Serkan Sayıner

Near East University · Faculty of Veterinary Medicine, Department of Biochemistry & Animal Hospital, Diagnostic Laboratory

Apical periodontitis is an inflammatory condition resulting from microbial invasion in the root canal system, causing periapical tissue destruction and bone resorption. This study investigated melatonin's effects, known for its antioxidant and anti-inflammatory properties, on experimentally induced apical periodontitis in rats. Three groups of rats...

Aim This study aimed to investigate the potential protective effects of N‐acetyl‐L‐cysteine (NAC) against apical periodontitis (AP) in rats with adriamycin (ADR)‐induced kidney and heart diseases. Methodology Fourty‐eight Wistar albino rats were divided into six groups: (1) Control group, (2) ADR group (1 mg/kg/day ip for 10 days), (3) AP Group (1...

Acetaminophen (APAP), widely used as an analgesic-antipyretic drug, can cause liver and kidney damage at high doses. This study explored the protective effects of a mucolytic agent and an antioxidant Ambroxol (AMB), against APAP-induced toxicity in rats. The experiment included four groups of Wistar albino rats each having 6 animals in both sexes:...

Objective: 5-Fluorouracil (5-FU), a widely administered anti-cancer drug, causes gastrointestinal damage through various mechanisms. This study aimed to investigate the ameliorative effect of silk fibroin (SF), which has anti-inflammatory and antioxidant properties, against 5 FU-induced gastrointestinal damage. Materials and methods: Wistar albino...

Objective: 5-Fluorouracil (5-FU), a widely administered anti-cancer drug, causes gastrointestinal damage through various mechanisms. This study aimed to investigate the ameliorative effect of silk fibroin (SF), which has anti-inflammatory and antioxidant properties, against 5 FU-induced gastrointestinal damage. Materials and methods: Wistar albino...

Objective: 5-Fluorouracil (5-FU), a widely administered anti-cancer drug, causes gastrointestinal damage through various mechanisms. This study aimed to investigate the ameliorative effect of silk fibroin (SF), which has anti-inflammatory and antioxidant properties, against 5 FU-induced gastrointestinal damage. Materials and methods: Wistar albino...

Objective: Chitosan possesses antioxidant properties and exhibits anti-inflammatory characteristics. The objective of the investigation was to assess the effectiveness of chitosan in protecting against hepatorenal injury induced by methotrexate (MTX), a medication utilized for immunosuppression and chemotherapy. Methods: Wistar albino rats were all...

Background: Ischemia-reperfusion (I/R) causes organ dysfunction as a result of the increased formation of various reactive oxygen metabolites, infiltration of inflammatory cells, interstitial edema, cellular dysfunction, and tissue death. Aim: The study aimed to investigate the cytoprotective effect of 2-mercaptoethanesulfonate (MESNA) against tiss...

Purpose: Several substances that have anti-inflammatory, antiproteinase, and anti-infective properties have been evaluated as modulators of the inflammatory response in periodontal disease. However, evidence for the anti-inflammatory and antioxidative activities of bromelain is limited. This study evaluated the impact of systemically administered...

Kocadal et al.: Exposure and risk assessment of glyphosate-based herbicide-3675-APPLIED ECOLOGY AND ENVIRONMENTAL RESEARCH 21(4):3675-3689. Abstract. Glyphosate (GLY) is an organophosphate herbicide that shows its effect by inhibiting the 5-enolpyruvylshikimate-3-phosphate synthase (EPSP synthase) in the shikimate biosynthetic pathway. After its ma...

Since the last months of 2019, SARS-CoV-2, commonly referred to as COVID-19, has impacted the global economy and health care industries. Previous studies on SARS-CoV-2 have shown that it can also affect household pets. Coronaviruses have long been associated with pets, and prophylaxis is provided through vaccination programs. Today, although the le...

The coronavirus disease-2019 (COVID-19), over the last 3 years has globally resulted in catastrophic widespread losses. Prevention and control of this disease has become a global priority for researchers and medical professionals due to high mortality rates, treatment costs and various losses (economic and fatalities). In recent times, the fact tha...

With the ongoing pandemic declared by the World Health Organization,the number of hospitalizations and deaths caused by COVID-19 is increasing dramatically. As new variants of SARS-CoV-2 emerge, new combination therapies are needed to reduce the risk of COVID-19spreadduring this time of increased transmission risk. In this case, it is vitalto stren...

The aim of this study was to investigate the cytoprotective effect of different doses of oxytocin (OT) and the underlying mechanisms of OT in the 5-FU model of intestinal mucositis. Twelve-week-old female albino Wistar rats were divided into five groups of six (n = 6) rats each (Control, OT 0.5 mg/kg, 5-FU+saline, 5-FU+OT 0.5 mg/kg, and 5-FU+OT 1 m...

