Sergey Kolesnikov

Sergey Kolesnikov
Russian Academy of Sciences | RAS · Sci Center Family Health and Human Reproduction Problems

professor,doctor of medical sciences, member of Russian Academy of Sciences

About

361
Publications
20,749
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718
Citations
Additional affiliations
September 2011 - present
Lomonosov Moscow State University
Position
  • Professor (Full)
Description
  • Social policy and health care policy
September 2005 - July 2010
Pirogov Russian National Research Medical University
Position
  • Professor (Full)
Description
  • Embryology and cell biology
October 2003 - July 2008
I.M. Sechenov First Moscow State Medical University
Position
  • Professor (Full)
Description
  • Legislation in the sphere of innovations
Education
August 1966 - July 1972

Publications

Publications (361)
Article
Pelvic venous disorder (PVD) in women is a polyetiological multifactorial disease characterized by a high prevalence (up to 80%), a high risk of infertility, and a progressive recurrent course. Morphological changes of the venous bed occur in PVD, contributing to retrograde blood flow and pelvic phlebohypertension. It is occur due to dynamic hyperv...
Article
The aim of this work was to study the levels of podocalyxin and β-2-microglobulin and parameters of lipid metabolism and carbonyl stress in type 1 diabetes mellitus (T1DM) patients with different levels of albuminuria. Materials and methods . 56 men of reproductive age with T1DM were divided into two groups: 24 patients with stage A1 albuminuria (g...
Article
The aim of our research was to assess the intensity of oxidative stress (OS) in children and adolescents with COVID-19 using the oxidative stress index (OSI). Methods and Results: The study was conducted between May 2020 and March 2021. The main group included 17 children and adolescents [8(47.1%) boys and 9(52.9%) girls; mean age of 12.35±4.01 ye...
Article
The aim of this research was to assess the level of lipid oxidation products level and the antioxidant defense state in young male patients with type 1 diabetes mellitus (T1DM) depending on the disease duration. Materials and Methods: A total of 57 men of young reproductive age (average age of 30.25±8.51 years) with T1DM and an unsatisfactory glyce...
Article
The study involved 271 patients (132 men and 139 women) with moderate COVID-19. Superoxide dismutase (SOD) activity in erythrocytes was measured spectrophotometrically. In total group of patients (divided into age groups of 18-35, 36-45, 46-60, and 61-90 years), higher SOD activity was found in the 18-35 age group in comparison with the groups 46-6...
Article
The SARS-CoV-2 pandemic has brought serious economic and social problems worldwide'. Due to its medical consequences, it is of importance to study the mechanisms of the disease and new therapeutic interventions, as well as rehabilitation processes. Despite the fact that the genome of the new coronavirus has been sequenced and studied, clinical and...
Book
Full-text available
ANNOTATION: The monograph is devoted to the comorbidity of one of the most common non-communicable diseases in the world - arterial hypertension and periodontitis. The probable pathophysiological mechanisms of association between these diseases have been disclosed. Based on the data of our own research and analysis of modern historical and foreign...
Article
Full-text available
BACKGROUND: Diabetic nephropathy is a specific kidney damage that affects up to 40% of type 1 diabetes mellitus patients. There is still insufficient knowledge about oxidative stress at the different levels of albuminuria.AIM: To assess the indicators of oxidative damage to lipids, DNA and antioxidant defense in men with type 1 diabetes mellitus an...
Book
Full-text available
The book is devoted to the actual problem of studying the influence of various modes of stress exposure (as a pathogenetic factor of arterial hypertension) on the components of the lipoperoxidation system and morphological change of tissues of the dentition in the experiment and clinic. Provides own research results of the system "lipid peroxidatio...
Article
Full-text available
Background .Heat shock effects can initiate apoptosis of oocytes and corpus luteum cells in mammalian ovaries. During folliculogenesis, follicular apoptosis is regulated by Bcl-2 and BAX proteins which are key effectors of granular cell death. Mechanisms of disruption of the ovarian corpus luteum development under heat stress remain largely unclear...
