to the deeper layers of skin for systemic absorption. Many appr...
Article
In this modern era, with the help of various advanced technologies, medical science has overcome most of the health-related issues successfully. Though, some diseases still remain unresolved due to various physiological barriers. One such condition is Alzheimer; a neurodegenerative disorder characterized by progressive memory impairment, behavioral...
Article
Full-text available
The aim of this work is to apply Box-Behnken design to optimize the transfersomes were formulated by modiᰛed rotary evaporation sonication technique using surfactant Tween 80. The response surface methodology was used having threefactored with three levels. The prepared formulations were characterized for vesicle shape, size, entrapment e婋ciency (%...
Article
Application of pharmaceutical nanotechnology (nanomedicines) for plant actives and extracts, is gaining a tremendous growth and interest among the scientists. This emerging herbal revolution has headed towards the development of another approaches for the delivery of poorly soluble herbal bioactives and plant extracts for enhancing their bioavailab...
Article
Ethnopharmacological relevance: Schleichera oleosa (Lour.) Oken. commonly known as 'Koshamra' in Ayurveda is a tropical tree readily found in Asia and is used to treat pain and rheumatism, as traditional medicine in different parts of India. However, scientific evidences to justify these claims are lacking. Considering the traditional use of S.ole...
Article
Background: Hydrogels are the polymeric network, which can retain large amount of water. Thus, these delivery systems always remained an issue of intensive research among the scientist fraternity. Objective: In this piece of work, we have reconnoitered the significance of the PEGylated anticancer loaded drug onto poloxamer based thermoresponsive...
Article
Drug induced hemolysis is a frequent complication associated with chemotherapy. It results from interaction of drug with erythrocyte membrane and leads to cell lysis. In recent past, various approaches were made to reduce drug-induced hemolysis, which includes drug polymer conjugation, drug delivery via colloidal carriers and hydrogels, co-administ...
Article
Drug induced hemolysis is a frequent complication associated with chemotherapy. It results from interaction of drug with erythrocyte membrane and leads to cell lysis. In recent past, various approaches were made to reduce drug-induced hemolysis, which includes drug polymer conjugation, drug delivery via colloidal carriers and hydrogels, co-administ...
Article
Novel drugs delivery systems (NDDS), formulations from plant actives and extracts are still a matter of thrust and hot cake among the researchers working with phytomedicine. Novel delivery systems such as polymeric liposomes, colloidisomes, aquasomes, ethosomes, niosomes, proliposomes, phytosomes®, nanoparticles, nanocapsules, nanoemulsions, micros...
Article
Full-text available
Flavanoids are known to have efficiency on wrinkling, dry rough skin, red blotchiness and hyperpigmented spots in aged skin. Hyaluronidase and elastase are considered to be an important factor in degradation of Extracellular Matrix components (ECM) leading to bacterial invasion, envenomation of various toxins among others. This study potentiate tha...
Article
A simple, sensitive, and specific thin-layer chromatography densitometric method has been developed for the quantitation of glycyrrhizinic acid. The poly herbal formulations containing Mulethi were widely used for expectorant and carminative in ancient times. The present paper deals with the development of a densitometric method for fingerprint of...
Article
The phyto-phospholipid complexation technique is a promising approach to improve the bioavailability and efficacy of flavonoids. The objective of this study was to improve the bioavailability and efficacy of luteolin by phospholipid complexation against inflammatory liver damage. The phospholipid complex of luteolin (LPC) was prepared by solvent ev...
Article
Full-text available
The aim of this study was to design a targeted drug delivery system carrying a natural anticancer drug Quercetin (Qu), specifically for skin cancer. A central composite design was applied separately for each ligand, and the quadratic model was used for the process. The surface morphology was confirmed by transmission electron microscopy (TEM) and F...
Article
Objective: Although the melphalan (ML) used extensively for the management of breast cancer, its clinical application is limited due to significant hemolytic activity. In the present work, a comparative analysis of two distinct in situ-based thermogelling polymers of PEGylated ML was performed. Methods: Briefly, the PEGylated conjugate of the me...
Article
Protein and peptide delivery by the use of stimuli triggered polymers remains to be the area of interest among the scientist and innovators. In-situ forming gel for the parenteral route in the form of hydrogel and implants are being utilized for various biomedical applications. The formulation of gel depends upon factors like temperature modulation...
Article
Objectives This study aims to develop novel carrier system incorporating luteolin, a poorly soluble biologically active plant active. Methods We investigated a lipid-based drug delivery system to enhance dissolution and absorption profile of luteolin. Luteolin was complexed with phospholipids, and the preparation was characterized. The formulation...
Article
Objectives In this study, we have used melphalan (ML) as a model drug, used extensively for the treatment of breast cancer. Due to its remarkable haemolytic activity, clinical application of this drug is limited.Methods We incorporated the two synthesized PEGylated melphalan conjugates, viz. MLPEG 2000 and MLPEG 5000, separately into the medium mol...
