Shahnawaz Ahmad Wani

Shahnawaz Ahmad Wani
Sher-i-Kashmir Institute of Medical Sciences | SKIMS · Advanced centre for human genetic

Doctor of Philosophy
Senior Researcher at RRIUM Srinagar, MINISTRY of AYUSH.

About

16
Publications
37,503
Reads
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57
Citations
Citations since 2017
12 Research Items
57 Citations
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Introduction
Calcium and nitric oxide interplay in vascular smooth muscle cells. Methodology:- Organ bath and Vascular smooth muscle cell culture. Currently working on docking of natural compounds with Proteins in relations to smooth muscles.
Additional affiliations
June 2019 - present
Jamia Millia Islamia
Position
  • Research Associate
September 2013 - June 2019
Jamia Millia Islamia
Position
  • PhD
Description
  • Title of Thesis "Effects of metal pollutants on cardiovascular system"
January 2013 - June 2013
Dr. B.R. Ambedkar Center for Biomedical Research
Position
  • TRANIEE(Dissertation)
Description
  • INTERGENOTYPIC VARIATIONS IN THE LEVELS OF NITRIC OXIDE IN HSP 70 GENE POLYMORPHISM IN PATEINTS WITH ESSENTIAL HYPERTENSION: A PLOT STUDY
Education
September 2013 - June 2019
Jamia Millia Islamia
Field of study
  • Effects of Metal pollutants on Cardiovascular system

Publications

Publications (16)
Article
Full-text available
The corona pandemic altered many traditional and historical norms of society and law. COVID-19 created a humanitarian crisis in some parts of globe, while pandemic privacy and civil liberties were under threat all over world. To combat the deadly virus, individual liberty and equality were compromised. This paper focuses on how India's health probl...
Article
Full-text available
The corona pandemic altered many traditional and historical norms of society and law. COVID-19 created a humanitarian crisis in some parts of globe, while pandemic privacy and civil liberties were under threat all over world. To combat the deadly virus, individual liberty and equality were compromised. This paper focuses on how India’s health probl...
Article
Full-text available
Purpose: The ameliorative potential of quercetin and resveratrol on isolated endothelium-intact aortic rings incubated with nickel was examined. Method: The effect of varying concentrations of quercetin and resveratrol was investigated on isolated Wistar rat aortic rings using an organ bath system over vasoconstrictor phenylephrine (PE) at 1 µM. To...
Article
Full-text available
Background: Psoriasis is a chronic immune-mediated skin disease that affects 125 million people worldwide, which is 2 to 3 percent of total population. Psoriasis is a common, chronic, inflammatory disease that is associated with an increased risk of cardiovascular, metabolic, and renal disease in a manner that varies with psoriasis severity and is...
Article
Full-text available
Hypertension is multifactorial and a serious chronic cardiovascular condition which affects the majority of population all over the world. Inflammation is a protective mechanism in response to infection or injury to the cells and maintains homeostasis within the body. However, sustained robust inflammation can cause vasoconstriction, provoking hype...
Article
Full-text available
Water is most abundant chemical in the human body and plays important role in the regulation and transport of nutrients and toxic wastes. Safe Drinking water is used for all types of domestic purposes, including drinking, food preparation and hygiene. This study was conducted on drinking water sold by drinking water trolley vendors to assess the ex...
Article
Full-text available
Abstract To investigate the mechanism of cobalt-mediated phenylephrine (PE)-induced contraction in endothelium-intact isolated Wistar rat aortic rings. Effect of dose-dependent concentrations of cobalt on PE-induced contraction was investigated in isolated Wistar rat aortic rings using an organ bath system. Aortic rings were pre-incubated with vera...
Article
Full-text available
Aim: To investigate the mechanism of nickel augmented phenylephrine (PE)-induced contraction in isolated segments of Wistar rat aorta. Materials and methods: Effect of varying concentrations of nickel on PE-induced contraction were investigated in isolated segments of Wistar rat aorta using an organ bath system. Aortic rings were pre-incubated w...
Article
Full-text available
Antioxidants can delay or inhibit the oxidation of lipids or other molecules by inhibiting the initiation or propagation of oxidative chain reactions and can thus prevent or repair damage to body's cells by reactive oxygen species. In our study we have selected Allium sativum bulbs, Mentha arvensis leaves and Murraya koenigii leaves for quantitativ...
Article
In recent years, considerable attention has been given to plant colorants for use in dyeing applications because of their newly discovered properties such as insect repellency, deodorizing, antioxidant, sun protection, and antibacterial activity. In view of their better biocompatibility, biodegradability, less-toxicity, natural colorants are gainin...
Conference Paper
Full-text available
Ni(II) toxicity caused by natural and anthropogenic sources is a global environmental concern for humans. Effect of Ni(II) and its mechanism of action on PE-induced contraction of rat isolated aorta was observed using organ bath system. A hyper-contractile response was seen at all the three Ni(II) concentrations used, i.e. 100 nM, 1 µM, and 100 µM....

Questions

Questions (44)
Question
Please share this question with expert in statistics if you don't know answere.
I am stuck here, as i am working on therapy and trying to evalute the changes in biomarker levels. So I have selected 5 patients and analysed their biomarker levels prior therapy and then after first therapy and followed by 2nd therapy. So as i apply anova results show significant difference in their mean values but due larger difference in their standard deviations i am getting non significant results
like in this table below.
Sample Size Mean Standard Deviation SE of Mean
vb bio 5 314.24 223.53627 99.96846
cb1 bio 5 329.7 215.54712 96.3956
CB II 5 371.6 280.77869 125.56805
So I want to know from all those good statsticians who are well aware about the clinical trial studies.
Please suggest
Am i performing statistics correctly?
Should not i worry about non significant results?
What are the statistical tests I should use?
How will I represent my data for publication purposes?
Please be eloberative in answers?
Try to teach like you are teaching to the fresher to this field.
Question
I am in need of cell lines related to vascular smooth muscle cells.
Can any body provide me vascular smooth muscle cells?
Question
I want to use R studio to get research articles from pubmed. I have installed both R and R studio and I know how to write program. But I am facing problem of getting data from pubmed. So Please share some basic notes or suggest all this in flow chart.
Thanks in advance
Question
Urgently needed a few protocols.
Regarding how to select dose for studying vascular reactivity for a particular drug. How to mention that in objectives?
And also share a protocol/procedure that will help to finalise the dose. I am studying vascular reactivity in Wistar rats.
Question
I have completed Ph.D. now I am looking for Post Doc Position. I would like to join this Project.
Question
  1. I want to understand meaning and interpretation of calcium sequestration. How this process causes hypercontraction?
  2. If we have endothelial dysfunction Can calcium uptake be responsible for contraction alone. Or both will be responsible.
Question
If we observe decreased contraction over PE in heavy metal incubated aorta. What does it mean? Please interpret

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