Shaghayegh Haghjooy Javanmard

Shaghayegh Haghjooy Javanmard
Isfahan University of Medical Sciences · Department of Physiology

Professor of physiology

About

378
Publications
48,834
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3,693
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Introduction
Shaghayegh Haghjooy Javanmard currently works at the Department of Physiology, Isfahan University of Medical Sciences. Shaghayegh does research in Bioinformatics, Cancer Research and Physiology. Their current project is 'Leptin in Autoinflammatory diseases'.
Skills and Expertise
Additional affiliations
October 2009 - October 2014
Isfahan University of Medical Sciences
Position
  • Head of Applied Physiology Research Center

Publications

Publications (378)
Article
Droplet-based microfluidic systems are promising tools for many biological applications from digitalized analysis to drug delivery and biomolecules synthesis. Among these, fabrication of microgels, particularly alginate microbeads, has substantial importance due to their capability for three-dimensional (3D) encapsulation of cells, drugs and other...
Article
A method is presented for measurements of secondary acoustic radiation forces acting on solid particles in a plain ultrasonic standing wave. The method allows for measurements of acoustic interaction forces between particles located in arbitrary positions such as in between a pressure node and a pressure antinode. By utilizing a model that consider...
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SARS-CoV-2 (COVID-19) is the causative organism for a pandemic disease with a high rate of infectivity and mortality. In this study, we aimed to assess the affinity between several available small molecule and proteins, including Abl kinase inhibitors, Janus kinase inhibitor, dipeptidyl peptidase 4 inhibitors, RNA-dependent RNA polymerase inhibitor...
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Objective: There is no conclusive evidence to suggest vitamin D level can prevent or treat infection with the new coronavirus disease 2019. This study aimed to investigate the effects of serum level of vitamin D in patients with coronavirus disease 2019 on death, severity, and hospitalization duration. Materials and methods: Baseline characteris...
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Introduction Breast cancer is one of the most prevalent cancers among women in Isfahan, Iran; however, its prevention is not desirable in this city. This disease poses several health, social and economic challenges for women. To promote women's self-care in breast cancer prevention, this study aims to design, implement and evaluate a self-care prog...
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Objective: Low-density lipoprotein cholesterol is the mainstay of diagnosis, treatment, and follow-up of patients with familial hypercholesterolemia, the most prevalent autosomal domi- nant disorder among humans. Since the reference measurement method (ultracentrifugation) is time-consuming and expensive, many formulas emerged to calculate low-den...
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Beta (β)-thalassemia is a group of human inherited abnormalities caused by various molecular defects, which involves a decrease or cessation in the balanced synthesis of the β-globin chains in hemoglobin structure. Traditional treatment for β-thalassemia major is allogeneic bone marrow transplantation (BMT) from a completely matched donor. The limi...
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miR‐200c‐3p is demonstrated to play the role of tumour suppressor in different tumours. However, the miR‐200c‐3p biological function in normal fibroblast (NF) and cancer‐associated fibroblast (CAF) remains unclear. This investigation aims to study the regulatory role of miR‐200c‐3p in the secretion of Interleukin‐2 (IL‐2) in CAF and NF. CAFs and NF...
Article
Background: The world is experiencing another pandemic called COVID-19. Several mathematical models have been proposed to examine the impact of health interventions in controlling pandemic growth. Method: In this study, we propose a fractional order distributed delay dynamic system, namely, EQIR model. In order to predict the outbreak, the propo...
Article
Background The transmembrane receptor podoplanin (PDPN) is a platelet aggregation-inducing factor, which is widely expressed in various malignant tumors such as squamous cell carcinomas, mesotheliomas, glioblastomas. Podoplanin regulates a pathway leading to cell invasion and migration. Glioblastoma multiforme (GBM) is the most aggressive and invas...
