Sergey Karpishchenko

Pavlov First Saint Petersburg State Medical University · ENT Department

Objective: to compare the effectiveness of intravenous β-blockers (BAB) metoprolol and esmolol during general combined anesthesia to reduce intraoperative bleeding in functional endoscopic sinus surgery. Material and methods. A total of 112 patients were included in a single-center prospective cohort study. Functional endoscopic sinus surgical (FES...

Introduction. Rhinosinusitis, along with adenoiditis, holds leading positions in terms of incidence among adults and children. About 10 million cases of rhinosinusitis per year are reported in Russia. Aim. To study the effectiveness and safety of secretolytic drugs in the treatment of acute rhinosinusitis in different groups of patients, features o...

Introduction. Endoscopic rhinosinus surgery stands out for its reduced complications and marked symptomatic improvement compared to open surgical approaches. However, local bleeding challenges may compromise the efficacy of minimally invasive procedures. Exploring terlipressin’s application in endoscopic rhinosinus surgery is a promising avenue, gi...

ilateral laryngeal paralysis is associated with an increased mortality and impairment in the quality of life. The primary treatment goal for all types of paralytic stenosis is to restore adequate breathing. The first surgical step for adult patients with paralytic stenosis is endoscopic laryngeal interventions to restore the airway lumen. The first...

Mucocele is a cystic distension of the walls of the paranasal sinuses. Persistent obstruction of the natural sinus passages due to a variety of reasons (trauma, allergic edema, etc.) contributes to the development of this condition. Mucoceles can develop in any paranasal sinus, occurring more frequently in the frontal sinus, followed by the sphenoi...

Snoring is a sound phenomenon that is often a symptom of more serious condition – OSAS (obstructive sleep apnea syndrome). All patients with complaints of nocturnal snoring, daytime sleepiness, breathing stops in sleep, in addition to the standard otorhinolaryngological examination at the initial consultation should be diagnosed using validated que...

INTRODUCTION . Isolated sphenoid sinus disease is a rare condition due to the topographic location of the sinus. In complicated cases and the occurrence of a chronic course, the main method of treatment is surgical cure. There are different approaches to the main sinus, the most effective and safest is endoscopic endonasal sphenotomy. However, in c...

ENT diseases are one of the most common reasons for visiting a doctor, especially in paediatric practice. The issue of interdisciplinary interactions between otorhinolaryngologists and paediatricians, their consistency in choosing therapy is extremely important. About 90% of morbidity rates relate to acute infectious respiratory viral etiology, whi...

Objective: The study was performed to assess the endoscopic state of the nasal mucosa after the use of local anti-inflammatory and antibacterial therapy, in particular, Polydexa nasal spray with phenylephrine containing Dexamethasone sodium metasulfobenzoate + Neomycin + Polymyxin B + Phenylephrine, and for the treatment of granulomatosis with pol...

The aim of the study was to identify the features of diagnosis and treatment of sphenoid sinus diseases in patients over 60 years old. Clinical manifestations, results of endoscopic and radiological examination methods, and surgical intervention tactics were compared between elderly patients and younger patients (aged 18–59 years) who sought treatm...

This article presents a rare clinical case of a newly diagnosed carcinoma of the nasal cavity in a young woman. The clinical symptoms of this disease are scarce, complaints are typical for most diseases of the ENT organs. The final verification of the diagnosis is possible on the basis of histological examination of the surgical material.

ARVI is the most common children infection: children aged 0–5 years suffer, on average, 6–8 episodes of ARVI per year; and in the 1–2 years of visiting kindergarten the incidence rate is higher for 10–15% than in unorganized children, and at school the latter get sick more often. The incidence of ARVI is the highest in the period from September to...

The article presents various types of acute rhinosinusitis progression in pediatric practice depending on the duration of the disease, based on the available modern consensus papers and clinical guidelines. The main clinical terminology of the nosological forms of rhinosinusitis was determined, and aspects of their differential diagnosis and stages...

Population aging, increasing in duration of active life dictate to keep the level of health and create conditions for prolongation and preservation of ability to work. An otorhinolaryngologist often has to deal with age-related changes occurring in the nasal cavity and paranasal sinuses. The study of age-related features occurring in the nasal cavi...

