Shaaban Kamel Mohamed

Shaaban Kamel Mohamed
Manchester Metropolitan University | MMU · Division of Chemistry and Environmental Science

PhD

About

714
Publications
49,141
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999
Citations
Citations since 2016
138 Research Items
619 Citations
2016201720182019202020212022050100150
2016201720182019202020212022050100150
2016201720182019202020212022050100150
2016201720182019202020212022050100150
Introduction
Visiting Professor of Organic Chemistry, Manchester Metropolitan University, Manchester, England. Research interest: Active pharmaceutical ingredient, Synthesis of Organic Molecules, Synthesis of Medicinal Compounds, Crystallography studies, Physical Organic characterisation and Reaction methodology.
Additional affiliations
August 2008 - November 2016
Manchester Metropolitan University
Position
  • Professor

Publications

Publications (714)
Article
Full-text available
In the title compound, C 24 H 23 FN 4 O 4 S·0.25H 2 O, the dihydropyrimidine ring is distinctly non-planar, with the flap C atom deviating by 0.297 (2) Å from the least-squares plane. In the crystal, zigzag chains are formed by N—H...N hydrogen bonds parallel to [010] and are connected into layers parallel to (100) by O—H...O, O—H...F, C—H...O, C—H...
Article
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The title molecule, C 21 H 26 N 2 O 3 , adopts a V-shaped conformation and is chiral at the C atom with methyl group attached at the common cut of the edges of the V-conformation and crystallizes as a racemate. It also contains an intramolecular O—H...N hydrogen bond. In the crystal, N—H...O hydrogen bonds form chains of molecules extending along t...
Article
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Three new series of isoquinolines, that is, 7-acetyl-3-acetonylsulfanyl-8-aryl-1,6-dimethyl-6-hydroxy-5,6,7,8-tetrahydroisoquinoline-4-carbonitriles (3a-c); 3-acetonylsulfanyl-8-aryl-1,6-dimethyl-7,8-dihydroisoquinoline-4-carbonitriles (4a-c); and 7-acetyl-8-aryl-1,6-dimethyl-3-ethylsulfanyl-7,8-dihydroisoquinoline-4-carbo-nitriles (6a,b) were care...
Article
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In the title molecule, C 23 H 20 Cl 2 N 4 O 3 S, the thiazole ring is planar while the pyrimidine unit fused to it adopts a screw-boat conformation. In the crystal, thick sheets parallel to the bc plane are formed by N—H...N, C—H...N and C—H...O hydrogen bonds together with π–π interactions between the formamido carbonyl groups and the thiazole rin...
Article
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The ibuprofen Schiff base ligand (HL) [HL = 2‐(4‐Isobutyl‐phenyl)‐propionic acid (3‐hydroxy‐naphthalen‐2‐ylmethylene)‐hydrazide] and its Cu (II), Ni (II), Zn (II), and VO (II) chelates were synthesized and characterized. The spectral data revealed that the Schiff base ligand HL coordinated to Cu (II), Ni (II), Zn (II) and VO (II) via azomethine nit...
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Although, Non-steroidal anti-inflammatory drugs (NSAIDs) are medicines that are widely used to relieve pain, reduce inflammation, and bring down high-temperature literature confirmed that they still have harmful side effects. Most of their side effects are in the digestive system due to the carboxylic group. As Naproxen is one of the NSAIDs, in thi...
Article
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Increasing the yield and nutritional value of faba beans is one of the main objectives of the common bean cultivar improvement programs due to its contribution to terminate protein deficiency malnutrition in developing countries and raising the income level of smallholder farmers. In this study, the technological quality of bean seeds from twenty-f...
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In the fall of 2019, a new type of coronavirus took place in Wuhan city, China, and rapidly spread across the world and urges the scientific community to develop antiviral therapeutic agents. In our effort we have synthesized a new hydrazide derivative, (E)-N'-(1-(4-bromophenyl)ethylidene)-2-(6-methoxynaphthalen-2-yl)propanehydrazide for this purpo...
Article
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This paper reports the synthesis of two new hydrazide derivatives, namely, (E)-N'-(4- bromobenzylidene)-2-(4-isobutylphenyl)propanehydrazide (4a) and (E)-N'-benzylidene-2-(4-isobutylphenyl)propanehydrazide (4b), respectively. The compounds were synthesized by the reaction of benzaldehyde with Ibuprofen acid hydrazide. Their structures were confirme...
