Serhat GumrukcuSeraph Research Institute · Translational Research
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Citations since 2017
15 Research Items
- Hijacking, or co-opting, virus machinery as a proposed novel mechanism of action in antiviral therapy research - Genetic and intracellular mechanisms that contribute to the resistance of long-term control of HIV - Preclinical, translational and clinical research on gene-modified bone marrow transplants - Mechanisms that contribute to graft-versus-tumor, graft-versus-leukemia or graft-versus-virus effects in allogeneic stem cell transplants and adoptive cell therapy models
More than 200 viruses infect humans but drugs are available for fewer than ten. To narrow the gap between 'bugs and drugs', a paradigm shift is required. The "one drug, one bug" approach should be supplemented by the "one drug, multiple bugs" strategy such that the host is targeted rather than the virus. The revolutionary viral superinfection thera...
In vivo proof-of-concept of a novel HBV cure strategy using a unique, proprietary vector construct expressing a non-functional, non-coding (nc)RNA (HBV Hijack RNA)
BACKGROUND Glioblastoma (GBM) is a highly aggressive brain tumor with poor survival outcomes. While conventional treatment strategies such as surgery, radiation, and chemotherapy can extend survival, the prognosis for GBM patients after 2 years remains low. One-year progression-free survival (PFS) and complete response (CR) with recurrent GBM is ex...
We evaluated the SARS-CoV-2-specific antiviral activities of gamma-delta T cells isolated from COVID-19 convalescent individuals
Hijacking Influenza polymerase as a potential pan-influenza treatment
Increased expression GCL modifier subunit alone confers substantial chemoprotection against busulfan
We utilize the virus and cellular machinery to kill the infected cells as a potential cure.
Overexpression of ALDH1 provided chemoprotection to CD34+ cell line and human stem/progenitor cells when exposed to low dose cyclophosphamide
ALDH1 overexpression promotes increased engraftment of HSPCs in vivo when combined with low dose cyclophosphamide chemoselection.
As the neck is a region where many important structures exist, neck trauma creates serios problems. The most of important is airway obstruction and urgent airway is critical. Neck trauma is classified as blunt and penetrating trauma. After blunt trauma to the larynx, laryngeal cartilage fractures, intralaryngeal edeama, recurrent nerve injury and t...
A 4-month-old boy with difficulty in breathing, coughing is admitted to hospital. Rib deformities seen in chest radiography combined with the congenital anomalies such as micrognathia, retrognathia, hypertelorism, low-set ears, pectus excavatum in physical examination lead to the diagnosis of cerebro-costo-mandibular syndrome. Cerebro-costo-mandibu...
Background: To determine whether clinical signs and symptoms of brain injury are sensitive indicators of traumatic brain injury (TBI) and skull fracture (SF) in pediatric patients admitted with head trauma. Methods: A retrospective cross-sectional analysis of all patients younger than 17 years of age admitted to the university-based pediatric Emerg...
This case report concerns a patient with fracture and primary dysfunction of a prosthetic valve. A 40-year-old man presented to the Emergency Department with a chief complaint of breakthrough pleuritic back pain and shortness of breath. Past surgical history was significant only for an aortic valve replacement and mitral valve replacement performed...
This is the first known case report of electrocardiographic (ECG) changes suggestive of coronary vasospasm following a centipede envenomation. A 60-year-old man presented to the emergency department (ED) 1 hour after being stung by a 12-cm centipede. He complained of right great toe pain that did not radiate to his leg. The patient had no known isc...
Hijacking virus machinery is a novel mechanism of action in antiviral research. We develop novel vectors and oligonucleotides that are designed to specifically be recognized by viral polymerases.
We are exploring genes that confer chemoprotection against cytotoxic agents to increase engraftment in autologous gene-modified non-myeloablative bone marrow transplants.