Seyed Khosrow Tayebati

Seyed Khosrow Tayebati
University of Camerino | UNICAM · EX Dipartimento di Medicina Sperimentale e Sanità Pubblica

PharmD, PhD

About

143
Publications
16,306
Reads
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2,657
Citations
Additional affiliations
January 2002 - June 2015
University of Camerino
Position
  • Professor of Cellulare Biology and Human Anatomy
September 1993 - present
University of Camerino
Position
  • Professor (Associate)
Education
November 1990 - February 1994
Università di Pisa
Field of study
  • Medicinal Chemistry

Publications

Publications (143)
Article
Full-text available
Obesity is a risk factor for cardiovascular diseases, frequently related to oxidative stress and inflammation. Dietary antioxidant compounds improve heart health. Here, we estimate the oxidative grade and inflammation in the heart of dietary-induced obese (DIO) rats after exposure to a high-fat diet compared to a standard diet. The effects of tart...
Article
Full-text available
During the recent COVID-19 pandemic, healthcare providers have been encouraged to increase their use of telemedicine and to adopt telemedicine platforms for the majority of their clients who have chronic illnesses. Due to the outbreak itself, almost all countries worldwide were placed under emergency lockdowns. In this paper, we reviewed the litera...
Article
Full-text available
The A2A adenosine receptor (A2AAR) is one of the four subtypes activated by nucleoside adenosine, and the molecules able to selectively counteract its action are attractive tools for neurodegenerative disorders. In order to find novel A2AAR ligands, two series of compounds based on purine and triazolotriazine scaffolds were synthesized and tested a...
Article
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Brain and retinal organoids are functional and dynamic in vitro three-dimensional (3D) structures derived from pluripotent stem cells that spontaneously organize themselves to their in vivo counterparts. Here, we review the main literature data of how these organoids have been developed through different protocols and how they have been technically...
Article
Full-text available
A link between obesity and cerebral health is receiving growing recognition. Here, we investigate in the frontal cortex and hippocampus the potential involvement of cholinergic markers in brain alterations previously reported in rats with obesity induced by diet (DIO) after long-term exposure (17 weeks) to a high-fat diet (HFD) in comparison with a...
Article
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Evidence suggests that transient receptor potential (TRP) ion channels dysfunction significantly contributes to the physiopathology of metabolic and neurological disorders. Dysregulation in functions and expression in genes encoding the TRP channels cause several inherited diseases in humans (the so-called ‘TRP channelopathies’), which affect the c...
Article
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The association between obesity and loss of cognitive performance has been recognized. Although there are data regarding the metabolic alterations in obese conditions and the development of neuroinflammation, no clear evidence concerning obesity-related cholinergic and synaptic impairments in the frontal cortex and hippocampus has been reported yet...
Article
Full-text available
Purpose There is increasing evidence for the involvement of dietary bioactive compounds in the cross-talk modulation of endocannabinoid system and some of the key regulators of transcriptional control for adipogenesis. Methods We aimed to characterize the expression of cannabinoid CB1/CB2 receptors and fatty acid amide hydrolase (FAAH) along with...
Article
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Renal and cardiac impairments are frequent events in the presence of hypertension. Organ damage is mainly linked to oxidative stress due to high blood pressure and may be reduced by antioxidant supplementation. Alpha-lipoic acid (ALA) is one of most effective antioxidants. It is widely used as a nutritional supplement in a racemic mixture (+/–), ev...
Article
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Abstract: Obesity represents one of the most important challenges in the contemporary world that must be overcome. Different pathological consequences of these physical conditions have been studied for more than 30 years. The most nagging effects were found early in the cardiovascular system. However, later, its negative impact was also investigate...
Article
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Overweight and obesity are key risk factors of cardiovascular disease (CVD). Obesity is currently presented as a pro-inflammatory state with an expansion in the outflow of inflammatory cytokines, such as interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α), alongside the expanded emission of leptin. The present review aimed to evaluate the...
Article
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Background: Tart cherries (Prunus cerasus L.) are a rich source of anthocyanins. They are phytochemical flavonoids found in red and blue fruits, and vegetables that can reduce hyperlipidemia. Visceral Adipose Tissue (VAT) has emerged as a major player in driving obesity-related inflammatory response. Methods: This study has investigated the pote...
Article
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The dysfunction of melanocortin signaling has been associated with obesity, given the important role in the regulation of energy homeostasis, food intake, satiety and body weight. In the hypothalamus, the melanocortin-3 receptor (MC3R) and melanocortin-4 receptor (MC4R) contribute to the stability of these processes, but MC3R and MC4R are also loca...