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Background: Health‑care workers (HCWs) as frontline soldiers are involved in the war against COVID‑19. Not only their protection from COVID‑19 is important but also their mental health is a concern. This study aimed to measure the psychological distress among HCWs in the time of COVID‑19 in Isfahan, Iran. Materials and Methods: A cross‑sectional st...
Article
The miR-21 detection is essential for the accurate and early diagnosis or prognosis of most diseases. In the current study, the miR-21 detection method was performed based on the exploitation of the simple colorimetric biosensor due to the unique surface plasmon resonance (SPR) absorption of gold nanoparticles. AuNPs were functionalized with the sp...
Article
Nitroxoline (NIT) is a quinoline antibiotic with anti-cancer effects which prevents cell migration by inhibition of cathepsin B enzyme. Cisplatin (CIS) is normally used for various kinds of malignancies such as metastatic breast cancer. The goal of the present study was increasing cellular toxicity and cell migration inhibition by co-delivery of NI...
Preprint
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Background: Patients with cancer are at an increased risk of mortality from COVID-19 infection. So, they are prioritized for vaccination. This study aims to report the clinical characteristics of patients who had a positive PCR test after being fully vaccinated by Sinopharm BIBP Vaccine. Methods: In this retrospective study, the data of patients...
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Bone marrow-derived mesenchymal stem cells (MSCs) offer a promising therapeutic method for cardiac tissue regeneration. However, to monitor the fate of MSCs for tissue repair, a better stem cell delivery carrier is needed. Developing a unique injectable and shear-thinning dual cross-linked hybrid hydrogel for MSC delivery for cardiac tissue enginee...
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In orchestrating the wound healing process, the immune system plays a critical role. Hence, controlling the immune system to repair skin defects is an attractive approach. The highly complex immune system includes the coordinated actions of several immune cells, which can produce various inflammatory and antiinflammatory cytokines and affect the he...
Article
Background Morphine is an analgesic agent used for cancer pain management. There have been recent concerns that the immunosuppressant properties of morphine can also promote cancer metastasis. Morphine is an agonist for toll like receptor 4 (TLR4) that has a dual role in cancer development. The promotor or inhibitor role of morphine in cancer progr...
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Previous studies suggested that patients with comorbidities including cancer had a higher risk of mortality or developing more severe forms of COVID-19. The interaction of cancer and COVID-19 is unrecognized and potential long-term effects of COVID-19 on cancer outcome remain to be explored. Furthermore, whether COVID‐19 increases the risk of cance...
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Background and aims: Familial hypercholesterolemia (FH) is an autosomal dominant genetic disorder of lipid metabolism which leads to premature cardiovascular diseases. In patients with FH, blood inflammatory markers may be disrupted; however, its extent is unclear. In this study, we aimed to evaluate the NLR (neutrophil to lymphocyte ratio), PLR (...
Article
Solvent type and solution viscosity are of great importance in affecting different traits of the electrospun scaffolds. This study aims to highlight the effect of different solvents on physicomechanical properties of PGS/PCL blend electrospun scaffolds. The PGS:PCL (2:1) blends were dissolved in five different solvent systems including DMF, DCM, DM...
Article
Familial hypercholesterolemia (FH) is linked to high levels of low-density lipoprotein cholesterol (LDL-C), atherosclerotic, and aortic stenosis to a lesser extent. We looked at the incidence of prevalent comorbid disorders other than cardiovascular disease (CVD), such as diabetes, chronic kidney disease (CKD), hypertension, and cancer in heterozyg...
Article
Background: Peripheral neurotoxicity is a common side effect of many anticancer chemotherapy drugs, including paclitaxel. Peripheral neurotoxicity may present as changes in sensory function and mild paresthesia that, in turn, can lead to alleviation of the prescribed dose of the medication. The aim of this study was to evaluate the effectiveness o...
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Leukemia inhibitory factor (LIF), as a member of the interleukin-6 cytokine family, plays a complex role in solid tumors. However, the effect of LIF as a tumor microenvironment factor on plasticity control in breast cancer remains largely unknown. In this study, an in vitro investigation is conducted to determine the crosstalk between breast cancer...