Article
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Regioselective cyclocondensation of 2,4-diacetyl-5-hydroxy-5-methyl-3-(3-nitrophenyl/4-nitrophenyl)cyclohexanones 1a,b with cyanothioacetamide afforded the corresponding 7-acetyl-4-cyano-1,6-dimethyl-6-hydroxy-8-(3- and -4-nitrophenyl)-5,6,7,8-tetrahydrosoquinoline-3(2H)-thiones 2a,b. Reaction of compounds 2a,b with ethyl iodide, 2-chloroacetamide...
Article
Ketonic hydrolysis of 7‐acetyl‐4‐cyano‐1,6‐dimethyl‐6‐hydroxy‐8‐phenyl‐5,6,7,8‐tetrahydro‐isoquinoline‐3(2H)‐thione (1) via heating with aqueous solution of potassium hydroxide resulted in both deacetylation and dehydration affording new 7,8‐dihydroisoquinoline scaffold (7,8‐DHISQ) 2. Two simple mechanistic approaches are postulated for this synthe...
Article
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In the title molecule, C 25 H 28 N 2 O 5 S, (alternative name ethyl 2-{[7-acetyl-4-cyano-6-hydroxy-8-(4-methoxyphenyl)-1,6-dimethyl-5,6,7,8-tetrahydroisoquinolin-3-yl]sulfanyl}acetate) the 4-methoxyphenyl group is disposed on one side of the bicyclic core and the oxygen atoms of the hydroxyl and acetyl groups are disposed on the other side. In the...
Article
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The asymmetric unit of the title compound, C 25 H 21 N 3 O 2 S, comprises four molecules. Their conformations differ primarily in the orientations of the styryl and the N -phenylcarboxamido groups. In the crystal, intermolecular N—H...N, C—H...O and C—H...S hydrogen-bonding contacts as well a C—H...π(ring) interactions lead to the formation of a la...
Article
The new Schiff base ligand 2,2'-{(4-chloro-1,2-phenylene)bis(nitrilo(E)methylylidene)}bis(4-bromophenol) (H2L) and its VO(II), Zn(II) and ZrO(II) metal chelates have been synthesized and characterized by spectral, powder x-ray diffraction (PXRD), molar conductance, magnetic measurements, thermal and elemental analyses. The molecular geometry of the...
Article
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Pyrimidine compounds continue to attract great interest in the field of organic synthesis due to their various chemical and biological applications observed, especially in recent times. As a result, this review covering some periods from 1957 to 2021 has been prepared to discuss some of the structural pathways of these compounds as well as some of...
Article
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Oxygen-containing heterocycles are largely distributed in natural and synthetic compounds. Coumarins are among the most famous heterocycles which possess one oxygen atom in their rings. Coumarins are classified as multifunctional scaffold and are used as anti-oxidant reagents, anti-inflammatory, anti-microbial, anti-fungal, anti-HIV active, analges...
Article
Aims This article describes the controlled synthesis and characterization of azo oxazolone as multifunctional group in which contain Carbonyl, imine and carbon double bond carbon bond, and their ring opening to azo-benzamide derivative in fast reaction( 5 90%). Objective UV, IR, proton-NMR, C13-NMR, Elemental analysis and MS spectrometry all synth...
Article
Full-text available
Pyrimidine compounds continue to attract great interest in the field of organic synthesis due to their various chemical and biological applications observed, especially in recent times. As a result, this review covering some periods from 1957 to 2021 has been prepared to discuss some of the structural pathways of these compounds as well as some of...
Article
For first time the new N-picolinoypicolinlamide was obtained as in situ ligand during the reaction of 2,4,6-ris(2-pyridyl)-,3,5-triazine with aqueous solution of CuNO3.3H2O and formed the corresponding complex [Cu(dipicolinoylamide)(NO3)(H2O)]. The crystal structure of the obtained complex was determined by x-ray structure. The complex crystallizes...
Article
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Different methods for the synthesis of pyridine derivatives as well as the chemical reactivity profiles and structures of these substances are reviewed. The utility of these compounds as precursors is emphasized in the synthesis of many heterocycles that are pharmacologically active organic compounds and agrochemicals. This review results from a li...
Article
A new thiazolidine derivative, 3,3'-ethane-1,2-diylbis(2-benzylidene-1,3-thiazolidin-4-one (4) was synthesized and the product obtained was characterized by NMR, IR and mass spectral studies, and the structure was confirmed by single crystal X-ray diffraction studies. The title compound crystallizes in the monoclinic space group P21/n, the unit cel...
Article
Full-text available
In the title molecule, C 21 H 20 N 2 O 3 S, the styryl and ester substituents are displaced to opposite sides of the plane of the pyridine ring. In the crystal, C—H...O hydrogen bonds form chains extending parallel to the a- axis direction, which pack with partial intercalation of the styryl and ester substituents. A Hirshfeld surface analysis indi...
