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Introduction
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September 2005 - March 2006
April 2004 - June 2004
May 1999 - present
Publications
Publications (62)
Stiff person syndrome (SPS) is a disease characterized by rigidity in the extremities, axial muscles, and abdominal muscles, severe and painful spasms, and accompanying gait disturbances. Stiff person syndrome is most common in adults between the ages of 20 to 50 and in female sex. The most frequently reported antibody in patients with SPS is antib...
Apomorphine is a dopamine agonist used in the treatment of some motor and non-motor complications during Parkinson’s disease, which could be administered as an intermittent or continuous infusion. Although apomorphine treatment has been shown to be effective on motor fluctuations and dyskinesias, there is no sufficient consensus regarding the admin...
Objective
To investigate the shape differences in the putamen of early-onset Parkinson’s patients compared with healthy controls and to assess and to assess sub-regional brain abnormalities.
Methods
This study was conducted using the 3-T MRI scans of 23 early-onset Parkinson’s patients and age and gender matched control subjects. Landmark coordina...
Objective To delineate the full phenotypic spectrum, discriminative features, piloting longitudinal progression data, and sample size calculations of replication factor complex subunit 1 (RFC1) repeat expansions, recently identified as causing cerebellar ataxia, neuropathy, vestibular are-flexia syndrome (CANVAS). Methods Multimodal RFC1 repeat scr...
Objective: A functional single nucleotide polymorphism, rs1611115, in the dopamine β-hydroxylase (DBH) gene, is reported to regulate plasma enzyme activity levels. Here, we report the first evaluation of this association in patients with early-onset Parkinson’s disease (EOPD) and healthy controls in the Turkish population.
Materials and Methods: We...
Genetic Parkinson's Disease
Background:
The genetic and epidemiological features of hereditary ataxias have been reported in several populations; however, Turkey is still unexplored. Due to high consanguinity, recessive ataxias are more common in Turkey than in Western European populations.
Objective:
To identify the prevalence and genetic structure of hereditary ataxias i...
Objective
To delineate the full phenotypic spectrum, discriminative features, piloting longitudinal progression data, and sample size calculations of RFC1-repeat expansions, recently identified as causing cerebellar ataxia, neuropathy, vestibular areflexia syndrome (CANVAS).
Methods
Multimodal RFC1 repeat screening (PCR, southern blot, whole-exome...
Objective: A functional single nucleotide polymorphism, rs1611115, in the dopamine β-hydroxylase (DBH) gene is reported to regulate plasma enzyme activity levels. Here, we report the first evaluation of this association in early-onset Parkinson’s disease (EOPD) patients and healthy controls in the Turkish population.
Materials and Methods: We evalu...
In the present study, we focused on investigating the contribution of functional dopamine D2 and D3 receptor variants to motor and/or non-motor symptoms of early onset Parkinson’s disease (EOPD). Three functional single nucleotide polymorphisms (SNPs), DRD3 rs6280, DRD2 rs2283265 and DRD2 rs1076560, were genotyped in 128 Turkish EOPD patients and t...
Purpose:
Our purpose was to determine the efficacy of levodopa carbidopa intestinal gel (LCIG) in a series of Turkish patients with Parkinson?s disease (PD).
Materials and methods:
We had telephone calls with 44 patients from 11 neurology centers who were on LCIG treatment were included in an eight items survey between September 2015 and June 20...
Susac's Syndrome (SS), which was first described in 1979, is a rare and presumably autoimmune disorder characterized by encephalopathy, hearing loss, and visual disturbance resulting from branch retinal artery occlusion (BRAO). This study reports 19 SS patients’ clinical characteristics, MRI features, CSF analysis, treatment strategies and outcomes...
ABSTRACT
Apomorphine infusion or injection is an important dopamine agonist non-oral treatment usually used in advanced
stage Parkinson’s disease with refractory motor fluctuations. Subcutaneous apomorphine is generally welltolerated, while adverse events are mostly mild and do not cause discontinuation of treatment. Apomorphine
treatment is more e...
Objective
In this study, quality of life and psychiatric comorbid disorders were investigated in patients with cervical dystonia and their spouses and we also investigated the effect of botulinum toxin (BTX) treatment on these parameters.
Material and method
Thirty patients with cervical dystonia (CD) on BTX treatment and their spouses (n = 30) we...
Aim/Background: Restless legs syndrome (RLS) is a frequent neurological and sleep disorder. Metabolic disorders are known to be related to sleep disorders. We prospectively evaluated whether obesity and its possible cofactors were related to the presence of RLS.
Materials and Methods: The study included 143 obese and 94 non-obese individuals. Obese...
Background:
Movement Disorders Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS) and Unified Dyskinesia Rating Scale (UDysRS) were developed as standard tools to rate Parkinson's disease (PD) and drug-induced dyskinesias of PD. As these scales have become widely used, there is a need for translation to non-English languages. Here we pre...
Background and aim
The effect of epigenetic modifications in the genes related to Parkinson’s disease (PD) is still unclear. In the present study, we investigated methylation status of SNCA and PARK2 genes in patients with early-onset Parkinson’s disease (EOPD).
