Séverine Henrard

Séverine Henrard
Université Catholique de Louvain - UCLouvain | UCLouvain · Institute of Health and Society

PhD, MSc, MPH

About

96
Publications
7,339
Reads
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1,219
Citations
Additional affiliations
September 2016 - present
Université Catholique de Louvain - UCLouvain
Position
  • Professor (Assistant)
September 2016 - present
Université Catholique de Louvain - UCLouvain
Position
  • Professor (Assistant)
September 2015 - August 2016
Université Catholique de Louvain - UCLouvain
Position
  • Lecturer
Education
September 2013 - September 2015
Université Catholique de Louvain - UCLouvain
Field of study
  • Statistics, option Biostatistics
June 2010 - December 2013
Université Catholique de Louvain - UCLouvain
Field of study
  • Medical Sciences
September 2007 - June 2009
Université Catholique de Louvain - UCLouvain
Field of study
  • Public Health, options Clinical Research and Epidemiology and Health Services Research

Publications

Publications (96)
Article
Importance: The most appropriate therapy for older adults with multimorbidity may depend on life expectancy (ie, mortality risk), and several scores have been developed to predict 1-year mortality risk. However, often, these mortality risk scores have not been externally validated in large sample sizes, and a head-to-head comparison in a prospecti...
Article
Purpose: In geriatric patients with type 2 diabetes (T2D), appropriate glycaemic control is crucial to avoid overtreatment and hypoglycaemia. This study compared glycaemic control appropriateness across three major clinical practice guidelines (CPGs). Methods: Retrospective study of geriatric older inpatients with T2D and glucose-lowering treatment...
Article
Full-text available
Background Inappropriate polypharmacy has been linked with adverse outcomes in older, multimorbid adults. OPERAM is a European cluster-randomized trial aimed at testing the effect of a structured pharmacotherapy optimization intervention on preventable drug-related hospital admissions in multimorbid adults with polypharmacy aged 70 years or older....
Article
Background: A palliative care approach (PCA), including advanced care planning (ACP), should be considered for patients with limited life expectancy. The Belgian Palliative Care Indicators Tool (Be-PICT) has been released to help identify patients who may benefit from such approach. This study aimed at measuring 1-year mortality and describe the q...
Article
Objectives We estimated the effect of pneumococcal vaccination (PV) on acute lower respiratory tract infections (LRTIs) in various age and risk groups using different methods within a causal inference methodological framework. Study Design and Setting We used data from a general practitioners’ morbidity registry for the year 2019. Both traditional...
Article
Full-text available
Aims The diagnosis of heart failure (HF) is an important problem in primary care. We previously demonstrated a 74% increase in registered HF diagnoses in primary care electronic health records (EHRs) following an extended audit procedure. What remains unclear is the accuracy of registered HF pre-audit and which EHR variables are most important in t...
Article
Background identifying drug-related hospital admissions (DRAs) in older people is difficult. A standardised chart review procedure has recently been developed. It includes an adjudication team (physician and pharmacist) screening using 26 triggers and then performing causality assessment to determine whether an adverse drug event (ADE) occurred (se...
Article
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Background: Drug-drug interactions (DDIs) are highly prevalent in older patients but little is known about prevalence of DDIs over time. Our main objective was to assess changes in the prevalence and characteristics of drug-drug interactions (DDIs) during a one-year period after hospital admission in older people, and associated risk factors. Met...
Article
Background Recommendations for individualised glycaemic management in older people with type 2 diabetes (T2D) have recently been provided in clinical practice guidelines (CPGs) issued by major scientific societies. The aim of this systematic review is to compare the content of these recommendations concerning health assessment, targets for glycaemi...
Article
Introduction An individualised glycated haemoglobin (HbA1c) target according to the patients’ health status is central in the glycaemic management of geriatric people with type 2 diabetes (T2D) in order to avoid hypoglycaemic events through an appropriate management of the glucose-lowering therapy (GLT). Current clinical practice guidelines (CPGs)...
Article
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Background An increasing number of older patients are hospitalised. Prognostic uncertainty causes hospital doctors to be reluctant to make the switch from cure to care. The Supportive and Palliative Care Indicators Tool (SPICT) has not been validated for prognostication in an older hospitalised population. Aim To validate SPICT as a prognostic too...
Article
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Hospital staff are a priority target group in the European COVID-19 vaccination strategy. Measuring the extent of COVID-19 vaccination hesitancy and understanding the reasons behind it are essential to be able to tailor effective communication campaigns. Using the Health Belief Model (HBM) as a theoretical framework, a survey was conducted among st...
