Shafeajafar Zoofaghari

• Doctor of Medicine
• Isfahan University of Medical Sciences

Objective: Acute low back pain is a common ailment and causes pain and disability. Physicians often prescribe nonsteroidal anti‑inflammatory drugs (NSAIDs) to treat acute low back pain; however, due attention has recently been drawn to muscle relaxants to reduce the severity of patients’ daily physical dysfunction. Therefore, this study aimed to ev...

A BSTRACT Objective Given the prevalence of methadone poisoning, this study was conducted to compare the cardiovascular complications following acute methadone poisoning in patients with and without a history of long-term methadone use. Methods In this retrospective study, information related to patients with acute methadone poisoning hospitalize...

The high annual mortality rate of organophosphorus (OP) poisoning indicates that the treatment is mostly ineffective in this regard. It has been suggested to add calcium channel blocking (CCB) drugs or magnesium sulfate (MgSO 4 ) to normal care to decrease the release of acetylcholine (ACh) at the cholinergic synapse. Moreover, the diagnosis of OP...

Background: This study evaluates the role of oral melatonin in improving vision in methanol toxicity since vision disorders are one of the side effects related to methanol toxicity and assumes the potential effects of melatonin in protecting neurons and optic nerves. Meanwhile, little attention has been paid by researchers to the effect of melatoni...

Objective This study aimed to assess the severity of poisoning, various scoring systems, including Sequential Organ Failure Assessment (SOFA) score, acute physiology and chronic health evaluation II (APACHE II), Simplified Acute Physiology Score (SAPS II), Modified APACHE II, and poisoning severity score (PSS) were used. In this study, we compared...

plasmapheresis in ALP

methadone poisoning

Organophosphate Poisoning

mobile application, approach to poisoned patient

organophosphate poisoning

Background: There is a high prevalence of intentional paraquat poisoning especially for suicide reported from many part of the world, with its negative effects on the lungs, kidneys, heart, and digestive system. This study was planned, aimed at investigating the efficacy of sucralfate in the treatment of oral paraquat poisoning with respect to its...

Background: Poisoning by opium and stimulants brings many patients to the poison emergency departments every year. This study planned to determine the risk factors for Opioid and Stimulant poisoning among patients admitted to the Khorshid Hospital.Methods: The present cross-sectional study was performed on 243 patients poisoned with opioids or stim...

Anti-viral and anti-cytokine drugs have been proven to be inadequate in ceasing the progression of the novel coronavirus disease, and severe cases are often associated with death or severe chronic injuries. In this respect, N-acetyl cysteine (NAC) has anti-oxidant, anti-inflammatory, and immune-modulating effects and has been revealed to be benefic...

The ingestion of pesticides for suicide commitment purposes is common in developing countries. We present a case of suicide with ingestion of mixed pesticides. The autopsy findings showed the presence of diazinon, chlorpyrifos, trifluralin, fenpropathrin, pyriproxyfen, and cypermethrin in his body. Clinicians managing poisoning cases need to be awa...

Organophosphate (OP) poisoning is prevalent in developing countries. Toxicity occurs by voluntary injection, inhalation, and absorption. Self-injection is rare. The current case report describes a 61-y/o male with subcutaneous self-injected one cc OP poisoning presenting with delayed drowsiness, nausea, and vomiting. He was treated and presented a...

Objective: Aluminum phosphide (ALP) (rice-tablet) is a common cause of adult poisoning in Iran, including Isfahan. So far, no effective treatment has been identified for this poisoning. We aimed to investigate the outcome of ALP poisoned patients admitted to the clinical toxicology ward of Khorshid Hospital in Isfahan from 2017 to 2019. Methods:...

The use of pesticides for suicide commitment purposes is a major problem. The present study reports a death due to committing suicide using combination of diazinon, Chlorpyrifos, Trifluralin, Fenpropathrin, Pyriproxyfen, and Cypermethrin. It is difficult to diagnose and treat patients poisoned with a combination of pesticides.

In case of mild to moderate cyanide poisoning, especially when standard antidote kits are not readily available, plasmapheresis can be utilized as an alternative option alongside supportive measures. In case of mild to moderate cyanide poisoning, especially when standard antidote kits are not readily available, plasmapheresis can be utilized as an...

Myocardial infarction (MI) with nonobstructive coronary arteries (MINOCA) is syndrome with clinical evidence of acute MI (AMI) with normal coronary arteries. This study reports the case of a 23‑year‑old single woman referring to the hospital with clinical manifestations of MI, with electrocardiography findings of slow ventricular tachycardia or acc...