Cystic lesions of the maxillary sinuses include cysts, polyps and neoplasms. Maxillary sinus cysts are benign lesions that are commonly an incidental finding during X–ray, since any symptoms do not accompany their presence. An urgent problem is the development of differential diagnostics, the determination of indications for surgical treatment and...

Introduction. Clinical manifestations of rhinitis have a negative impact not only on the physical, social, and psychological health of children, but also on their parents, especially in families with a first child. Nasal congestion, nasal breathing difficulty cause problems with sleep and feeding. Aim of the study. To estimate the occurrence of rhi...

The purpose of this study was to analyze results of simultaneous septoplasty and functional endoscopic sinus surgery in children. The study included 341 children who underwent endoscopic functional sinus surgery. The average age of patients was 11.2 ± 0.4 years. The follow – up period was 33.06 ± 6.9 months. Endoscopic septoplasty was performed sim...

After septoplasty procedure and removing of nasal packing, numerous symptoms usually appear that result from inflammation. Objective: To evaluate the effect of nasal spray Polydexa with phenylephrine on the postoperative period and bacterial contamination in the nasal cavity after septoplasty and inferior turbinectomy. Material and methods: The...

Objective: To evaluate the thermal effects of a 970 nm diode laser and select the modes necessary for the safe and effective use of this laser to reduce the nasal septum elevation (NSB) in volume in vitro. Material and methods: Laser exposure was carried out through a quartz fiber with a diameter of 400 μm in a continuous contact mode at a power...

Cystic fibrosis is genetic multisystem disorder with a predominant lesion of the respiratory tract. The duration and quality of life of these patients depends on the state of respiratory function. Progressive lung dysfunction is still the leading cause of mortality patients with cystic fibrosis. End-stage lung diseases in patients with cystic fibro...

The article presents the results of studying the features of the endoscopic picture of acute rhinosinusitis in patients with anemia and neutropenia, who underwent hematopoietic stem cell transplantation (HSCT). The questions of the influence of the level of hemoglobin on the presence of hyperemia of the mucous membrane of the nasal cavity, as well...

This article presents clinical case of external auditory canal osteoma and postoperative management of this patients. In this publication the etiology of this pathology, as well as the clinical manifestations that accompany this pathological condition are described. We present a literature review and our own experience of treatment this group of pa...

The article presents the results of a study of the prevalence of acute (exacerbation of chronic) otorhinolaryngological pathology at the stages of hematopoietic stem cell transplantation (HSCT). The frequency of the studied pathology was assessed at the stage of pre-transplant screening, at the stage before graft engraftment and at the stage after...

In the presence of a paradoxically curved middle nasal turbinate, treatment tactics may be different. To achieve the best effect in the treatment of chronic rhinosinusitis, in some cases, a complete resection of the middle nasal turbinate is performed. However, in this group of patients in the postoperative period, complaints may appear from the qu...

Sore throat is a common complaint among children and adults. In addition to infection, causes of sore throat include non-infectious pathological conditions. Among possible causes are viruses, bacteria, fungal flora. Identification of etiology significantly affects the disease management. The prescription of systemic antimicrobial agents is justifie...

Tonsillopharyngitis is a common disease among pediatric patients. Visits associated with sore throat account for 6 to 8% of all visits to pediatricians and general practitioners. Tonsillopharyngitis can have both infectious and non-infectious etiologies. In pediatric practice, most cases of upper respiratory tract infections are of viral origin, es...

The main idea of our manuscript is prevention of frontal recess stenosis after endoscopic endonasal frontal sinus surgery and septoplasty during to acute and chronic frontal sinuses pathology. Purpose: To offer an effective method to prevent postoperative frontal recess stenosis after endoscopic endonasal frontal sinus surgery and surgical correc...

The purpose of the work: Is to study the efficacy of treatment of exacerbation of chronic tubotympanic purulent otitis media with Otofa drug with the active substance Rifamycin. Material and methods: Performed a retrospective analysis of 37 medical histories of patients who applied to the otorhinolaryngology clinic with a diagnosis of exacerbati...

