Sergey Albertin

• Senior Researcher at Pavlov Institute of Physiology of the Russian Academy of Sciences

This article discusses the neurophysiological mechanisms underlying the spatiotemporal integration of different brain structures and the physiological systems of the body on performance of different types of motivated goal-oriented behavior.

Experiments on rats were carried out to study the effects of fragmentation of visual navigation signals on search behavior in a radial maze with asymmetrical food reinforcement. The dopaminergic system of the brain was found to have an important role in impairments to the animals’ invariant perception of significant sensory objects on removal of on...

An original head holder and a training procedure designed for better adaptation of animals to rigid immobilization carried out in experiments in the awake drug-free state without body and limb restraining are described. The head holder can be used autonomously or in combination with a standard stereotaxic apparatus; it provides possibilities for st...

Experiments in rats addressing searching behavior in a maze with symmetrical reinforcement demonstrated an effect consisting of preference for food presented in a particular form. The dopaminergic system of the brain was shown to have an important role in forming reinforcement preference when the sensory properties of the food presented to the expe...

Experiments on rats showed that sessions of retraining to find a new preferred reinforcement location in a radial maze, continuously repeated on the experimental day, led to impairment of the animals’ ability to use navigational orientation as the most adaptive tactic for maximizing reinforcement, with retention of less productive conditioned refle...

This article describes an original method for studying the physiological mechanisms of food preference. The method can be used to study the selective role of visual and orosensory food-related stimuli in the selection of the preferred food and to model the processes forming food and drug dependence in animal experiments. The role of fractional food...

Introducing of urgent relearning in radial maze, consisting of one or two shifts of reward position in raw without any gap between behavioral sessions, resulted to inability of animals to use optimal navigational strategy to find preferable reward in maze while keeping responding to int-ra-maze stimuli. Procedural introducing of time-out between te...

It has been shown that food seeking behavior in rats performing in different types of mazes is controlled by discrete reward pattern related to change in attractive properties of reinforcement and dopamine activity plays a critical role in motivation and food preference processing. The data obtained suggest that behavior as well as amphetamine effe...

An article describes the original method allowing to study a mechanism of food preference related to the sensory properties of foods in animals. The method gives a good possibility to select the role of visual and orosensory signaling in food preference as well as to model the processes of physiological and pathological food and drug dependence in...

The paper describes a model of intentional form of tremor developed in experiments in animals. Experiments with lesion of nucleus caudatus revealed the important role of this structure to regulate normal relationships between activity of reciprocal muscles under producing the non stereotypic forms of motor behavior. The model may be used to study t...

A modern classification of invasive procedures developed according to International Bioethical Principles has been presented. The experimental data convincingly demonstrate that using of noninvasive approaches and techniques give a good opportunity to reduce a number of animals recruited in experiment as well as to keep the normal (not distressful)...

Seeking behavior of rats in a radial maze with asymmetric reward was studied by means of synchronous recording of cell activity in the hippocampus and ventral striatum. The synchrony of cell activity in the hippocampus and nucleus accumbens was modulated by spatial position and reward; the important role in this synchronization can be played by the...

Present paper describes an original technique aimed to overcome some problems of rigid closed-loop experiment by introducing in electrical circuit of automated computer system the specially developed electro-mechanical device – programmable photographic recorder, equipped with special marker. This photo-recorder was designed to provide the registra...

In experiments on cats with injury of the cortico- and rubro-spinal pathways, we studied the dynamics of recovery of operant (instrumental) food-procuring reactions at different durations of presurgery learning of animals. Operant manipulatory food-procuring movements were realized under conditions of horizontal and vertical tests, which required t...

2 520 154 (13) C2 РОССИЙСКАЯ ФЕДЕРАЦИЯ (51) МПК G09B 23/28 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ ИЗОБРЕТЕНИЯ К ПАТЕНТУ (72) Автор(ы): Альбертин Сергей Викторович (RU) (21)(22) Заявка: 2012144593/14, 12.10.2012 (24) Дата начала отсчета срока действия патента: 12.10.2012 (73) Патентообладатель(и): Альбертин Серг...

A conditioned reflex method was developed for the diagnosis of attention deficit hyperactivity disorder using an automated apparatus containing a radial maze with a hidden search object (reward), where successful task solution depended on the subject's attention to the spatial locations of sensory signals indicating the location of the search objec...

