Seung hwan Yang

Seung hwan Yang
Chonnam National University · School of Biotechnology and Chemical Engineering

Professor (Full)

About

309
Publications
64,654
Reads
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4,182
Citations
Introduction
My research interest are in the area of development of natural metabolite formulation and functional nutraceuticals and pharmaceuticals. Here I introduce my Lab. Major Projects: 1) Functional food: Studying the role in disease prevention and health improvement. 2) Nutra and Pharmaceutical Materials: Exploring health beneficial impacts and discovering novel compounds. 3) Development of Probiotics, Prebiotics and Synbiotics for human and poultry. 4) Neuroprotective effects of Scrophularia buergeriana extracts in vitro and in vivo. 5) Exploring genetic and biochemical architecture and diversity in Legume.
Additional affiliations
March 2020 - April 2022
Chonnam National University
Position
  • Professor
September 2016 - February 2020
Chonnam National University
Position
  • Professor (Associate)
March 2015 - August 2016
Myongji University
Position
  • Managing Director
Education
August 1998 - March 2002
Nara Institute of Science and Technology
Field of study
  • Graduate School of Biological Sciences

Publications

Publications (309)
Article
To reach the sustainable development goals on health management in Litopenaeus vannamei shrimp culture, Pediococcus pentosaceus AB01 was supplemented in shrimp diet. In this study, the control diet and three experimental diets containing P. pentosaceus AB01 (108 , 109 , 1010 CFU/g) were separately introduced to L. vannamei for a 28 days feeding tri...
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Optimum growing temperature is necessary for maximum yield-potential in any crop. The global atmospheric temperature is changing more rapidly and irregularly every year. High temperature at the flowering/reproductive stage in rice causes partial to complete pollen sterility, resulting in significant reduction in grain yield. Green Super Rice (GSR)...
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Plants evolve diverse mechanisms to eliminate the drastic effect of biotic and abiotic stresses. Drought is the most hazardous abiotic stress causing huge losses to crop yield worldwide. Osmotic stress decreases relative water and chlorophyll content and increases the accumulation of osmolytes, epicuticular wax content, antioxidant enzymatic activi...
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Climatic variability has been acquiring an extensive consideration due to its widespread ability to impact food production and livelihoods. Climate change has the potential to intersperse global approaches in alleviating hunger and undernutrition. It is hypothesized that climate shifts bring substantial negative impacts on food production systems,...
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Climatic variability has been acquiring an extensive consideration due to its widespread ability to impact food production and livelihoods. Climate change has the potential to intersperse global approaches in alleviating hunger and undernutrition. It is hypothesized that climate shifts bring substantial negative impacts on food production systems,...
Article
Scrophularia buergeriana (SB) was once thought to be an herbal remedy with a wide range of uses. Lactobacillus transformation improves the medicinal benefits of biological substances. However, the effect of fermented SBE in macrophages on inflammatory expression is unknown. Furthermore, the synergistic effects of SBE and lactic acid bacteria (LAB)...
Article
Anti-osteoarthritis Effects of the Combination of Boswellia serrata, Curcuma longa, and Terminalia chebula Extracts in Interleukin-1β-stimulated Human Articular Chondrocytes
Article
The abundance and structural composition of nitrogen (N) transformation-related microbial communities under certain environmental conditions provide sufficient information about N cycle under different soil conditions. This study aims to explore the major challenge of low N use efficiency (NUE) and N dynamics in aerobic rice systems and reveal the...
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The abundance and structural composition of nitrogen (N) transformation-related microbial communities under certain environmental conditions provide sufficient information about N cycle under different soil conditions. This study aims to explore the major challenge of low N use efficiency (NUE) and N dynamics in aerobic rice systems and reveal the...
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Heavy metal toxicity reduces the growth and development of crop plants growing in metal-contaminated regions. Disposal of industrial waste in agricultural areas has negative effects on the physiochemical activities of plants. This research aimed to examine the fulvic acid (FA)-mediated efficacy of Brassica napus L. regarding stress tolerance in soi...
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Abioticstress such as drought is a potential threat posing a severe challenge to wheat production across the globe. The current study comparatively delineated the performance of elite Pakistani bread wheat genotypes at physiological (chlorophyll, canopy temperature, cell membrane percentage stability and leaf relative water content), agronomic (pla...
Article
MENU 보문(Article) Food Microbiology (FM) | Bioactive Compounds or Metabolites: Function and Application Microbiol. Biotechnol. Lett. 2022; 50(1): 15-21 https://doi.org/10.48022/mbl.2111.11001 Received: November 1, 2021; Revised: December 22, 2021; Accepted: January 17, 2022 Anti-Inflammatory Effects of the Chemical Compounds Obtained from Cela...
