Serhat Keser

Firat University · Department of Chemistry

In the present study, antimicrobial, antiradical and anticancer properties with phytochemical compounds of endemic Scorzonera semicana DC., which grown in Elazig (from Turkey) around and consumed as a vegetable, were investigated. The antiradical properties of extracts were determined via DPPH, ABTS, OH radical scavenging activities, and their anti...

Tchihatchewia isatidea Boiss (Brassicaceae) is known among the public as “Reddish Bride”, “Paint and Bridal Flower”. Flower parts are used for painting and flowering branches for treatment of cough. In this study, anticancer properties of water, ethanol and methanol extracts of Tchihatchewia isatidea flower parts were investigated against human bre...

In this paper, Ce/Sm co-doped hydroxyapatites (HAps) were synthesized by a wet chemical route. The amount of Ce was kept at constant at the value of at.% 0.4, and the second dopant of Sm was used at different amounts of at.% 0, 0.6, 1.2, and 1.8, respectively. The effects of these co-dopants on the crystal structure, morphology, and thermal propert...

In this study, the crystal structure, functional groups, morphological structure, elemental compositions, antimicrobial activity, and structural changes in the SBF of Zn-based HAp samples, synthesized by sol-gel method, doped with chitosan (CTS) at different amounts, were investigated. The crystal structure of the synthesized samples was determined...

The present study describes the effects of dopants of Mn and/or Ni on the structural, magnetic and in vivo/in vitro performances of β-tricalcium phosphate (β-TCP) bioceramics synthesized by a sol-gel method. Both types of dopants caused significant effects on the structure-related parameters of β-TCP, including the crystallite dimensions and lattic...

1.0 at% Ag-containing hydroxyapatites (HAps) doped with the different amounts of Gd (e.g., 0, 0.8, 1.6 and 2.4 at%) were synthesized by a wet chemical method and their dielectric properties were investigated before and after gamma irradiation. The changes in the relative permittivity and alternating current (AC) conductivity values of the as-synthe...

Rheum ribes L. (rhubarb) is belonging to Polygonaceae, and its roots and fresh shoots are consumed as vegetable in Turkey. This plant is considered to be one of the most important pharmaceutical raw materials in Middle East. In this study, the antiradical, antimicrobial, cytotoxic and bioactive properties of water, ethanol, and methanol extracts of...

Hypericum scabrum L. has been widely used in traditional medicine for the treatment of many diseases just as the other Hypericum species. In the present study, the antiradical, antimicrobial and cytotoxic activities of water and ethanol extracts of H. scabrum flowers were investigated. Their phytochemical contents and composition were also determin...

The pepper fruits keep very important place in the human nutrition and contain some important components in terms of human health. Capsicum frutescens can be consumed both fresh and dry, and has been used in made powdered spices and sauces. In this study, the antiradical activities, phytochemical contents, antimicrobial, antiproliferative activitie...

ZnO powder has been synthesized, characterized experimentally and its theoretical modeling carried out by density functional theory (DFT). The experimental and theoretical results were compared with each other and with the available data in the literature. A detailed crystal structure analysis was carried out using X-ray diffraction (XRD) data. Exp...

Tchihatchewia isatidea Boiss (Brassicaceae) is known among the public as “Reddish Bride”, “Paint and Bridal Flower”. Flower parts are used for painting and flowering branches for treatment of cough. In this study, anticancer properties of water, ethanol and methanol extracts of Tchihatchewia isatidea flower parts were determined against human ches...

In the present paper, Mg-substituted hydroxyapatites with the morphology, composed of the stacked plate- and rod-like structures, were prepared at the temperature of 600 °C by combustion method using glycerine as a fuel. A significant decrease in the crystallite size values calculated for both Scherrer and Williamson-Hall methods is found. The crys...

Usually grown on rocky, stony, gravelly arid slopes, it is an endemic species and it is used in the treatment of dyestuff, dye and bride, T. Isatidea, which is known as bride, dye and bride. In Elazig province, it is known that the flowers of the plant are boiled and used against cough. In this study, phenol, flavonoid, vitamin and fatty acid conte...

