Seyyed Mohammad Miri

Kowsar Corporation · Management

Background: Colorectal cancer (CRC) is the third common cause of malignancy in Iran, and its incidence rate has been raised due to an increase in individual and environmental risk factors. Objectives: The present study aimed to define the role of human papillomavirus (HPV) infection in CRC, then by drawing a phylogenetic tree, we aimed to analysis...

BACKGROUND: Hepatitis C virus (HCV) genotype distribution is different in various regions. A variety of strategies could be used to detect HCV genotypes and subtypes. The aim of the present study was to introduce a genotyping method by an in-house protocol that could be used to determine HCV drug-resistant variants and phylogeny studies. METHODS: S...

Background The utilization of indexes for the diagnosis of non-alcoholic fatty liver disease (NAFLD) can be valuable. This study was conducted to determine the ability of the Framingham steatosis index (FSI) to distinguish between people with NAFLD and those without and to predict people at risk of NAFLD to establish the need for lifestyle modifica...

Objectives Several popular cardiovascular risk assessment tools have been developed in Western countries; however, the predictive abilities of these tools have not been evaluated in Middle Eastern countries. The present study aimed to determine the abilities of cardiovascular risk assessment tools in a population-based study in Northern Iran. Stud...

Introduction: The pandemic coronavirus disease 2019 or COVID-19 is infecting as fast as possible in more than 200 countries and creating the most horrible domino-like demolition ever seen. From its beginning in Wuhan, China, the SARS-CoV-2 infected the similar groups of 100,000 patients in 67, 11, 4, and 2 days. Healthcare workers are in the frontl...

Context: Within only 30 days after the first announcement of infection with “SARS-CoV-2” in Wuhan, it spread to more than 20 countries and become a pandemic by WHO as a “high alarming level of infection” with 136,343 involved cases all over the world. Methods: To uncover more about the probable gastrointestinal transmission and its clinical manifes...

Context: Hepatitis D virus (HDV) infection, as the main coinfection in patients with chronic hepatitis B, leads to progressive liver disease. Elucidating the global distribution of HDV genotypes may be beneficial for the development of HDV vaccines and antiviral agents. Objectives: Through this systematic review, we aimed to present a clear picture...

Breakdowns of the 7-year war in Syria, especially in the health care infrastructures, such as water networks, and in the basic health requirements, such as public hospitals, emergency equipment from one side and emigration of the skilled resources from the country from the other side, has led to a disaster not only for the residents and neighboring...

Background: Sustained virologic response (SVR) to pegylated-interferon (PegIFN) and ribavirin (RBV) in hepatitis C virus (HCV)- infected patients could be predicted by detection of serum HCV RNA whereas detection of HCV RNA in other reservoirs such as peripheral blood mononuclear cells (PBMCs) for prediction of treatment response is still a mystery...

Background and Aims: The presence of the hepatitis C virus (HCV) in cells of extrahepatic organs like peripheral blood mononuclear cells (PBMCs) have important implications for transmission, disease progression, and effective treatment of HCV-infected patients. The impact of host genetics such as polymorphisms near Interferon lambda 3 (IFNL3) on cl...

Background: Occult hepatitis B infection (OBI) is determined by finding hepatitis B virus (HBV)DNAin the liver cells of the patients with negative tests for HBV surface antigen. It is more common in patients with hepatitis C virus (HCV) infection which can be transmitted by blood transfusion and is frequently seen in hemophilia and thalassemia pati...

Context: Occult HCV infection (OCI) is defined as the presence of HCV-RNA in hepatocytes and the absence of HCV in the serum according to usual tests. We aimed to define OCI and provide information about the currently available diagnostic methods. Then we focus on specific groups that are at high risk of OCI and finally investigate immune response...

Background and aims: Hepatitis caused by hepatitis B virus (HBV) and hepatitis C virus (HCV) infection has emerged as a major public health problem throughout the world. HBV and HCV induce different stress responses in the hepatocytes that ultimately lead to damage to these cells. Dysregulation of cell death pathways such as apoptosis, autophagy an...

Background and aims: Autoimmune hepatitis (AIH) is a chronic inflammatory liver disease with unknown cause, characterized by a loss of tolerance to hepatocyte specific autoantigens. If untreated, AIH can lead to the destruction of hepatic parenchyma, cirrhosis and liver failure. A growing body of evidence suggests involvement of apoptosis, autophag...

