Seung Bong Bong Hong

Sungkyunkwan University | SKKU · Department of Neurology

Background: Neurology in Korea is a field of clinical practice and research that has been developing for over 30 years, but due to its relatively short history, public awareness is low compared to other clinical fields. The Korean Neurological Association conducted a survey to evaluate the Korean public’s awareness of neurology and the necessity of...

Due to the rapid growth in sleep medicine’s professional content, several countries have recognized sleep medicine as an independent specialty. The practice of sleep medicine and the demand for this service in Asian countries are expanding. At this point of growth, the accreditation of sleep medicine specialists is paramount to patient care and the...

Brain single-photon emission computed tomography (SPECT) is a functional nuclear imaging technique that can provide a regional map of cerebral blood flow (CBF) changes during the interictal or ictal period in patients with epilepsy and other neurological disorders. The radiotracer for brain SPECT is rapidly taken up by the brain within 30–60 s afte...

This long-term open-label extension (OLE) trial was conducted to evaluate the long-term safety and tolerability of brivaracetam (BRV) at individualized doses in patients with epilepsy and focal (partial-onset) or generalized onset seizures, or Unverricht–Lundborg disease (ULD). A secondary objective was to evaluate efficacy of BRV in the subgroups...

People of different ethnic or racial backgrounds may experience variations in pharmacokinetic and pharmacodynamic responses to drug therapies. Our post hoc analysis evaluated the efficacy, safety, and tolerability of perampanel in Asian and non‐Asian populations with refractory focal seizures with or without focal to bilateral tonic‐clonic (FBTC) s...

We defined the maximally activated cortical area as the highest t-value in source analysis of “EEG with maximal CR”. Notes: The cingulate gyrus (left stimulation, t-value 5.84, p<0.01, MNI coordinate -10, 10, 35) and medial frontal gyrus (right stimulation, t-value 7.58, p<0.01, MNI coordinate 10, 65, -15) showed the highest t-value with stimulatio...

Mask of CM that is target of DBS insertion. Notes: The CM mask used as a seed point of tractography analysis. The target coordinates for the CM nucleus were as follows: 10 mm lateral from midline, 1 mm anterior to the PC, and 1 mm above the ICL. We made the CM mask (8 mm3 volume) in a standard MNI space using FSLView (version 3.2.0, FMRIB Centre, U...

Objective Deep brain stimulation (DBS) of the centromedian thalamic nucleus (CM) can be an alternative treatment option for intractable epilepsy patients. Since CM may be involved in widespread cortico-subcortical networks, identification of the cortical sub-networks specific to the target stimuli may provide further understanding on the underlying...

Narcolepsy is a neurological disorder characterized by excessive daytime sleepiness, cataplexy, hypnagogic hallucination, and sleep paralysis. Narcolepsy is caused by damage of hypocretin producing neurons in the lateral hypothalamus. The association of narcolepsy with HLA DQB1*0602 and high incidence following H1N1 pandemic in china, vaccination w...

Narcolepsy is a chronic neurologic disorder with the abnormal regulation of the sleep-wake cycle, resulting in excessive daytime sleepiness, disturbed nocturnal sleep, and manifestations related to rapid eye movement sleep, such as cataplexy, sleep paralysis, and hypnagogic hallucination. Over the past decade, numerous neuroimaging studies have bee...

Objectives: To evaluate dose-response relationship of BGG492 as add-on therapy to 1-3 antiepileptic drugs in patients with partial-onset seizures and to investigate safety and tolerability of BGG492. Methods: This was a 12-week, randomized, double-blind, placebo-controlled, phase II dose-titration study (core study) with a 30-week, flexible-dose...

Objective To evaluate the efficacy and safety of adjunctive eslicarbazepine acetate (ESL) in patients with refractory partial-onset seizures. Methods This randomized, placebo-controlled, double-blind, parallel-group, phase III study was conducted at 173 centers in 19 countries, including the United States and Canada. Eligible patients were aged ≥1...

Figure S1. Patient disposition.

Appendix S1. The 304 study team.