Materials and methods
The promoter region methylation status of SNCA and PARK2 genes w...
Aim/Background: Restless legs syndrome (RLS) is a frequent neurological and sleep disorder. Metabolic disorders are known to be related to sleep disorders. We prospectively evaluated whether obesity and its possible cofactors were related to the presence of RLS. Materials and Methods: The study included 143 obese and 94 non-obese individuals. Obese...
Encephalitis associated with leucine-rich glioma inactivated 1 (LGI1) antibodies
is often encountered in elderly male patients and may infrequently present
with isolated syndromes. A 6-year-old boy was admitted with acute onset
severe oral and facial stereotypic and choreiform movements. On his neurologic
examination, he had repetitive and rhythmic...
The widespread use of immunosuppressive agents has significantly increased the rates of successful solid-organ and stem cell transplants, especially with liver and kidney. Cyclosporine and tacrolimus are most commonly used for this purpose. Although these agents have different mechanisms of action, both have various adverse effects, including nause...
Encephalitis associated with leucine-rich glioma inactivated 1 (LGI1) antibodies is often encountered in elderly male patients and may infrequently present with isolated syndromes. A 6-year-old boy was admitted with acute onset severe oral and facial stereotypic and choreiform movements. On his neurologic examination, he had repetitive and rhythmic...
Here, we present a child presenting with acute onset chorea together with orolingual stereotypes associated with antibodies against LGI1 and increased ASO titration.
A 6-year-old boy was admitted to the the Pediatric Intensive Care Unit with acute onset severe oral and facial stereotypic and choreiform movements and loss of consciousness. On his ne...
Background/aim:
Dementia is common in Parkinson disease (PD). Since magnetic resonance imaging has been used, hippocampal atrophy has been shown in PD patients with or without dementia. In this study we sought the correlation of cognitive decline with bilateral hippocampal volume in PD patients.
Materials and methods:
Thirty-three patients with...
Objective: In 70% of patients with cervical dystonia (CD), the clinical presentation includes the symptom of pain. In this study, we aimed to define the types and clinical characteristics of the pain and to investigate whether this pain is a result of central sensitization by evaluating pre- and post-botulinum toxin (BoNT) treatment pain threshold...
Introduction:
Our aim was to conduct a retrospective review to demonstrate the clinical, radiological, and electrophysiological features of patients with sporadic Creutzfeldt-Jacob disease (sCJD).
Method:
A total of 10 patients (5 female and 5 male, with a mean age of 45 years from a range of 40 to 67 years) out of 8.259 adult patients hospitali...
Painful jumping stump is characterized by persistent choreiform or myoclonic involuntary movements and severe neuropathic pain in the stump of a limb following amputation. This syndrome is also defined as " trepidation du moignon " , convulsive movements of the stump " or " jumpy stump " .The pathophysiology and etiology have not yet been clearly d...
Objectives: This study aims to investigate the efficacy of the clinical scales used for the evaluation of gait and balance in the patients with Parkinson's disease (PD). Patients and Methods: The study enrolled a total of 40 patients with PD (24 males, 16 females; mean age 61.8±8.5 years; range 53 to 70 years). Cognitive functions were evaluated us...
To evaluate and compare the effectiveness of magnesium sulfate (MgSO(4)) and mannitol in the treatment of posterior reversible encephalopathy syndrome (PRES) in eclamptic women.
This retrospective analysis includes 62 eclamptic women between 22 and 40 weeks of gestation who were diagnosed with PRES in a tertiary care center. To treat neurological s...
OBJECTİVE: Moyamoya disease is usually seen in Japanese ethnicity, with an unknown ethiology and is a rare cerebral vasculopathy. We aimed to compare the patients with Moyamoya disease during the ages of childhood or adulthood in our departments with literature data. MATERIAL AND METHODS: We analysed 10 patients retrospectively according to age, ge...
The aim of this study was to examine the structural-neurochemical abnormalities of the frontal white matter (FWM), deep gray matter nuclei, and pons in patients with Wilson's disease (WD) using proton magnetic resonance spectroscopy (MRS) and diffusion-weighted imaging (DWI).
Nine patients with WD and 14 age-matched controls were examined with MRS....
Objective: In this study, we aimed to evaluate the cognitive functions in Parkinson’s disease patients with using neuropsychological assessment and to identify its clinical correlates in Parkinson’s disease.Methods: Thirty-three patients with idiopatic Parkinson’s disease (PD) and 16 control subjects who are being followed by the Neurology Outpatie...
Objective: In this study, we investigated hyperhomocysteinemia, as well as carotid intima-media thickness (CIMT) measurements using carotid Doppler ultrasonography, in Parkinson patients on levodopa treatment. Methods: This study was carried out on 23 patients with Parkinson's disease and 21 age-and gender-matched healthy volunteers. Carotid D...
Restless leg syndrome (RLS) has negative effects on the quality of life of the patients. Epidemiological studies on RLS are limited.
