
Seyed Rasoul ZakaviMashhad University of Medical Sciences | MUMS · Nuclear Medicine Research Center (NMRC)
Seyed Rasoul Zakavi
MD, IBNM ,FANMB
About
222
Publications
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Introduction
I am professor of Nuclear Medicine in Nuclear Medicine Research Center in Mashhad University of Medical Sciences. My main research interest is Nuclear thyroidology, Nuclear Cardiology and Nuclear Oncology including PET/CT and theranostics. I am also Editor in Chief of "Asia Oceania Journal of Nuclear Medicine and Biology".
Additional affiliations
October 1995 - present
January 2010 - October 2015
Education
September 1992 - September 1995
October 1985 - April 1992
Publications
Publications (222)
Differentiated thyroid carcinoma (DTC) is the most common endocrine malignancy. Total thyroidectomy with subsequent radioactive iodine therapy (RIT) followed by levothyroxine consumption is a routine approach to deal with DTC. Widespread use of RIT in patients with DTC has raised concerns about its potential adverse effects on female reproductive o...
Aim A lymphoscintigraphy is a crucial diagnostic tool for visualizing lymph nodes. This scan plays a significant role in determining the treatment and recovery plan for the patients. Due to the small lymph node size, obtaining high-quality images is important to prevent inaccurate results. We aimed to identify the most effective method for enhancin...
The objective of this study was to develop an automated pipeline that enhances thyroid disease classification using thyroid scintigraphy images, aiming to decrease assessment time and increase diagnostic accuracy. Anterior thyroid scintigraphy images from 2,643 patients were collected and categorized into diffuse goiter (DG), multinodal goiter (MNG...
Objective To compare the eighth and seventh editions of TNM staging (TNM-8 and TNM-7) on disease-related mortality, persistent disease, and response to treatment in patients with differentiated thyroid cancer (DTC).
Methods and Materials We studied 400 patients (79% female) with DTC with a mean age of 40.93±14.11 years. TNM staging was recorded acc...
The ⁶⁸ Ga-FAPI (fibroblast activation protein inhibitor) radiotracer is a novel and versatile tool in nuclear medicine, exhibiting potential for use in various conditions due to its significant upregulation in cancerous and inflammatory conditions, particularly those involving fibrotic and infectious processes. In this report, we present the case o...
Background:
Following thyroidectomy, radioiodine therapy is the standard management of differentiated thyroid cancer. The effects of such treatment on testicular function remained a concern for cases and clinicians.
Objective:
We aimed to observe changes in fertility indicators in men treated with ablation.
Materials and methods:
In this prosp...
We aimed to investigate the role of [ 18 F]FDG positron emission tomography/computed tomography (PET/CT) in the early detection of arterial wall inflammation (AWI) in melanoma patients receiving immune checkpoint inhibitors (ICIs). Our retrospective study enrolled 95 melanoma patients who had received ICIs. Inclusion criteria were ICI therapy for a...
Optimal growth and development in childhood and adolescence is crucial for lifelong
health and well-being1–6
. Here we used data from 2,325 population-based studies, with
measurements of height and weight from 71 million participants, to report the height
and body-mass index (BMI) of children and adolescents aged 5–19 years on the basis
of rural an...
A 61-year-old woman with a history of metastatic follicular thyroid carcinoma became radioiodine-refractory following two doses of radioiodine (RAI) therapy (cumulative = 230 mCi). While no RAI-avid lesion was noticed in the last post-ablation whole-body radioiodine scan (WBIS), she reported sternal pain, which was accompanied by rapidly rising thy...
Objectives:
The coronavirus pandemic caused by SARS-CoV-2 commenced in late 2019, and global wide vaccination appears to be the only reasonable solution to fight this dreadful virus. There are two main types of COVID-19 immunization using viral vector and mRNA-based vaccines. However, the impact of each of type on 18F-FDG PET/CT needs to be accura...
Purpose: Micro-SPECT system has recently been introduced on nuclear medicine in the preclinical and research in which NaI (Tl) and Cadmium Telluride (CdTe) are used as the gamma-ray detectors with more generally use of NaI (Tl). The present study aimed to evaluate different thicknesses of the NaI (Tl) and (CdTe) detectors on functional parameters o...
Introduction: Differentiated thyroid cancer (DTC) is the most common endocrine malignancy. This malignancy generally has an excellent prognosis with more than 90% long term survival. Consequently, life quality improvement is the first priority especially in the young DTC survivors. In classic management of a new DTC patient, each therapeutic modali...