Article
Full-text available
INTRODUCTION: Having justice for easy access to health services may probably be a standard feature and indisputable right of all health policies. The health policy of Iran enunciates this right. Unfortunately, as may happen in many countries, the execution of this policy depends on different factors. Among these parameters should be quoted as the s...
Article
The novel coronavirus, later identified as SARS-CoV-2, originating from Wuhan in China in November 2019, quickly spread around the world becoming a pandemic. Despite the knowledge of previous coronaviruses, such as those responsible for the SARS and MERS-CoV epidemic, there is no drug or prophylaxis treatment to this day. The rapid succession of sc...
Article
Full-text available
Metabolic syndrome (MetS) is an association between obesity, dyslipidemia, hyperglycemia, hypertension, and insulin resistance. A relationship between MetS and vascular dementia was hypothesized. The purpose of this work is to investigate brain microanatomy alterations in obese Zucker rats (OZRs), as a model of MetS, compared to their counterparts...
Article
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The accumulation of adipose tissue increases the risk of several diseases. The fruits-intake, containing phytochemicals, is inversely correlated with their development. This study evaluated the effects of anthocyanin-rich tart cherries in diet-induced obese (DIO) rats. DIO rats were exposed to a high-fat diet with the supplementation of tart cherry...
Article
Full-text available
Metabolic syndrome (MetS) is a predictor of cardiovascular diseases, commonly associated with oxidative stress and inflammation. However, the pathogenic mechanisms are not yet fully elucidated. The aim of the study is to evaluate the oxidative status and inflammation in the heart of obese Zucker rats (OZRs) and lean Zucker rats (LZRs) at different...
Article
Full-text available
Evidence suggests that obesity adversely affects brain function. High body mass index, hypertension, dyslipidemia, insulin resistance, and diabetes are risk factors for increasing cognitive decline. Tart cherries (Prunus Cerasus L.) are rich in anthocyanins and components that modify lipid metabolism. This study evaluated the effects of tart cherri...
Article
Full-text available
Background and objectives: Having fair access to medical services may probably be a standard feature and indisputable right of all health policies. The health policy of Iran enunciates this right. Unfortunately, as may happen in many countries, the execution of this policy depends on different factors. Among these parameters, the suitable distribut...
Article
Full-text available
1) Background: Diabetes is a common chronic disease and a leading cause of death. Early diagnosis gives patients with diabetes the opportunity to improve their dietary habits and lifestyle and manage the disease successfully. Several studies have explored the use of machine learning (ML) techniques to predict and diagnose this disease. In this stud...
Article
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Access to healthcare services is critical to good health, yet residents of internal areas face a variety of access barriers. The obstacles faced by health care providers and patients in rural areas are vastly different from those in urban areas. This might be caused by economic factors, cultural and social differences, educational shortcomings, lac...
Article
Down syndrome (DS) is an important genetic disease that besides cerebral functions involves many other body systems. The postnatal approach to treat this genetic disease includes intervention on various related diseases (e.g. heart failure, respiratory, oral, ear and hearing disorders). Different treatments proposed barely improve the quality of li...
Article
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Background: The contents of the ship pharmacy, namely “medicine chest” and its compliance with the respective regulations concerning the type of drugs to be provided for merchant vessels involved in long distance voyages and without a doctor on board were analysed. The current existing disparity between regulations can make medical assistance more...
Article
Background: Due to recent advancements in the computing technologies, process-mining algorithms can consequently apply complex numerical calculations in big data analysis with quick repetitions. It involved primarily in real-time systems such as banking, transport, and hospitals. However, process mining tending to play a vital role in the healthcar...
Article
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The worldwide demographical trend is changing towards a more elderly population. In particular, this phenomenon is increasing the number of neurodegenerative disease cases (e.g., Alzheimer’s disease) in advanced countries. Therefore, there is a fertile field for neuroprotective approaches to address this problem. A useful strategy to protect the me...
Presentation
The systemic effects, such as increased fat mass, hypertension, insulin resistance and metabolic disorders, have been identified as factors that may lead to cognitive dysfunction. For these reasons obesity represents a risk factor for the development of cerebrovascular disease and cognitive decline. To investigate the possible relationships between...
Poster
INTRODUCTION. Obesity, is considered a medical challenge for its increase worldwide. It represents also an independent risk factor for the development of cerebrovascular disease and of cognitive im-pairment. This work has assessed the relationships between obesity and brain injury by investigating brain morphology in rats developing obesity (diet-i...
