Sergey Rudnev

• PhD
• Senior Researcher at Institute of Numerical Mathematics, Russian Academy of Sciences

In this book, the data on growth, development, body composition and metabolic rate of Russians are described based on the results of the cross-sectional bioimpedance study of 2 092 695 Russian males and females that was conducted in 2010-2012. Using extensions of the conventional LMS method, the smoothed reference centile curves and the parameters...

A mathematical model of long-term immune defense against infection was used to estimate the energy involved in the principal processes of immune resistance during periods of health and infection. From these values, an optimal level of energy was determined for immune response depending on infection burden. The present findings suggest that weak but...

Based on the results of the cross-sectional anthropological study of 2364 Russian children and adolescents aged 7-17 years, we suggest simple prediction formulae for automated bioimpedance-based evaluation of endomorphy and mesomorphy components of the Heath-Carter somatotype: ENDOBIA = 0.5282×FMi + 0.2580×BMI - 0.04822×BM - 1.881 (r2=0.81, SEE=0.6...

Background. The probability of cranial lesions in fibrous dysplasia reaches 50%. A pre-operative computer-assisted planning provides opportunities for precise radical bone resection and customized xenograft manufacturing. Objective. To evaluate postoperative outcomes in patients with fibrous dysplasia of the cranial vault and base, achived by means...

Relevance of the problem. In congenital transsphenoidal and sphenoethmoidal encephaloceles, several functionally important structures may be included in the hernial sac, such as the anterior cerebral artery, pituitary gland, optic nerve, and walls of the third ventricle. Our aim is to analyze a series of patients with these types of congenital basa...

Introduction. A number of diseases, including craniosynostosis, basal encephaloceles, and fibrous dysplasia, can be accompanied by deformities in the facial skeleton and the skull base. To quantify the degree of pathological deformity and the dynamics of skull bone growth in these patients, data from healthy children’s growth processes is needed. T...

Introduction. One of the traditional tasks of biological anthropology is the study of the morphological status of the indigenous populations. Our aim was to study the somatic status and bioimpedance body composition of young men of Altai and Russian ethnicities aged 17–24 years living in urban and rural areas of the Altai Republic. Materials and me...

Objective. To develop the criteria for assessing nutritional status in Moscow adults using bioimpedance analysis data. Materials and methods. The research used data from a non-clinical, cross-sectional, observational study on the body composition of Moscow adults aged 18-96 in Moscow health centers between 2010 and 2019 by the method of bioimpedanc...

Background. Body composition assessment plays an important role in characterizing physical development, monitoring health status, diagnosing nutritional disorders, and assessing disease risks. Objective. To develop the criteria for assessing nutritional status in Moscow children and adolescents using bioimpedance analysis data. Materials and method...

Introduction. In recent years, laser-based rangefinders have been considered as a possible alternative to mechanical anthropometers. One of these instruments is the KAFA-Laser anthropometer (KAFA, Russia). Our aim was to test the accuracy and reproducibility of the KAFA-Laser anthropometer when measuring height of anthropometric points. Materials a...

This manual contains problems with detailed solutions for the topics covered in the course “Algebra and Geometry” taught at the Faculty of Computational Mathematics and Cybernetics at Lomonosov Moscow State University during the first semester. It is assumed that the reader has a basic understanding of the following concepts: algebra of geometric v...

Arguments are presented in support of the hypothesis that the famous stone ships in Northern Europe are Christian medieval structures, originating from the imperial rite of royal burial in ancient Egypt, Romea (Byzantium), and the Rus-Horde, which is its symbolic reflection. Subsequently, the tradition of building stone ships for honorable burials...

Introduction. Due to the wide variety of ethnogeographic features and ecological niches, environmental differences as well as changes in living conditions, the study of the morphological status of indigenous populations of Russia retains its significance. Our aim was to study the somatic status and BIA body composition of young women of Altai and R...

Background Intracranial volume (ICV) is an important indicator of the development of the brain and skull in children. At present, there is a lack of ICV growth standards based on large infant and children samples. Our aim was to assess the normal range of the ICV variation in Russian children using a modern automatic system for constructing the end...

This manual contains methodological materials accompanying the educational process: the course program, seminar plans, colloquium programs, test materials, and questions for the exams.

The collection includes materials of scientific research and development presented at the VII All-Russian scientific and practical conference with international participation "Sports Informatics Day" on December 4-5, 2023. The issues of the use of digital technologies in sports training and education, in the tasks of monitoring, testing and diagnos...

