Seyed Ali Asghar Moshtaghie

Seyed Ali Asghar Moshtaghie
Isfahan University of Medical Sciences · Clinical Biochemistry Department

Professor of Clinical Chem Clinical Biochem
Currently I am working as a full professor of clinic Biochem as well as clinic Chem in Azad University

About

110
Publications
47,876
Reads
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738
Citations
Citations since 2016
17 Research Items
319 Citations
20162017201820192020202120220102030405060
20162017201820192020202120220102030405060
20162017201820192020202120220102030405060
20162017201820192020202120220102030405060
Introduction
I am Professor of Clinical Biochemistry as well as clinical chemistry with specialty in trace elements metabolism in health and disease. I am also interested in high molecular weight ALKP and its regulation by trace elements as well as hormones. This is specific isoenzyme of ALP. I recently interested in nanometal effects on biochemical processes in animals.
Additional affiliations
January 2012 - present
Islamic Azad University Falavarjan Branch
Position
  • Islamic Azad University
January 2008 - present
Islamic Azad University Falavarjan Branch
Position
  • BSc and MSc Biochemical Courses
January 2008 - June 2015
Islamic Azad University Falavarjan Branch
Position
  • Professor
Education
January 1987 - January 1988
Newcastle University
Field of study
  • Clinical Enzymology
January 1984 - December 1987
Newcastle University
Field of study
  • Clinical Biochemistry
January 1977 - August 1980
University of Dayton
Field of study
  • Clinical Chemistry

Publications

Publications (110)
Article
Full-text available
Thyroid cancer is the most common sort of endocrine-related cancer with more prevalent in women and elderly individuals which has quickly widespread expansion in worldwide over the recent decades. Common features of malignant thyroid cells are to have accelerated metabolism and increased glucose uptake to optimize their energy supply which provides...
Article
Full-text available
Background: A dysregulated iron metabolism can lead to a wide range of diseases, and investigating this issue is vital for the development of therapeutics. Furthermore, trace elements such as lanthanum have been shown to interfere with iron uptake. Objectives: Therefore, this study aimed to evaluate the intestinal uptake of lanthanum and its compet...
Article
Alpha-linolenic acid (ALA) is one of the necessary fatty acids for the human body. It is a precursor for synthesizing eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). The consumption of ALA as an anti-inflammatory factor plays a significant role in preventing cardiovascular diseases. The current study was investigated to evaluate the bin...
Chapter
Full-text available
Common capabilities of thyroid malignant cells are accelerating metabolism and increasing glucose uptake to optimize energy supply for growth. In tumor cells, keeping the power load required for cell survival is essential and glucose transporters are capable of promoting this task. GLUT-1 and GLUT3 are promising goals for the development of anti-ca...
Article
Full-text available
Thyroid cancer is the most common sort of endocrine-related cancer with more prevalent in women and elderly individuals which has quickly widespread expansion in worldwide over the recent decades. Common features of malignant thyroid cells are to have accelerated metabolism and increased glucose uptake to optimize their energy supply which provides...
Preprint
Full-text available
Thyroid cancer is one of the most frequently diagnosed cancers in women and the elderly. Like all cells, thyroid cancer cells need energy to survive. One way they stay nourished is by hijacking the machinery that regulates glucose in the body particularly molecules known as glucose transporters, or GLUTs, which help the body absorb energy-rich gluc...
Article
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Abstract Background: Cardiovascular disease (CVD) and inflammation are among the most common causes of mortality in dialysis patients and factors such as chronic inflammation, dyslipidemia and elevated homocysteine levels may underlie the increased risk of CVD. This study aimed to investigate levels of inflammatory markers, homocysteine, lipid prof...
Article
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Background: Considering the importance of the alkaline phosphatase enzyme for growth of liver cells and the presence of zinc in this regard the purpose of this project was to evaluate the Protective effect of zinc on the Alkaline Phosphatase Activity in rats exposed to Arsenic. Methods: In this experimental study, a total of 48 male Wistar rats...