Article
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The conformation of the title compound, C 13 H 11 NO 2 , is partially determined by a strong, intramolecular O—H...O hydrogen bond. The crystal packing consists of strongly corrugated layers parallel to the ac plane and associated through C—H...π(ring) interactions. A Hirshfeld surface analysis of the crystal structure indicates that the most signi...
Article
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The title molecule, C 29 H 29 N 3 O 4 S, adopts a conformation with the two phenyl substituents disposed on opposite sides of the mean plane of the isoquinoline unit. In the crystal, corrugated layers of molecules are formed by N—H...O, C—H...N and C—H...S hydrogen bonds together with C—H...π(ring) interactions. These layers are connected by C—H......
Article
Full-text available
Different methods for the synthesis of pyridine derivatives as well as the chemical reactivity profiles and structures of these substances are reviewed. The utility of these compounds as precursors is emphasized in the synthesis of many heterocycles that are pharmacologically active organic compounds and agrochemicals. This review results from a li...
Article
Full-text available
In the title molecule, C 28 H 25 Cl 2 N 3 O 3 S, the heterocyclic portion of the tetrahydroisoquinoline unit is planar while the cyclohexene ring adopts a twist-boat conformation. The two 4-chlorophenyl groups extend away from one side of this unit while the hydroxyl and acetyl groups extend away from the opposite side and form an intramolecular O—...
Article
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In the title compound, C 33 H 26 N 4 O 4 , the two fused five-membered rings and their N-bound aromatic substituents form a pincer-like motif. The relative conformations about the three chiral carbon atoms are established. In the crystal, a combination of C—H...O and C—H...N hydrogen bonds and C—H...π(ring) interactions leads to the formation of la...
Article
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In the title molecular salt, C 26 H 24 N 3 S ⁺ ·Br ⁻ , the dihedral angles between the thiazole ring and its attached phenyl and benzoyl rings are 54.81 (7) and 85.51 (7)°, respectively. In the crystal, ion pairs are linked by C—H...Br and N—H...Br hydrogen bonds and are connected into helical chains extending along the c -axis direction by weak, e...
Article
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7-Acetyl-8-aryl-4-cyano-1,6-dimethyl-6-hydroxy-5,6,7,8-tetrahydroisoquinolin-3(2H)-thiones 2a,b are prepared and dehydrated to give 7-acetyl-8-aryl-4-cyano-1,6-dimethyl-6-hydroxy-7,8-dihydrodroisoquinolin-3(2H)-thiones 6a,b via a novel method by heating with acetyl chloride in acetic acid. The reaction of both compounds 2a,b and 6a,b with N-aryl-2-...
Article
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The starting compounds 7-acetyl-8-aryl-4-cyano-1,6-dimethyl-6-hydroxy-5,6,7,8-tetrahydroisoquinoline(2H)-3-thiones 3a,b were synthesized and reacted with some N-aryl-2-chloroacetamides 4a–e in the presence of sodium acetate to produce 7-acetyl-8-aryl-3-(N-arylcarbamoylmethylsulfanyl)-4-cyano-1,6-dimethyl-6-hydroxy-5,6,7,8-tetrahydroisoquinolines 5a...
Article
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In the title compounds C 23 H 21 ClN 2 O 3 [ I , namely 1-(4-chlorophenyl)-4-(4-methylphenyl)-3,8-dioxo-1,2,5,6,7,8-hexahydroquine-3-carboxylic acid] and C 24 H 22 N 2 O 3 [ II , namely 4-(4-methoxyphenyl)-1-(4-methylphenyl)-2,5-dioxo-1,2,5,6,7,8-hexahydroquinoline-3-carbonitrile], each of the cyclohexene and dihydropyridine rings of the 1,2,5,6,7,...
Article
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The conformation about the central benzene ring in the molecule of (I), C 20 H 19 N 3 O 2 , is partially determined by an intramolecular N—H...O hydrogen bond. In the crystal, chains parallel to the c axis are generated by intermolecular N—H...O hydrogen bonds with the chains assembled into a three-dimensional network structure by intermolecular C—...
Article
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In the title compound, C 27 H 33 NO 5 , a 3,3,6,6-tetramethyltetrahydroacridine-1,8-dione ring system carries an ethyl acetate substituent on the acridine N atom and an o -hydroxyphenyl ring on the central methine C atom of the dihydropyridine ring. The benzene ring is inclined to the acridine ring system at an angle of 80.45 (7)° and this conforma...