Background: Digoxin is extensively prescribed for cardiac diseases, so its chronic or acute toxicity commonly occur. Although digoxin specific antibodies (anti-digoxin Fab) are recommended to be used in patients with cardiac symptoms of digoxin toxicity, there is ongoing controversy about the effectiveness and dose of anti-digoxin Fab. Because our...

Organophosphate poisoning by self-injection is rare. Current case report describes a man with subcutaneous self-injected OP. poisoning presenting with delayed. He was treated with pralidoxime. Through the observation, dose and the time between poisoning until time to start treatment we can conclude different presentations and outcomes of OP poisoni...

Background: Digoxin is extensively prescribed for cardiac diseases, so its chronic or acute toxicity commonly occur. Although digoxin specific antibodies (anti-digoxin Fab) are recommended to be used in patients with cardiac symptoms of digoxin toxicity, there is ongoing controversy about the effectiveness and dose of anti-digoxin Fab. Because our...

Serotonin toxicity is a common but often unrecognized toxicological condition. In most cases, a combination of two or more serotonergic drugs can cause serotonin syndrome. We describe a case of serotonin toxicity in a 17-year-old woman, secondary to suicidal ingestion of 1000 mg lamotrigine and 400 mg citalopram, which has been rarely reported. Our...

Selective serotonin reuptake inhibitors (SSRIs) are widely used in the treatment of many types of mental disorders. Citalopram is commonly used as a new generation of SSRIs in this regard; however, unfortunately, its overdose is associated with seizure and heart disorders. The reported case in the present study indicated recurrent seizures, nonspec...

Suicide with cyanides is relatively rare but highly lethal. The lethal oral dose of cyanide salts is 200 mg, and concentrations >3 mg/L may be potentially lethal. The symptoms of poisoning are predominating in the central nervous system and cardiovascular system. We report the case of a 43-year-old goldsmith man who presented with self-poisoning by...

Poisoning with any of the colchicine or chloroquine drugs is rare. These drugs exert therapeutic and toxic effects on tissues by different mechanisms. Colchicine is used to treat a number of rheumatologic diseases and heart problems. In addition, chloroquine is used to treat malaria and some inflammatory diseases. There is a small gap between the t...

suicide and month of birth

toxicity

colchicine case report

Background: One of the most frequent causes of death is poisoning worldwide. Investigating the causes of mortality due to poisoning profoundly affects making decisions and improving standards for preventing adverse events. Therefore, to better understand this problem and evaluate the causes, this study aimed to determine the risk of suicide using t...

Minoxidil is an antihypertensive direct vasodilator that can cause severe toxicity when sufficiently ingested. We report a case of accidental ingestion of 5 ml topical minoxidil solution 5% presented with chest pain and new-onset ST depressions. After giving IV saline and performing echocardiography/angiography, the patient fully recovered without...

Proposed Management Protocol for Acute Aluminum Phosphide Poisoning

The components of the newly proposed management/treatment protocol are gastric evacuation, castor oil, calcium gluconate, magnesium sulfate, albumin, hyperinsulinemia–euglycemia therapy, amiodarone, sodium bicarbonate, N-acetyl salicylic acid, Vitamin C (acsorbic acid), Vitamin E, methylene blue, coenzyme Q-10, silymarin, curcuma, and pralidoxime....

Dear Editor, Paraquat (PQ, 1,1′-dimethyl-4,4′-bipyridinium dichloride) is one of the most toxic pesticides available here in the Middle East. Clinical manifestations and outcomes of acute PQ poisoning depend on the volume of PQ ingested orally. Ingestion of as little as 5 mL of the 20% weight/volume PQ solution is sufficient to cause death in more...

Background Although the use of sterile gloves for minor and major surgical repairs is the current standard of care, use of non-sterile and clean gloves has been shown to be safe in certain procedures. In this study, we compared the infection rates of contaminated lacerations repaired with sterile versus non-sterile gloves. Materials and methods A...

Surgical site infection is one of frequent nosocomial infections which can lead in severe medical conditions and costs for patient. On the other hand, using sterile or non-sterile gloves in surgery impose different costs to health settings. Lack of enough evidences about the incidence of surgical site infection of contaminated wounds when applying...

Background: The Singh index is an inexpensive simple method to evaluate bone density, commonly used to assess osteoporosis is based on the radio-logical appearance of the trabecular bone structure of the proximal femur on a plain antero-posterior (AP) radiograph. The purpose of this study was to compare between Singh index and bone mineral density...