Shadabi Bano

Shadabi Bano
Jamia Millia Islamia · Department of Biosciences

Doctor of Philosophy

About

8
Publications
2,571
Reads
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56
Citations
Citations since 2017
7 Research Items
54 Citations
201720182019202020212022202302468101214
201720182019202020212022202302468101214
201720182019202020212022202302468101214
201720182019202020212022202302468101214
Additional affiliations
October 2014 - present
Jamia Millia Islamia
Position
  • Researcher

Publications

Publications (8)
Article
Thromboembolic diseases are a major cause of mortality in human and the currently available anticoagulants are associated with various drawbacks, therefore the search for anticoagulants that have better safety profile is highly desirable. Compounds that are part of the dietary routine can be modified to possibly increase their anticoagulant potenti...
Article
Full-text available
Neuroserpin is a serine protease inhibitor expressed mainly in the brain and at low levels in other tissues like the kidney, testis, heart, and spinal cord. It is involved in the inhibition of tissue plasminogen activator (tPA), plasmin, and to a lesser extent, urokinase‐type plasminogen (uPA). Neuroserpin has also been shown to plays non‐inhibitor...
Article
Neuroserpin (NS) is an inhibitory protein of serpin super family, its shutter region variants have high propensity to aggregate leading to pathological disorders like familial encephalopathy with NS inclusion bodies (FENIB). Helix F and β-sheet A of NS participate in the tissue plasminogen activator (tPA) inhibition but the mechanism is not yet com...
Article
Full-text available
Antithrombin (AT) deficiency is a rare but strong risk factor for the thrombosis development. Mutations in gene encoding AT (SERPINC1) have provided a detailed understanding of AT deficiency and subsequent development of thrombotic complications. In the present study, we describe a case of thrombotic patient with reduced AT activity and normal AT a...
Article
Heparin cofactor II (HCII) is predominantly expressed in the liver and inhibits thrombin in blood plasma to influence the blood coagulation cascade. Its deficiency is associated with arterial thrombosis. Its cleavage by neutrophil elastase produces fragment that helps in neutrophil chemotaxis in the acute inflammatory response in human. In the pres...
Article
Full-text available
Aims Design and synthesis of a novel 3, 3', 4', 5, 7-O- pentasulfated Quercetin (QPS) as activator of protein disulfide isomerase (PDI). Main Methods Based on an in silico analysis we show that QPS binds to a and b domain of PDI (-7.4 kcal/mol) unlike PDI inhibitor quercetin 3-rutinoside (Q3R) that binds at substrate binding domain b (-8.0 kcal/mo...
Article
Pro-coagulant, anti-coagulant and fibrinolytic pathways are responsible for maintaining haemostatic balance under physiological conditions. Any deviation from these pathways would result in hypercoagulability leading to life threatening diseases like myocardial infarction, stroke, portal vein thrombosis, deep vein thrombosis (DVT) and pulmonary emb...

Questions

Questions (2)
Question
Hi,
I am using an enzyme whose mol wt is mentioned in a range and pack size is as 100KU and mentioned activity is 180U/mg . I want to know how to prepare micromolar concentration of it?
Question
One protein has pI value is  6.34 and the other one has 6.41. I want to  separate these protein,

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Projects

Project (1)