Article
Full-text available
Choline is involved in relevant neurochemical processes. In particular, it is the precursor and metabolite of acetylcholine (ACh). Choline is an essential component of different membrane phospholipids that are involved in intraneuronal signal transduction. On the other hand, cholinergic precursors are involved in ACh release and carry out a neuropr...
Article
Full-text available
Background: Telemedicine applications have been increasing due to the development of new computer science technologies and of more advanced telemedical devices. Various types of telerehabilitation treatments and their relative intensities and duration have been reported. Objective: The objective of this review is to provide a detailed overview o...
Poster
Full-text available
Excessive accumulation of adipose tissue correlates with metabolic changes that increase the risk of cardiovascular and cerebrovascular disease. Hypertension, impaired glucose tolerance, insulin resis-tance and dyslipidemia often accompanied obesity. The excess of fat storage in the abdomen is the prime cause of the metabolic abnormalities and ther...
Article
Background: Worldwide, at least 2.8 million people die each year as a result of being overweight or obese. Obesity leads to metabolic syndrome, a pathological condition characterized by adverse metabolic effects on blood pressure, cholesterol, triglycerides and insulin resistance. Population- based investigations have suggested that obesity and me...
Article
Full-text available
Background: Ships should carry mandatory given amounts of medicinal products and basic first aid items, collectively known as the ship's medicine chest. Type and quantities of these products/items are suggested by the World Health Organisation (WHO) and regulated by individual flag states. In countries that lack national legislation, it is assumed...
Presentation
Obesity is an excessive or abnormal accumulation of adipose tissue due to a high-caloric diet and/or reduced physical activity. Statistical analysis revealed that more than 2 billion people worldwide are overweight and of these over 600 million are obese. Obesity is now considered more and more a medical challenge. Furthermore obesity may involve t...
Poster
Cholinergic hypofunction is a common trait of adult-onset dementia including Alzheimer’s disease (AD) and vascular dementia (VaD). Cholinergic replacing approaches represent an obvious strategy for treating cognitive dysfunctions due to impaired cholinergic neurotransmission. Cholinergic precursors increasing choline availability and acetylcholine...
Poster
The present study has investigated the brain cholinergic pattern in Obese Zucker rats (OZRs) compared with controls lean Zucker rats (LZRs) at different ages. This to clarify the possible relationships between Mets, cerebral injury and cholinergic system impairment.
Poster
Increased food intake, reduced physical activity and altered metabolic processes are the variables that affect energy balance inducing obesity. Obesity is now considered an increas-ingly medical challenge. Actually, the prevalence of obesity has increased dramatically worldwide over the last decades and has now reached epidemic proportions. On the...
Article
Background: Spontaneously hypertensive rats (SHR) represent a model of hypertension and vascular injury. In the past decade, SHR were also considered as a model of vascular dementia. Several studies have shown that cerebrovascular changes in SHR may mimic brain vascular diseases of hypertensive individuals. Vascular and cerebrovascular changes duri...
Article
Choline is a quaternary ammonium salt, and being an essential component of different membrane phospholipids (PLs) contributes to the structural integrity of cell membranes. Choline-containing phospholipids (CCPLs) include phosphatidylcholine (PC), sphingomyelin (SM), and choline alphoscerate (GPC). PC is the major phospholipid in most eukaryotic ce...
Article
Endothelial cells represent an important vascular site of signaling and development of damage during ischemia, inflammation and other pathological conditions. Excessive reactive oxygen species production causes pathological activation of endothelium including exposure of cell to adhesion molecules. Intercellular adhesion molecule-1 (ICAM-1), vascul...
Article
Lymphocytes possess an independent cholinergic system. We assessed the expression of muscarinic cholinergic receptors in lymphocytes from 49 asthmatic children and 10 age matched controls using Western blot. We demonstrated that CD4+ and CD8+ T cells expressed M2 and M4 muscarinic receptors which density were significantly increased in asthmatic ch...
Article
Cholinergic precursors increasing choline availability and acetylcholine synthesis/release may represent a therapeutic approach for countering cognitive impairment occurring in adult-onset dementia disorders. Choline alphoscerate (alpha-gliceryl-phosphoryl-choline, GPC) is among cholinergic precursors the most effective in enhancing acetylcholine b...
Article
Metabolic syndrome (MetS) is defined as a combination of glucose intolerance, arterial hypertension, dyslipidemia and obesity with insulin resistance as the main cause of these imbalances. In general, obesity increases the risk of vascular diseases. Both cardiovascular and cerebrovascular disorders are often linked to impaired cognitive functions....