A comprehensive investigation of nutritional status of children with oncological diseases using reference methods of body composition analysis is of interest for optimizing nutritional support during and after cancer treatment. In this paper, we report the first clinical use of the deuterium dilution method for body composition assessment in childr...

Introduction. Bioelectrical impedance analysis (BIA) is an indirect method of body composition assessment. The equipment for BIA measurements is produced in many countries including Russia and may differ in electrical current frequencies, measurement schemes and built-in algorithms for the evaluation of body composition. In view of this, body compo...

Despite the presence of body composition studies in Russia, there are no current reviews on this topic, and the results are relatively rarely published abroad. Our aim was to describe the history and current state of this research work, to list unresolved problems, and to outline possible developmental trends. For completeness, in the initial part...

An empirical Benford's law which describes the probability of the appearance of certain first significant digits in many distributions taken from real life, is used to identify anomalies in various kinds of data. Our aim was to test Benford's law to assess the quality of mass preventive screening data on the example of bioelectrical impedance analy...

Extensive bioelectrical impedance analysis (BIA) data have the potential of health monitoring and the assessment of health risks at the population level. The importance of BIA data lies in their availability and abundance for many countries. In Russia, mass BIA data are generated by the national network of health centers (HCs). Our aim was to descr...

A comparative study of the calipers GPM (DKSH, Switzerland), Holtain (Holtain Ltd, Great Britain), the caliper designed by V.E. Deryabin, and the sliding caliper GPM (Martin type) was carried out by the four measurers. The study was conducted using a metal caliper checking gauge GPM, a ‘sandwiches’ of soft silicone rubber kSil™ GP250 (Silicon Engin...

In this work, current methodology and state of body composition studies in athletes are described. Computer science-related issues and prospects of body composition research are outlined, including that of data collection, comparability, utilization, and management.

Получены оценки изменений антропометрических показателей и состава тела кандидатов в сборную команду страны по водному поло в процессе 3-недельной тренировки в среднегорье, приведены модельные характеристики предстартовой готовности, дано сравнение с общей популяцией. Отобранные в стартовый состав сборной спортсмены отличались значимо более высокой...

Background & aims: Body mass index is a simple anthropometric measure (kg/m2) used as an indirect estimate of body fat in individuals, and in assessments of population health and comparisons between populations. Bioelectrical impedance analysis (BIA) is often used to provide additional information on body fat and fat-free mass, and has been used t...

Arguments are given in support of the hypothesis that the famous stone ships of Northern Europe are Christian medieval structures, owing their origin to the imperial rite of royal burial in ancient Egypt, Romea (Byzantium) and the Russia-Horde, being its symbolic reflection. Subsequently, the construction of stone ships became a local tradition of...

Background: Childhood exposure to organochlorines has been associated with alterations in somatic growth. We evaluated the associations of peri-pubertal serum levels of dioxin-like compounds (DLCs) and nondioxin-like polychlorinated biphenyls (NDL-PCBs), with adolescent growth, body composition, and near adult height (NAH) in a longitudinal cohort...

Using cross-sectional anthropometric data of 897 ethnically Russian individuals aged 16-61 years from the European part of Russia (Arkhangelsk, Moscow, and Samara), we checked the accuracy of our previously proposed bioimpedance-based formulae for the assessment of the endomorphy and mesomorphy ratings of the Heath-Carter somatotype, and suggested...

Краткое информационное сообщение о недавнем очередном международном симпозиуме по исследованиям состава тела in vivo (25-27 июня 2018 г., Медицинский центр Колумбийского университета, Нью-Йорк, США) и истории их проведения с библиографическими ссылками. Обозначены основные темы представленных докладов, а также некоторые актуальные вопросы и перспек...

В докладе рассмотрены элементы современной методологии исследований состава тела человека. Дана краткая характеристика возможностей и ограничений методов оценки состава тела, в том числе при их применении у спортсменов. Представлены некоторые результаты изучения состава тела у альпинистов и спортсменов-скалолазов.

Mathematical modeling of immunosenescence is the new area of research focused on quantitative analyses of factors and mechanisms involved in agingrelated changes developing in the immune system. The research methods in these area emerged at the interface of the immunology, gerontology, mathematics, and computer modeling. Mathematical modeling of im...

Презентация краткого обзорного доклада, посвящённого истории развития и применения импедансометрии в России. Основное внимание уделяется одной из разновидностей метода - биоимпедансному анализу состава тела.