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Polysaccharides from marine algae exhibit beneficial biological activities. In this study, we examined the effect of Codium fragile extract (CFE) on prebiotic and anti-obesity activity through in vitro experiments. CFE increases the growth of specific beneficial microbial populations with concomitant decrease in pathogenic microbes. Further, total...
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Abiotic stress, particularly heat stress, affects various parts of the cotton plant and ultimately impacts the seed cotton yield. Different portions of a single cotton plant of a cultivar exhibit variable responses to stress during reproductive and vegetative phases. To test this hypothesis, physiological and morphological traits related to heat st...
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Sesame cultivars perform differently in various environments comprising specific locations and years. Micronutrient fertilizers increase crop yields and can enhance resistance to environmental hazards and contribute to potential yield. For assessing the effect of environment and micronutrients, field experiments were carried out at three different...
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Hot pepper (Capsicum annum L.) is a major spice crop and is used worldwide for its nutritional value. In the field, its plant is susceptible to various fungal diseases, including fusarium wilt, caused by soil-borne fungus Fusarium oxysporum f. sp. capsici, which can survive in the soil for several years. The infected plant can be recognized by the...
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Gui Zhen Cao is an herbal formulation that has been documented in Chinese traditional medicine as a remedy for diarrhea, dysentery, inflammation, and toxicity. The sources of this formulation (Bidens pilosa L., Bidens biternata (Lour.) Merr. & Sherff, Bidens bipinnata L.) are also listed in ethnomedicinal reports all over the world. In this study,...
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The demand for cotton fibres is increasing due to growing global population while its production is facing challenges from an unpredictable rise in temperature owing to rapidly changing climatic conditions. High temperature stress is a major stumbling block relative to agricultural production around the world. Therefore, the development of thermo-s...
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Scrophulariae Radix (SR) has an important role as a medicinal plant, the roots of which are recorded used to cure fever, swelling, constipation, pharyngitis, laryngitis, neuritis, sore throat, rheumatism, and arthritis in Asia for more than two thousand years. In this paper, the studies published on Scrophularia buergeriana (SB) and Scrophularia ni...
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Polysaccharides are key bioactive compounds in lotus plumule tea, but their anti-diabetes activities remain unclear. The purpose of this study was to investigate the prebiotic activities of a novel polysaccharide fraction from the Nelumbo nucifera lotus plumule, and to examine its regulation of glucose metabolism in insulin-resistant HepG2 cells. T...
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We evaluated the effectiveness of Scrophularia buergeriana extract (Brainon) on cognitive dysfunction and determined its underlying mechanisms in a scopolamine (SCO)-treated mouse model of memory impairment. Brainon treatment for 28 days ameliorated the symptoms of memory impairment as indicated by the results of both passive avoidance performance...
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East Asian region is home to wild soybean and has high topographic complexity. Measuring genetic diversity and geographical distribution patterns are essential steps to expand the germplasm base. We used SoySNP6K to determine the genetic diversity and population genetic structure of the wild soybean populations from four East-Asian geographies i.e....
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Amomum tsao-ko Crevost et Lemaire (Zingiberaceae) is a medicinal herb found in Southeast Asia that is used for the treatment of malaria, abdominal pain, dyspepsia, etc. The aim of this study was to investigate the effect of an ethanol extract of Amomum tsao-ko (EAT) on obesity and hyperlipidemia in C57BL/6 mice fed a high-carbohydrate diet (HCD). F...
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Research studies on conservative genetics of endangered plants are very important to establish the management plans to conserve biodiversity. Rosewood is an evergreen tree of the Amazon region and its essential oil has great acceptance in the medical and cosmetic industry. The present study aimed to explore the genetic diversity and population stru...
Article
Galactan is a major sulfate polysaccharide in the red seaweed, Pyropia yezoensis. In the present study, the prebiotic potential and anticancer activities of three sulfate galactans with different molecular weights (GPYcrude, GPY300, and GPY10) were evaluated in vitro. Monosaccharide composition and structural analyses of these sulfate galactans sho...
Research Proposal
We have used CRISPR/Cas9 with or without DNA repair template in both corn and soybean for a range of applications including enhancing drought tolerance, improving isoflavone compositions, and endowing herbicide tolerance.
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In the present study, we assessed the extraction of low molecular weight soluble polysaccharides (MESP) from soybean by-products using microwave-assisted enzymatic technology and proposed the chemical structure of MESP using Fourier transform-infrared spectroscopy, gas chromatography, and 1 H and 13 C nuclear magnetic resonance spectrum analysis. T...