Article
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In the crystal, the molecule of the title compound, C 26 H 20 N 2 O 3 , has crystallographically imposed twofold rotation symmetry. The crystal packing consists of layers parallel to the ab plane formed by O—H...N and C—H...O hydrogen bonds. Between the layers, C—H...π interactions are observed.
Article
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In the title molecule, C 28 H 27 N 3 O 3 S, the heterocyclic portion of the tetrahydroisoquinoline unit is planar and an intramolecular N—H...N hydrogen bond and a C—H...π(ring) interaction help to determine the overall conformation. In the crystal, a layer structure with the layers parallel to (10\overline{1}) is generated by O—H...O and C—H...O h...
Article
The current investigation seeks to explore the adsorption mechanism of newly synthesized Naproxen-based hydrazones on mild steel (MS) surface in 1.0 M HCl solution and their corrosion inhibition efficiencies. To this end, two hydrazone derivatives namely, (E)-N′-(1-(4-chlorophenyl)ethylidene)-2-(6-methoxynaphthalen-2-yl)propanehydrazide (PHD\ \Cl)...
Article
Increasing scientific focus has recently been placed on inhibiting the corrosion of metals and their alloys in acidic environments. In doing so, an understanding and explanation of the adsorption of two environmentally friendly corrosion inhibitors, namely (E)-2-(6-methoxynaphthalen-2-yl)-N'-(1-phenylethylidene)propanehydrazide (PHD-H) and (E)-N'-(...
Article
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During the past years, there has been an increasingly important emphasis on the study of corrosion inhibitors because of their performance in inhibiting the dissolution of metals in various corrosive mediums, making research into the use of environmentally safer substances a goal for corrosion scientists. On this wise, the anti-corrosive performanc...
Article
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The corrosion-inhibiting performance of (E)-N’-(4-bromobenzylidene)-2-(6-methoxynaphthalen-2-yl) propanehydrazide (BPH) and (E)-N’-(4-(dimethylamino) benzylidene)-2-(6-methoxynaphthalen-2-yl) propanehydrazide (MPH) for mild steel (MS) in 1.0 M HCl was investigated using electrochemical methods, weight loss measurements, and scanning electron micros...
Article
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ThisArticle deals with the stepwise synthesis and spectroscopic characterization of some new azo benzofuran derivatives Is Article deals with the stepwise synthesis and spectroscopic characterization of some , started from the diazotization of substituted aniline coupled with 2-hydroxy benzaldehyde. On reacting of the azo of 2-hydroxy benzaldehyde...
Article
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This Article deals with the stepwise synthesis and spectroscopic characterization of some new azo benzofuran derivatives, started fromthe diazotization of substituted aniline coupled with 2-hydroxy benzaldehyde. On reacting of the azo of 2-hydroxy benzaldehyde with p-bromo phenacyl bromide, the benzofuran (3a-g) are obtained. The structure of the n...
Article
The novel oxonine 2, 4 have been synthesized by the reaction of 1,3-indandione with 4-bromo-2-hydroxybenzaldehyde and/or 2-hydroxy-1-naphthaldehyde in the presence of 1,3-diaminopropan-2-ol as green basic catalyst. On the other hand, the reaction of 1,3-cyclohexanediones with 2-hydroxy aromatic aldehydes under the same reaction condition afforded x...
Article
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In this paper, a combined experimental and theoretical study was conducted to explain the scientific mechanism of adsorption of two hydrazone derivatives (HDZs) containing mefenamic acid (MA) namely, (E)-2-((2,3-dimethylphenyl)amino)-N'-(thiophen-2-ylmethylene)benzohydrazide (HDZ-S) and (E)-2-((2,3-dimethylphenyl)amino)-N'-(furan-2-ylmethylene)benz...
Article
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Mild steel corrosion in HCl solution is an example of corrosion in acidic mediums. The ongoing research efforts to develop novel environmentally friendly corrosion inhibitors raise questions regarding their ability to effectively protect steel from corrosion. Herein, a series of experimental studies were conducted to explain the scientific mechanis...
Article
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Nature produces large quantities of superbly complex and highly reliable microcapsules. The micrometre-sized Lycopodium clavatum spores are one example of these robust capsules. The encapsulation of erythromycin (EM) and bacitracin (BAC) antibiotics into the Lycopodium clavatum sporopollenin (LCS) extracted from these spore species is explored for...
Article
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In the structure of the title compound C33H29BrClNO4, (I), the hexa­hydro-2H-acridine ring system has a hy­droxy­ethyl substituent on the N atom and a 3-bromo-6-chloro-2-hy­droxy­phenyl substituent on the central C atom at the 9-position. An unusual feature of the mol­ecule is that the substituents at the 3- and 5-positions of the outer cyclo­hexen...