Ni/Al, Ni/Mn and Al/Mn co-doped monetite samples, as well as the undoped monetite, were prepared via wet chemical method. The structural characterization of the as-synthesized samples was done using X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM) and energy dispersive X-ray (EDX) spectrosc...

We describe the temperature dependence of the vibrational, rotational and translational partition functions of the activated complex of hydroxyapatite (HAp). Computed data show that the vibrational modes have a larger contribution towards the partition function of HAp compared to the rotational and translational contributions. X-ray diffraction (XR...

It is known that Celtis species have been used in healing wound, epilepsy crisis, and stomach pain among the people. The antiradical (DPPH, OH, ABTS) activities, phytochemical compounds (total proanthocyanidin, total flavonoid, total phenolic, flavonoids, phenolic acids, sterols, lipid soluble vitamins, fatty acids), antimicrobial, antiproliferativ...

This study measures the effects of Pistacia terebinthus flower extract on the amounts of lipid peroxidation (LPO), total protein, glutathione, and enzyme activities in blood. It also measures the effects of the plant extract on glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) enzyme activities and it arrives at the conclusion that GSH...

A glass with the composition of the SiO2–Na2O–CaO–P2O5 was synthesized by sol–gel method at temperature of 900 °C, and then yttrium-, silver- and cerium-containing glasses were prepared at the same conditions using this base system. The structural and thermal properties of the glass samples were investigated by X-ray diffraction, Fourier transform...

In present work, the effect of citric acid (CA) addition in different amounts (0, 1, 5 and 10 ml) on the structure of hydroxyapatite (HAp) was investigated using X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM) and energy dispersive X-ray (EDX) spectroscopy techniques. The crystallite dimen...

Calcium phosphate ceramics with various Ca/P ratios of 1, 2, 3, 4 and 8 were synthesized via sol-gel route. The effects of Ca/P molar ratio on structural, morphological and dielectric properties were investigated in detail using X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy and dielectric meas...

Zr/Mg, Zr/Sr and Zr/Zn co-doped hydroxyapatite samples, having high crystallinity, prepared by sol–gel synthesis were characterized via X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM) and energy dispersive X-ray (EDX) spectroscopy. Based on the XRD results, it is shown that the kind of co-...

Pine oil has antiseptic, expectorant and antioxidant properties and has been used for treatment of rheumatism, respiratory and urinary system and skin diseases. We aimed to determine protective effects of pine oil (PO) on the lipid-soluble vitamins, cholesterol, GSH, total protein, MDA, fatty acid levels of brain tissue of the streptozotocin-induce...

This study aims to examine the antioxidant effects of some Mannich bases containing bis-1, 2, 4 triazole, which are synthesized afresh. The antioxidant activities of the derivatives were measured using different methods in this study, including reducing power capacity, metal chelating activity, superoxide anion radicals scavenging activity, H2O2 sc...

Achillea millefolium L., Crataegus monogyna subsp. monogyna Jacq., Rubus discolor L., Salvia multicaulis Vahl., Morus alba L. and Pistacia terebinthus L. plants are consumed for some medicinal or nutritional purposes. The chemical composition, vitamins, sterols and fatty acid contents of these plants were presented in this study. Vitamin and sterol...

In the present study, in vitro antioxidant activities of ethanol and water extracts of Rubus discolor L. leaves, flower, unripe and ripe fruits were investigated. Additionally, the antioxidant and protective properties of R. discolor flower (RD) water extract on some important biochemical parameters against hydrogen peroxide (HP)-induced oxidative...

Pure hydroxyapatite and cobalt-containing calcium orthophosphate ceramics were synthesized by the sol-gel method and their properties were analyzed by Fourier transform infrared spectroscopy, X-ray diffraction, dielectric impedance spectroscopy and scanning electron microscopy techniques. The average crystallite size of the samples was found to be...