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Osteoarthritis (OA) is a general joint illness caused by the destruction of joint cartilage, and is common in the population of old people. Its occurrence is related to inflammatory reactions and cartilage degradation. AyuFlex ® is an aqueous extract of Terminalia chebula fruit, and T. chebula has been utilized extensively in several traditional or...
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The aim of this study was to determine the anti-osteoarthritic effects of LI73014F2, which consists of Terminalia chebula fruit, Curcuma longa rhizome, and Boswellia serrata gum resin in a 2:1:2 ratio, in the monosodium iodoacetate (MIA)-induced osteoarthritis (OA) rat model. LI73014F2 was orally administered once per day for three weeks. Weight-be...
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Scrophularia buergeriana (SB) Miq. (Scrophulariaceae) has been used to help cure swelling and fever and has reported antioxidant and neuro-protective effects. However, few mechanism-based studies have evaluated the memory-improving effects in a beta-amyloid induced memory loss model. As a result of Scrophularia buergeriana extract (SBE) administrat...
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This study focused on the preparation and characterization of anti-wrinkle peptides from the salted and fermented shrimp (Acetes japonicus) inoculated with Salinivibrio cibaria BAO-01 (SFSC). The results showed the proximate composition of SFSC to be 9.23% water, 75.32% protein, 0.23% fat, and 13.3 mg/g ash. Interestingly, the S. cibaria fermentati...
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Lactobacillus fermentum MJM60397 was subjected to in vitro safety tests and in vivo probiotic characterization. The MJM60397 strain was susceptible to antibiotics and was found to be non-mucinolytic and non-hemolytic, and does not produce bioamines. In addition, MJM60397 tolerated simulated oro-gastrointestinal conditions and adhered to Caco-2 cell...
Research Proposal
Development and Productization of Bio-Health Care Material for Anti-obesity & Improved Gut Health using Codium fragile
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The study was aimed to characterize the probiotic properties of Lactobacillus paracasei subsp. paracasei strain KNI9 and its antagonistic activity against Yersinia enterocolitica subsp. enterocolitica. The strain KNI9 was susceptible to antibiotics such as chloramphenicol, tetracycline, erythromycin, and streptomycin recommended by European food sa...
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Safflower is an important oilseed crop mainly grown in the arid and semi‐arid regions of the world. The aim of this study was to explore phenotypic and genetic diversity, population structure, and marker‐trait association for 100‐seed weight in 94 safflower accessions originating from 26 countries using silicoDArT markers. Analysis of variance reve...
Article
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Safflower is an important oilseed crop mainly grown in the arid and semi-arid regions of the world. The aim of this study was to explore phenotypic and genetic diversity, population structure, and marker-trait association for 100-seed weight in 94 safflower accessions originating from 26 countries using silicoDArT markers. Analysis of variance reve...
Article
Aim: Studies on the anticancer effects of synbiotic fermented soymilk are rare. The aim of the present study was to evaluate the effect of synbiotic fermented soymilk supplemented with xylooligosaccharides and inoculated with Weissella cibaria FB069 (FSMXW) in the proliferation of colon cancer cell and compare it with the effect of soymilk inocula...
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Osteoarthritis (OA) is one of the most well-characterized joint diseases and is associated with chondrocyte inflammation, metalloproteinase upregulation and apoptosis. LI73014F2 is a novel composition prepared from aqueous extract of Terminalia chebula fruit, alcohol extract of Curcuma longa rhizome, and Boswellia serrata extract at 2:1:2 ratio. Ea...
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Atopic dermatitis (AD) is a chronic inflammatory disease. Combretum quadrangulare (C. quadrangulare) is used as a traditional medicine to improve various pathologies in Southeast Asia. In this study, we investigated the effects of C. quadrangulare ethanol extract (CQ) on 1-chloro-2,4-dinitrobenzene (DNCB)-induced AD like skin lesions in BALB/c mice...
Article
Nonsense-mediated mRNA decay (NMD), an mRNA quality control process, has been implicated in plant immunity. A subset of fully spliced (FS) transcripts of Arabidopsis resistance (R) genes are reportedly upregulated during bacterial infection. Here, we report that 81.2% and 65.1% of FS natural TIR-NBS-LRR (TNL) and CC-NBS-LRR (CNL) transcripts, respe...
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Plant landraces represent a repository of a gene pool, local adaptation of their domestic species, and thereby are considered a great source of genetic variations. Such genetic variation can be helpful to mitigate the current and future food challenges. A total of 183 common bean accessions including three commercial varieties collected from 19 Tur...