Article
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In Belgium, linezolid is indicated for pneumonia and skin and soft tissue infections, but is more broadly used, due to its oral bioavailability and activity against multiresistant organisms. This could increase the risk of adverse drug reactions (ADR), notably hematological disorders (anemia, thrombocytopenia), neuropathy, or lactic acidosis. We an...
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Background Benzodiazepine receptor agonists (BZRA), which include benzodiazepines and z-drugs, are commonly prescribed for insomnia and anxiety in older adults, and used often long term. Yet, the risk–benefit ratio of BZRA use in older adults may be unfavorable and many recommendations suggest avoidance or a maximal treatment duration of 4 weeks. T...
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At Cliniques universitaires Saint-Luc, we analyzed the first cohort of geriatric patients admitted for COVID-19 (Mahiat et al., 2020). The study population consisted of 50 consecutive patients admitted between March 11 and April 17, 2020 to the geriatric COVID-19 units of our Belgian academic hospital, with severe acute respiratory syndrome coronav...
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Objectives. Although the majority of COVID19-related in-hospital deaths were reported in patients over 75 years of age, this population has been scarcely described so far. This study was aimed at describing the clinical presentation and in-hospital mortality rate of these geriatric patients. Methods. This retrospective cohort studied the first 50...
Article
Background The STOPPFrail criteria were developed to assist physicians in deprescribing medications among frail patients approaching end of life. We aimed to measure the prevalence of potentially inappropriate medications (PIMs) and to describe changes over time, using STOPPFrail, in frail nursing home residents (NHRs) with limited life expectancy...
Article
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Background Glucose-lowering therapy (GLT) should be individualized in older patients with type 2 diabetes (T2D) according to their health status and their life expectancy. This study aimed at assessing the inappropriateness of GLT prescribing and the one-year mortality rate in geriatric patients with T2D. Methods Retrospective cohort study of cons...
Article
BACKGROUND/OBJECTIVES To describe the use and deprescribing of benzodiazepine receptor agonists (BZRAs) among nursing home residents (NHRs), to evaluate appropriateness of use and to identify factors associated with BZRA use and deprescribing. DESIGN Posthoc analysis of the Collaborative Approach to Optimize Medication Use for Older People in Nurs...
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Introduction: Health-related quality of life evaluation is recognized as an important outcome in the assessment of boys with haemophilia. In fact, reliable health-related quality of life data are even more critical in developing countries to advocate for government agencies to develop national haemophilia care programmes. However, validated tools...
Article
Pneumococcal vaccination coverage of adults at risk for pneumococcal disease is below recommended levels. There is no observational data on pneumococcal vaccination and the incidence of lower respiratory tract infections in a general adult population. The current study had the objective to explore the incidence of lower respiratory tract infections...
Article
Full-text available
Background: Older patients with type 2 diabetes mellitus represent a heterogeneous group in terms of metabolic profile. It makes glucose-lowering-therapy (GLT) complex to manage, as it needs to be individualised according to the patient profile. This study aimed to identify and characterize subgroups existing among older patients with diabetes. Me...
Article
Objectives: To investigate the impact of a complex multifaceted intervention on the appropriateness of prescribing for Belgian nursing home (NH) residents. Design: A multicenter, nonblinded, cluster-randomized controlled trial, with randomization at the NH level, was set up [Cluster-Controlled Trial of an Intervention to Improve Prescribing in N...
Article
Objectives. To investigate the dose-response relationship between cardiovascular or psychotropic medication dosages and falling orthostatic blood pressure in geriatric inpatients. Methods. This cross-sectional study included 100 consecutive geriatric inpatients of a Belgian hospital. The end points were the maximum changes of systolic (sBP) and dia...
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Full-text available
Objectives The aim of this paper was to describe the time trends in the prevalence of multimorbidity and polypharmacy in Flanders (Belgium) between 2000 and 2015, while controlling for age and sex. Methods Data were available from Intego, a Flemish-Belgian general practice-based morbidity registration network. The practice population between 2000...
Data
Number of people in the yearly contact group and the practice population in Intego between 2000 and 2015. (DOCX)
Data
Participation of practices during study period. (DOCX)
Data
Logistic regression (age groups considered as a continuous variable to test for the trend), with multimorbidity in 2015 as the outcome. (DOCX)
Article
Full-text available
Introduction: Older patients with Type 2 Diabetes Mellitus (T2DM) represent a heterogeneous group regarding their metabolic profile. It complicates glucose-lowering-therapy’s (GLT) choice and management, as it should be adjusted to this severity of T2DM. This study aimed to identify subgroups existing among older patients with T2DM. Methods: Retr...