Thyroid Computer-Aided Diagnosis (CAD) systems have been developed to assist radiologists in improving efficiency, reliability, and diagnosis performance. Often the performance of these CAD systems is evaluated with different datasets that make it incomparable. A valuable thyroid ultrasound (US) dataset is presented in this work. This dataset consi...
Objective
The aim of this study was to investigate the relationship between sonographic vascularity and echogenicity of the thyroid lobes, compared with a participant’s body mass index (BMI).
Materials and Methods
A total of 3722 participations, with varied BMI, were included in the study. For all the participants, the thyroid-stimulating hormone...
Background:
Accurate staging is crucial to determine the type of treatment for patients with bladder cancer (BCa), especially in high-risk cases. We aimed to assess the role of bone scan in the initial staging of muscle-invasive bladder carcinoma (MIBC).
Material and methods:
Forty-five patients with MIBC were referred to our tertiary clinic to...
We investigate the accuracy of direct attenuation correction (AC) in the image domain for myocardial perfusion SPECT (single-photon emission computed tomography) imaging (MPI-SPECT) using residual (ResNet) and UNet deep convolutional neural networks. MPI-SPECT 99m Tc-sestamibi images of 99 patients were retrospectively included. UNet and ResNet net...
Objectives:
Accurate detection and competent management of thyroid nodules, as a common disease, basically depends on the reliability of the ultrasonography (US) report. In this research, we evaluated inter and intra-observer variation among ultrasonography reporters, based on ACR-TIRADS.
Methods:
In this retrospective study, 345 thyroid US imag...
Background
The term non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) was recently proposed as a non-malignant thyroid lesion with indolent behavior that does not require post-operative radio-iodine treatment. We are reporting a case of NIFTP with bone metastasis that is the second case reported so far.
Case pre...
Background
The coronavirus disease-2019 (COVID-19) pandemic significantly affected management of cardiovascular disease around the world. The effect of the pandemic on volume of cardiovascular diagnostic procedures is not known.
Objectives
This study sought to evaluate the effects of the early phase of the COVID-19 pandemic on cardiovascular diagn...
Background
Hypertension can be detected at the primary health-care level and low-cost treatments can effectively control hypertension. We aimed to measure the prevalence of hypertension and progress in its detection, treatment, and control from 1990 to 2019 for 200 countries and territories.
Methods
We used data from 1990 to 2019 on people aged 30...
A 33-year-old female with a history of total thyroidectomy for papillary thyroid carcinoma was referred to the nuclear medicine department for ablative radioiodine therapy. Post ablation scan showed an area of intense iodine uptake on the left side of the pelvic region, corresponding to the large well-defined heterogeneous mass in the left ovary in...
A 68 years old man with prostate carcinoma was referred for ⁶⁸Ga-PSMA PET/CT scan because of recent significant rise of PSA. He complained of muscle weakness and fatigue, since 3 weeks before the scan, without dyspnea or shortness of breath. In his ⁶⁸Ga-PSMA-611 PET/CT study, widespread skeletal metastasis, as well as liver involvement were noticed...
Impact of COVID-19 on Cardiovascular Testing in the United States Versus the Rest of the World
Objectives
This study sought to quantify and compare the decline in volumes of cardiovascular procedures between the United States and non-US institutions during the early phase of the coronavirus disease-2019 (COVID-19) pandemic.
Background
The COVID-19 pandemic has disrupted the care of many non-COVID-19 illnesses. Reductions in diagnostic cardi...
Background:
Familial non-medullary thyroid cancer (NMTC) are supposed to be more aggressive and require more frequent treatment compared to non-familial thyroid cancer.
Objectives:
This matched case-control study aimed to compare the response to treatment between the matched case-control groups of familial and sporadic NMTC.
Methods:
This is a...
From 1985 to 2016, the prevalence of underweight decreased, and that of obesity and severe obesity increased, in most regions, with significant variation in the magnitude of these changes across regions. We investigated how much change in mean body mass index (BMI) explains changes in the prevalence of underweight, obesity, and severe obesity in di...
From 1985 to 2016, the prevalence of underweight decreased, and that of obesity and severe obesity increased, in most regions, with significant variation in the magnitude of these changes across regions. We investigated how much change in mean body mass index (BMI) explains changes in the prevalence of underweight, obesity, and severe obesity in di...