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Coronavirus disease-2019, also known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was a disaster in 2020. Accurate and early diagnosis of coronavirus disease-2019 (COVID-19) is still essential for health policymaking. Reverse transcriptase-polymerase chain reaction (RT-PCR) has been performed as the operational gold standard for...
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Acoustophoretic microfluidic devices have been developed for accurate, label-free, contactless, and non-invasive manipulation of bioparticles in different biofluids. However, their widespread application is limited due to the need for the use of high quality microchannels made of materials with high specific acoustic impedances relative to the flui...
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Background: Understanding the close interaction between the specialties of cardiology and oncology is necessary for early detection of cardiovascular disease (CVD) events in cancer patients. For the risk assessment of CVD in Breast and Colorectal Cancers (CIBC) study, in the current study we aimed to validate a questionnaire for the assessment of...
Preprint
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Background: The COVID-19 pandemic challenges the healthcare system to provide enough resources to battle the pandemic without jeopardizing routine treatments. As a result, this is important that we can predict the outcomes of patients at the time of admission. This study aims to apply different machine learning (ML) models for predicting Intensive...
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Publications Red Blood Cell Distribution Width (RDW) as a Predictor of In-Hospital Mortality in COVID-19 Patients; a Cross Sectional Study publication dateOct 13, 2021 publication descriptionArchives of Academic Emergency Medicine (AAEM) publication descriptionAbstract Introduction: Red blood cell distribution width (RDW) has been introduced as a...
Article
Microgels with embedded distinct compartments are robust tools for creating different physiochemical scaffolding conditions by co-encapsulation of various cargoes. This work presents a robust, rapid, and low-cost approach for one-step fabrication of multicompartmental microgels using droplet-based microfluidic systems. After selective modification...
Article
Familial hypercholesterolemia (FH) is the most common genetic disease which accelerates the development of premature coronary artery disease (CAD) in young adults if remains untreated. The overall prevalence of FH is currently unknown and is usually underdiagnosed and undertreated worldwide. FH registry in different geographical area is a mission t...
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Cancers evolve as a result of the accelerated proliferation of cancer cells in a complicated, enriched, and active microenvironment. Tumor microenvironment (TME) components are the master regulators of any step of cancer development. The tumor microenvironment is composed of many cellular and noncellular components that contribute to the evolution...
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COVID-19 is still a deadly disease that remains yet a major challenge for humans. In recent times, many large pharmaceutical and non-pharmaceutical companies have invested a lot of time and cost in fighting this disease. In this regard, today's scientific knowledge shows that designing and producing an effective vaccine is the best possible way to...
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Background Already at hospital admission, clinicians require simple tools to identify hospitalized COVID-19 patients at high risk of mortality. Such tools can significantly improve resource allocation and patient management within hospitals. From the statistical point of view, extended time-to-event models are required to account for competing risk...
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Background: There are no data on the association between clinical course and comorbidity in Iranian patients with COVID-19. Aims: To determine noncommunicable disease (NCD), clinical characteristics and prognosis of patients hospitalized with COVID-19 in Isfahan, Islamic Republic of Iran. Methods: This multicentric retrospective observational...
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Heart failure (HF) is a major consequence of many cardiovascular diseases with high rate of morbidity and mortality. Early diagnosis and prevention are hampered by the lack of informative biomarkers. The aim of this study was to perform a meta-analysis of the miRNA expression profiling studies in HF to identify novel candidate biomarkers or/and the...
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Despite the promising anti-cancer properties of the polyoxometalates (POMs) compound, they have not yet been reported for clinical use due to their general toxicity. This study reports the synthesis of tocopherol succinate (TS)-polyoxomolybdate (POMo) conjugate (T2POMo) as a novel organic–inorganic hybrid conjugate of POMo and evaluating its anti-c...