Article
Background Older persons are at significant risk of drug-related admissions (DRAs). We previously demonstrated that 27% of hospitalizations in geriatric patients were associated with potentially inappropriate medicines (PIMs) and/or potential prescribing omissions (PPOs) identified by the Screening Tool of Older People’s Prescriptions/Screening Too...
Article
Introduction: Accuracy of thyroid cartilage fenestration during Montgomery thyroplasty (MTIS) is considered a key success factor. The primary aim of the study was to retrospectively evaluate the accuracy of fenestration. Furthermore, recent publications indicate a possible discrepancy in MTIS voice outcomes related to gender. The secondary aim of...
Article
Full-text available
Objectives To assess the prevalence and incidence of heart failure (HF) stages A to C/D and their evolution over a 16-year period. Additionally, trends in comorbidities and cardiovascular (CV) treatment in patients with HF were studied in the same period. Design Registry-based study. Setting Primary care, Flanders, Belgium. Participants Data wer...
Article
Objectives: Different parenting practices contribute differently to the development of adolescent self-care. However, little is known about the impact of consistent parenting practices on adolescent self-care and metabolic control. Our study aimed to explore the association between parenting practices and adolescent metabolic control when both pare...
Article
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Background The current study evaluated time trends of statin use and incidence of recurrent CVD in secondary prevention from 1999 to 2013 and investigated which factors were associated with statin use in secondary prevention. Methods Intego is a primary care registration network with 111 general practitioners working in 48 practices in Flanders, B...
Article
Introduction Atrial fibrillation is an arrhythmia that puts patients at risk of developing thromboembolic events, including stroke, heart failure, hospitalisation and death, and decreases quality of life. In order to prevent thromboembolic events oral anticoagulants must be initiated in high-risk patients, as defined by a CHA2DS2-VASc score score ≥...
Article
Introduction Atrial fibrillation (AF) is a cardiac arrhythmia that is associated with a higher risk of thromboembolic events, e.g. stroke. The prevention of thromboembolic events relies on the initiation of antithrombotic therapy, including oral anticoagulants (OAC). According to guidelines, patients at high risk of thromboembolic event, as defined...
Article
Background/objectives: Our aim was to describe the prevalence of potentially inappropriate medications (PIMs) and potential prescribing omissions (PPOs) in Belgian nursing homes and to identify characteristics of residents, general practitioners (GPs), and nursing homes (NHs) that are associated with the number of PIMs and PPOs. Design: A cross-...
Article
Background: Evidence suggests that providing care for a disabled elderly person may have implications for the caregiver's own health (decreased immunity, hypertension, and depression). Objective: Explore if older spousal caregivers are at greater risks of frailty compared to older people without a load of care. Design: Case-control study. Set...
Article
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Background: Very preterm birth (24 to < 32 week's gestation) is a major public health issue due to its prevalence, the clinical and ethical questions it raises and the associated costs. It raises two major clinical and ethical dilemma: (i) during the perinatal period, whether or not to actively manage a baby born very prematurely and (ii) during t...
Article
Background A clinical decision support system (CDSS) linked to the computerized physician order entry may help improve prescription appropriateness in inpatients with renal insufficiency. Objective To evaluate the impact on prescription appropriateness of a CDSS prescriber alert for 85 drugs in renal failure patients. Setting Before-after study in...
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Objective The aim of this multi‐centric cross‐sectional study was to examine the permanency of Montgomery Thyroplasty (MTIS) results from a patient's perspective. Design The study consisted of collecting Voice Handicap Index (VHI‐30) questionnaires from patients who had been previously been operated with MTIS between 2 and 12 years before. Very lo...
Article
Background Associations between irritable bowel syndrome and other health problems have been described, but comprehensive reports are missing, especially in primary care. Aims To investigate which health problems are associated with irritable bowel syndrome, how they cluster together and when they are typically diagnosed relative to irritable bowe...
Article
To the Editor An increased risk of major bleeding was found for the concurrent use of NOACs and amiodarone, fluconazole, rifampin, and phenytoin.¹ Rifampin and phenytoin are not inhibitors of P-glycoprotein and CYP3A4, as stated by the authors, but instead are strong inducers.² Rifampin has been shown to decrease plasma levels of apixaban, dabigatr...
Article
Background: Identifying patients with heart failure (HF) in general practice is challenging. Our aim was to provide an overview of methods used to identify patients with HF in general practice and to assess their impact on patient characteristics. Methods and results: A systematic review was conducted using MEDLINE, EMBASE and CENTRAL. Taken tog...
