Shahir Mazaheri

• MD
• Professor (Associate) at farshchian(Sina) Hospital,hamadan medical university

Background: Stroke is a major health problem and leading cause of mortality worldwide. This study aimed to evaluate the consequences of intravascular interventions in patients with acute ischemic stroke with and without intravenous tissue plasminogen activator (tPA) injection. Methods: This prospective cohort study was conducted on 120 patients wit...

Purpose Sonic hedgehog (SHH) signaling pathway in oxidative stress condition has been acknowledged as a key trigger for angiogenesis and collateral vessel growth in the ischemic brain, and it exerts a protective effect on neuronal cells during oxidative stress. Methods A total of sixty patients (n = 30 good collateral profile and n = 30 poor colla...

Backgrounds: Environmental factors such as bacterial infections, as well as genetic factors—in particular the human leukocyte antigen (HLA) alleles—have been implicated in the etiology of multiple sclerosis (MS). This study aims to explore the relationship between Helicobacter pylori infection, HLA alleles, and disease severity in Iranian MS patien...

Multiple sclerosis (MS) is the most common inflammatory demyelinating disease in the central nervous system. It is one of the major causes of disability in young adults. Early diagnosis and treatment of this disease could decrease later disability and additional costs. In this cross-sectional analytical study, a total of 351 patients were selected...

Background: Subarachnoid hemorrhage (SAH) is one of the most costly and important causes of death and disability worldwide. Aneurysmal type of this hemorrhage has high fatality and permanent disability rates. Objectives: In the present study, demographic and clinical characteristics of SAH with and without an aneurysm were compared. Methods: In thi...

Background and Objective: Evidence is indicative of the positive effect of citicoline administration in stroke patients; however, there are controversies over this issue. Regarding this, the present study was conducted to investigate the efficacy of citicoline in acute stroke patients. Materials and Methods: This randomized clinical trial was condu...

Background: The C-reactive protein (CRP) level, as an early prognostic factor of functional outcome after stroke, may be of clinical importance. The aim of this study was to determine the prognostic value of CRP on functional outcome and death in stroke patients. Methods: This prospective study was conducted from 2015 to 2016 in Hamadan province...

Background & Objective: Although antiepileptic drugs have controlled the epilepsy attacks substantially, the side-effects are still considered as a problem to the patients. The aim of this study was to compare the effects of sodium valproate and carbamazepine on sexual function in men with epilepsy. Materials & Methods: In this cross-sectional stud...

Introduction: Optimal time of referral aftr stroke and the use of new therapies, such as r-tPA and blood pressure control, could accelerate symptoms recovery aftr stroke. Th aim of this study was to investigate factors contributing to the delay in referral to hospitals aftr the occurrence of acute stroke. Methods: Ths analytic-descriptive study inc...

Background and purpose: Cerebral venous sinuses thrombosis (CVST) is an uncommon type of stroke with an incidence of 3-4 cases per million. There have been reports of higher incidence of this disease in Iran. Our objective is to describe the incidence, clinical presentation, predisposing factors, and outcomes of CVST at Sina Hospital in Hamadan, w...

Introduction & Objective: Stroke is the third cause of death in developed countries and the most common neurologic disease resulting in disability. Nowadays, several risk factors for stroke are recognized properly. Life style and risk factors such as hypertension and diabetes are different among various cultures and countries. This study was design...

Background: Migraine is the most frequent type of primary headache. It has been demonstrated that H. pylori infection eradication has a possible role in the reduction of migraine headache but needs to be examined in different settings using Urea Breath Test (UBT). This clinical trial was conducted to evaluate the effect of the H. pylori eradication...

Introduction & Objective: Mechanisms underlying migraine precipitation are largely unknown. Helicobacter pylori (H. pylori) infection has recently been associated with various extraintestinal pathologies and migraine. The relation between Helicobacter pylori and Migraine is controversial. The aim of this study was to investigate the correlation of...

Optic neuritis (ON) can be the first presentation of multiple sclerosis (MS) or neuromyelitis optica (NMO). Anti-aquaporin-4 IgG (AQP4 IgG) is a highly specific and moderately sensitive biomarker for NMO. This study was designed to assess the rate of seropositivity for AQP4 IgG, and the short-term outcome of patients presenting with single isolated...

Migraine is considered to be a polygenic multifactorial disease with various environmental and genetic etiologies. Tumor necrosis factor-alpha (TNF-α), a potent immunomodulator and pro-inflammatory cytokine, has been implicated in many pathological processes in brain. The hypothesis of this study was that migraine without aura (MWA) might be associ...