Article
Full-text available
Cadmium (Cd) is a highly toxic element, which may cause toxicity to most organs in the body. Zinc (Zn) and magnesium (Mg) are essential minerals with probable benefits on Cd harmful effects. Finding an efficient and non-pathological treatment against Cd toxicity seems promising. Fifty adult rats were divided into ten experimental groups of five rat...
Article
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Background: Arsenic is one of the toxic metals. And its accumulating in liver. The aim of this study was to evaluate the effects of arsenic on alkaline phosphatase activity and its high and low molecular isoenzymes as indexes for liver function. Methods: In this experiment 36 male Wistar rats were randomly allocated into six groups. In a short-term...
Article
Full-text available
Background: One of the valuable tests for diagnosis of cardiovascular and liver diseases is measuring of AST activity. One of the main enzymes of transaminases group is aspartate aminotransferase. Previous Studies have shown that some alteration may occur in mitochondria function as the result of different disease or taking different medication; th...
Article
Naproxin,Mefenamic acid and paracetamol when administrated to rats liver enzyme activities have been changed significantlt in comparison to untreated controls.
Article
Full-text available
Cd is a toxic metal that has a destructive impact on most organ systems. This work aims to determine Zn or Mg protective effects against Cd renal toxicity. In this study, rats were divided into six groups. The Cd group was treated with 1 mg Cd/kg, and the control group received 0.5 cm(3) normal saline, intraperitoneally. The other four groups recei...
Article
Full-text available
Background Violent poisoning by cadmium in human is created through drinks or meals which have packed in the metallic tins with cadmium plating. The symptoms of variation in the mineral metabolism of bones are observed and different conditions maybe appeared. The toxic (poisonous) effect due to cadmium can be neutralized by intervening zinc. This s...
Article
Full-text available
Background & Aims: Arsenic (As) is one of the toxic metals. Zinc (Zn) supplementation could have a protective effect against arsenic toxicity because of their antagonistic properties. In this study, the influence of Zn on toxicity that is caused by As on serum parameters related to liver function has been investigated. Materials & Methods: In th...
Article
Background: Cadmium (Cd) is a heavy metal that has widespread use. It enters the food chain in different ways, including soil and water. Cadmium can cause dysfunction of different body organs. Zinc (Zn) and magnesium (Mg) supplementation can have protective effects against cadmium toxicity due to their antagonistic and antioxidants properties. This...
Article
Background: Copper (Cu) is one of the most important heavy metals. Due to Cu importance and its widespread use in medicine and industries, the study of its impact on human life and disorders of vital parameters would be necessary. This study has been investigated the toxicity of Cu on serum parameters related to renal function. Materials and Method...
Article
Background and purpose: The E23K polymorphism of ATP-sensitive potassium channel kcnj11 gene leads to the conversion of glutamate to lysine amino acids and this substitution is associated with increased risk of several diseases such as diabetes. We aimed to examine the association between kcnj11 E23K variation and risk of type 2 diabetes mellitus (...
Conference Paper
Background: Zinc (Zn), magnesium (Mg) and copper (Cu) are essential trace mineral which are necessary for health and growth and are particularly important for the function and activity of over 200 metalloenzymes. These elements appear to have the preventive effects on lipid profile as a risk factor of cardiovascular disease (CVD). In the present st...
Article
Full-text available
The intention of this study was to investigate the toxic effect of cobalt on the bone metabolism of rats, including calcium, inorganic phosphorus, and bone-specific alkaline phosphatase of serum during short-and long-term experiments. Rats were injected intraperitoneally (IP) with either 16 mg kg(-1) BW of cobalt for 5 and 10 days or 6 mg kg-1 BW f...
