Sergio Barbieri

Sergio Barbieri
Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico | Policlinico Maggiore · Clinical Neurophysiology

PhD in Neuroscience

About

168
Publications
22,948
Reads
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6,275
Citations
Additional affiliations
January 2010 - present
Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico
Position
  • Managing Director
October 1987 - present
Università degli Studi, Milan
Position
  • Professor
Education
January 1981 - September 1982
Mayo Graduate School of Medicine
Field of study
  • Clinical Neurophysiology

Publications

Publications (168)
Article
Full-text available
Implanting deep brain stimulation (DBS) electrodes in patients with Parkinson’s disease often results in the appearance of a non-infectious, delayed-onset edema that disappears over time. However, the time window between the DBS electrode and DBS stimulating device implant is often used to record local field potentials (LFPs) which are used both to...
Article
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Psychological distress among healthcare professionals, although already a common condition, was exacerbated by the COVID-19 pandemic. This effect has been generally self-reported or assessed through questionnaires. We aimed to identify potential abnormalities in the electrical activity of the brain of healthcare workers, operating in different role...
Article
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This review discussed the effects of the impact of the Coronavirus Disease 2019 (COVID-19) pandemic on the psychological wellbeing of people with Parkinson's disease (PD) focusing specifically on depressive symptoms, anxiety levels, sleep, and quality of life (QoL). Together with motor symptoms, psychological symptoms are common and disabling condi...
Article
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Traditionally, medical care and research in Parkinson’s disease (PD) have been conducted through in-person visit. The recent Coronavirus Disease 2019 (COVID-19) pandemic has profoundly impacted the delivery of in-person clinical care. We conducted an online survey to investigate the impact of COVID-19 on access to telehealth care, interviewing both...
Article
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Objectives Despite the large amount of literature examining the potential influence of subthalamic nucleus deep brain stimulation (STN-DBS) on psychiatric symptoms and cognitive disorders, only a few studies have focused on its effect on personality. We investigated the correlation between total electrical energy delivered (TEED) and the occurrence...
Article
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Infant botulism is a rare and underdiagnosed disease caused by BoNT-producing clostridia that can temporarily colonize the intestinal lumen of infants less than one year of age. The diagnosis may be challenging because of its rareness, especially in patients showing atypical presentations or concomitant coinfections. In this paper, we report the fi...
Article
Infant botulism is a rare and underdiagnosed disease caused by BoNT-producing clostridia that can temporarily colonize the intestinal lumen of infants less than one year of age. The diagnosis may be challenging because of its rareness, especially in patients showing atypical presentations or concomitant coinfections. In this paper, we report the fi...
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Background and Aims: Chronic pain is a complex clinical condition, often devastating for patients and unmanageable with pharmacological treatments. Converging evidence suggests that transcutaneous spinal Direct Current Stimulation (tsDCS) might represent a complementary therapy in managing chronic pain. In this randomized, double-blind and sham-con...
Article
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This study compares the effects on motor symptoms between conventional deep brain stimulation (cDBS) and closed-loop adaptive deep brain stimulation (aDBS) in patients with Parkinson’s Disease. The aDBS stimulation is controlled by the power in the beta band (12–35 Hz) of local field potentials recorded directly by subthalamic nucleus electrodes. E...
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IntroductionCoronavirus disease 2019 (COVID-19) is associated to neuromuscular symptoms in up to 10.7% of hospitalized patients. Nevertheless, the extent of muscular involvement in infected subjects with no signs of myopathy has never been assessed with neurophysiological investigations.Methods Over a 3-week period — from April 30 through May 20, 2...
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Background: Adaptive Deep Brain Stimulation (aDBS) is now considered as a new feasible and effective paradigm to deliver DBS to patients with Parkinson's disease (PD) in such a way that not only stimulation is personalized and finely tuned to the instantaneous patient's state, but also motor improvement is obtained with a lower amount of energy tra...
Article
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The first outbreak of COVID-19 in Italy was confirmed on February 21, 2020. Subsequently, COVID-19 turned into a global pandemic, causing a global health emergency, triggering an unprecedented event in the modern era. This study assessed the immediate psychological impact of the COVID-19 epidemic on emotional health and well-being. An ad hoc questi...
Article
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Background: The new coronavirus (SARS-CoV-2) shows several similarities with previous outbreaks of Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS). Aim of this systematic review and meta-analysis is to provide evidence of the psychopathologic burden on health care workers (HCWs) of the first two deadly coronavi...
Article
Objective: To evaluate the role of the cerebellum and spinal cord in cognitive processes, we assessed changes in event-related potentials (ERPs), before and after different combinations of spinal and cerebellar direct current stimulation (tDCS) in healthy subjects. Method: We enrolled 37 volunteers (11 males and 26 females, aged 20-50 years), wh...