Article
The blood brain barrier (BBB) is the site of exchange between blood and the nervous tissue. Damage of it may impair physiological balance between blood stream and nervous tissue. Metabolic syndrome (MetS) is defined by several interconnected physiological, biochemical, and metabolic factors directly related to obesity. It increases the risk of athe...
Article
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ABSTRACT Background: Health practitioners of different disciplines (physicians, paramedic personnel, pharmacists) should possess adequate ICT (Information and Communication Technology) skills and practical competence on these technologies. Pharmacy practice requires a relevant flow of information, collection and handling of which could be facilitat...
Article
Peripheral neuropathies are in general characterized by hyperalgesia and allodynia with alterations of muscular sensitivity and functions. Selected antioxidants have been proposed as a potential therapeutic agents in the treatment or prevention of several pathologies related to oxidative stress. Thioctic acid is an antioxidant existing in nature an...
Article
Accumulation of intimal vascular smooth muscle cells is a trait of atherosclerosis. Endothelial cells lining vascular luminal surface represent an important site of signalling and development of damage induced by reactive oxygen species (ROS) during ischemia, inflammation and other pathological conditions. Targeted delivery of ROS modulating enzyme...
Article
Purpose of this research was to analyse the rare diseases drug supply paths in the Italian region of Campania (Health District 47 of the Local Medical Company Naples 1), with a particular focus on current regulations in this field, and quantify the economic incidence of such pathologies in each quarter of 2007 and 2008. Rare, or orphan, diseases ar...
Article
Metabolic syndrome (MetS) is a disorder characterized primarily by the development of insulin resistance. Insulin resistance and subsequent hyperinsulinemia, originating from abdominal obesity, increases the risk of cerebrovascular and cardiovascular disease and all-cause mortality. Obesity is probably a risk factor for Alzheimer's disease and vasc...
Article
Full-text available
Oxidative stress is an imbalance between the production of free radicals and antioxidant defense mechanisms, potentially leading to tissue damage. Oxidative stress has a key role in the development of cerebrovascular and/or neurodegenerative diseases. This phenomenon is mainly mediated by an enhanced superoxide production by the vascular endotheliu...
Article
Full-text available
Abstract Choline participates in several relevant neurochemical processes. It is the precursor and metabolite of acetylcholine (ACh), plays a role in single-carbon metabolism and is an essential component of different membrane phospholipids (PLs). PLs are structural components of cell membranes involved in intraneuronal signal transduction. This pa...
Article
Full-text available
Peripheral neuropathies are heterogeneous disorders presenting often with hyperalgesia and allodynia. This study has assessed if chronic constriction injury (CCI) of sciatic nerve is accompanied by increased oxidative stress and central nervous system (CNS) changes and if these changes are sensitive to treatment with thioctic acid. Thioctic acid is...
Article
Metabolism of oxygen by cells can generate potentially dangerous reactive oxygen species (ROS). Endothelial cells lining vascular luminal surface are an important site of signalling molecules and a ROS target during ischemia, inflammation and other pathological conditions. Targeted delivery of ROS modulating enzymes conjugated with antibodies to en...
Article
Arterial hypertension is accompanied by significant cardiovascular and renal changes as well as by increased production of reactive oxygen species (ROS) Spontaneously hypertensive rats (SHR) are a widely used animal model in hypertension research. They are normotensive at birth and develop hypertension gradually. From the 6th month hypertension bec...
Article
Choline-containing phospholipids were proposed as cognition enhancing agents, but evidence on their activity is controversial. CDP-choline (cytidine-5´-diphosphocholine, CDP) and choline alphoscerate (L-alpha-glyceryl-phosphorylcholine, GPC) represent the choline-containing phospholipids with larger clinical evidence in the treatment of sequelae of...
Article
Pharmacological treatment of disorders affecting the central nervous system (CNS) is a complex task. Different parameters may negatively influence effective targeting of the CNS and drug compliance, for example, poor brain-blood barrier (BBB) permeability, patient forgetfulness or neglect, and lack of collaboration between caregivers and patients....
Article
Arterial hypertension is the main risk factor for stroke and plays a role in the development of vascular cognitive impairment (VCI) and vascular dementia (VaD). An association between hypertension and reduced cerebral blood flow and VCI is documented and arterial hypertension in midlife is associated with a higher probability of cognitive impairmen...
Article
Full-text available
Cholinergic hypofunction is a trait of Alzheimer's disease and vascular dementia and countering it is one of the main therapeutic strategies available for these disorders. Cholinergic transporters control cellular mechanisms of acetylcholine (ACh) synthesis and release at presynaptic terminals. This study has assessed the influence of 4 week treatm...