Article
Plant landraces represent a repository of a gene pool, local adaptation of their domestic species, and thereby are considered a great source of genetic variations. Such genetic variation can be helpful to mitigate the current and future food challenges. A total of 183 common bean accessions including three commercial varieties collected from 19 Tur...
Article
Full-text available
Mustard leaf kimchi contains numerous functional compounds that have various health benefits. However, the underlying mechanisms of their anti-inflammatory effects are unclear. In this study, changes in the mustard leaf kimchi phenolics profile after fermentation with or without Lactobacillus plantarum were determined using liquid chromatography-ma...
Article
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The roots of Scrophularia buergeriana were extracted with 80% aqueous Methanol and the concentrates were partitioned into EtOAc, n-BuOH, and H 2 O fractions. The repeated silica gel or octadecyl SiO 2 column, and medium pressure liquid chromatographies for the n-BuOH fraction led to isolation of phenylethanoid glycosides and iridoid glycosides. The...
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Laurel is a medicinally important plant and is known to the world for its essential oil. Turkey is the main market in the laurel leaf trade by sharing about 90% of the world trade. Here we made an effort to elucidate genetic diversity and population structure of 94 Turkish laurel genotypes collected from 26 provinces and four geographical regions u...
Article
The aim of the present study was to evaluate the neuroprotective effect of Citrus aurantium extract (CAE) and nobiletin against amyloid β 1‑42 (Aβ 1‑42)‑induced spatial learning and memory impairment in mice. After injecting Aβ 1‑42 (5 µl/2.5 min, intracerebroventricular injection), amnesic mice were orally administered CAE and nobiletin for 28 day...
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Rice bran is considered a natural source of antioxidants. In this study, rice bran was fermented with lactic acid bacteria to increase its antioxidant activity. Four strains isolated from fermented food, Lactobacillus plantarum MJM60383, Lactococcus lactis subsp. lactis MJM60392, Lactobacillus fermentum MJM60393, and Lactobacillus paracasei MJM6039...
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Chitinases are a group of hydrolytic enzymes that catalyze chitin, nd are synthesized by a wide variety of organisms. In nature, microbial chitinases are primarily responsible for chitin decomposition. Several chitinases have been reported and characterized, and they are garnering increasing attention for their uses in a wide range of applications....
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Cholesterol-lowering activity is an important health benefit of lactic acid bacteria (LAB). This study aimed to screen LAB strains with cholesterol-lowering activities from salted fermented shrimp and evaluate probiotic characteristics and cholesterol-lowering potentials of these LAB isolates. Among 191 lactic acid strains isolated from traditional...
Article
Exponential increase of heavy metal toxicant in the human body is a growing health‐related problem. In the present study, Pediococcus pentosaceus FB145 and FB181 strains were isolated from fermented seafood and served as highly Cd‐resistant strains. The unchanged structural cells of P. pentosaceus strains after treatment with Cd cations were invest...
Patent
Novel chitinase-producing salinivibrio sp. strain and use thereof
Article
In this study, we propose a squid jeotgal, Korean fermented seafood, supplement with different soy isoflavones supplements, followed by fermentation for different time intervals at 4°C to increase the antioxidant activity and improve the food value. In the first month, fermented jeotgals with at lowconcentration (2 mg g −1 ) of added soy isoflavone...
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Yak-Kong (YK), a small black soybean (Glycine max) in Korea, contained higher concentrations of antioxidants than ordinary black soybean or yellow soybean in our previous study. We prepared the fermented YK extract by using a novel lactic acid bacterium, Pediococcus pentosaceus AOA2017 (AOA2017) isolated from Eleusine coracana, and found that the a...
Article
Full-text available
Mustard kimchi consumption reduces cholesterol levels in rats. To identify lactic acid bacteria (LAB) in kimchi which exert this effect, 20 LAB isolates were evaluated for cholesterol reduction in an in vitro screen. The FB111 strain showed the highest cholesterol-lowering activity and was identified as Leuconostoc mesenteroides. This strain was ch...
Article
Aims This study focuses on the development of a new strategy xylooligosaccharide (XOS) production from aqueous ammonia pretreated rice straw (A‐PRS), followed by β‐xylosidase hydrolysis produced by the newly identified strain Weissella cibaria FB069. Methods and Results We report a higher efficiency of A‐PRS, including the removal of lignin and in...
Book
Gloriosa superba (G. superba) is a semi-woody, perennial climber, tuberous and monocot plant that belongs to the Colchicaceae family of the order Liliales. It is a medicinal plant, which grows in regions with an elevation of more than 1500 meters above sea level. It is native to the tropical and southern part of Africa. The name Gloriosa originated...