To determine the prevalence of RLS among people aged 40 years and above in Orhangazi district of Bursa, Turkey.
The study was carried out between 2004 and 2005. This population-based study was conducted in two phases....
Gait ignition failure (GIF) classifications all had major limitations. Few years ago, a new and simpler classification was proposed by Liston. The aim of this paper is to discuss three GIF patients with respect to this new classification. All three patients presented with hesitation to start walking and turning and their neurological examination re...
To find out the estimated prevalence and clinical features of tremor and its subtypes, such as essential tremor (ET) or physiological tremor (PT), by means of a population-based study in the Orhangazi district of Bursa, Turkey.Our study was carried out between June 2004 and September 2005 among adults aged 40 years or more in Orhangazi, Bursa, Turk...
Objective: We aimed to determine the Parkinson's disease patient factors that increase caregiver burden and depression. Method: 57 consecutive patients and their caregivers were enrolled. Hamilton Depression Rating Scale (HDRS), Montgomery-Åsberg Depression Scale (MADRS), Hamilton Anxiety Rating Scale (HARS), and Caregiver Burden Scale (CBS) were a...
Dystonia is defined as an abnormal movement characterized by
sustained muscular contractions, frequently causing twisting and
repetitive movements or abnormal posturing. Antipsychotics are one
of the most common drugs that cause dystonic reactions (Fines et al.,
1999). Laryngeal dystonia (LD) is a potentially fatal type of dystonia
caused by laryng...
We describe a case with adult onset motor tics after peripheral trauma. A 43-year-old man suffered a left shoulder dislocation during a motorcycle accident 21 years ago. Within 2 weeks after the injury, he noticed the gradual onset of involuntary jerking movements of his left shoulder, which was markedly exacerbated after second left shoulder injur...
Hereditary chin tremor (HCT) is characterized by rhythmical, involuntary movements of the chin muscles usually inherited in an autosomal dominant pattern. We describe a 74-year old man with familial, childhood-onset chin tremor, and a 3-year history of progressive hand tremor, gait difficulty, and other parkinsonian features. Since chin tremor ofte...
Objective: Evaluation of psychiatric disorders in Parkinson's disease (PD) patients. Method: Enrolled patients are evaluated by two psychiatrists via semi-structured interview. Hamilton Depresion Rating Scale (HDRS), Hamilton Anxiety Rating Scale (HARS), Geriatric Depression Scale (GDS), BEHAVE-AD-FW, Mini Mental Status Examination (MMSE), Unified...
General practitioners (GPs) diagnose and treat headache in primary care settings. The objective of this study was to investigate the effect of a 2-day headache education programme for GPs primarily on diagnostic accuracy. The education programme included theoretical lectures and face-to-face patient evaluation with headache specialists. Three GPs e...
Susac's syndrome is a vasospastic disease resulting from bilateral microangiopathy of the brain, cochlea and retina. It is characterized by encephalopathy, bilateral sensorineural fluctuating hearing loss and visual loss. It is very uncommon and usually affects women during young adulthood. Since all three symptoms of the triad may not be present,...
Adolescent headaches, particularly migraine, might present with different features from adult headaches. The objectives of this study were to investigate the characteristics of tension-type headache and migraine, to find the sensitivity and specificity of the diagnostic criteria of the IHS classification according to age and gender.
A multistep, st...
We reviewed 51 patients (32 female, 19 male) with cerebral venous thorombosis were included in our study between 1997 and 2004 years. Diagnosis was confirmed by magnetic resonance (MR) and MR angiography of brain vessels. Headache was observed in 88% of cases, papilledema 59%, focal neurological deficitis 71%, confusion 31%, coma 18%, seizures 22%...
2008;11(1): 45-56 ÖZET Parkinson hastalığı (PH), kronik progressif nörodejeneratif bir hareket bozukluğu hastalığıdır. Hastalığı tamamen önleyici bir tedavi olmamasına rağmen çeşitli ilaç ya da cerrahi yöntemlerle hastalık semptomlarında belirgin düzelmeler sağlanmaktadır. Levodopanın etkinliğinin gösterilmesi ile de hastalığın seyri ve tedavisinde...
ZET Amaç: Bu çal›flmada, Bursa ili Orhangazi ilçesinde yaflayan, 40 yafl ve üzeri popülasyondaki hareket bozukluklar›n›n prevalans oranla-r›n›n bildirilmesi amaçland›. Hastalar ve Yöntem: Çal›flmam›z üç fazl› olarak planland›. Faz I'de; 1256 olgu halk sa¤l›¤› ve nöroloji asistanlar› taraf›ndan kap›-ka-p›, ev ziyaretleri fleklinde k›sa anket formu d...
Evaluation of Psychiatric Disorders in Parkinson's Disease Objective: Research of psychiatric disorders in Parkinson's disease (PD) patients. Method: Enrolled patients are evaluated by two psychiatrists via semi-structured interview. Hamil- ton Depresion Rating Scale (HDRS), Hamilton Anxiety Rating Scale (HARS), Geriatric Depression Scale (GDS), BE...