Sesha Subramanian

• Research Schloar
• Yenepoya Research Centre Yenepoya (Deemed to be University)

Having antioxidant properties of nanomaterials plays an important role in developing cosmeceuticals and pharmaceuticals to treat various diseases that occur through reactive oxygen species (ROS). Nanomaterials with enzyme-like properties can suppress ROS, which can be useful for the development of medicinal substances. Recently, transition metal na...

Bone tissue engineering is a growing field that provides solutions for the treatment of bone deformities, injuries, diseases, and anomalies by replacing autograft and allograft procedures. Various scaffolding materials have been used for the construction of bone tissue, including metals, ceramics, and polymers. This study investigates an innovative...

Hydroxyapatite (HA) is an extensively used biomaterial for dental and orthopaedic applications because of its biocompatibility and biomimetic nature. HA is extensively used as a bone-graft substitute. HA bone graft substitutes of bovine or synthetic origins have been extensively studied. However, caprine-based HA has not been explored. In this stud...

Silver nanoparticles have been extensively studied and used for biological and biomedical applications due to its antimicrobial properties. In this study, we have developed silver nanoparticles with saponin (S-AgNPs) using microwave-mediated methodology and physiochemically characterised and evaluated its anticancer potential. According to UV–visib...

Cancer remains the most challenging health problem worldwide, affecting millions of lives and significantly affecting the quality of life of patients. Traditional cancer treatment options often have various side effects and may not always result in the complete eradication of cancer. With emerging technology, nanotechnology has become a promising a...

Due to the limitations of the current treatment approaches of allograft and autograft techniques, treating bone disorders is a significant challenge. To address these shortcomings, a novel biomaterial composite is required. This study presents the preparation and fabrication of a novel biomaterial composite scaffold that combines poly (D, L-lactide...

Natural polysaccharide chitosan is the second most widely used polymeric material after cellulose. Due to its biocompatibility characteristics and ease of modification, chitosan and its derivatives, especially carboxymethyl chitosan, have recently attracted much attention for their use in biosensing applications. The applications are determined by...

Biomimetic materials for better bone graft substitutes are a thrust area of research among researchers and clinicians. Autografts, allografts, and synthetic grafts are often utilized to repair and regenerate bone defects. Autografts are still considered the gold-standard method/material to treat bone-related issues with satisfactory outcomes. It is...

Nanoparticle-based therapy has gained much attention in the pharmaceutical industry. Fucoidan is a sulfated polysaccharide naturally derived from marine brown algae and is widely used for medical applications. We explore preparation of fucoidan-based nanoparticles and their biomedical applications in the current review. The fucoidan-based nanoparti...

In the recent years, mesoporous bioactive glass (MBG) based 3D printed scaffolds have been envisaged widely for bone tissue engineering potential. The earlier reports on 3D printed MBG based scaffolds for bone tissue engineering application are dedicated to pneumatic extrusion, which involves utilization of solvent and tedious process steps for pre...

Alginate-based biomaterials have been extensively studied for bone tissue engineering. Scaffolds, microspheres, and hydrogels can be developed using alginate, which is biocompatible, biodegradable, and able to deliver growth factors and drugs. Alginate microspheres can be produced using crosslinking, microfluidic, three-dimensional printing, extrus...

Significant development has been achieved in searching the biocompatible biomaterials for various biological and biomedical applications. For example, Chitooligosacchairdes (COS), the derivative of chitosan, is a water-soluble natural cationic biopolymer that has been extensively used for biological, tissue engineering, and drug delivery applicatio...

Tissue engineering has recently gained much attention in developing artificial tissue to repair and replace defective or diseased tissue/organs. Materials, cells, and growth factors play an important role in constructing artificial tissue. Materials can be derived through synthetic as well as the natural source, which can act as an extracellular ma...

In recent years, enormous research has been carried out on the utilization of polysaccharides-based nanoparticles for biomedical applications including biosensors, drug delivery, wound healing, and tissue engineering. These polysaccharides nanoparticles include chitosan, alginate, and starch that are gaining much attention due to abundant, biocompa...

Nanotechnology is the promising biotechnology filed that holds the numerous applications in modern medicine. The use of the nanosized particles draws much attention in artificial implant fabricating systems. The nanosize particles influence both in vitro and in vivo properties. The shape, charge, and surface topography of the nanoparticles hold the...

About 2.2 million bone graft operations are performed per year worldwide to treat bone defects caused by motor defects, congenital disabilities, bone tumors, and other causes. Autografts, allografts, and synthetic grafts are widely used for bone graft substitutes. Even though autograft is the gold standard for treating bone defects, there is a prob...

Regeneration of defective or diseased tissue by 3D-printed biomaterials is an emerging area of research, and 3D printing technology will meet the shortage of organ transplantation and therapeutic clinical applications. The development of novel bio-inks for 3D printing has challenges, including the rheological, physical, chemical, and biological pro...

Millions of bone graft procedures are performed by clinicians to treat defective and diseased bone to improve the quality of a patient's life. Bone is a hierarchically structured tissue that is composed of nano-hydroxyapatite (nHA), collagen and other ingredients. Autograft, allograft and synthetic graft are widely used techniques to treat bone-rel...

The current study was carried out to isolate, culture, characterize and cryopreserve the granulosa stem cells from buffalo ovaries. Granulosa stem cells were cultured in DMEM containing15% FBS, 1% penicillin/ streptomycin and 1%L-glutamine in 5% CO2 with humidified air at 38.5±0.5˚C. After 3 days of culture different morphologies of cells were obse...