This study aimed to examine the distribution of feline calicivirus (FCV), feline herpesvirus (FHV), and feline panleukopenia virus (FPLV), which cause neonatal feline viral diseases in kittens aged one to three months, using a Dot-ELISA bases antibody test kit. The studied parameters included the animals" sex, clinical signs and the Dot-ELISA test...

Irinotecan (CPT-11) is a chemotherapeutic agent involved in the treatment regimens for several malignancies such as colorectal cancer. N-acetylcysteine (NAC) is a strong antioxidant and anti-inflammatory agent used in the treatment of several diseases related to oxidative stress and inflammation. This study aimed at investigating whether NAC provid...

We investigated the protective effects of pycnogenol (PYC), a natural anti-oxidant with an anti-inflammatory effect, on the acetaminophen (APAP)-induced hepatorenal injury in rats. Wistar albino rats were divided into four experimental groups: control, PYC (10 mg/kg, ip), APAP (1000 mg/kg), and APAP+PYC groups. Rats were decapitated 24 hours after...

In this study, we measured the serum concentration of anti-Mullerian hormone (AMH), C-reactive protein (CRP), progesterone (P4), and the complete blood count (CBC) in pregnant and non-pregnant bitches. The aim was to investigate the suitability of these parameters for monitoring canine pregnancy. Blood samples were collected from all bitches introd...

Alpha-lipoic acid (ALA) is extensively utilized in multivitamin formulas and anti-aging products. The purpose of this study was to investigate the potential protective benefits of ALA on 5-fluorouracil (5-FU)-induced gastrointestinal mucositis in Wistar albino rats. Tissues from the stomach, small intestine, and large intestine were excised, and bl...

Aim: The aim of the study is to examine the effect of Ambroxol on pro-inflammatory cytokines TNF-α and IL-1β released after liver ischemia-reperfusion injury. Materials and Methods: The study was approved by the Near East University local animal ethics committee (Approval no: 2019-96). Twenty-four Wistar albino rats were divided into 3 groups as Co...

The aim of the present study was to evaluate the inhibitory effects of oxytocin on the development of periodontitis based on its properties against bone loss and resorption. Thirty-two Wistar albino rats were divided into four equal groups: control , periodontitis + saline, periodontitis + 0.5 mg/kg/day oxytocin, and periodontitis + 1 mg/kg/day oxy...

NLRP3 (NOD-, LRR- and pyrin domain-containing protein 3) is an inflammasome associated with oral and general health. There is a bidirectional relationship between the oral cavity and systemic health. The primary reason for this situation is the similarity in pathways for chronic inflammatory diseases both in the oral cavity and systemically. Period...

Introduction:We examined the effects of chitosan (CTS) for reducing cisplatin (CIS)-induced hepatorenal toxicity in a rat model.Methods:A hepatorenal toxicity model was established by administering a single dose of 7 mg/kg CIS intraperitoneally (i.p) to Wistar albino rats. After seven days of once-daily normal saline or CTS (200 mg/kg; po) treatmen...

Objectives: Ischemia-reperfusion injury is a life-threatening clinical problem that can occur after transplantation or a number of clinical procedures. The purpose of the study was to investigate the effects of Ambroxol on kidney damage caused by experimentally induced ischemia-reperfusion injury in rats. Materials and methods: Wistar albino rat...

This study focused on the ketogenic diet (KD) effects on oxidative posttranslational protein modification (PPM) as presumptive factors implicated in epileptogenesis. A 28-day of KD treatment was performed. The corneal kindling model of epileptogenesis was used. Four groups of adult male ICR mice (25–30 g) were randomized in standard rodent chow (SR...

The omicron variant (B.529) of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which emerged in late 2021, caused panic worldwide due to its contagiousness and multiple mutations in the spike protein compared to the Delta variant (B.617.2). There is currently no specific antiviral available to treat Coronavirus disease 2019 (COVID...

Background Methotrexate (MTX), a chemotherapeutic agent, is known to cause oral mucositis. Chitosan has been shown to have a protective effect in inflammatory animal models. This research aimed to examine the protective effect of chitosan against oral mucositis caused by MTX. Methods and results Wistar albino rats were randomly divided into three...

The purpose of the study was to investigate the therapeutic effects of α-lipoic acid (ALA) on an induced-acute pulpitis model in rats. Twenty-four Wistar albino rats were randomly divided into three groups: control, induced-acute pulpitis (PULP) and PULP + ALA groups. In the PULP and PULP + ALA groups, the crowns of the maxillary left incisors were...