Pure hydroxyapatite and cobalt-containing calcium orthophosphate ceramics were synthesized by the sol–gel method and their properties were analyzed by Fourier transform infrared spectroscopy, X–ray diffraction, dielectrical impedance spectroscopy and scanning electron microscopy techniques. The average crystallite size of the samples was found to b...

In this study, it was determined antioxidant activities and phenolic, flavonoid, phytosterol, lipid soluble vitamin and fatty acid contents of bitter almond kernel extract (BAE). Antioxidant activities of BAE was investigated by DPPH center dot, ABTS(center dot+), OH center dot radical scavenging, metal chelating activity and determination of lipid...

Firethorn fruits have been used in traditional medicine owing to their diuretic, cardiac and tonic properties. In this study, the antiradical activities and phenolic, phytosterol, lipid-soluble vitamin and fatty acid contents of firethorn fruits were investigated. Antiradical activities of firethorn extracts (ethanol, water, methanol, acetone and d...

Almond belong to Rosaceae family and it is a rich source of nutrients because of phytochemicals including phenolic compounds, phytosterols, flavonoids, phenolic acids, vitamins and fatty acids. In this study, we determined antioxidant activities and phenolic, flavonoid, phytosterol, lipid soluble vitamin and fatty acid contents of almond kernel ext...

Aim: The antioxidant and pharmacological effects of hawthorn have mainly been attributed to the polyphenolic contents. The aim of this research is to determine some bioactive compounds and antioxidant properties of hawthorn aqueous and ethanol extracts of leaves, flowers, and ripened fruits. Materials and methods: For this purpose, antioxidant a...

Ag- and Ba-doped hydroxyapatite (HAp) samples were synthesized by sol–gel method. The crystallite sizes for all the samples were found to vary from 26 to 39 nm. Neither Ag nor Ba did result in dramatic changes in the morphology of all the samples, and the Ca/P molar ratio was varied. The dielectric parameters of the samples were changed with the do...

Achillea millefolium (Asteraceae, yarrow) has been used in folk medicine against several disturbances including skin inflammations, spasmodic and gastrointestinal disorders. In this study, ethanol and water extracts were prepared from A. millefolium flowers, leaves and seeds. Antioxidant activities were measured by ferric thiocyanate method, and H2...

Novel six Cu(II), Ni(II), and Zn(II) complexes with Schiff bases derived from 4-aminobenzoic acid with terephtaldehyde and amino acids (glycine, β-alanine). Structures have been proposed from elemental analysis, UV–Vis, IR, NMR, TGA, DTA, and magnetic measurements. Spectroscopic studies suggest that coordination occurs through azomethine nitrogen,...

The crystal structure, thermal, dielectrical, alternating current conductivity and microstructure properties of lithium calcium phosphate ceramics synthesized by the sol gel method were investigated. The average crystallite size, crystallinity, activation energy and enthalpy of crystallization of Ca10Li(PO4)(7) ceramics were determined. The X-ray d...

Novel six Cu(II), Ni(II), and Zn(II) complexes with Schiff bases derived from 4-aminobenzoic acid with terephtaldehyde and amino acids (glycine, β-alanine). Structures have been proposed from elemental analysis, UV–Vis, IR, NMR, TGA, DTA, and magnetic measurements. Spectroscopic studies suggest that coordination occurs through azomethine nitrogen,...

A series of N-ethylpiperazine substitute thioureas [C6N2H13NHCSNHR], where R = -C3H5 (L 1 ), -C10H7 (L 2 ), and -C7H7 (L 3 ), and their copper (II) complexes have been synthesized. These ligands and complexes have been characterized by elemental analyses, IR, 1H and 13C-NMR spectra, UV-Vis, magnetic susceptibility, thermogravimetrical analyses, and...

Doğal bir antioksidan kaynağı olan bitkilerin antioksidan özelliklerinin belirlenmesi ile ilgili çalışmalar son zamanlarda büyük bir ivme ile artmaktadır. Özellikle halk arasında tıbbi amaçlı kullanılan bitkiler ile gıda sektöründe kullanılan bazı bitkiler antioksidan çalışmaların odak noktasını teşkil etmektedir. Ülkemizdeki endemik bitki türlerin...

