Sergey Riumin

• Master of Science
• Biologist at Pavlov First Saint Petersburg State Medical University

Here we present a rare case of Fanconi anemia in a 31-year-old Syrian male patient at the early stage of MDS/AML transformation. His bone marrow cells showed 1q and 3q gains combined with severely sup- pressed TP53 gene expression, along with low WT1 and BAALC gene expression.

A discovery of nonrandom recurrent interstitial aberration at the long arm of chromosome 5 was made by Van den Berghe et al. in 1974. For a long time, this entity was classified as myelodysplastic syndrome (MDS). Meanwhile, its definition as well as classification criteria were repeatedly changed due to both clinical studies and advances in new tec...

Favorable prognostic significance of sole trisomy 8 and its associations with additional chromosome aberrations was confirmed in 7 adult and 3 pediatric patients with myelodysplastic syndromes treated with hematopoietic stem cell transplantation (HSCT). The group of comparison included 10 MDS patients with sole monosomy 7 or 5 chromosome and those...

An intriguing outcome of hybridisation is the emergence of clonally and hemiclonally reproducing hybrids, that can sustain, reproduce, and lead to the emergence of polyploid forms. However, the maintenance of diploid and polyploid hybrid complexes in natural populations remains unresolved. We selected water frogs from the Pelophylax esculentus comp...

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

In most organisms, cells typically maintain genome integrity, as radical genome reorganization leads to dramatic consequences. However, certain organisms, ranging from unicellular ciliates to vertebrates, are able to selectively eliminate specific parts of their genome during certain stages of development. Moreover, partial or complete elimination...