Sergey Pinyaev

• Phd
• Lecturer at Mordovia State University

When bacteria interact with red blood cells, the plasma membrane receives signals from the microorganism adhesins, and the functional work of the erythrocyte as a whole depends on the biomembrane phospholipid condition. However, the microorganism effect on the structural and functional properties of the red blood cell membrane, as well as on the he...

When bacteria interact with red blood cells, the plasma membrane receives signals from the microorganism adhesins, and the functional work of the erythrocyte as a whole depends on the biomembrane phospholipid condition. However, the microorganism effect on the structural and functional properties of the red blood cell membrane, as well as on the he...

It was shown recently that bacterial strains, which can act specifically against malignant cells, can be used efficiently in cancer therapy. Many appropriate bacterial strains are either pathogenic or invasive and there is a substantial shortage of methods with which to monitor in vivo the distribution of bacteria used in this way. Here, it is prop...

The paper considers the process of injury to peripheral nerve fibers and the possibility of influencing their regeneration through reactions mediated by interaction with receptors that activate signaling pathways. Pathways such as RAS/ERK, PI3K, PLC-γ, JAK-STAT, MAPK/ERK, JNK and p38MAPK are key in signal transduction through biochemical cascade re...

Morphological and functional characteristics of erythrocytes, hemoglobin, and erythropoietin level in the venous blood were evaluated by laser interference microscopy, Raman spectroscopy with a short-focus extreme aperture lens monochromator, and by ELISA, respectively, in 30 patients with verified moderate COVID-19 at the time of hospitalization a...

In this paper, the erythrocytes of healthy donors and people with a confirmed diagnosis of COVID-19 were tested by Raman spectroscopy and laser interference microscopy. We argue that erythrocytes (red blood cells) in COVID-19 patients have an irregular shape, and their morphometric characteristics are impaired in comparison to healthy red blood cel...

Recently, it has been shown that several bacterial strains can be very efficient in cancer treatment since they possess many important properties such as self-targeting, ease of detection, sensing and toxicity against tumors. However, there are only a few relevant candidates for such an approach, as targeting and detection one of the biggest challe...

Many nanomedicine approaches are struggling to reach high enough effectiveness in delivery if applied systemically. The perspective is sought to explore the clinical practices currently used for localized treatment. In this study, we combine in vivo targeting of carriers sensitive to the external magnetic field with clinically used endovascular del...

It has been shown that the intensification of oxidative processes is observed when somatic nerves of rats are damaged. Accumulation of malondialdehyde occurs, and the phase properties of the lipid bilayer change, especially in the distal part of the nerve. Under the same conditions, there are multidirectional changes in the activity of antioxidant...

It has been shown that in the somatic nerve’s lipids, both during excitation and transection, changes occur with the composition of individual phospholipids and in phospholipids fatty acids, which changes the phase state of the myelin and nerve fiber axolemma lipid bilayer. A main contribution in the nerve degenerative processes is dependent on the...

Nano- and microencapsulation has proven to be a useful technique for the construction of drug delivery vehicles for use in vascular medicine. However, the possibility of using these techniques within the lung as an inhalation delivery mechanism has not been previously considered. A critical element of particle delivery to the lung is the degree of...

Biodistribution of submicron vaterite particles in vivo during 72 h. Figure demonstrates in vivo fluorescence images of mouse’s whole body in two views (abdomen and back). Biodistribution after intratracheal instillation of (A) 0.65 μm, (B) 1.35 μm, (C) 3.15 μm size particles with adsorbed BSA-Cy7 conjugate and (D) free Cy7 dye.

Biodistribution in organs of submicron vaterite particles 72 h post-instillation ex vivo. Biodistribution of 0.65, 1.35, and 3.15 μm size particles adsorbed with BSA-Cy7 conjugate or BSA-Cy7 alone after 72 h (A) in the lungs, (B) in other organs. Data are expressed as mean value ± SD, n = 3 mice per group. ∗p < 0.05, ∗∗p < 0.01.

Normalized fluorescence intensity spectrum. The fluorescence peaks of the samples with a maximum at a frequency of 760 nm corresponds to a fluorescent Cy7 dye. The insets show the Cy7 molecular structure.

Lactoferrin (Lf) has considerable potential as a functional ingredient in food, cosmetic and pharmaceutical applications. However, the bioavailability of Lf is limited as it is susceptible to digestive enzymes in gastrointestinal tract. The shells comprising alternate layers of bovine serum albumin (BSA) and tannic acid (TA) were tested as Lf encap...

It has been established that nerve injury is accompanied by an increase in the content of lysophospholipids and an increased activity both Ca2 + - dependent and Ca2 + - independent phospholipase A2. The introduction of the drug enhances the regenerative processes in damaged nerve that is manifested in the restoration of orderliness of the membranes...