Sergeii Pavlov

• Zaporizhia State Medical and Pharmaceutical University

The study of mitochondrial dysfunction has become increasingly pivotal in elucidating the pathophysiology of various cerebral pathologies, particularly neurodegenerative disorders. Mitochondria are essential for cellular energy metabolism, regulation of reactive oxygen species (ROS), calcium homeostasis, and the execution of apoptotic processes. Di...

Prenatal hypoxia (PH) is a key factor in the development of long-term cardiovascular disorders, which are caused by various mechanisms of endothelial dysfunction (ED), including those associated with NO deficiency. This emphasizes the potential of therapeutic agents with NO modulator properties, such as Thiotriazoline, Angiolin, Mildronate, and L-a...

The study of mitochondrial dysfunction has become increasingly pivotal in elucidating the pathophysiology of various cerebral pathologies, particularly neurodegenerative disorders. Mitochondria are essential for cellular energy metabolism, regulation of reactive oxygen species (ROS), calcium homeostasis, and the execution of apoptotic processes. Di...

Prenatal hypoxia plays a crucial role in programming long-term cardiovascular dysfunction through mechanisms like endothelial dysfunction and nitric oxide system impairment, highlighting the potential of therapeutic agents, such as thiotriazoline, angiolin, mildronate, and L-arginine, for mitigating these adverse effects. Methods. Levels of sEPCR,...

Sodium-glucose cotransporter 2 inhibitors (SGLT2i) have a favorable impact on the kidney function in patients with heart failure (HF), while there is no clear evidence of what factors predict this effect. The aim of the study was to identify plausible predictors for kidney function outcome among patients with HF and investigate their association wi...

Background. Sodium-glucose cotransporter 2 inhibitors (SGLT2i) had a favorable impact on the kidney function in heart failure (HF) patients, while there is no clear evidence of what factors predict this effect. The aim of the study was to identify plausible predictors for kidney function outcome among HF patients and investigate their association w...

We hypothesize that serum irisin can have additional discriminative potency for heart failure (HF) in individuals with type 2 diabetes mellitus (T2DM). The study group comprised 226 consecutive T2DM patients (153 patients with any HF phenotypes and 30 patients without HF) aged 41 to 65 years. The plasma levels N-terminal brain natriuretic pro-pepti...

COVID-19 leads to disruption of the blood coagulation system, to thrombosis, hypercoagulability, as a result, to an increased risk of strokes and heart attacks. During COVID-19, endothelial dysfunction develops associated with NO deficiency with decrease in the level of SH compounds. Tiazotic acid (Thiotriazoline) has immunomodulatory, anti-inflamm...

Today the fighting against COVID-19 and post-COVID syndrome remains an important and complex problem for both doctors and pharmacists who develop new methods, drugs and treatment regimens for the struggle with this disease and introduce them into the clinic. A number of drugs used in the treatment of COVID-19 are already known - antiviral drugs, IL...

Patients with severe aortic valve stenosis and concomitant pulmonary hypertension show a significantly reduced survival prognosis. Right heart catheterization as a preoperative diagnostic tool to determine pulmonary hypertension has been largely abandoned in recent years in favor of echocardiographic criteria. Clinically, determination of echocardi...

Purpose of the article: to study the effect of acelysine and nimodipine on certain endothelial dysfunction indicators and to evaluate their therapeutic efficacy after subarachnoid hemorrhage in rats. Materials and Methods: an experimental study was carried out using 50 Wistar rats of both sexes. Spontaneous subarachnoid hemorrhage was modeled in an...

different inhibitors of NO-synthase in conditions of experi- mental cerebral ischemia by their capability to limit reactions of oxidative and nitrosative stress. In the given study a non-selective NOS inhibitor - N-nitro-L- arginine; a highly selective inhibitor of neuronal NOS – N-propyl- L-arginine and a highly selective competitive inhibitor of...

The purpose of the given research is to study the efficiency of different inhibitors of NO-synthase in conditions of experimental cerebral ischemia by their capability to limit reactions of oxidative and nitrosative stress. In the given study a non-selective NOS inhibitor - N-nitro-L-arginine; a highly selective inhibitor of neuronal NOS - N-propyl...

Currently, central nervous and cardiovascular system disorders of hypoxia genesis are widely treated with drugs that restore blood flow, as well as drugs that affect cell metabolism, namely, individual units of adaptive molecular-biochemical reactions. Of particular interest are pharma-correction methods of affecting synthesis and expression of Klo...

Klotho protein is a powerful regulator of various metabolic pathways including endothelial integration, cell adaptation processes, ion transport, signal transduction, regulation of calcium, potassium, parathyroid hormone, phosphates and glucose metabolism, and reduction of oxidative stress. Klotho protein ensures its biological effects through bind...

РЕФЕРАТ Отчет о НИР 44 страницы, 17 таблиц, 10 фотографий Библиография 45 источников литературы. ДОКЛИНИЧЕСКОЕ ИССЛЕДОВАНИЕ НООТРОПНОГО И НЕЙРОПРОТЕКТИВНОГО ДЕЙСТВИЯ ТИОЦЕТАМА В УСЛОВИЯХ ЭКСПЕРИМЕНТАЛЬНОЙ ФЕТОПЛАЦЕНТАРНОЙ НЕДОСТАТОЧНОСТИ Ключевые слова тиоцетам, фетоплацентарная недостаточность, нейротропное действие. Проведенными доклиническими ис...

A considerable number of experimental and clinical studies devoted to the study of the metabolic therapy in the acute period of myocardial infarction (MI) have been conducted in recent years. However, the molecular and biochemical processes of metabolic adaptation to ischemia still remain underexplored. Currently, cytoprotectors are being searched...