Article
Full-text available
Abstract Exposure to hexavalent chromium compounds is associated with the risk of lung cancer, dermatitis, gastrointestinal ulcers, and other tissue damages. The aim of this study was to compare liver isoenzyme and total serum activities of aspartate aminotransferase (AST) as cytotoxic biomarkers of acute and chronic cytotoxicity of CrVI. We invest...
Article
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Due to the severe hazardous influences of lead (Pb(2+)) on iron-related diseases, the effects of Pb(2+) on serum parameters associated with iron metabolism have been studied in this project. Male Wistar rats weighing 200-250 g were treated with Pb(2+) for the short and long period of times. The animals received daily intraperitoneal injection of 10...
Article
Full-text available
Catecholamine is a group of neurotransmitters that is believed to be responsible for the normal function of animal brain. Physiological and behavioral changes of human body have been reported due to the damage of the brain function following lead exposure. Due to the assumption of lead disposal in brain tissue with two year for its half-life, which...
Article
Full-text available
The probable protective effects of copper on the acetylcholinesterase activity and the catecholamine levels in cerebellum, cortex and mid-brain of rat, which was intoxicated by aluminum, were studied during short and long terms. In this respect, male Wistar rats weighing 200-250 g were received daily intraperitoneal doses of aluminum, copper and al...
Article
Full-text available
Common carp fish (Cyprinus carpio Linnaeus, 1758) were exposed to varying concentrations of waterborne cadmium (10, 50 and 100 ppb) during 30, 60 and 90 days, respectively. At the end of each experiment time, the influence of cadmium on fish growth parameters including total length (TL) and weight (W) were measured and its accumulation in muscles w...
Article
Full-text available
Rat Everted Gut Sac (EGS) model was employed to study the intestinal uptake of titanium and iron. Incubation of freshly prepared rat EGS in Earle's medium pH = 7.4 containing titanium showed that the absorption of titanium as well as iron was a dose dependent process. Ascorbic acid enhanced the absorption of both metal ions, while NaF (1 mM) as an...
Article
Full-text available
Oxidation of low-density lipoprotein (LDL) has been strongly suggested as a key factor in the pathogenesis of atherosclerosis. Thus, the inclusion of some anti-oxidant compounds in daily dietary food stuff may inhibit the production of oxidized LDL and may decrease both the development and the progression of atherosclerosis. The present work invest...
Article
Full-text available
The short term effects of waterborne cadmium (Cd(+2)) on the levels of serum parameters related to bone metabolism including calcium (Ca), inorganic phosphorus (P(i)) and alkaline phosphatase (ALP) in common carp fish (Cyprinus carpio L.) were studied. Fish were treated with varying concentrations of Cd(+2) (0.22, 1.1 and 2.2 mg l(-1)) daily for 14...
Article
Full-text available
It is believed that titanium may interfere with iron metabolism in terms of absorption, transportation, utilization and storage in the cells. The present investigation was designed to study and compare the binding of iron and titanium to human serum Apo transferrin (apo-htf). Present results show that Ti(III) ions bind to transferrin and form a new...
Article
Lipoprotein lipase (LPL) is a major lipolytic enzyme in the intravascular metabolism of postprandial triglyceride-rich lipoproteins. This enzyme is synthesized and secreted by tissues and transported to the capillary endothelial surface. Decreased activity of this enzyme is suggested to be involved in arterial sequestration of lipoproteins and thus...
Article
Full-text available
The relationship between lead (Pb) toxicity and changes in the kinetic characteristics of serum, liver and brain high and low molecular weight alkaline phosphatase isoenzymes has been examined in this document. Alkaline phosphatase is a family of phosphomonoesterases that was measured in serum, liver and brain using paranitrophenol phosphate (pNPP)...
Article
Alkaline phosphatase is a family of ecto-phosphomonoesterases that can be resolved into two bands on polyacrylamide gel electrophoresis, a high-molecular mass form (Mr>1 000 000) and a low molecular mass form (Mr: 150000). The relationship between aluminium treatment and changes in the activity of serum, liver and brain high and low molecular weigh...