Article
Full-text available
The aim of this research was to evaluate the integral oxidative stress index (OSI) level in Asian girls and boys with exogenous-constitutional obesity. Methods and Results: A total of 170 Asian adolescents aged 12-18 years were examined: 26 girls and 28 boys with constitutional obesity (main group, MG); 59 girls and 57 boys - healthy adolescents (c...
Article
Obstructive jaundice caused by cholangiocarcinoma takes a special place among malignant disorders and surgical pathology in Russia. Involvement of nonspecific immunity and the role of neutrophils in carcinogenesis are ambiguously evaluated. The aim of this study was to study functional activity of peripheral blood neutrophilic granulocytes and thei...
Article
The aim of this cross-sectional observational study is to determine the contribution of polymorphisms of energy metabolism genes into metabolic disorders in Russian and Buryat adolescents with overweight and obesity. The study included 354 Russian and Buryat adolescents aged 13-18 years. Body mass index and serum levels of glucose, insulin, and lep...
Article
Full-text available
Boron neutron capture therapy (BNCT) can become an instrument for patients with malignant neoplasms of the rectum and colon. Here we evaluate the effectiveness of BNCT performed at the accelerator based epithermal neutron source at G. I. Budker Institute of Nuclear Physics, Siberian Division of Russian Academy of Sciences, in relation to subcutaneo...
Article
Objective. To reveal changes in lipid peroxidation parameters and antioxidant protection components against the background of standard non-pharmacological therapy for exogenous constitutional obesity in adolescents of different sex. Patients and methods. Forty-six adolescents aged 12–17 years with obesity were examined before and after non-pharmaco...
Article
Objective: To evaluate a relative telomere length in patients with obstructive sleep apnea (OSA) before and after a 6-month course of continuous positive airway pressure (CPAP) therapy. Material and methods: Seventy-five men participated in the study, including 50 men with OSA (the main group 1) and 25 men without OSA (the control group). The av...
Article
This article is devoted to the study of the features of the dynamics of speech function (using associative activity as an example) in the circadian cycle of children and adolescents with hypertension (HTN). The research aims to distinguish between various approaches to teaching them. All participants were divided into the following two groups: the...
Article
Pelvic venous insufficiency (PVI) in women is widespread and is closely associated with the risk of reproductive disorders (in 15–25% of patients) and a high rate of the disease recurrence after treatment. The factors involved in venous wall damage include atherogenic stimuli and chronic endotoxin aggression due to inflammatory processes. The chang...
Article
Full-text available
Background. The COVID-19 pandemic has raised the importance of this problem to the first stage and has affected healthcare system around the world. Despite the more favorable COVID-19 course, the child population should be at focus of special attention, due to the active participation in its distribution. The course of COVID-19 includes a cascade o...
Article
Obstructive jaundice (OJ) is the most common syndrome among diseases of the hepatopancreatoduodenal region and is found in 12-45% of cases. OJ may be benign and malignant etiology. Despite the evidence of the participation of bilirubin in reducing the bactericidal properties of neutrophils, there are no data currently on changes in the functioning...
Article
The relevance of studies related to the features of respiratory disorders during sleep is undeniable due to the steady growth of the worldwide prevalence of apnea syndrome, which leads to a decrease in quality of life, the risk of early cardiovascular diseases together with cerebrovascular, endocrine, and pulmonary disorders. The aim of this study...
Article
We analyze results of recent studies demonstrating unfavorable state of the reproductive health in the male population that manifested not only in spermatogenesis deterioration, but also in oxidative stress (both systemic and in seminal fluid). The data on the effect of ROS and components of the antioxidant defense system on gamete quality in men w...
Article
Serum serotonin levels were determined by HPLC in 30 patients with diagnosed obstructive sleep apnea syndrome before and after 3-month course of PAP-therapy and in 14 subjects without obstructive sleep apnea symptoms. It was found that elimination of hypoxic conditions was associated with an increase in serotonin level. The results demonstrate the...
Article
The content of carbonyl compounds (methylglyoxal and TBA-reactive substances) and components of the glutathione system (activities of glutathione-dependent enzymes, content of oxidized and reduced glutathione) and their interrelationships were studied in men of young reproductive age with type 1 diabetes mellitus at the stages of normo- and microal...