Article
Full-text available
Photosensitization is a process in which the skin reacts to exposure to ultraviolet radiations. There are various associated dermatological consequences like photoxicity and photoallergic reactions which make the disease more complicated. There are various drugs which together with solar radiations worsen the situation of photosensitivity and hence...
Article
The continuous exposure of skin to ultraviolet radiations generates reactive oxygen species leading to photoaging in which degradation of dermal collagen and degeneration of elastic fibers occurs. Matrix metalloproteinase [MMP] enzymes are the proteolytic enzymes which have significant potentiality of cleaving Extracellular Matrix [ECM] against Ult...
Article
Full-text available
Ageing and hormones are inter-related terms playing crucial role in human’s life. Dehydroepiandrosterone, commonly known DHEA, is among those hormones which directly interfere with the ageing process and its effects is remarkably visible. The role of DHEA in fighting against the signs of aging have been tested for a long time. Recent researches in...
Article
Stimuli triggered polymers provides a variety of applications related with the biomedical fields. Among various stimuli triggered mechanisms, thermoresponsive have been extensively investigated, as they are relatively more convenient and effective stimuli for biomedical applications. In contemporary for achieving the sustained action of proteins, p...
Article
Full-text available
This study describes the release and retention of a herbal lipophilic drug in sustained and controlled manner in skin layers, given topically, intended for skin cancer. Quercetin -loaded nanoparticles were prepared by nanoprecipitation technique using ethylcellulose as polymer. Ethylcellulose was selected as it is biocompatible, but non-biodegradab...
Article
The phyto-phospholipid complexation technique has emerged as one of the leading methods of improving bioavailability of phytopharmaceuticals having poor competency of solubilizing and crossing the biological membranes. Several plant actives in spite having potent in vitro pharmacological activities have failed to demonstrate similar in vivo respons...
Article
Wound is one of the oldest suffering associated with the mankind and its history is as old as humanity. Advances in the field of medical sciences created a pile of knowledge and paved the path for the development of a separate branch specifically devoted for wound healing. The understanding and treatment strategies for wound healing have gone throu...
Article
Wound is one of the oldest suffering associated with the mankind and its history is as old as humanity. Advances in the field of medical sciences created a pile of knowledge and paved the path for the development of a separate branch specifically devoted for wound healing. The understanding and treatment strategies for wound healing have gone throu...
Article
Introduction: Current research efforts focused on the design and evaluation of drug delivery systems that are easy to administer require decreased administration frequency, and provide sustained drug release in order to increase clinical efficacy and compliance of the patients. The gel forming smart polymeric formulations offer numerous applicatio...
Article
Transdermal drug delivery system (TDDS) utilizes the skin as executable route for drug administration but the foremost barrier against drug permeability is the stratum corneum and therefore, it limits therapeutic bioavailability of the bioactive. This review focuses on the recent advancements in the TDDS which include iontophoresis, sonophoresis, e...
Article
Full-text available
Traditional medicines that formed the basis of health care throughout the world since the earliest days of mankind are still widely used and have considerable importance in international trade. Recognition of their clinical, pharmaceutical, and economic value is still growing, although this varies widely between countries and therefore regulation o...
Article
Full-text available
Botanical photochemoprotectives are used because they act on various stages to prevent skin cancer and photoaging. The aim of this study was to prepare herbal creams from various photochemoprotective herbs and to perform efficacy studies on them by using physicochemical, microbiological, safety, psychometric, biophysical, and sun protection factor...
Article
Balacaturbhadrika churna is an Ayurvedic formulation widely used in diarrhoea, fever, cough and asthma. The present article is an attempt to establish the scientific basis of one of the reputed Ayurvedic formulation. Investigations were carried out to study the physicochemical, phytochemical and spectrophotometric analysis of formulation. The value...
Article
The Drakshadi gutika is effective for amlapitta, hrddahakanthadaha, trsna, murccha, agnimandaya and amavata is official in Ayurveduc formulary in India. Quantification of active principles through modern analytical tools is essential for establishing the authenticity, creditability, prescription and usage of Ayurvedic medicines/herbal formulations....
Article
The poly herbal formulations containing ginger are widely used for different medicinal properties. The present paper deals with the development of spectrophotometric fingerprint for estimation of 6- Gingerol in raw materials and market formulations. However, there has been an attempt to standardize the polyherbal formulations containing 6-Gingerol...
Article
Full-text available
The poly herbal formulations containing ginger are widely used for different medicinal properties. The present paper deals with the development of densitometric method for fingerprint of ginger mainly using 6-gingerol in the form of densitogram following charring of the chromatographic as internal standard that could be useful for marker-based qual...
Article
Full-text available
Curcuminoids obtained from Curcuma longa have properties like photoprotection, antiaging, anti-wrinkle, moisturizing, antioxidant, astringent, anti-irritant, antimicrobial and anti-inflammatory activities. Our aim was to develop a stable nano-transfersomes loaded cream which could correct the morphological defects and penetrate deeper to the cellul...