Background: Hepatitis A and E virus (HAV and HEV) infections are acute and self-limited diseases that usually spread through oral-fecal route. Also, blood transfusion as a possible route of entrically transmitted hepatitis has been suggested. Hemophilia and thalassemia patients are highly at risk of transfusion-transmissible viruses (HBV, HCV, and...

The prevalence of hepatitis C in Iran is 1% and 18% in general population and thalassemia patients respectively. The cost effectiveness analysis of adding Ribavirin to Peginterferon alfa-2a (PEG IFN alfa-2a) as a combination treatment strategy of chronic hepatitis C in thalassemia patients in comparison with monotherapy could help clinicians and po...

Background: Hepatitis A and E virus (HAV and HEV) infections are acute and self-limited diseases that usually spread through oral-fecal route. Also, blood transfusion as a possible route of entrically transmitted hepatitis has been suggested. Hemophilia and thalassemia patients are highly at risk of transfusion-transmissible viruses (HBV, HCV, and...

Background: The lifestyle from the point of sociology refers to the way a person lives to one’s own ability but basically and due to its importance with health and wellness means choosing the best method for improving health aspects in one person’s life. Lifestyle is discussed in different religious as well as several countries. Objectives: Due to...

The impact factor (IF), as the most important criterion for journal's quality measurement, is affected by the self-citation and number of publications in each journal. To find out the relationship between the number of publications and self-citations in a journal, and their correlations with IF. Self-citations and impact factors of nine top gastroe...

Mutations have been described in all of the four open reading frames of the hepatitis B virus (HBV), however, from a clinical perspective the surface escape mutant is the most troublesome. Hepatitis B surface antigen (HBsAg) variants may impair diagnosis, or allow the virus to escape vaccine-induced immunity or passive immunoglobulin therapy. HBV m...

Citation analysis as one of the most widely used methods of bibliometrics can be used for computing the various impact measures for scholars based on data from citation databases. Journal Citation Reports (JCR) from Thomson Reuters provides annual report in the form of impact factor (IF) for each journal. We aimed to evaluate the citation parameter...

Living in a region with a high prevalence of liver diseases especially Hepatitis B and C Virus infec-tions is not sufficient to compensate the gap of knowledge in the field of hepatology. Despite the fact that the knowledge in the field of hepatology is in logarithmic increasing, we are still facing many challenges and gaps in hepatology. There are...

Occult hepatitis B (OHB), or persistent HBV DNA in patients who are hepatitis B surface antigen (HBsAg) negative, is a recently recognized entity. In an attempt to summarize the issues, this review presents an overview of the current proposed hypothesis on the clinical relevance and also updates the knowledge on the classification of OHB in differe...

Hepatitis C is a major reason of morbidity and mortality among hemophilia patients. Although combination therapy with peginterferon (peg-INF) and ribavirin is considered as standard treatment for chronic hepatitis C (CHC), but more evidence of the efficacy and safety is needed. In this study, efficacy and tolerability of combination therapy with pe...

Hepatitis B virus (HBV) remains a serious public health problem worldwide, accounting for high morbidity and mortality rates as well as significant personal, societal, and economic costs. Hepatitis B is a preventable disease; a safe and effective vaccine has been available for 30 years. The World Health Organization aims to control HBV worldwide by...

Treatment guidelines contraindicate ribavirin for treatment of hepatitis C virus (HCV) infection in thalassemia major patients. Nevertheless, the current evidence suggests that ribavirin might be tolerated by these patients. Despite this evidence, low dose ribavirin combination therapy has not been compared with peginterferon monotherapy in these p...

We read with interest the published article by Nikbakht et al.. in your journal recently (1). The study reported the low prevalence of hepatitis B virus (HBV) infection among 712 infertile couples in Ahvaz, but higher hepatitis C virus (HCV) infection than the previous reported studies from Iran (2). Although the study could determine a complete se...

The distribution of blood lipids, glucose and their determinants in thalassemic patients with chronic hepatitis C virus (HCV) infection has rarely been investigated. Thus, we aimed to investigate the relationship between both liver histologic findings and viral markers and serum lipids in thalassemic patients chronically infected with HCV. We enrol...

Patients with chronic hepatitis B infection should be followed up to identify possible changes in disease status, such as HBsAg seronversion. There are little data on the outcome of such cases, and the response rate to HBV vaccine has not been discussed extensively.