Background:
The aim of this study was to define prognostic value and optimal threshold of first thyroglobulin (fTg) measured after thyroidectomy and just before radio-iodine therapy (RIT), in low/intermediate risk patients with differentiated thyroid cancer (DTC).
Methods:
This is a retrospective study in 383 patients with DTC who were treated w...
BACKGROUND: The aim of this study was to define prognostic value and optimal threshold of first thyroglobulin (fTg) measured after thyroid-ectomy and just before radio-iodine therapy (RIT), in low/intermediate risk patients with differentiated thyroid cancer (DTC). METHODS: This is a retrospective study in 383 patients with DTC who were treated wit...
Objective: In this work, we set out to investigate the accuracy of direct attenuation correction (AC) in the image domain for the myocardial perfusion SPECT imaging (MPI-SPECT) using two residual (ResNet) and UNet deep convolutional neural networks. Methods: The MPI-SPECT 99mTc-sestamibi images of 99 participants were retrospectively examined. UNet...
PurposeTo investigate the ability of 18F-FDG PET/CT to assess the response of patients with metastatic melanoma to immunotherapy.MethodsA comprehensive search of the literature for studies examining the prognostic value of 18F-FDG PET/CT in monitoring the response of patients with metastatic melanoma to immunotherapy was performed. We also screened...
A 68 years old man with prostate carcinoma was referred for 68 Ga-PSMA PET/CT scan because of recent significant rise of PSA. He complained of muscle weakness and fatigue, since 3 weeks before the scan, without dyspnea or shortness of breath. In his 68 Ga-PSMA-611 PET/CT study, widespread skeletal metastasis, as well as liver involvement were notic...
Immunotherapy using programmed cell death (PD)-1 blockers is a promising therapeutic modality for non-small-cell lung cancer (NSCLC). Therefore, defining the most accurate response criteria for immunotherapy monitoring is of great importance in patient management. This study aimed to compare the correlation between survival outcome and response ass...
Background
The rising burden of premature mortality for Non-Communicable Diseases (NCDs) in developing countries necessitates the institutionalization of a comprehensive surveillance framework to track trends and provide evidence to design, implement, and evaluate preventive strategies. This study aims to conduct an organization-based prospective c...
Background
The rising burden of premature mortality for Non-Communicable Diseases (NCDs) in developing countries necessitates the institutionalization of a comprehensive surveillance framework to track trends and provide evidence to design, implement, and evaluate preventive strategies. This study aims to conduct an organization-based prospective c...
A 50 years old woman with history of pancreatic neuroendocrine tumor diagnosed 2 years ago, which has not been surgically removed,was referred to our department for a 99m Tc-Octreotate in order to evaluate the somatostatin receptor status. She was treated with regular sandostatin injections and chemotherapy. Her CT scan which was previously perform...
Background
Comparable global data on health and nutrition of school-aged children and adolescents are scarce. We aimed to estimate age trajectories and time trends in mean height and mean body-mass index (BMI), which measures weight gain beyond what is expected from height gain, for school-aged children and adolescents.
Methods
For this pooled ana...
High blood cholesterol is typically considered a feature of wealthy western countries1,2. However, dietary and behavioural determinants of blood cholesterol are changing rapidly throughout the world³ and countries are using lipid-lowering medications at varying rates. These changes can have distinct effects on the levels of high-density lipoprotein...
Background: Differentiated thyroid cancer (DTC) is the most prevalent endocrine cancer. Evidence showed a significant association between diet and DTC. Thus, this study aimed to assess the relationship between dietary intakes and DTC. Methods: This case-control study was accomplished among 300 adult patients and 300 matched (age and gender) control...
Purpose:
The study aims to define the effect of different dose strategies on ophthalmic complications in patients with Graves' disease (GD).
Methods:
All the patients with GD and no or inactive ophthalmopathy (clinical activity score; CAS < 3) underwent Snellen chart examination, measurement of proptosis, thyroid volume, and radioactive iodine u...
Objectives:
99mTc-PSMA SPECT/CT is a cost effective alternative for 68Ga-PSMA PET/CT. The aim of this study was to directly compare these two techniques in patients with prostate cancer.
Methods:
28 man with prostate cancer were studied using 99mTc-PSMA SPECT/CT and 68Ga-PSMA PET/CT in a short time period (<60 days). No intervention was done bet...
Background: Papillary thyroid carcinoma (PTC) is considered the most frequent thyroid malignancy (85-90%) with a good prognosis. However, its frequent recurrence increases mortality and morbidity. In this inquiry we investigated the prevalence of risk factors of PTC recurrence and disease free survival after thyroidectomy and central neck dissectio...