Purpose: To evaluate the efficacy and safety of lamotrigine monotherapy in patients with newly diagnosed partial seizures including secondarily generalized seizures or generalized tonic-clonic seizures, and those with recurrent seizures in Japan and South Korea.Methods: The study was a multi-center, open-label, evaluation of lamotrigine monotherapy...

There are at least five types of alterations of consciousness that occur during epileptic seizures: auras with illusions or hallucinations, dyscognitive seizures, epileptic delirium, dialeptic seizures, and epileptic coma. Each of these types of alterations of consciousness has a specific semiology and a distinct pathophysiologic mechanism. In this...

Patients with epilepsy caused by mid-grade and high-grade tumors do not usually undergo formal presurgical epilepsy evaluations before tumor resection. However, a minority of these patients may benefit significantly from just such a structured presurgical evaluation especially when seizure freedom or seizure reduction is a surgical aim in addition...

Sleep comprises one third of human life and is very important for maintaining healthy mental and physical states. Sleep disorders disturbing normal sleep are very common and may induce serious consequences. Sleep disorder medicine is based on the concept of two different states (waking and sleep) of the human brain. The problems of the waking consc...

Objectives: We investigated the demographic, clinical and polysomnographic features in rapid eye movement (REM) sleep behavior disorder (RBD). Methods: We enrolled the consecutive 53 patients with untreated RBD confirmed by ICSD-2 criteria. All patients showed typical sleep related injurious or disruptive behavior on history and REM sleep without a...

The synthesis, characterization, and catalytic properties of the new medium-pore zeolite TNU-9 are described.

The structure of a novel large pore gallosilicate zeolite, TNU-7, has been refined from X-ray powder diffraction data. The silicate framework is built up from two different types of layer which are shown by X-ray and electron diffraction to be arranged in a fully ordered way. This gives rise to 12-MR pores and asymmetric cation distributions. TNU-7...

Determination of the local environment of aluminum in zeolites after various post-synthesis treatments is important for understanding structure-performance relationships. MCM-22 zeolites, synthesized with different silicon-to-aluminum ratios, were treated under various conditions: direct calcination in air, calcination in ammonia and oxygen, and am...

The use of flexible, linear diquaternary alkylammonium ions (CH 3)2(C2H5)N+(CH 2)nN+-(C2H5)(CH 3)2 (Me4Et2-diquat-n) and (C 2H5)2(CH3)N+(CH 2)nN+(CH3)(C2H 5)2 (Et4Me2-diquat-n) with n = 4-6 as structure-directing agents in zeolite syntheses is described. Among the ammonium ions studied here, the Et4Me2-diquat-4 and Et4Me2-diquat-6 ions were found t...

The use of flexible, linear diquaternary alkylarmmonium ions (CH3)(2)(C2H5)N+(CH2)N+-(C2H5)(CH3)(2) (Me4Et2-diquat-n) and (C2H5)(2)(CH3)N+(CH2)(n)N+(CH3)(C2H5)(2) (Et4Me2-diquat-n) with n = 4-6 as struture-directing agents in zeolite syntheses is described. Among the ammonium ions studied here, the Et4Me2-diqtiat-4 and Et4Me2-diquat-6 ions were fou...

Ten to 15% of general population suffers from excessive daytime sleepiness (EDS). EDS is observed more frequently in school-age children or young adults than in middle-aged adults. The most common cause of EDS is “voluntary” sleep restriction causing night sleep deprivation. Among the EDS conditions arising from central nervous system dysfuncti...

This chapter describes the synthesis and characterization of zeolite ZSM-25 in the presence of sodium and tetraethylammonium cations. The overall characterization results suggest that ZSM-25 is probably an 8-ring or constrained 10-ring pore material containing 4-rings as the smallest structural unit. However, the proton form of ZSM-25 is found to h...

This chapter presents the hydrothermal syntheses of a series of gallosilicate molecular sieves, denoted TNU-n (Taejon National University Number n, where n = 1–7). The introduction of gallium (Ga) into silicate frameworks is found to be a viable route to the discovery of novel low-silica zeolite structures. Among the materials prepared, TNU-3 and T...