Interferon, as an immunomodulatory agent, may be responsible for reactivation of Brucellosis in immunocompromised patients such as subjects with thalassemia. We report a case of 52 year old man with brucellosis reactivation during the therapy with Pegylated Interferon-alpha for chronic HCV infection. History included: previous living in rural area,...

Background: To evaluate the strength of association and to determine the best prediction of response in terms of sensitivity and specificity among quantitative baseline HBV-DNA levels in blood serum in patients with chronic hepatitis B (CHB) infection who treated with interferon-alpha-2b. Patients and methods: Totally, 78 CHB patients with serum HB...

Background: Chronic hepatitis C virus (HCV) infection is the major cause of liver disease related morbidity andmortality in hemophilic patients who needs regular blood product administration. Although genotype of infectingHCV is one of the prime predictors of response to antiviral therapy however, its distribution in hemophilic patientsis still unc...

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Chronic hepatitis C virus infection (HCV) is a major comorbidity in patients with haemophilia. Peginterferon alpha and ribavirin is current standard anti-HCV therapy but there is little information about safety and efficacy of peginterferon alpha-2a and ribavirin combination therapy in these patients. In an open-label single-treatment arm cohort st...

Aims: One of the main research references in universities is thesis. Conducting the research in different majors of medicine promote the medical sciences and better conducting of student theses according to the given standards is of considerable importance. The aim of the study was to assess students' theses and medical assistance in terms of the o...

Background and Aims: To determine changes (trends) in infection rates of hepatitis B surface antigen (HBsAg), hepatitis C virus (HCV), human immunodeficiency virus (HIV), and syphilis in Iranian blood donor population.Methods: Specimens of 1,004,889 volunteer blood donors in Tehran blood transfusion service from 2003 to 2005 were screened for HBsAg...

This study sought to determine the seroprevalence of the hepatitis D virus (HDV), the risk factors and its association with the severity of liver disease. Continuous patients at Tabriz and Tehran Hepatitis Clinics were enrolled during 2007-2008 in a cross-sectional study. Demographic data and possible risk factors for infection were recorded for al...

Hepatitis C virus (HCV) infection is the most common transfusion-transmitted disease in multiply transfused patients worldwide. In this study, the aim was to investigate distribution of HCV genotypes in Iranian patients with thalassemia. Blood samples were received from 280 multiply transfused patients with thalassemia with chronic hepatitis C who...

Background: Hepatitis C virus (HCV) infection is the most common transfusion transmitted disease in poly-transfused patients worldwide. In this study we aimed to evaluate the effects of pegylated interferon alfa-2a (PEG-IFN A-2a) in reducing serum ALT and eradicating serum hepatitis C virus (HCV) RNA in HCV infected polytransfused thalassemic patie...

Plagiarism is the unauthorized use or close imitation of the language and thoughts of another author and the representation of them as one's own original work (1). The National Library of Medicine (NLM) defines a duplicate publication as one that 'substantially duplicates another article without acknowledgement' (2). Scientific misconduct may take...

This study was conducted to evaluate the 16-year efficacy of hepatitis B virus (HBV) vaccine in healthcare workers of Oil Company Hospital, Tehran, Iran. Two hundred healthcare workers were enrolled in the study in 1989. All HBV markers were tested and those with positive HBV markers, positive antihepatitis C virus or anti-HIV were excluded from th...

To determine the frequency of hepatitis B, hepatitis C, Human Immunodeficiency Virus (HIV) and syphilis infections in Iranian blood donors. The prevalence of serological markers of hepatitis B, hepatitis C, HIV and syphilis infections were evaluated in 318029 consecutive volunteer blood donors attending to Tehran blood transfusion service from Marc...

We studied bone mineral density (BMD) changes in Iranian patients with end-stage renal disease (ESRD) within 11 months after renal transplantation. Among 68 ESRD candidates for renal transplantation, the BMD at the femur and the spine were assessed using a DEXA Norland scanner. Linear regression analysis was used to identify risk factors associated...

Background-Prolongation of ventricular depolarization time (QRS duration), particularly in left bundle branch block (LBBB), is commonly associated with many cardiac diseases. We propose that the QRS duration and degree of left-axis deviation (LAD) identify significant left ventricular (LV) systolic dysfunction in patients with LBBB. Methods-In this...