Article
Gastric cancer, especially in later stages, is resistant to chemotherapy. The prevalence of gastric cancer increases after the age of 40, and its peak is in the 7th decade of life. The proteins tau (tubulin associated unit) and stathmin are overexpressed in gastric cancer and contribute to the progression of the disease by increasing cancer cell pr...
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Background: Familial hypercholesterolemia (FH) is a common autosomal dominant disease. Its diagnosis in Iran was uncommon. Iran registry of FH (IRFH) has been started from 2017 from Isfahan. In this study, we report the four-year FH registry. Methods: The Iran FH registry is an ongoing study which is followed by a dynamic cohort. It has been sta...
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Microfluidic chemical gradient generators enable precise spatiotemporal control of chemotactic signals to study cellular behavior with high resolution and reliability. However, time and cost consuming preparation steps for cell adhesion in microchannels as well as requirement of pumping facilities usually complicate the application of the microflui...
Article
Extracellular vesicles (EVs) are cell‐derived nanoscale vesicles involved in intracellular communication and the transportation of biomarkers. EVs released by mesenchymal stem cells have been recently reported to play a role in cell‐free therapy of many diseases. However, the demand for better research tools to replace the tedious conventional meth...
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is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The SARS-CoV-2 virus strains has geographical diversity associated with diverse severity, mortality rate, and response to treatment that were characterized using phylogenetic network analysis of SARS-CoV-2 genomes. Although, there is no explicit and integrative explanation f...
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Colorectal cancer (CRC) is the third most common cause of cancer globally and the fourth attributable cause of mortality and morbidity due to cancer. An emerging factor contributing to CRC is the gut microbiota and the cellular changes associated with it. Further insights on this may help in the prevention, diagnosis and new therapeutic approaches...
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Organoids are powerful systems to facilitate the study of individuals' disorders and personalized treatments. Likewise, emerging this technology has improved the chance of translatability of drugs for pre-clinical therapies and mimicking the complexity of organs, while it proposes numerous approaches for human disease modeling, tissue engineering,...
Preprint
Full-text available
Background: Already at the time of hospital admission, clinicians require simple tools to identify hospitalized COVID-19 patients at high risk of mortality. Such tools can significantly improve resource allocation and patient management within hospitals. From the statistical point of view, extended time-to-event models are required to account for c...
Preprint
Full-text available
Background The most common malignancy is breast cancer, among women in the world. Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer. Cancer associated fibroblasts (CAFs) play a critical role to support tumor cells in all aspect of cancer development such as cell proliferation, migration and angiogenesis. MiRNAs ar...
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COVID-19 has led to a pandemic, affecting almost all countries in a few months. In this work, we applied selected deep learning models including multilayer perceptron, random forest, and different versions of long short-term memory (LSTM), using three data sources to train the models, including COVID-19 occurrences, basic information like coded cou...
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The multifaceted destructions caused by COVID-19 have been compared to that of World War II. What makes the situation even more complicated is the ambiguity about the duration and ultimate spread of the pandemic. It is especially critical for the governments, healthcare systems, and economic sectors to have an estimate of the future of this disaste...
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The COVID-19 pandemic has now imposed an enormous global burden as well as a large mortality in a short time period. Although there is no promising treatment, identification of early predictors of in-hospital mortality would be critically important in reducing its worldwide mortality. We aimed to suggest a prediction model for in-hospital mortality...
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Digital health as a rapidly growing medical field relies comprehensively on human health data. Conventionally, the collection of health data is mediated by officially diagnostic instruments, operated by health professionals in clinical environments and under strict regulatory conditions. Mobile health, telemedicine, and other smart devices with Int...
Preprint
Full-text available
Up to now, polyoxometalates (POMs) have shown encouraging anti-tumor activities. Unfortunately, the general toxicity with a fateful characteristic has prevented their further clinical application as inorganic drugs. In this study, we synthesized tocopherol succinate-polyoxomolybdate conjugate (T 2 POMo) as a new organic-inorganic hybrid and evaluat...