The author suggests a technique for assessing selectivity of perception which involves presentation to subjects on a screen of an image of a test-object as a two-dimensional labyrinth with concealed objects of search. The objects can be discovered with the help of landmarks by means of purposeful motor responses. The process is accompanied by selec...

A new conditioned reflexes approach for assessment of attention deficit hyperactivity disorder (ADHD) symptoms in children has been used. Successful solving of behavioral task was related with the ability of children to shift their attention on spatially located sensory signals in radial labyrinth with asymmetric schedule of rewards. The innovative...

Studies on rats demonstrated that lesioning of the medial shell of the nucleus accumbens led to impairment of the ability of experimental rats to perform error-free identification of the arm containing the largest amount of reinforcement in a radial maze. The behavioral deficit was not associated with impaired motivation or sensorimotor learning ab...

In order to better understand the impact of hippocampal processing on downstream neural structures and cognitive functions, neurons were simultaneously recorded in the hippocampus and in basal ganglia zones receiving inputs from hippocampus directly (the nucleus accumbens shell) or indirectly via the prefrontal cortex (nucleus accumbens core and ve...

A series of models of the SÉZh-3 stereotaxic apparatus, from the A. A. Bogomolets Institute of Physiology, Ukraine, has been used in electrophysiological studies of the brain and spinal cord in animals [4]. However, the fixing elements in this apparatus are positioned on a number of separate vertical stands, which results in some specific difficult...

The role of medial shell of the nucleus accumbens in acquisition of spatial behavior was studied in rats performing choice task in radial maze with asymmetrical water reinforcement. It has been found that the nucleus accumbens lesioned rats failed in finding larger rewards but preserve their reward-seeking behavior guided by visual discriminative s...

The goal of this study was to help better understand the importance of the nucleus accumbens (Nacc) in the processing of position and reward value information for goal-directed orientation behaviors. Sixteen male Long-Evans rats, under partial water deprivation, were trained in a plus-maze to find water rewards in the respective arms which were lit...

Administration of dopamine into the dorsal part of the caudate nucleus' head hindered the instrumental feeding conditioning with tonic form of motor response in cats. In preliminarily conditioned animals, dopamine impaired the tonic phase of the conditioned response and, consequently, made them loose the ability to synchronize the food-seeking moto...

Suboccipital administration of the oligopeptide to adult cats and white rats in a dose of 15 and 20 micrograms/kg induces the appearance of electrographic (delta-sleep) and behavioral sleep within 15-25 min. Administration of the oligopeptide induces a substantial increase in the thresholds of the response of the EEG to phonostimulation. A substant...

The paper is devoted to the study of the neostriatum role in the mechanism of instrumental learning. In the experiments on cats with damaged dorsal segment of the caudate nucleus head, deficit of forming new instrumental reflexes and achieving complex tasks was revealed. Damage of the caudate neucleus had a most pronounced negative influence on the...

Experiments on adult cats with isolated cerebral cortex show that suboccipital olygopeptide administration (10 and 15 mg/kg) induces electrographic manifestation of the slow wave sleep (SWS) in the isolated cortex. Slow synchronous waves reflecting the onset of SWS appear in the isolated cortex 0.2-1.5 sec earlier than in the control hemisphere. Th...

Emotional stress was developed in cats by putting them in one cage with dogs for 24 hours. Then the 24 hours sleep-walking cycles records revealed prolonged REM stage in day time or at night in five animals out of seven, and in six animals a general increase of REM sleep duration over 24 hours. Simultaneously, in six animals the length of drowsines...

Emotional stress was induced in cats by putting them in one cage with dogs for 24 hr. The 24-hr sleep-walking cycles revealed prolonged a REM stage in day time or at night in 5 animals out of 7, and in 6 animals there was a general increase of REM sleep duration over 24 hr. Simultaneously, in 6 animals the length of drowsiness and of deep slow-wave...

In cats, changes of the brain electric activity were followed by local temperature shifts in isolated and in intact cortex: the transition from slow wave sleep to paradoxical sleep and from quiet to active wakefulness were accompanied by increasing of the cortex temperature, while transition from paradoxical sleep to slow sleep decreased the temper...

In cats with isolated cerebral cortex, with the aid of electordes indwelled into different cortical layers, first electrographic changes during onset of sleep were shown to occur, as with intact cortex, in the lower layers of the isolated cortex. 3-4 months after the cortex isolation, changes of electrical activity during sleep occured simultaneous...