Article
Full-text available
Background and Objective: An everted intestinal sac (EGS) technique has been used to extensively estimate the transport and intestinal absorption in rats. Therefore, a number of factors such as pH and the nature of solvent may play an important role in fatty acid uptake by entrocytes. There are reports indicating that fatty acid transport is affect...
Article
Full-text available
The relationship between manganese (Mn) treatment and changes in the activities of serum, liver, and brain high and low molecular weight alkaline phosphatase (ALP) activity was investigated. Results obtained showed that every other day intrapritoneally injection of 175 µmol kg Mn to male rats for two consecutive weeks produced decreased levels of l...
Article
Full-text available
The everted gut sac technique has been used to investigate the effect of Vibrio vulnificus on water and electrolyte (Na(+), K(+), Cl(-), HCO(3)(-)) transport on the intestine of sea bream (Sparus aurata L.). Both the anterior and the posterior intestine were incubated in a medium containing 10(8) V. vulnificus cells ml(-1) at 25 degrees C for 2 h....
Article
Full-text available
The potential to cause tissue damage by metal ions is the matter of widespread investigation. Titanium salts are widely used in industry for ceramic painting, in pharmacy for tablet coating and making chemical sunscreens and in medicine as photo catalysts with bactericidal activity. This may address the idea that the exposure to these salts could p...
Article
Full-text available
The current study was designed to investigate the effects of cadmium administration on the AST (Aspartate aminotransferase) and its isoenzyme activities in the serum and liver for durations of 15 and 60 days, respectively. AST isoenzymes were separated by gel filtration chromatography technique and evaluated kinetically. Results showed significant...
Article
Full-text available
Fish diseases create a menace to aquaculture farms. They provoke disastrous economic losses and sanitary risks for the consumer. The present study aims to investigate the effect of the bacteria, Aeromonas hydrophila on water and electrolyte (Na+, K+, Cl-, HCO3-) flux of Mugil cephalus (L, 1758) intestine. Anterior, middle and distal gut segments of...
Article
The effects of selenium as an antioxidant on erythrocyte Sodium-Lithium Countertransport (SLC) activity and plasma parameters have not already been studied in full detail. In the present study, the relationship between selenium and SLC activity, plasma parameters (lipids, lipoproteins, sodium, potassium, urea and creatinine) was investigated. Male...
Article
Full-text available
Lead is a common environmental toxic element for almost all biological systems. The nervous system is the primary target for the lead exposure. In the past few years, increasing considerations have been given to investigate the interaction occurring between toxic metals and some essential metals including Se and Zn with Pb. It has been shown that s...
Article
Full-text available
Oxidation of low density lipoprotein (LDL) has been strongly implicated in the phathogenesis of atherosclerosis. The use of oxidants in dietary food stuff may lead to the production of oxidized LDL and may increase both the development and the progression of atherosclerosis. The present work investigated the effects of some elements including: copp...
Article
Full-text available
The characteristics of manganese and iron binding to human apotransferrin (apo-tf) have been investigated and compared in this study. Both metal ions were taken up by human apo-tf and formed complexes, with the maximum absorbances observed at 410 and 340 nm for manganese-transferrin (Mn-tf) and 465 nm for iron-transferrin (Fe-tf). Addition of manga...
Article
Full-text available
مقدمه: عناصر مختلف قادر به تداخل با جذب اسیدهاي چرب هستند. املاح تیتانیم امروزه به عنوان رنگدانه رنگسفید Ø در ساختبسیاري از محصولات صنعتی از جمله پلاستیک، جوهر کاغذ، سرامیک، داروها، مواد آرایشی، غذاها و رنگسازي بکارمیرود. اخیرا عوارض جانبی این عنصر بر متابولیسم سلولی مشخصو گزارشات متعددي از اثرات سمی این ماده منتشر گردیده است. تهیه گردید. سپس Evert...