Conference Paper
Full-text available
to analyze the state of lipid metabolism and antioxidant status in Mongoloid girls with obesity Studies were conducted in 22 girls (mean age – 15.06±1.53 years) with the first degree exogenously constitutional obesity of and in 48 girls of control group (mean age – 14.25±2.42 years). All girls by ethnicity were Mongoloids. Lipid components (total c...
Conference Paper
To study lipid peroxidation and periodontal tissues regional blood flow parameters in adolescents with arterial hypertension and periodontal diseases 94 adolescents group with arterial hypertension (AH) and periodontal disease (n=57, mean age of 14.7±1.89 years) and a group without AH and with periodontal disease (n=37, mean age of 14.57±2.01 years...
Article
We performed comparative analysis of 8-hydroxy-2'-deoxyguanosine in women in different climax stages with and without insomnia. The study involved 90 women aged 45 to 60 years divided into perimenopausal (n=30) and postmenopausal (n=60) groups. After questioning using special sleep questionnaires (Insomnia Severity Index, Epworth Sleepiness Scale,...
Article
Introduction: Mechanical jaundice (MJ) or bile duct blockage occurs when the bile ducts' patency is impaired, and the bile flow has stopped. One of the main pathogenetic factors developing complications with MJ is immune system imbalance, particularly its phagocytic link. The purpose of the study was to understand neutrophils' functional activity d...
Article
The review presents modern views about the role of oxidative stress reactions in the pathogenesis of types 1 and 2 diabetes mellitus and their complications based on the analysis of experimental and clinical studies. The sources of increased ROS generation in diabetes are specified, including the main pathways of altered glucose metabolism, oxidati...
Book
Full-text available
Palliative care as an area of interdisciplinary interaction. From theory to practice. Book. Authors: Grigorieva N.S., Kolesnikov S.I., Chubarova T.V. , 2021, URSS. LENAND PA, Moscow, 400 pages. ISBN: 978-5-9710-8734-2 Annotation: In the monograph palliative care is analyzed from the point of view of an interdisciplinary approach, with the authors...
Article
Full-text available
Aim. To assess the state of the ‘lipid peroxidation – antioxidant defense’ system using an integral indicator (coefficient of oxidative stress) in women with ovarian hyperandrogenism in various periods of reproductive age.Materials and methods. During an annual preventive medical examination at the Scientific Сentre for Family Health and Human Repr...
Article
The processes of free radical lipid oxidation were studied in 47 patients with moderate to severe obstructive sleep apnea syndrome before and after 1-month course of CPAP-therapy (continuous positive airway pressure). The control group consisted of 13 people without clinically confirmed apnea. The material for the study was serum, blood plasma, and...
Article
Expression of proapoptotic Bad and antiapoptotic Bcl-2 proteins in ovarian follicular apparatus of Wistar rats was evaluated on days 3, 7, and 14 after single experimental hyperthermia (EH) followed by therapeutic correction with subcutaneous melatonin (0.1 mg) dissolved in 0.2 ml physiological saline (PS) injected daily for 3 days. Duration of EH...
Article
Full-text available
The study of adolescent obesity and pathogenic factors of its development is getting more and more important as the disease aggravates in adulthood. The serious progress in the study of the pathogenesis of this process can be achieved by analyzing the molecular mechanisms of the obesity development in childhood and adolescence. An individual approa...
Chapter
Full-text available
The history of active worldwide scientific research on mechanisms of aging and the age-associated diseases counts more than five decades. Of these, among the numerous theories of aging, at least 50 years dominated the free radical theory of aging. Since mitochondria were found to be the major producers of free radicals, the research on aging became...
Article
The spread of a new strain of coronavirus, SARS-CoV-2, a pandemic poses serious health problem for all humanity. In comparison with the previous outbreaks of coronavirus infection in 2002 and 2012, COVID-19 infection has high rates of lethality, contagiousness and comorbidity. The effective methods of prevention and treatment are extremely limited....
Article
We studied changes in LPO processes and antioxidant protection system in women with ovarian hyperandrogenism at various periods of reproductive age 18-45 years. An age-related decrease in total antioxidant activity and accumulation of secondary LPO products, ketodiens and coupled trienes, were found; these changes were accompanied by an increase in...