Article
An Italian 13-year-old boy immunosuppressed due to kidney transplant presented in November 2018 with acute flaccid paralysis with anterior horn cell involvement resembling the clinical, radiological, and laboratory features of poliomyelitis. Enterovirus was molecularly identified in cerebral spinal fluid and stool samples and the sequence analysis...
Article
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Health data autonomously collected by users are presently considered as largely beneficial for wellness, prevention, disease management, as well as clinical research, especially when longitudinal, chronic, home-based monitoring is needed. However, data quality and reliability are the main barriers to overcome, in order to exploit such potential. To...
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Febrile Infection‐Related Epilepsy Syndrome (FIRES) is a severe epileptic encephalopathy with presumed inflammatory origin and lacking effective treatments. Anakinra is the human recombinant interleukin 1‐receptor antagonist clinically used in autoinflammatory or autoimmune conditions. We report R1 1 a case of FIRES where the spatial and temporal m...
Article
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Objective: Hereditary spastic paraplegia (HSP) represents a heterogeneous group of neurodegenerative diseases characterized by progressive spasticity and lower limb weakness. We assessed the effects of transcutaneous spinal direct current stimulation (tsDCS) in HSP. Design: A double-blind, randomized, crossover and sham-controlled study. Setting: F...
Article
Objective to define the prevalence and the characteristics of peri‐electrode edema in a prospective cohort of patients undergoing deep brain stimulation (DBS) surgery and to correlate it with clinical findings. Methods we performed brain MRI between 7 and 20 days after surgery in 19 consecutive patients undergoing DBS surgery for Parkinson's disea...
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Integrating patient-generated data into clinical research would improve the reliability of results, especially when longitudinal, chronic, home-based monitoring is needed. To this end, we designed, implemented, and tested a system that allows integrating patient-generated data into electronic case report form (eCRF), using a standards based archite...
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Objectives: To assess the feasibility and clinical efficacy of local field potentials (LFPs)-based adaptive deep brain stimulation (aDBS) in patients with advanced Parkinson disease (PD) during daily activities in an open-label, nonblinded study. Methods: We monitored neurophysiologic and clinical fluctuations during 2 perioperative experimental...
Article
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Deep brain stimulation (DBS) has emerged as a novel therapy for the treatment of several movement and neuropsychiatric disorders, and may also be suitable for the treatment of Tourette syndrome (TS). The main DBS targets used to date in patients with TS are located within the basal ganglia-thalamo-cortical circuit involved in the pathophysiology of...
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Neurophysiological testing of the pelvic floor is recognized as an essential tool to identify pathophysiological mechanisms of pelvic floor disorders, support clinical diagnosis, and aid in therapeutic decisions. Nevertheless, the diagnostic value of these tests in specific neurological diseases of the pelvic floor is not completely clarified. Seek...
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Focal hand dystonia (FHD) in musicians is a movement disorder causing abnormal movements and irregularities in playing. Since weak electrical currents applied to the brain induce persistent excitability changes in humans, cathodal tDCS was proposed as a possible non-invasive approach for modulating cortical excitability in patients with FHD. Howeve...
Poster
Introduction tsDCS is a novel non-invasive tool to modulate human spinal cord function (Cogiamanian et al., 2008). Anodal tsDCS is known to reduce the post activaction depression of the H reflex in the lower limb (Winkler et al., 2010), and to induce a leftward shift of the stimulus–response curve of the H reflex, with no effect on H max/M max rati...
Article
Introduction Sleep disturbance has been recognized as a common and significant complication linked to decreased quality of life in patients with neuropsychiatric disease. Currently, pharmacological therapy is the most common treatment for sleep disturbance, although benefits tend to be limited. Objective We assessed whether transcranial direct cur...
Article
Background: Recent clinical evidence supports a targeted therapeutic approach for genetic epileptic encephalopathies based on the molecular dysfunction. Patient description: A 2-day-old male infant presented with epileptic encephalopathy characterized by burst-suppression EEG background and tonic-clonic migrating partial seizures. The condition...
Article
Purpose: Patients with Parkinson's disease (PD) variably report sexual dysfunctions. We assessed sexuality in PD by comparing sexual function between a large group of patients with idiopathic PD and a group of subjects without PD. Methods: We recruited 121 patients with mild-to-moderate PD (aged 40-80 years) from four Italian Movement Disorder Clin...
Article
Objective: The adaptive deep brain stimulation (aDBS) controlled by local field potentials (LFPs) is considered a promising treatment for advanced Parkinson's disease (PD). The clinical research investigating aDBS functioning is currently performed using external DBS systems that require LFP recording through the temporary externalisation of DBS l...
Article
Purpose: Patients with Parkinson's disease (PD) variably report sexual dysfunctions. We assessed sexuality in PD by comparing sexual function between a large group of patients with idiopathic PD and a group of subjects without PD. Methods: We recruited 121 patients with mild-to-moderate PD (aged 40-80years) from four Italian Movement Disorder Cl...