The experience of performing bilateral tonsillectomy under general anesthesia for two patients with a transplanted kidney receiving immunosuppressive therapy is presented. In both patients after surgery, pain and inflammatory changes in the postsurgery wound were minimal. However, in the postsurgery period, infection was observed in patients, this...

This article presents the clinical case of a woman aged 61 years with massive bilateral synechial obstruction of the nasal cavity after anterior tamponade with clinical manifestations in the form of a significant deterioration in nasal breathing, nasal congestion, postnasal nasal congestion and recurrent sinusitis. The stages of diagnosis of pathol...

This review article attempts to systematize and summarize the data on the major age-related pathophysiological, biomechanical, and histological processes that contribute to the progression of nasal breathing impairment or the appearance of these symptoms in elderly patients. The specifics of risk assessment of deviated septum surgery using various...

The aim of our work was the experimental development of the optimal laser radiation regime (laser wavelength 980 nm) for dissecting scars of the upper respiratory tract in terms of lateral thermal damage to surrounding tissues. Thermal damage is of fundamental importance when exposed to scar tissue, since it leads to inflammation in the dissection...

This article reviews current surgical techniques for a deviated septum and, in particular, focuses on the comparison of conventional and endoscopic approaches to septoplasty. Relevant issues of the anatomy and physiology of the nasal septum affecting the course of the comorbidities of the nasal cavity and the surrounding structures are discussed. T...

The aim: To characterize methods of extraction of foreign bodies of maxillary sinuses, features of postoperative treatment of patients. Material and methods: The experience of treatment of patients with maxillary sinuses foreign bodies in the clinic of ENT of PFSMU of St.Petersburg is presented. In 2019 124 patients undergo treatment of maxillar...

Endoscopic endonasal dacryocystorhinostomy (EN-DCR) is a modern and effective method for the surgical treatment of distal part obstruction of lacrimal pathway. Unsuccessful outcome and dacryocystitis relapses may be associated with concomitant rhinological pathology. Deviation of the nasal septum in the surgical area can affect the operation and co...

Introduction: The main aim of the work was to describe a rare clinical case of osteoma of inferior turbinate. The interest of the case is that such tumors are extremely rare. Results: A female patient of 63 years old attended an ENT clinic. She complained on absence of nasal breath at the right side and headache. After a full ENT-examination, an...

The current state of the patients’ management with nasal polyposis and allergic rhinitis has become the basis for a deep analysis of the currently available data on the prevalence of diseases (with a focus on severe forms), as well, available possibilities and disadvantages of conservative therapy are considered. The approaches to assessing the sev...

Septoplasty is one of the three most frequently performed operations in otorhinolaryngology. The history of the development has more than 200 years. The research and analysis of the features of different methods of this surgical treatment does not lose interest to this day. The article presents an analysis of the restoration of the functions of the...

Pott's puffy tumor (PPT) is a frontal subperiosteal abscess associated with underlying frontal bone osteomyelitis. It is most common among children and adolescents. Trauma and recurrent sinusitis may be the trigger factors for the abscess formation. The main causative pathogens belong to the groups of streptococci, staphylococci and anaerobes. In t...

Currently, the pathology of the nasal cavity and paranasal sinuses is an urgent public health problem. Rhinosinusitis is one of the leading causes of patients seeking medical attention. In addition to traditional anti-inflammatory, antibacterial, decongestant and antihistamine therapy, agents with mucolytic properties are widely used. The basis of...

The problem of allergic rhinosinusopathies is one of the most pressing in modern rhinology. It has drawn the attention of clinicians for several decades. Allergic rhinitis is a common disease, the onset of which often come in early childhood. In later life, this disease significantly reduces the quality of life. The widespread prevalence of allergi...

This article describes the mechanism of action of topical decongestants from the perspective of their efficient and safe use in paediatric otorhinolaryngology. It also presents the structure of the most common nosologies in the outpatient unit of otorhinolaryngological practice.

The purpose of the work was to study the sinusitis diagnostic and clinical features in pregnant women. The pregnant women group (27 human) with sinusitis from 816 pregnant women with nasal congestion and/or nasal discharge was analyzed. The examination included: taking anamnesis, ENT examining, clinical blood test. The frequency of sinusitis in pre...