Dear Editor, The COVID-19 pandemic remains an important healthproblem, potentially worsened by emerging mutant strains.Although vaccination studies have been rapidly carried out,the definitive treatment protocol for the disease has not yetbeen established. Therefore, treatment suggestions and studiescontinue to have importance. Until the end of the...

Dietary exposure to mycotoxins is a matter of great concern in terms of public health and regulatory bodies worldwide. Contamination of meat products with mycotoxigenic fungi and production of aflatoxins (AFs), ochratoxin A (OTA) and other mycotoxins can occur at different points of the manufacturing steps, from farm to fork. Among all microorganis...

Tumour markers, also known as biomarkers, might be proteins, conjugated proteins, peptides, or carbohydrates. Tumour markers are substances that are created by cancer cells or by the organism in response to cancer. According to the dictionary of cancer terms published online by the National Cancer Institute (NCI), a biomarker is “A biological molec...

Objectives: The aim of the study is to examine the effect of Ambroxol on TNF-α and IL-1β released after liver ischemia-reperfusion injury. Background: Many drugs are being tried to reduce ischemia-reperfusion injury, which is life threating problem after many liver surgeries. In this study, it was investigated whether Ambroxol reduces the releas...

SAH, H.; GÜLMEZ, N.; SÖYLER, G.; SAYINER, S.; SEHIRLI, A. Ö. & KÜKNER, A. Effect of kefir on increased apoptosis in liver and kidney in cisplatin toxicity. Int. J. Morphol., 40(2):480-488, 2022. SUMMARY: Cisplatin is a chemotherapeutic agent inducing liver and kidney damage. In this study, we intended to investigate the impact of kefir beverage, an...

Although the types of coronaviruses seen in animals differ, recent studies have also shown that they are affected by COVID-19, known as SARS-CoV-2. The impact of COVID-19 on animals is a factor that should be followed carefully, especially since different variants appear in humans every day and this disease is transmitted from human to animal. Th...

Nigella sativa (NS) has a protective effect on cellular damage caused by oxidative stress. Selenium has an antioxidative effect. Toxocara canis is one of the nematodes causing visceral larva migrans. Men infected with this parasite ingesting an embryonic egg. It is more common in children between 1-4 years than adults. From the ingested embryonic e...

Although the vaccines for COVID-19 are expected to decrease morbidity and mortality rates, there are few good choices for post-infection damage to multiple tissues, such as lungs due to oxidant damage caused by the expression of cytokines that increase immune system activation. Alpha-lipoic acid (ALA) is generally regarded as a universal antioxidan...

I. Background: Methotrexate (MTX), a chemotherapeutic agent, is known to cause oral mucositis. Chitosan has been shown to have a protective effect in inflammatory animal models. This research aimed to examine the protective effect of chitosan against oral mucositis caused by MTX. II. Methods and Results: Wistar albino rats were randomly divided int...

The cellular utilization of oxygen leads to the generation of free radicals in organisms. The accumulation of these free radicals contributes significantly to aging and several age-related diseases. Angiotensin II can contribute to DNA damage through oxidative stress by activating the NAD(P)H oxidase pathway, which in turn results in the production...

The values of luteal blood flow (LBF), total corpus luteum (CL) area (TAR), and progesterone (P4), during and after OvSynch (OvS) protocol in comfort (CP; n = 40) and hot periods (HP; n = 40) were compared. We investigated how low and high P4 values obtained before the application affected the parameters above during CP and HP periods. Blood sample...

A highly transmissible severe acute respiratory coronavirus 2 (SARS-CoV-2) caused the coronavirus diseases 2019 (COVID-19) pandemic, which resulted the highest morbidity and mortality rates among SARS-CoV and MERS-CoV. SARS-CoV-2 B.1.1.7 variant indicated the higher transmission among human-to-human and increasing hospitalisation. SARS-CoV-2 infect...

The SARS-CoV-2 infection has led to a global pandemic which has led to almost 4 million deaths worldwide. However, to date, a specifi c antiviral drug does not exist to treat the disease and control the virus. Here, we focus on the potential use of bromelain in line with its anti-oxidant, anti-infl ammatory, and immunomodulatory effects. Additional...

Chitin is the second most available polysaccharide in nature after cellulose. It is found abundantly in the exoskeleton of arthropods such as insects, crabs, lobsters, and its presence in the fungi cell wall. The deacetylation of Chitin yields the formation of Chitosan, which has multiple exceptional properties. These include biocompatible, biodegr...