Grape is one of the world's largest fruit crops, with an approximate annual production of 58 million metric tons, and it is well known that the grape skins, seeds and stems, waste products generated during wine and grape juice processing, are rich sources of polyphenols. It contains flavonoids, phenolic acids and stilbenes. In this study, we tried...

The genus Phlomis L. belongs to the Lamiaceae family and encompasses 100 species native to Turkey, North Africa, Europe and Asia. It is a popular herbal tea enjoyed for its taste and aroma. Phlomis species are used to treat various conditions such as diabetes, gastric ulcer, hemorrhoids, inflammation and wounds. In this study, ethanol and water ext...

The aim of this research is to examine effects of antioxidants resveratrol, lipoic acid, catechin and carcinogen potassium bromate on the level of lipophylic vitamins and cholesterol in liver, lung and kidney tissue of Wistar albino rats. In this study, total 50 Wistar rats were randomly divided into five groups: 1. Control (C), 2. KBrO 3 (K) (40 m...

The hydroxyapatite and hydroxyapatite-based bioceramics with high Al contents were synthesized using sol–gel method, and their characterization was carried out by X-ray diffraction, Fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy. With the increase of Al content, the crystallinity is dramatically decreased, and the phas...

The aim of this study was to examine the effects of potassium bromate, catechin, lipoic acid and resveratrol on the level of fatty acids, lipophylic vitamins and cholesterol in muscle of Wistar rats. In this study, Wistar rats were randomly divided into five groups: 1. Control (C), 2. KBrO 3 (K), 3. Catechin+KBrO 3 (Cat), 4. Lipoic Acid+KBrO 3 (LA)...

The aim of this research is to determine H 2 O 2 radical scavenging and total antioxidant activity of Crataegus monogyna (hawthorn) water and ethanol extracts of leaves, flowers and fruits. Hawthorn leaves, flowers, and berries are used in traditional medicine in the treatment of chronic heart failure, high blood pressure, arrhythmia, and various d...

In the present study, Wistar rats were randomly divided into three groups: 1. Control (C), 2. KBrO 3 (K), 3. Resveratrol+KBrO 3 (R). In tissues, cholesterol and vitamins analyses were performed by HPLC. According to our results, while the level of cholesterol increased in the K group, its level decreased in the R group when compared to C group in t...

Achillea millefolium L. is a member of the Asteraceae family that is commonly referred to as 'yarrow' and has been used in folk medicine against several disturbances including skin inflammations, spasmodic and gastrointestinal disorders, as well as hepato-biliary complaints. Ethanol and water extracts were prepared from powdered A. millefolium flow...

Resveratrol is a phytoalexin, highly abundant in skins of red grapes, peanuts and blueberries. The aim of this study was to examine the effects of resveratrol and kidney carcinogen potassium bromate on the levels of vitamin E and cholesterol in heart, muscle and brains of old female Wistar rats. All analyses were measured by high performance liquid...

Resveratrol is a phytoalexin, highly abundant in skins of red grapes, peanuts and blue berries. The aim of this study is to examine effects of antioxidant resveratrol and carcinogen potassium bromate on the level of fatty acids in serum and erythrocytes of old female Wistar albino rats. In this study, Wistar rats were randomly divided into three gr...

Glutathione is a tripeptide ubiquitously distributed in living cells, which play an important role in the intracellular protective mechanism against oxidative stress. There are many methods for glutathione analysis including spectrophotometric, fluorometric and bioluminometric assays, often applied to HPLC. In this study, an improved and modified m...

Resveratrol is a natural polyphenolic compound and it is found in number of edible plants, especially grapes and peanuts, has been shown to have anti-inflammatory, anti-oxidant, anti-tumor and anti-platelet activities. The aim of the study was to examine the effects of resveratrol on the level of malondialdehyde (MDA), homocysteine, cholesterol, GS...