Article
Sub-optimal clinical outcomes of conventional deep brain stimulation (cDBS) in treating Parkinson's Disease (PD) have boosted the development of new solutions to improve DBS therapy. Adaptive DBS (aDBS), consisting of closed-loop, real-time changing of stimulation parameters according to the patient's clinical state, promises to achieve this goal a...
Article
Introduction: Posterior reversible encephalopathy syndrome (PRES) with status epilepticus may occur after liver transplant. This may rarely lead to refractory epilepsy and hippocampal sclerosis (HS). Case description: We report the first case of epilepsy surgery in a liver-transplanted patient with refractory temporal lobe epilepsy. A 3-year-old...
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Quantitative electroencephalography (qEEG) showed that Alzheimer's disease (AD) is characterized by increased theta power, decreased alpha and beta power, and decreased coherence in the alpha and theta band in posterior regions. These abnormalities are thought to be associated with functional disconnections among cortical areas, death of cortical n...
Article
Introduction: Guillain-Barré syndrome may rarely manifest as a peripheral locked-in syndrome. Case: After 2 days of rhinitis, a 6-month-old infant was intubated in the emergency room for sudden onset respiratory failure. Neurological examination showed generalized areflexic flaccid paralysis with no detectable interaction that resembled a coma....
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Syntaxin Binding Protein 1 (STXBP1) mutations determine a central neurotransmission dysfunction through impairment of the synaptic vesicle release, thus causing a spectrum of phenotypes varying from syndromic and non-syndromic epilepsy to intellectual disability of variable degree. Among the antiepileptic drugs, levetiracetam has a unique mechanism...
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The Silences of the Archives, the Reknown of the Story. The Martin Guerre affair has been told many times since Jean de Coras and Guillaume Lesueur published their stories in 1561. It is in many ways a perfect intrigue with uncanny resemblance, persuasive deception and a surprizing end when the two Martin stood face to face, memory to memory, befor...
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INTRODUCTION: The thalamus is a deep-seated and crucial structure for the sensory-motor system. It has been longly considered a surgically inaccessible area due to the morbidity associated with surgical resections. In fact, astrocytomas of the thalamus usually undergo bioptic procedures followed by adjuvant treatments (if indicated). Intra-operativ...
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INTRODUCTION: Intra-operative neurophysiological monitoring and brain mapping techniques represent nowadays the gold standard for surgical resection of brain tumors. Brain mapping usually requires the exposure of a large area of brain cortex in order to identify the different eloquent sites (e.g. primary motor strip, speech arrest sites). Thus, rel...
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To report our electrophysiological protocol for suspected neuromuscular junction disorders in 0–4 months old infants recovered in intensive care unit. In the period 2009–2012 five 0–4 months infants with a suspected neuromuscular junction disorder (NJD) were examined with a comprehensive electrophysiological assessment (CEA) involving: nerve conduc...
Article
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Objective There are to date few studies investigating the effects of spinal direct current stimulation (tsDCS) on spinal ascending tract and reflexes. Whether tsDCS interferes with conduction along pyramidal tract at a spinal level is unknown. Methods Eleven healthy subjects underwent anodal and cathodal tsDCS of the thoracic spinal cord, at the T...
Article
Refractory neonatal and early infantile epilepsy represent a major therapeutical and diagnostic challenge. Conventional antiepileptic drugs sometimes demonstrate limited efficacy and off-label drugs are often considered. When two drugs reveal ineffective, the possibility of a response to a third antiepileptic drug is usually considered low. We repo...
Article
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Congenital myasthenic syndromes are inherited disorders caused by various defects in neuromuscular transmission. Although the typical presentation is fatigable weakness with prominent cranial involvement, neonates can lack these hallmark manifestations, and in those with choline acetyltransferase gene mutations, basal electrophysiological testing c...
Article
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We review the data concerning the neurophysiology of deep brain stimulation (DBS) in humans, especially in reference to Parkinson's disease. The electric field generated by DBS interacts with the brain in complex ways, and several variables could influence the DBS-induced biophysical and clinical effects. The neurophysiology of DBS comprises the DB...
Article
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In the past 10 years renewed interest has centered on non-invasive transcutaneous weak direct currents applied over the scalp to modulate cortical excitability ("brain polarization" or transcranial direct current stimulation, tDCS). Extensive literature shows that tDCS induces marked changes in cortical excitability that outlast stimulation. Aiming...
Article
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New adaptive systems for deep brain stimulation (DBS) could in the near future optimize stimulation settings online so as to achieve better control over the clinical fluctuations in Parkinson's disease (PD). Local field potentials (LFPs) recorded from the subthalamic nucleus (STN) in PD patients show that levodopa and DBS modulate STN oscillations....