Fundamental issues in various areas of bioimpedance application, such as impedance cardiography, electrical impedance tomography, and bioimpedance analysis of body composition and spectroscopy, require mathematical models. Highly inhomogeneous and anisotropic structure of the human body makes the numerical simulation of bioimpedance measurements th...

Презентация, основанная на материалах первого российского экспериментального сравнительного исследования различных типов калиперов (устройств для измерения кожно-жировых складок) отечественного и зарубежного производства.

Калиперометрия, или измерение толщины кожно-жировых складок на определённых участках тела, традици-онно используется в биологической и медицинской антропологии для характеристики подкожного жироотложения, оценки типа телосложения, состава тела и нутритивного статуса. Результаты калиперометрии зависят не только от техники измерений, но и от типа кал...

Presentation of the joint talk given at the 17th International Symposium on Mathematical and Computational Biology (BIOMAT-2017), see http://www.biomat.org/biomat2017/scientificprogramme2017.html

A prototype automated system for the analysis and processing raw data of mass population screening in the Russian health centers (HCs), software program HCViewer, is developed. In it, essential elements of big data, including data filtering (i.e., detection and removal of outliers and fraud cases), statistics and spatial visualization are implement...

Презентация доклада на конгрессе по физиотерапии, лечебной физкультуре и реабилитации, посвященного оценке состава тела и соматотипа по схеме Хит-Картера у детей, излеченных от онкологических заболеваний.

Обоснование. Единственным источником массовых данных антропометрии и состава тела детей и подростков в России является скрининговое обследование в центрах здоровья. Ранее была представлена обобщенная характеристика физического развития и состава тела населения по данным центров здоровья и опубликованы центильные таблицы изменчивости признаков, при...

На основании данных поперечного комплексного антропологического обследования выборки русского населения Восточной Сибири (3954 людей мужского и женского пола в возрасте от 16 до 86 лет) представлена характеристика половозрастных различий типов телосложения в конституциональной схеме Хит—Картера. Средние соматотипы в подгруппах русских мужчин и женщ...

Along with traditional anthropometric methods, various schemes of somatotyping and body composition assessment are used for the individual and population characteristics of physical development. Of them, the bioimpedance analysis (BIA) is the most common due to non-invasiveness, portability, relative reliability and ease of use. In our previous wor...

Статья опубликована в электронном ж-ле "Социальные аспекты здоровья населения" (2015, 46(6): 1): http://vestnik.mednet.ru/content/view/716/27/lang,ru/ Резюме. Актуальность темы. Национальная сеть центров здоровья представляет собой сложную распределённую систему, которая в постоянном режиме, начиная с 2010 года, генерирует массовые данные профилак...

Статья опубликована в электронном ж-ле "Социальные аспекты здоровья населения" (2015, 45(5): 1): http://vestnik.mednet.ru/content/view/706/27/lang,ru/ Актуальность темы. На сегодняшний день Федеральный информационный ресурс центров здоровья является единственным в России источником массовых данных углублённого профилактического скрининга. Цель ис...

Here, we report first results on the development of computational health information technology for monitoring chronic non-communicable diseases (NCDs) risks in Russia based on data of the large-scale ongoing population survey in Health Centers (HCs). The technology involve algorithms for automated raw data process and generation of joint database,...

The results of our cross-sectional bioimpedance study of children aged 7–17 years cured of cancer during follow-up (patients’ group, n = 552, remission time range 0–15 years) and of age-matched healthy controls (n = 1,500) show significant intergroup differences in body height and body composition parameters. The most pronounced alterations in the...

Resting energy expenditure (REE) by indirect calorimetry and body composition by bioimpedance analysis are studied in three groups of children aged 5–18 years. Group 1 (n = 181) – patients in remission of cancer, group 2 (n = 55) – children with oncology diseases receiving chemotherapy or who are in the early period after hematopoietic stem cell tr...

Here, we report first results of the large-scale ongoing bioelectrical impedance body composition study in Russians. By the end of 2012, 216 out of 800 Russian Health Centres submitted raw bioimpedance data on 844,221 adults and children aged 5–80 years, representing nearly 0.6% of the Russian population, who were accessed cross-sectionally using t...

In this work, an adaptive unstructured tetrahedral mesh generation technology is applied for simulation of segmental bioimpedance measurements using high-resolution whole-body model of the Visible Human Project man. Sensitivity field distributions for a conventional tetrapolar, as well as eight- and ten-electrode measurement configurations are obta...