Cholestasis is associated with the accumulation of bile acids and bilirubin in the hepatocytes and leads to liver injury. Pregnane X Receptor (PXR) coordinates protective hepatic responses to toxic stimuli, and this receptor was reported to stimulate bile secretion by increasing MRP2 expression. Since PXR activators were reported to be anti-inflamm...

There are no organs that are not affected by SARS-CoV-2, known as COVID-19, which is the most critical health problem of the last year. Angiotensin-Converting Enzyme-2 (ACE-2) and transmembrane protease serine 2 (TMPRSS2), which are responsible for virus invasion, are also secreted in the brain. Therefore, it suggests that this virus may invade bra...

Since enzymes such as transmembrane serine protease 2 (TMPRSS2) and angiotensin converting enzyme-2 (ACE2) responsible for the invasion of the SARS-CoV-2 virus, known as COVID-19, are also expressed in the gastrointestinal system and liver. The virus also infects these tissues. Inflammatory pathways are activated by the impairment of T cell activit...

The physiological processes of most living organisms follow a rhythmic pattern, which is controlled by the interaction between environmental cues and the internal circadian timing system. Different regulatory circadian genes are expressed in most cells and tissues, and disruptions in the sleep–wake cycle affect these genes, which may result in meta...

Daily new information emerges regarding the COVID-19, infection of SARS-CoV-2, which is considered a global pandemic. Angiotensin-converting enzyme 2 (ACE2) and transmembrane protease serine 2 (TMPRSS2) are required to complete the viral invasion pathway and are present in the oral mucosa, gingiva and periodontal pocket. Thus, increasing the likeli...

Aim: The aim of this study was to investigate the possible therapeutic impacts of two pineal hormones, melatonin and 5-methoxytryptophol (5-MTX), in a rat model of acute pulpitis by analyzing biochemical and histopathological parameters. Methods: This research was done using 32 male and female Wistar albino rats with weight between 200 and 250 g...

Declared as a pandemic by the World Health Organization, COVID-19 causes damage to tissues with the cytokine storm. It even causes death in people who are fond of it. In this case, the role of the immune system is vital. In particular, the cycle of melatonin and 5-methoxytryptophol released from the pineal hormone ensures that immunity continues fo...

Introduction In suicidal cases and childhood home accidents, tongue and oesophagus tissues are commonly damaged by the corrosive burn. Surgical interventions may cause scar formations, and severe burns treatment methods are limited. This study aims to investigate bromelain, a phytotherapeutic product, on the corrosive burn as a non-surgical option...

The aim of this study was to assess the effects of deep-frying palm oil on a number of sperm and biochemical parameters with or without low-(Ex1) and high-intensity (Ex2) swimming exercises. Mice (32 BALB/c type) were equally divided into four groups (control, palm oil, palm oil+Ex1 and palm oil+Ex2). The increase in epididymal fat weight in case o...

Our study aimed to monitor the alterations in antioxidant enzyme activities and the metabolic profileparameters and their relationships in dairy cows during different reproductive stages (gestational-, dry-,pre- and post-partum). The collection of blood samples from thirty healthy pregnant Holstein cows tookplace at a commercial dairy farm, between...

SARS-CoV-2 infection has led to COVID-19 outbreak worldwide. To date, a specific antiviral drug does not exist to treat the disease and control the virus. In this paper, we have explored the potential utility of alpha lipoic acid, an anti-inflammatory and antioxidant molecule, for treatment. Alpha lipoic acid exhibits strong antioxidant properties...

COVID-19 caused by the SARS-CoV-2 outbreak quickly has turned into a pandemic. However, no specific antiviral agent is yet available. In this communication, we aimed to evaluate the significance of CD147 protein and the potential protective effect of melatonin that is mediated by this protein in COVID-19. CD147 is a glycoprotein that is responsible...

COVID-19 caused by the SARS-CoV-2 outbreak quickly has turned into a pandemic. However, no specific antiviral agent is yet available. In this communication, we aimed to evaluate the significance of CD147 protein and the potential protective effect of melatonin that is mediated by this protein in COVID-19. CD147 is a glycoprotein that is responsible...

The protective effects of ACE inhibitor, Captopril, and angiotensin receptor blocker, Valsartan, were evaluated in the treatment of chronic renal failure (CRF) with and without the presence of N-acetylcysteine (NAC). The renal mass of Wistar albino rats was reduced at a rate of 5/6. Captopril, Valsartan and NAC were applied intra-peritoneal alone o...