Introduction: Allogenic transplantation of hemopoetic stem cells (allo-THSC) is one of the most effective treatment methods for Hurler syndrome, aimed at maximal correction of complications related to the genetic disorder. Presence of infection in the recipient is an adverse risk factor, affecting the possibility of starting the conditioning regim...

Introduction: Despite the large number of studies and clinical observations on timely analgesia in the postoperative period, there are no clearly formulated views on the nature of the pain syndrome, and there are no modern protocols for the treatment of pain after tonsillectomy. Purpose: The purpose of the study was to identify the effect of a h...

Antrochoanal polyps (ACP) are benign tumors, mainly originating from the maxillary sinus. The incidence in children is high – up to 35% of all chronic polypous rhinosinusitis. Endoscopic examination of the nasal cavity and computed tomography of the paranasal sinuses (PS CT) are generally used for ACP diagnostics. The medical treatment of ACP is de...

Today, in domestic and foreign literature, there exist numerous works related to hearing improvement in the post-surgical period and the reduction of the bone-air gap, which has proven rather high efficacy of such otosclerosis treatment method as piston stapedoplasty. However, little attention has been paid to the problem of the inner air structure...

Sore throat is one of the most common complaints faced by doctors of various specialties. This symptom accompanies many diseases of the pharynx and larynx, and may be a manifestation of certain diseases that are not associated with the respiratory tract. When choosing therapy, it is necessary by doctors to rationally use the criteria for the appoin...

Maxillary sinus foreign bodies are interrelated with different types of treatment of pathologies of teeth of the maxilla. Foreign bodies can be presented by pins, sillers, impression materials, teeth, dental implants etc. Features of anatomical development of maxilla, degree of pneumatization of it and many other factors promote hit of the foreign...

Congenital atresia of the choanas (CVC) is a violation of the patency of the nasal cavity associated with its complete or partial infection of the connective, cartilage or bone tissue. CVC is a consequence of the preservation of the nasal palatine membrane, which occurs between the 6th and 12th weeks of gestation, due to the approach and successive...

Introduction: Sinusitis is one of the most common infectious complications at the stages of hematopoietic stem cell transplantation. Diagnosis and treatment patients whith cytopenia often causes difficulties for otorhinolaryngologists. Objective: To analyze the possibility of puncture of the maxillary sinuses in patients whith cytopenia after hemop...

The authors analyzed computer models of air currents in the nasal cavity and maxillary sinus after surgical interventions, and was used by computational fluid dynamics (CFD). The aim of the work is to simulate air flows in the nasal cavity and maxillary sinus in the norm, after endoscopic infundibulum opening and after endoscopic maxillary sinus su...

Septal deviations may obstruct nasal breathing at the deformation side and trigger the development of pathological process in the nasal cavity and paranasal sinuses. Therefore, it becomes necessary to perform a complex of surgical interventions on the nasal cavity structures to restore the lost functions and to eliminate the pathological process in...

The nasal swell body (NSB) is a structure in the form of mucosa thickening from the nasal cavity bottom up to the middle nasal concha. The septal swell body was first described by Wustrow in the 17th century, he indicated it as an “intumescentia septi nasi anterior”; later, in 1900, P. Schiefferdecker studied the vasculature of the first third of t...

Functional endoscopic sinus surgery (FESS) is an effective and safe surgical technique, which revolutionized the surgical management of nasal cavity and paranasal sinus diseases. The intimate connection between paranasal sinuses and the orbit places the orbital content at a risk of injury during sinus surgery, especially that of ethmoid sinuses. Th...

The objective of the present work was to evaluate the effectiveness of the combination of azelastine hydrochloride and mometasone furoate for the intranasal application to treat the patients presenting with seasonal allergic rhinitis. A total of 60 subjects suffering from seasonal allergic rhinitis were available for the observation. All the patien...

Problem: A 49-year-old man presented with a median palatine cyst, as an incidental finding in a work-up of vision disturbance, due to a cyst in the sphenoid sinus. Methodology: The median palatine cyst was removed with a diode laser in the contact mode under endoscopic vision; forceps were used to remove the sphenoid sinus cyst. Results: Follo...