Here, we describe the results of a cross-sectional bioimpedance study of body composition in 552 Russian children and adolescents aged 7-17 years in remission of various types of cancer (remission time 0-15 years, median 4 years). A sample of 1500 apparently healthy individuals of the same age interval was used for comparison. Our data show high fr...

A technology for high-resolution efficient numerical modelling of bioimpedance measurements is considered that includes 3D image segmentation, adaptive unstructured tetrahedral mesh generation, finite-element discretization, and analysis of simulation data. The first-order convergence of the proposed numerical methods on a series of unmatched meshes a...

Using ordinary differential equations, we propose a mathematical model describing an “averaged” dynamics of variables involved in which some parameters are shown to be important characteristics of lung resistance. The model consists of modified D.A. Lauffenburger’s mathematical model for inflammatory reaction in lungs, and the model of humoral immu...

Elevated degree of body fatness and changes in other body composition parameters are known to be common effects of treatment for acute lymphoblastic leukemia (ALL) in children. In order to study peculiarities of somatic growth and development in ALL survivors, we describe the results of BIA body composition analysis of 112 boys and 108 girls aged 5...

The proposed manual summarizes and systematizes advancements in anthropological and biophysical methods to study human body. Designed primarily for training and skills development of physical culture, sports medicine and fitness. Addressed to a wide audience, including undergraduate and graduate students of sports and pedagogical universities, spor...

This book focuses on theory and applications of bioelectric impedance analysis of human body composition. Essential physical, metrological aspects and measurement techniques, as well as capabilities of modern BIA equipment and software are considered. Data on variability of BIA body composition parameters in norm and disease are represented. A broa...

A scheme relating population genetics and TB epidemiology data in Russia is proposed. For this, a genetic susceptibility index is suggested based on relative risk estimates and published data on genetic polymorphisms of various ethnic groups. The index correlates well (r=0.746; p<0.05) with TB morbidity in genetically and geographically distant pop...

Mathematical modeling of immunosenescence is the new area of research emerging at the interface of the immunology, gerontology, and mathematics. In this paper we outline basic variables important for modeling aging immunity. We discuss the role of evolution in shaping pattern of aging in the immune system of modern humans. We investigate mathematic...

Comparative analysis of the results of low-resolution DNA typing in 80 patients with pulmonary tuberculosis and 300 healthy blood donors provided a basis for the description of HLA-DRB1 markers of hereditary predisposition to this disease. It was shown that DRB1*13 allelic group is associated with susceptibility to this pathology and DRB1*11 group...

We describe the results of anthropological study of healthy Russian children which included both anthropometry and bioimpedance analysis of body composition (n=946). The whole-body impedance was measured according to a conventional tetrapolar scheme using BIA analyzer ABC-01 "Medass" (SRC Medass, Russia). We report a normal ranges for phase angle a...

Книга посвящена развитию кибернетических моделей в геронтологии, описывающих согласованную динамику характеристик на различных уровнях организации. Эти модели позволяют прояснить молекулярно-генетическую и физиологическую основу наблюдаемых изменений динамики индивидуального и популяционного старения населения и могут быть использованы я исследован...

Modeling of t cell population development and estimation of resource allocation effectiveness S.G.Rudnev1, A.A.Romanyukha1, A.I.Yashin2 1Institute of Numerical Mathematics, Russian Academy of Sciences 2Center for Demographic Studies, Duke University, USA In this paper, the mathematical model of age-related changes in population of peripheral T cel...

In this paper, a recently developed mathematical model of age related changes in population of peripheral T cells (Romanyukha, Yashin, 2003) is used to describe ontogenetic changes of the immune system. The treatise is based on the assumption of linear dependence of antigen load from basal metabolic rate, which, in turn, depends on body mass follow...

In this book, we present an overview of the contemporary technologies and methods for the human body composition assessment in vivo. A range of their applications involves a spectrum of fundamental and applied biomedical problems, such as estimation of physical fitness on individual and population levels, diagnosis and treatment of obesity and oste...

In this paper, we analyze the structure of equations in the earlier proposed mathematical model of the dynamics of age-related changes in population of peripheral T lymphocytes. To investigate behavior of the model solutions in a wide range of values of variables we introduce a linear relation between the rate of T lymphocytes proliferation and the...

A VARIATIONAL PRINCIPLE FOR MODELING INFECTION IMMUNITY BY THE EXAMPLE OF PNEUMONIA A.A.Romanyukha, S.G.Rudnev • Institute for Numerical Mathematics, RAS The paper deals with investigation of general principles which regulate infection immunity depending on environmental factors. An approach is considered basing on the assumption that a relationshi...