Article
Background The use of STOPP–START criteria during hospitalization reduced inappropriate medications in randomized controlled trials. Objective To evaluate whether the implementation of a screening tool (short version of STOPP–START criteria) in routine geriatric practice reduces potentially inappropriate medications (PIM) and potential prescribing...
Article
Objectives: Caregiving is often associated with burden and chronic stress. Sense of coherence (SOC) may help the caregivers in coping with their stress and was identified as a positive factor for health outcomes and quality of life. We aimed to study the links between SOC, burden, depression and positive affects among caregivers of frail older pat...
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Objective Our objectives were to (1) describe the evolution of the underuse of anticoagulants in older people with atrial fibrillation (AF) and a CHADS2 score ≥ 2 since direct oral anticoagulants (DOACs) were introduced to the market and (2) describe factors associated with this underuse. Methods We conducted a retrospective cross-sectional study i...
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Full-text available
The total body weight-based dosing strategy currently used in the prophylactic treatment of hemophilia A may not be appropriate for all populations. The assumptions that guide weight-based dosing are not valid in overweight and obese populations, resulting in overdosing and ineffective resource utilization. We explored different weight metrics incl...
Article
Background: Various methods exist to estimate disease prevalences. The aim of this study was to determine whether dispensed, self-reported and prescribed medication data could be used to estimate the prevalence of diabetes mellitus and thyroid disorders. Second, these pharmaco-epidemiological estimates were compared with prevalences based on self-...
Article
Aims: To assess factors associated with Prolonged Inaction (PI) in insulin-naïve patients with Type 2 Diabetes Mellitus (T2DM). PI was defined as the absence of treatment initiation or intensification for ≥12 months despite HbA1c >7% (53mmol/mol). Methods: A retrospective cohort study was conducted based on data from Intego, a Flemish General Pr...
Article
Objective: This study aimed to determine whether the shape of the thyroid cartilage and gender influence voice outcomes after a Montgomery thyroplasty implant system (MTIS). Methods: A retrospective cohort study was performed on 20 consecutive patients who underwent MTIS. Voice outcome variables were the relative decrease in Voice Handicap Index...
Article
Purpose: The purpose of the study is to identify predictors of underuse of sedation scales and daily sedation interruption (DSI). Methods: We surveyed all physicians and seven nurses in every Belgian intensive care unit (ICU), addressing practices and perceptions on guideline recommendations. Underuse was defined for sedation scales as use less...
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Background To date, there has been no comprehensive study on the association between atrial fibrillation (AF) and multimorbidity. The present study investigated the epidemiology of AF and the association between multimorbidity and the onset of AF. In addition, the correlation between multimorbidity and the use of anticoagulants and the risk of cere...
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Background: Ageing has become a worldwide reality and presents new challenges for the health-care system. Research has shown that potentially inappropriate prescribing, both potentially inappropriate medications and potentially prescribing omissions, is highly prevalent in older people, especially in the nursing home setting. The presence of poten...
Article
Introduction Treatment of haemophilia A (HA) requires infusions of factor VIII (FVIII) concentrates. The number of FVIII units infused to obtain a specific circulating FVIII level is calculated with the formula: [body weight (BW) (kg) × desired FVIII increase (%)]/2, with the assumption that each unit of FVIII infused per kg of BW increases the cir...
Article
Introduction: Haemophilia is a rare genetic haemorrhagic disease characterized by partial or complete deficiency of coagulation factor VIII, for haemophilia A, or IX, for haemophilia B. As in any other medical research domain, the field of haemophilia research is increasingly concerned with finding factors associated with binary or continuous outc...
Research
Full-text available
No clinical reason justifies withholding anticoagulation in older patients with atrial fibrillation and high stroke risk
Article
Rare diseases, which affect less than 5 persons in 10,000, have become a public health priority in Belgium and the European Union (EU). Towards the end of 1999, the European Parliament and Council of EU published the regulation (EC) No 141/2000 on orphan medicinal products that are intended for the diagnosis, prevention, or treatment of rare diseas...
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Background: Over the last 50 years, clinical research investigating new treatments has been transforming the care of patients with haemophilia but we still have a long way to go and most clinical investigators are facing difficulties in recruiting appropriate candidates. A survey was conducted to evaluate what motivates people with haemophilia to...
Article
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Type I thyroplasty—also called medialization thyroplasty (MT)—is considered as an effective treatment for glottic incompetence in general and for abductor vocal fold palsy in particular. In the past there have been some concerns about the experience a laryngeal framework surgeon should have in order achieve an acceptable voice outcome. To assess th...