Проведенными доклиническими исследованиями на двух моделях фе-топлацентарной недостаточности была показана выраженная фетопротективная, нейропротективная и ноотропная активность препарата «Тиоцетам» при его парентеральном введении экспериментальным животным в дозе 250 мг/кг. ФПН Важным моментом в действии тиоцетама было его непосредственное влияние...

In the article by authors is shown ability of HSP-proteins in experimental researches in vitro in conditions MFPinduced hypoxia in suspension of neurons to start mechanisms of additional production of energy on dicarbonic site of cycle Crebs with possible involving mitochondrial-citosol shunts, that causes a high probability of preservation of neur...

В монографии изложены современные представления о патологических изменениях в нервной ткани в условиях церебральной патологии (нейроапоптоз, митохондриальная дисфункция, оксидативный стресс, гиперпродукция оксида азота (NO), гиперэкспрессия ранних генов), а также представлены основные современные препараты, использующиеся как для первичной, так и д...

Соотношение оксида азота и тиол¬дисульфидной системы является фактором, определяющим дальнейшую судьбу нейрона в условиях ишемии, а именно — тип его гибели. В условиях ишемических повреждений головного мозга в ранние сроки развивается нитрозирующий стресс, приводя к нитрозированию тиолов, изменяя тиол¬дисульфидное равновесие белков митохондриальной...

We studied the involvement of HSP70 and Hif1b genes in the development of pathological changes in the brains of experimental animals during ischemia. We found neuro� and mitoprotective charac� teristics of heat shock protein HSP70 and Hif1b in vitro and under cerebral ischemia due to stabilization of molecules damaged by oxidation, inhibition of ni...

INFLUENCE OF THE SELECTIVE ESROGEN RECEPTOR MODULATORS ON THE EXPRESSION AND SYNTHESIS OF HSP 70 PROTEINS IN CARDIOMYOCYTES OF RATS WITH EXPERIMENTAL ACUTE MYOCARD INFARCTION

According to modern ideas, in myocardial infarction a cascade of pathobiochemical reactions is triggered directly in the ischemic focus, leading to a disturbance in the metabolism of cardiomyocytes, the launch of "parasitral" energy-producing reactions, the development of mitochondrial dysfunction, the complete blockade of the macroergic compounds...

Вперше на основі комплексних досліджень in vitro та при моделюванні церебральної ішемії сформовані системні уявлення про роль мітохондріальної дисфункції у розвитку патобіохімічних, морфофункціональних змін клітин головного мозку. Встановлено, що моделювання церебральної ішемії та гіпоксії in vitro призводило до порушень функціональної активності м...

The influence of citicoline, phenylpiracetam, pentoxifylline and N-phenylacetyl-L-prolylglycine on cognitive processes and functional state of mitochondria in the neocortex of alloxan-diabetic rats has been studied. The drug effects on cognitive processes were assessed using passive avoidance tests in the dark-light camera. Latent period and the nu...

We studied the neurochemical aspects of the neuroprotective action of a selective modulator of the estrogen receptors, tamoxifen citrate, in a model of acute cerebral ischemia (ACI). It was shown that modeling of cerebral ischemia is followed by pathobiochemical changes in the brain tissue: a rapid shift of thioldisulfide homeostasis, intensificati...

It was established in experiments on the rats in the acute period of modeling pituitrin-isadrin myocardial infarction the formation of nitrogen monoxide decreases along with its accelerated transformation into peroxynitrite. It was evidenced by more than double inhibition of NO synthase activity in the myocardium and by decreasing the amount of nit...

Under modelling of brain ischemia in rats the antioxidant and cerebroprotective action of new N-,S-chinazolone derivative--compound NC-224 has been established. The compensation of pathobiochemical abnormalities in the system "LPO-antioxidant protection" is observed, indicators of carbohydrate metabolism and energy-supply, and morpho-functional sta...

Modulators of estrogen receptors play a significant role in cerebral activity and in the regulation of vital functions of the whole organisms. This work objective is to enlarge knowledge of Tamoxifen neuroprotective action and to determine neuroprotective action of Tibolone (both are modulators of estrogen receptors) studying their influence on ant...

Acute or chronic brain ischemia induces a cascade of pathobiochemical reactions that finally result in the development of focal neurological deficit, dyscirculatory encephalopathy, or the death of a patient. We studied the effects of ischemia at different time points, including 1, 6, 24, 48, 72, and 120 h, and 21 days. During the period of the stro...

We studied the involvement of HSP70 and Hif1b genes in the development of pathological changes in the brains of experimental animals during ischemia. We found neuro- and mitoprotective characteristics of heat shock protein HSP70 and Hif1b in vitro and under cerebral ischemia due to stabilization of molecules damaged by oxidation, inhibition of nitr...

Toxicological pharmacological study of the molecular complex of nifedipine and glycyrrhizic acid 1:10 (glycidipine) obtained using mechanochemical technique was carried out. High hypotensive and cardioprotective effects of the agent were demonstrated. Chronic administration (45 days) produced no toxic effects in vital organs and systems of Wistar r...

In experimental studies in rats with chronic alloxan-induced hyperglycemia, it was found that the use of piracetam for 20 days, pramiracetam and ginkgo biloba extract to varying degrees help to reduce the effects of mitochondrial dysfunction and energy deficiency in brain neurons. The basis of these mechanisms is the prevention of mitochondrial ope...

Chronic administration of cerebrocurin and cerebrolysin to Mongolian jirds with acute cerebral stroke model led to a decrease in the mitochondrial dysfunction on the 4th day, which was manifested by their ability to inhibit the mitochondrial permeability transition pore opening, normalize the energy metabolism, and enhance c-fos gene expression. In...