Preprint
Full-text available
Background: Breast cancer is one of the most prevalent cancers among women in Isfahan, Iran but unfortunately its prevention is not desirable in this city. This disease poses several healths, social and economic burdens upon women. In order to promote women's self-care in breast cancer prevention, this study aims to design, implement and evaluate a...
Article
Full-text available
Hypoxia is a common feature of solid tumors, and develops because of the rapid growth of the tumor that outstrips the oxygen supply, and impaired blood flow due to the formation of abnormal blood vessels supplying the tumor. It has been reported that tumor hypoxia can: activate angiogenesis, thereby enhancing invasiveness and risk of metastasis; in...
Preprint
Full-text available
Microfluidic chemical gradient generators enable precise spatiotemporal control of chemotactic signals to study cellular behavior with high resolution and reliability. However, time and cost consuming preparation steps for cell adhesion in microchannels as well as the requirement of pumping facilities usually complicate the application of the micro...
Article
Objective Vascular cell adhesion molecule 1 (VCAM-1) plays an important role in tumour cell adhesion to endothelial cells. Some tumour cells also show aberrant expression of VCAM‐1. Toll-like receptor 4 (TLR4) agonists can increase VCAM-1 expression. Morphine, an opioid receptor agonist, is also a TLR4 agonist. In this study, we aimed to evaluate w...
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Background: Rapid increases in cases of COVID-19 were observed in multiple cities in Iran towards the start of the pandemic. However, the true infection rate remains unknown. We aimed to assess the seroprevalence of antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in 18 cities of Iran as an indicator of the infection...
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Breast cancer is the second leading cause of cancer-related death among females, worldwide. The cytokines are proteins that have a significant role in the development of tumor growth. Leukemia inhibitory factor (LIF) of the interleukin-6 cytokines superfamily plays a significant role, by the modulation of many signaling pathways. This study summari...
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The COVID-19 is rapidly scattering worldwide, and the number of cases in the Eastern Mediterranean Region is rising. Thus, there is a need for immediate targeted actions. We designed a longitudinal study in a hot outbreak zone to analyze the serial findings between infected patients for detecting temporal changes from February 2020. In a hospital-b...
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Humans have always been encountered to big infectious diseases outbreak throughout the history. In December 2019, novel coronavirus (COVID-19) was first noticed as an agent causing insidious pneumonia in Wuhan, China. COVID-19 was spread rapidly from Wuhan to the rest of the world. Until late June 2020, it infected more than 10,000,000 people and c...
Preprint
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Background: 2019-nCoV (COVID-19) is a pandemic disease with a high infectivity and mortality. The prevention and treatment of COVID-19 have become urgent matters for consideration. It often takes several years to develop new drugs, or vaccines, based on the usual clinical trial process. This dwell-time can be shortened by repurposing previously app...
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Background: In vitro models are common tools in nephrology research. However, their validity has rarely been scrutinized. Materials and Methods: Considering the critical role of transforming growth factor (TGF)-β and hypoxia pathways in kidney fibrosis, kidney-derived cells were exposed to TGF-β and/or hypoxic conditions and the expression levels o...
Article
The coronavirus COVID-19 is affecting 213 countries and territories around the world. Iran was one of the first affected countries by this virus. Isfahan, as the third most populated province of Iran, experienced a noticeable epidemic. The prediction of epidemic size, peak value, and peak time can help policymakers in correct decisions. In this stu...
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Objectives: Oxidative stress plays a major role in endothelial dysfunction. Citral is a monoterpene aldehyde with antioxidant properties. This study aimed to investigate the effect of citral on human umbilical vein endothelial cells (HUVECs) under hydrogen peroxide (H2O2)-induced oxidative stress. Materials and methods: The cells were treated wi...
Preprint
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47 The COVID-19 is rapidly scattering worldwide, and the number of cases in the 48 Eastern Mediterranean Region is rising. Thus, there is a need for immediate targeted 49