The application of a diode laser is becoming more common in the present-day medicine. The use of this type of laser in various fields of medicine is stipulated by its biological effect that depends on the laser wavelength, power and operation mode. In the literature sources we found enough information about the use of CO2, erbium, holmium laser for...

Dacryocystorhinostomy (DCRS) performed with a variety of surgical approaches is the most common surgical procedure aimed at restoring the tear outflow. However, regardless of the chosen method, surgery sometimes provides only temporary effect and requires re-intervention (revision). This article presents the analysis of clinical observation of a ca...

Aim: This multicenter study was focused on the identification of the microorganisms inhabiting the maxillary sinus and middle nasal meatus in chronic rhinosinusitis. Methodology: 112 middle meatus swabs and 112 maxillary sinus aspirates from 103 patients were available for culture. Results: A total of 244 strains of microorganisms representing more...

The authors present the results and describe the methods of the experimental studies aimed at the evaluation of the biological effects of laser-assisted treatment of ENT pathologies at the wavelengths of 810 nm, 980 nm, and 1470 nm in comparison with the results obtained with the use of a radiofrequency scalpel in biological tissues having differen...

The objective of the present study was to improve the procedures for extended and restricted laser-assisted laryngoplasty in the patients presenting withparalytic laryngeal stenosis and to evaluate the outcome of the surgical interventionsdiffering in extent. The study included 51 patients (47 women and 4 men) at the age varying from 18 to 78 years...

This article is designed to report the results of the analysis ofacademic, scientific, and clinical activities of the Department of Otorhinolaryngology of the I.P. Pavlov Saint-Peterburg First State Medical University.

This article was designed to summarize the experience gained withendoscopic endonasal removal of paranasal sinus osteomas during the period from January 2013 till February 2016. In addition a review of the relevant literature is presented encompassing the publicationsthat provide information about etiology, pathogenesis, clinical picture, diagnosti...

The objective of the present study was to analyze the potential of cone beam computed tomography of the temporal bones in the patients presenting with otosclerosis for the detection of surgically significant specific structural features of the labyrinth wall of the tympanic cavity. More than 400 tomograms of the temporal bones were obtained with th...

The objective of the present study was to analyze and summarize the literature publications concerning tonsillitis and related (tonsillogenic) pathological conditions. The retrospective analysis of these materials made it possible to collect and summarize information about the influence of palatine tonsillar pathology (chronic tonsillitis) on the f...

Aim: This multicenter study was focused on the identification of the microorganisms inhabiting the maxillary sinus and middle nasal meatus in chronic rhinosinusitis. Methodology: 112 middle meatus swabs and 112 maxillary sinus aspirates from 103 patients were available for culture. Results: A total of 244 strains of microorganisms representing...

Problem: A 25-year-old man presented with a large osteoma in the right ethmoidal sinus. Methodology: The osteoma was removed by an endoscopic endonasal approach with a curved diamond drill and an electromagnetic navigation system. Result: Computed tomography 3 days after surgery showed complete removal of the osteoma and normal position of the...

The objective of the present work was to study the possibility and technical peculiarities of planned tracheotomy in the hematological patients with thrombocytopenia and coagulopathy suffering severe concomitant pathology. A total of 45 tracheotomies were performed in hematological patients during the period from 2009 till July 2012. The case histo...

Zeneker's diverticulum (pharyngeal diverticulum) is a pathological sac-like protrusion of the mucous membrane at the posterior nasopharyngeal wall. Surgical operation is the principal method for the treatment of this rather rare disease. In the present paper, two cases of its successful management by means of laser-assisted endoscopic diverticuloto...

A case of successful endoscopic correction of grade II laryngeal stenosis under general anesthesia and respiratory support is reported. High-frequency jet ventilation of the lungs was accomplished through a transtracheally introduced catheter.

The problem of recurrent respiratory papillomatosis (RRP) thus far remains unresolved despite a large number of surgical and conservative methods proposed to address it. Photodynamic therapy is an up-to-date tool for the treatment of various neoplasms based on the interaction between the light and a photosensitizing agent (PA) that gives rise to ac...