Sevinc ILKAR ERDAGI

Sevinc ILKAR ERDAGI
Kocaeli University · Department of Chemistry

Doctor of Philosophy

About

19
Publications
1,684
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336
Citations
Additional affiliations
December 2010 - December 2015
Kocaeli University
Position
  • Research Assistant

Publications

Publications (19)
Article
Full-text available
Novel bioactive ternary nickel (II) complexes, [Ni(5BrSal‐Phe)(phen)] (1) and [Ni(5BrSal‐Tyr)(phen)] (2) (5BrSal‐Tyr: Schiff base derived from 5‐bromosalicylaldehyde and L‐tyrosine, 5BrSal‐Phe: Schiff base derived from 5‐bromosalicylaldehyde and L‐phenylalanine, phen: 1,10‐phenanthroline), have been synthesized and characterized by electronic absor...
Article
Schiff bases are most the widely used class of molecules and their metal complexes are utilized as medicinally important scaffolds due to their versatile biological profile. So herein, we have...
Article
Cu(II) and Ni(II) complexes, [Cu(NNN)2](NO3)2 (1) and [Ni(NNN)2](NO3)2 (2) (NNN-donor ligand: 2,2′:6′,2″-terpyridine), have been synthesized and characterized by electronic absorption spectroscopy, CHN analysis, FTIR, ESI-MS and X-ray crystallography techniques. Interaction of the complexes 1 and 2 with biomolecules (calf thymus DNA (CT-DNA) and bo...
Article
Steroidal bileşikler, hormon reseptörleri ve steroidojenik enzimler için ligandlar veya substratlar olarak görev yaparlar. Bu bileşikler, hücre büyümesi ve çoğalma gibi birçok biyolojik süreçte etkili rol oynarlar. Daha önce yapılan çalışmalar steroid bileşiklerinin kanser hücrelerini hedefleme ve kanser tedavisinde kullanma potansiyelini göstermek...
Article
Full-text available
In this study, hymecromone with known therapeutic aspects was conjugated with steroids a class of natural products that widely exhibited broad biological functions. Cholic acid, diosgenin, cholesterol, DHEA, and testosterone were selected as steroid moiety, each of which has a different biological mechanism of action. This study focused on developi...
Article
Full-text available
In this study, a novel steroidal conjugate was prepared via a convenient click chemistry technique. -sitosterol (BS), a widely distributed phytosterol throughout the plant kingdom, was chosen as a steroidal component. It is known that BS uses in the stabilization of cell membranes and has beneficial effects in different diseases. On the other hand...
Article
Full-text available
The present study focuses on the synthesis of spirostan derivatives as potential drug candidates for biological applications. Recently, spirostan derivatives containing the hetero‐atom have attracted great scientific attention due to their anti‐cancer, anti‐diabetes, and anti‐inflammatory properties. In this study, nitrogen‐containing novel spirost...
Article
The present study contains a comprehensive study of steroid and umbelliferone-based modified poly(ε-caprolactone)s as a potential carrier for the drug delivery systems. The modified PCLs were successfully synthesized via a combined ring-opening polymerization and “click” chemistry technique. Herein, the α-end of the PCL polymer chain was modified w...
Article
Diosgenin is a steroidal sapogenin ((25R)-spirost-5-en-3β-ol) occurs abundantly in therapeutic herbs such as Dioscorea alata, Smilax China, and Trigonella foenum graecum. It demonstrates a wide range of pharmacological activities and medicinal properties in a large of experimental and theoretical studies. It also constitutes an important class of c...
Article
The current study explores the facile fabrication of multilayer self-assembled electrostatic oil-in-water Pickering emulsions (PEs) using quaternized nanocellulose (Q-NC) and diosgenin-conjugate alginate (DGN-ALG) particles as stabilizers to form hydrocolloid nanocarriers. The conditions of formulation such as storage time, pH, temperature and salt...
Article
The present study focuses on the synthesis and evaluation of neomycin-loaded hydrogels as potential substrate for wound healing application. Herein, genipin crosslinked gelatin interpenetrated diosgenin-modified nanocellulose (DGN-NC) hydrogels were synthesized. The hydrogels' chemical structures as well as surface morphology, mechanical property,...
Article
The purpose of the present study was to develop nanoparticulate drug carrier systems for anticancer drugs and evaluate their efficacy by in vitro anticancer assays and release studies. Herein, diosgenin (DGN) was chemically conjugated to polymeric carrier via a cleavable ester bond. We developed, methoxy poly (ethylene glycol) (MPEG) as the shell,...
Article
Full-text available
The aim of this study was to design and synthesize amphiphilic supramolecular structures consisting of curcumin and diosgenin-terminated poly (ethylene glycol). Diosgenin, a natural plant extract, has proven to possess significant biological activities such as anti-tumor, anti-diabetes, anti-inflammatory, anti-cancer, and effect on improving memory...
Article
Coumarin and curcumin have a wide spectrum of biological and pharmacological activities including antioxidant, anti-inflammatory, antimicrobial and anticancer but hindered therapeutic applications due to low stability and poor solubility in water. The main objective of the current study was to overcome these drawbacks via improved bioavailability by...
Article
Full-text available
The alcoholysis of the epoxides of α- and β-pinene catalysed by tetracyanoethylene form the 8-alkyl ethers of trans-sobrerol and 7,8-dihydroxy-p-menth-1-ene, respectively.

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