Article
Full-text available
The relationship between lead treatment and changes in the concentration of serum, liver and brain high and low molecular weight alkaline phosphatase has been investigated in this manuscript. Results obtained showed that every other day intrapritoneally injection of 39.5 μmol kg<SUP>-1</SUP> of lead as (Pb(CH<SUB>3</SUB>COO)<SUB>2</SUB>.3H<SUB>2...
Article
Full-text available
The relationship between aluminium and rabbit erythrocyte sodium-lithium countertransport (SLC) activity has been investigated in vivo and in vitro . Male rabbits (1350±50 g) were used for the experiments. In vivo studies were performed by intrapritoneally injection of aluminium chloride (ALCL<sub>3</sub>.6H<sub>2</sub>O) every other day for 2 week...
Article
Full-text available
The major aim of this investigation was to examine the interactions of manganese and iron absorption by rat Everted Gut Sac (EGS). Iron absorption by rat EGS was completed within 60 min of incubation time, whereas manganese absorption was occurred within 30 min. Absorption of both metals by EGS was dose and time dependent processes. Manganese absor...
Article
Full-text available
The relationship between aluminium treatment and changes in the concentration of serum, liver and brain high- and low molecular weight alkaline phosphatase has been investigated in this manuscript. Results obtained showed that every other day intrapritoneally injection of 186 μmol kg<SUP>-1</SUP> of aluminium (AlCl<SUB>3</SUB>.6H<SUB>2</SUB>O),...
Article
Full-text available
Titanium (Ti) is a relatively abundant element that has found growing applications in medical science and recently some of Ti compounds are introduced as anticancer drugs. In spite of very limited data which exist on the Ti metabolism, some proteins might be involved in the mechanism of action of Ti. Up to our knowledge, there is not any report in...
Article
Full-text available
Drug protein binding phenomena can lead to some interesting drug-drug interactions when one drug displaces another in the binding site. Studies of protein binding are conducted by several methods including equilibrium dialysis, ultra-filtration and chromatographic methods. Gel filtration is a simple chromatographic method in protein binding studies...
Article
Grewia tenax roots, leaves, juice and fruit decoctions have been used in Africa and Southeast Asiatic countries for a variety of medical purposes. In this investigation, we report the effect of aqueous extract of Grewia tenax fruit (AEGTF) on the variation in vitro of iron absorption. The incubation of freshly prepared rat everted gut sac (EGS) in...
Article
Full-text available
Use of treated waste water in agriculture can increase the risk of enteric infection by direct contact or by consumption of products like fruits and vegetables which are irrigated by treated waste water. The major aim of this study was to investigate the effect of environmental strains of Salmonella enterica serovar typhimurium (a strain which was...
Article
The major aim of this investigation was to examine the effect of aqueous extract of Prasium majus`s L. leaves (AEPML) on intestinal influx of water and electrolytes by Everted Gut Sac (EGS). Four segments of rat intestine were detected and used (duodenum, jejunum, ileum and colon). The extract of the plant was used with two concentrations,8 and 16...
Article
Full-text available
Lithium is widely used in medicine as an anti-depressive drug. In spite of abundant literature, questions on the side effects of lithium ions are far from being answered. In this study, the effects of lithium on biochemical parameters related to lipid metabolism were investigated. Male Wistar rats were treated with different doses of lithium for a...
Article
Full-text available
Background: Cobalt (Co) is an essential trace element. Available data suggest an interaction between cobalt and other ele- ments. In this study the characteristics of Co and iron (Fe) bindings to human apo-transferrin (apo-tf) have been investigated and compared. Methods: Using spectrophotometric titration and equilibrium dialysis techniques, the b...
Article
Full-text available
The short and long term effects of chromium toxicity on brain catecholamines and acetylcholinesterase levels were investigated. Rats were injected daily with varying amounts of chromium. The short term (2 h) administration of chromium (8 mmol/kg) reduced catecholamines level of cerebellum, mid-brain and brain-cortex by 22.8, 19.4 and 21.2% respecti...