Article
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Poor corrosion resistance of mild steel (MS) is a serious concern in many industrial applications. Application of corrosion inhibitors is a possible solution to combat steel corrosion. As yet, there is very little research reported focusing on hydrazone derivatives as corrosion inhibitors, here we present a combined experimental and theoretical stu...
Article
Here, we reported two methods for the synthesis of multi‐substituted imidazoles, firstly via four‐component cyclocondensation reaction of benzil, aliphatic amines (allylamine or pentylamine), and aromatic aldehyde and ammonium acetate. Using an ionic liquid catalyst namely, diethyl ammonium hydrogen sulfate, and under solvent‐free conditions. Secon...
Article
The dimer of 9-anthraldehyde, namely heptacyclo[8.6.6.6 2,9 .0 3,8 .0 11,16 .0 17,22 .0 23,28 ]octacosa-3,5,7,11,13,15,17(22),18,20,23(28),24,26-dodecaene-1,9-carbaldehyde, C 30 H 20 O 2 , has been synthesized by refluxing an ethanol solution in the presence of M (ClO 4 ) 2 and 1,3-diaminopropan-2-ol ( M = Co ²⁺ or Cu ²⁺ ). Its structure has been d...
Article
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In the title compound, C 24 H 23 N 3 O 2 , the cyclohexene and 1,4-dihydropyridine rings of the 1,4,5,6,7,8-hexahydroquinoline ring system each adopt a twisted-boat conformation. The dihedral angle between the benzene rings is 13.89 (10)°. In the crystal, molecules are linked through pairs of amino–nitrile N—H...N hydrogen bonds, forming inversion...
Article
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In the title nitrone, C 22 H 17 N 3 O, the dihedral angles between the central pyrazole ring and pendant N-bound, C-bound and nitrone-bound phenyl rings are 20.93 (6), 41.27 (6), and 32.57 (6)°, respectively. In the crystal, (101) layers are generated by C—H...O hydrogen bonds coupled with C—H...π(ring) and offset π–π stacking interactions.
Article
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The asymmetric unit of the title compound, C 22 H 14 O 6 , consists of two independent molecules differing in the orientations of the ester groups. In one molecule, the two terminal benzene rings are inclined to the central benzene ring by 4.99 (13) and 77.46 (13)°, while in the other the corresponding angles are 11.03 (13) and 88.09 (12)°. In the...
Article
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The molecule of the title compound, C 15 H 15 N 3 O 3 , is twisted, with the dihedral angle between the pyridyl and benzene rings being 58.34 (6)°. In the crystal, amide-N—H...O(amide) and imine-C—H...O(amide) hydrogen bonds lead to zigzag (glide symmetry) chains extending along the c axis which are joined into layers parallel to the [100] directio...
Article
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The asymmetric unit of the title compound, C 18 H 15 N 3 O 2 S, comprises two independent molecules, which differ primarily in the orientations of the acetyl and p -anisyl substituents, each being rotated in opposite directions from the mean plane of the pyridine ring. The major feature of the molecular packing is the formation of a two-dimensional...
Article
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In the title compound, C 21 H 22 N 4 O 2 S, the dihedral angle between the pyrazole ring and adjacent benzene ring is 6.4 (1)°. The molecular conformation is influenced by intramolecular N—H...O and C—H...O hydrogen bonds. In the crystal, N—H...O hydrogen bonds plus C—H...π and π–π stacking interactions form chains extending in the a -axis directio...
Article
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In the title molecule, C 19 H 17 N 3 O 3 S, the bicyclic core is planar [maximum deviation = 0.0205 (1) Å-axis direction through π–π-stacking interactions between the bicyclic units with a small alternation in the interplanar distances along the stack. The stacks are held together by N—H...N and C—H...O hydrogen bonds. The carboethoxy substituent i...
Article
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In the title compound, C 22 H 20 ClN 3 O, the dihedral angle between the planes of the chlorophenyl and dimethylphenyl rings is 66.50 (9)°. These rings make dihedral angles 47.79 (8) and 69.24 (9)°, respectively, with the central benzene ring. In the crystal, molecules are linked into a three-dimensional supramolecular network by N—H...O, C—H...O h...
Article
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The title compound, C 24 H 21 N 3 O 3 , crystallizes with two unique but closely r.m.s. overlay fit = 0.215 Å) comparable molecules (1 and 2) in the asymmetric unit of the triclinic unit cell. In molecule 1, the dihedral angles between the central imidazlole ring and the benzene-ring substituents are 42.51 (9), 45.41 (9) and 56.92 (8)°, respectivel...