Article
Modern views about pathogenetic role of oxidative stress reactions in types 1 and 2 diabetes mellitus (DM) genesis and their complications are presented, based on the analysis of experimental and clinical studies. The sources of increased generation of reactive oxygen species in diabetes are specified, including not only the six main pathways of al...
Article
Age-dependent diseases high social burden makes relevant medical technologies development and implementation of human aging process functional state various disorders prenosological diagnosis, treatment and prevention. Age-related activity decrease of the brain functional state and its interdependence with the sleep-wake continuum leads to prematur...
Article
Full-text available
In various pathological conditions such as diabetes mellitus, the cellular redox balance can be disturbed and these alterations may persist even after blood glucose levels have returned to normal. Antioxidant therapies, including α-lipoic acid, are widely used to treat various systemic diseases including diabetes mellitus. The aim of this study was...
Article
Full-text available
Lipid profile comparative analysis was performed to reveal the interdependence of lipids with Circadian locomoter output cycles protein kaput (CLOCK) 3111T/C gene polymorphism in menopausal women with/without a body mass index (BMI) of ≥25 kg/m2. Methods: A total of 193 female volunteers aged 45 to 60 years were divided into two groups: Those with...
Article
Full-text available
Background: The aim of this study was to assess the dependence of advanced oxidation protein products (AOPPs) levels on the genotype of the CLOCK 3111T/C SNP in Caucasian menopausal women with and without insomnia. Methods and Results: The study involved 105 Caucasian menopausal women volunteers aged between 45 and 60 years. The Pittsburgh Sleep Qu...
Article
Background: The aim of this study was to estimate the blood levels of interleukins (ILs) and tissue factor (TF) in rat blood when modeling acute mesenteric ischemia (AMI) in various stages and during reperfusion. Methods and Results: The study was performed on white non-linear male rats, weighing 200±25g. AMI was simulated by ligating the cranial m...
Article
The aim of our study was to identify the changes in the indicators of lipid peroxidation (LPO) and antioxidant defense (AOD) in women with endocrine infertility. Methods and Results: The study included 358 women of reproductive age. Based on clinical and laboratory data, two groups were formed: the control group (CG) and the main group (MG). CG con...
Article
Full-text available
Introduction — Nocturnal intermittent hypoxia in obstructive sleep apnea (OSA) causes cellular stress and consequent change in inducible heat shock protein 70 (HSP70) level. Thus, the objective of this study was to determine the relationship among nocturnal hypoxia and the serum HSP70 level in patients with severe OSA. Material and Methods — The s...
Article
We evaluated the protective effect of ademetionine, cytoflavin, and dihydroquercetin on activity of serum enzymes in rats treated with high doses of sodium valproate for 28 days. Ademetionine and cytoflavin produced the greatest protective effect, the effect of dihydroquercetin was less pronounced. In rats treated with ademetionine, AST activity de...
Article
Background: Despite the active study of the main pathogenetic mechanisms of benign breast diseases, there is still insufficient information on the lipid peroxidation – antioxidant defense processes activity in women with diffuse mastopathy in the course of menstrual cycle. Such knowledge is necessary for the early detection and prevention of hyperp...
Article
Background: Our previous study of the lipid peroxidation and antioxidant defense system (LPO-AOS) state in women with chronic viral hepatitis (CVH) showed the content of fat-soluble vitamin alpha tocopherol significant reduction. Reproductive health of women with CVH needs special attention. The objectives of this study was to determine the frequen...
Article
Full-text available
The emergence of viral respiratory pathogens with high pandemic potential, such as the SARS-CoV-2, poses a serious public health problem, with a very limited arsenal of effective tools and techniques to prevent and treat a new pandemic infection. The literature on the involvement of reactive oxygen species in the pathogenesis of coronavirus infecti...
Article
We performed comparative analysis of hemodynamic in the periodontal microcirculatory bed in adolescents with arterial hypertension (AH) and morphological changes in the periodontal tissues of in hypertensive ISIAH rats of comparable biological age. In the periodontal tissues of adolescents with hypertension, the blood flow velocity and index of per...