Background:
Differentiated Thyroid Cancer (DTC) is the most common endocrine cancer with an increasing trend worldwide. Dietary pattern as a modifiable factor may be associated with DTC.
Objective:
The present study aimed to evaluate the association between major dietary patterns and risk of DTC.
Methods:
A case control study was conducted amo...
A 73-year-old man with history of prostatic adenocarcinoma radical prostatectomy underwent 99m Tc-MDP whole-body bone scan and subsequent 68 Ga-labeled prostate-specific membrane antigen (PSMA) ligand PET/CT for restaging due to a gradual rise of prostate-specific antigen levels. Whole-body bone scan showed two focal zones of slightly increased upt...
Introduction: finding optimum time of post ablation whole body iodine scan in patients with differentiated thyroid cancer(DTC) treated with I-131. Materials and Methods: 20 patients with DTC, who were treated with I 131 undergone post ablation whole body iodine scan (WBIS) in days 4, 7 and 9 after treatment. A dual head gamma camera (e-cam, Siemens...
Introduction: Iodine therapy after surgery is the gold standard treatment in patients with differentiated thyroid cancer. It is important to evaluate the effect of this treatment on future pregnancies of women who received iodine therapy. This review article was performed with aim to evaluate the pregnancy complications in patients who received iod...
Objective(s)
TSH suppression by Levothyroxine consumption is a mainstay of thyroid cancer treatment. Tablet-splitting is a worldwide approach in dose adjustment in patients. However, it is highly recommended to evaluate the validity of tablet splitting for each distinctive drug by clinical trials before routinely using tablet halves in clinical pra...
Introduction: Myocardial perfusion SPECT by 99mTc-Sestamibi and 99mTc-Tetrofosmin radiopharmaceuticals usually presents a false significant increase in the radiotracer uptake in the inferior myocardium due to the uptake in organs such as liver, bowel, stomach and biliary system. The present study evaluated a suitable Slit angle for differentiating...
Objective(s): TSH suppression by Levothyroxine consumption is a mainstay
of thyroid cancer treatment. Tablet-splitting is a worldwide approach in dose
adjustment in patients. However, it is highly recommended to evaluate the validity
of tablet splitting for each distinctive drug by clinical trials before routinely using
tablet halves in clinica...
Extraosseous accumulation of technetium-99m-methyl diphosphonate (99mTc-MDP) on bone scan is not common. This phenomenon is often attributed to abnormality of calcium metabolism and has been reported in a variety of conditions including metabolic diseases and malignancies.
A five years old boy is presented here, who was admitted to the pediatric em...
Background:
Radioiodine ablation may be associated with improved survival in patients with intermediate-risk follicular cell differentiated thyroid cancer (FCDTC). The aim of this study was to compare ablation efficacy of 1110 versus 5500 MBq of iodine-131 (I) in FCDTC patients with intermediate risk.
Methods:
Thirty-nine patients with intermedi...
Synthetic somatostatin analogs have been posed as a potential source of error in somatostatin receptor imaging by interfering with tumor detection; however, experimental models and clinical studies have shown a complex mechanism of octreotide effect on tumors. This study aimed to assess whether (68)Ga-DOTATATE uptake differs before and after treatm...
The specific absorbed fraction (SAF) of energy is an essential element of internal dose assessment. Here reported a set of SAFs calculated for selected organs of a human voxel-based phantom. The Monte Carlo transport code GATE version 6.1 was used to simulate monoenergetic photons and electrons with energies ranging from 10 keV to 2 MeV. The partic...
Background: The specific absorbed fraction (SAF) of energy is an essential element of internal dose assessment. Objectives: Here we report a set of SAFs calculated for selected organs of ahuman computational phantom. Materials and Methods: The Monte Carlo transport code GATE version 6.1 was used to simulate monoenergetic photons and elec- trons wit...
Single-photon emission computed tomography (SPECT)-based tracers are easily available and more widely used than positron emission tomography (PET)-based tracers, and SPECT imaging still remains the most prevalent nuclear medicine imaging modality worldwide. The aim of this study is to implement an image-based Monte Carlo method for patient-specific...
AOJNMB is striving for excellence. Our journal is publishing its 4th volume of publication and we are delighted to observe on time publication of this journal with important scientific articles. On November 2015, 11th Asia Oceania Congress of Nuclear Medicine & Biology (AOCNMB) was held in Jeju International Convention Center (JICC) in Korea with h...