Seyed Hossein Mostafavi

University of California, Riverside | UCR · Department of Bioengineering

Anthracene (AN) attachment to silica nanoparticles leads to multiple fluorescence lifetimes, due to different environments on the silica surface. Under ultraviolet (365 nm) illumination, the AN surface groups undergo a [4 + 4] photodimerization reaction that cross-links the nanoparticles and induces aggregation. The kinetics of both intra- and inte...

The aim of the current study was the development of nanosuspension stability in nanoprecipitation using microfluidic devices. Also, it is desirable to understand how the microfluidic preparation parameters influenced the stability of the stable-iodine (¹²⁷I) nanosuspension. In optimization process through artificial neural networks (ANNs), the rela...

Photoisomerization of molecules dissolved in a polymer film can modulate its properties. In a previous paper (Mostafavi, S. H.; Macromolecules 2018, 51, 2388−2394), it was found that the ultraviolet light-induced photoisomerization of spiropyran dopants could substantially increase adhesion to a glass surface. In this work, a different photochromic...

This paper explores whether the photochromic reaction of a molecule embedded in a polymer film can affect its surface adhesion properties, as measured by shear strength and delamination in water. The adherence of polystyrene (PS) to glass was chosen as a model system. Two commercially available photochromes—a spiropyran derivative 1′,3′-dihydro-1′,...

Nanoparticles (NPs) play an important role in anticancer delivery systems. Surface modified NPs with hydrophilic polymers such as human serum albumin (HSA) have long half-life in the blood circulation system. The method of modified nanoprecipitation was utilized for encapsulation of paclitaxel (PTX) in poly (lactic-co-glycolic acid) (PLGA). Para-ma...

The aim of the present study was to formulate poly (lactide-co-glycolide) (PLGA) nanoparticles loaded with 18-β-glycyrrhetinic acid (GLA) with appropriate physicochemical properties and antimicrobial activity. GLA loaded PLGA nanoparticles were prepared with different drug to polymer ratios, acetone contents and sonication times and the antibacteri...

In this study, nanosuspension of stable iodine (127I) was prepared by nanoprecipitation process in microfluidic devices. Then, size of particles was optimized using artificial neural networks (ANNs) modeling. The size of prepared particles was evaluated by dynamic light scattering. The response surfaces obtained from ANNs model illustrated the dete...

Abstract The aim of this study was to find a model using artificial neural networks (ANNs) to predict PLGA-PMBH nanoparticles (NPs) size in preparation by modified nanoprecipitation. The input variables were polymer content, drug content, power of sonication and ratio of organic/aqueous phase (i.e. acetone/water), while the NPs size of PLGA-PMBH wa...

The aim of this study was to find a model using artificial neural networks (ANNs) to predict PLGA-PMBH nanoparticles (NPs) size in preparation by modified nanoprecipitation. The input variables were polymer content, drug content, power of sonication and ratio of organic/aqueous phase (i.e. acetone/water), while the NPs size of PLGA-PMBH was assumed...

In this study a 3-factor, 3-level Box-Behnken design was used to prepare optimized docetaxel (DTX) loaded pegylated poly lactide-co-glycolide (PEG-PLGA) Nanoparticles (NPs) with polymer concentration (X1), drug concentration (X2) and ratio of the organic to aqueous solvent (X3) as the independent variables and particle size (Y1), poly dispersity in...

The geographic map of cancer prevalence differs due to environmental and dietary factors in various populations. High prevalence of a number of cancers in some regions is thought to be attributed to local dietary habits. Dorema aucheri (Bilhar) is used commonly as an herbal medicine in some regions including Iran. The aim of this study was to evalu...

Citation: Mostafavi SH, Jayachandra Babu R (2013) Nano-Sized Drug Delivery. J Mol Pharm Org Process Res 1: e108. doi:10.4172/jmpopr.1000e108 Copyright: © 2013 Mostafavi SH, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in...

A large number of new development drugs are soluble poorly in both organic and aqueous media which shows a low bioavailability using formulation traditional methods. A promising approach to solve this problem is the formation of nanosuspensions. The main advantages of this approach are its application for the most drugs and doing it simply. In this...

Nanoparticle (NP) has been shown significantly affect in antitumor drug delivery systems. Biodistribution of targeted and non-targeted NPs in an organ is an important concept in this aria. PLGA is a widely used polymer for fabricating ‘nanoparticles’ because of its suitable properties, and hence has been the centre of focus for developing drug-load...

Background and the purpose of the study The purpose of this study was to prepare pegylated poly lactide-co-glycolide (PEG-PLGA) nanoparticles (NPs) loaded with roxithromycin (RXN) with appropriate physicochemical properties and antibacterial activity. Roxithromycin, a semi-synthetic derivative of erythromycin, is more stable than erythromycin under...

Nanoparticles (NP) prepared through the self-assembly of amphiphilic block copolymers have concerned substantial attention for the enhanced delivery of inadequately water soluble compounds. Moreover, Albumin which is choose to use in this study is the most abundant protein in human serum, of which the concentration is approximately 5% (w/v). The fu...

Preparation of nanoparticles (NPs) using solvent evaporation method is influenced by various factors; the desired nanomedicines are generally achieved by trial and error method with no specific rule. we used a 3-factor, 3-level Box–Behnken design to optimize (DTX)-loaded PLGA-b-PEG nanoparticles nanoparticle formulation with polymer concentration (...