Vitamin A, calcium (Ca), phosphorus (P) and magnesium (Mg) are essential components for the health and reproductive yield of dairy cows. In this study, it is aimed to profile the calcium, phosphorus and magnesium elements together with vitamin A, which are important components in cattle bred and reared in Northern Cyprus. To analyse these parameter...

Aim To investigate the possible therapeutic effects of alpha‐lipoic acid (ALA) in a model of chronic apical periodontitis in rats by analysing biochemical, histopathological and micro‐CT parameters. Methodology The study was approved by the Animal Ethics Committee of the Near East University. Thirty‐two Wistar rats were divided into four groups of...

Abstract The aim of this study was to investigate the effects of dietary sunflower oil and fried sunflower oil on reproductive sperm parameters, blood lipid profiles, lipid peroxidation and to additionally investigate the protective effects of probiotics. Five experimental groups were established using BALB/c type mice (n=8). A standard pellet mous...

This study was designed to assess the possible protective effect of alpha‐lipoic acid (ALA) on apical periodontitis (AP)‐induced cardiac injury. Wistar albino rats were randomized into four groups: control; ALA; AP; and ALA + AP. Rats of the control and ALA groups were not endodontically treated, but saline and ALA (100 mg kg⁻¹) were administered....

The aim of this study was to evaluate milk glutathione peroxidase (GPx) and superoxide dismutase (SOD) levels in Damascus goats with subclinical mastitis. According to the somatic cell counts (SCCs), 193 Damascus goats included in the study were divided into healthy (n = 75; SCC <1000 × 10 ³ cell/mL) and mastitis (n = 118; SCC ≥1000 × 10 ³ cell/mL)...

In the study, blood and milk samples were taken from fifty-eight cows at 28, 30, 32 and 40 days after artificial insemination (AI). Transrectal ultrasonography (TRUS) was performed on all cows on days 30 and 40 after AI. Measurements were carried out on 9 cows whose pregnancy was confirmed and 9 cows whose embryonic mortality (EM) was determined. I...

The aim of this study was to compare the accuracy of bovine pregnancy-associated glycoproteins (bPAG) and bovine pregnancy-specific protein B (bPSP-B) tests with transrectal ultrasonography (TRUS) for early pregnancy diagnosis in dairy cows. The study was carried out on 58 Holstein cows. Blood and milk samples were collected on days 20, 25, 28, 30,...

Floppy Kid Disease (FKD) is a condition which is characterized with metabolic acidosis, generalized anorexia and muscle weakness that can be seen in young goat kids. During the course of an investigation on goat kids suffering from muscle weakness and increased deaths in a goat farm in Cyprus, 10 kids were evaluated. Hematological and biochemical e...

A 14-year old, castrated, female terrier was referred to Near East Animal Hospital with a complaint of red eye. Ophthalmoscopic examination revealed superficial corneal vascularization originating from conjunctiva and encompassing proximal one-third of cornea in 10-02 o’clock position together with photophobia and vision loss. Schirmer tear test wa...

The aim of this study was to establish the current state of blood selenium and vitamin E levels in heifers, together with roughage selenium levels in eight livestock regions of Northern Cyprus from two different seasons. We also evaluated whether these concentrations were adequate. Heifer blood, feed samples including concentrate feed or roughage w...

It is aimed to investigate the effect of vitamin E, powerful antioxidant (alpha-tocopherol succinate) on antioxidant enzyme activities in hepatocellular carcinoma (HepG2) cells. The hepatocellular carcinoma cell line HepG2 was used and the cells were cultured in the absence (control) or presence of different dose of vitamin E (50 mM, 50 mu M and 10...

Koenzim Q (2-metil-5, 6 dimetoksi-1, 4-benzokinon, KoQ, Ubikinon, UQ) tum hucrelerde ve membranlarda bulunan, baslica mitokondriyal solunum zincirinde kilit rol oynayan ve hucre metabolizmasi icin son derece onemli bir molekuldur. Koenzim Q, guclu lipofilik bir antioksidan olarak lipoproteinleri ve hucre membranlarini korumaktadir. Ilk zamanlar agi...

Recently, there has been a few information on the effects of mobile phone-exposed on reproduction. The aim of this study to determine the effects of antioxidants namely EGCG and NAC on the serum testosteron levels in the cell phone-exposed guinea pigs. Three-months-old male Guinea pigs were randomized into 6 groups; sham group, not exposed to mobil...

It has been reported that mobile phones induce free radical formation. Epigallocatechin Gallate (EGCG) and N-Acetylcysteine (NAC) were recently found to be potent antioxidants. The present study was carried out to determine the protective effects of antioxidants namely EGCG and NAC against the mobile phone-induced oxidative stress. Three-month-old...