Serge Reichlin

Universitätsspital Basel

We developed a visualization tool and a methodology to support strategic planning of hospital service portfolios. Hospitals in Switzerland are reimbursed with a fixed fee per case. The fixed-fee model makes medical services comparable from a financial point of view. In order to take advantage of this model, the data that characterizes the medical s...

In a field study we compared usage and acceptance of a mobile lifestyle coaching application with a traditional web application. The participants (N=40) documented health behaviour (activity and healthy nutrition) daily, trying to reach a defined goal. In addition, health questionnaires and social facilitation features were provided to enhance moti...

Telemedicine is defined as the delivery of health-care and sharing of medical knowledge over a distance using telecommunication systems. The term telemedicine is usually associated with modern telecommunication systems: transmission of electronic medical records and images, remote monitoring of a patient's vital parameters, teleconferencing and int...

Automated collection and storage of medical data leads to large amounts of heterogeneous and time-dependent information. Out of this follows the problem of how to access and interpret this data, in order to support therapeutic decision making. Telemedical disease management holds great potential for the efficient and effective treatment of chronic...

It is not exactly known how ED physicians perform in evaluating cardiac systolic murmurs. In 203 consecutive medical ED patients with systolic murmur, we compared the initial clinical evaluation, including auscultation, with transthoracic echocardiography. Of the 203 patients, 132 (65%) had innocent murmurs and 71 patients (35%) had valvular heart...

Patients with community-acquired pneumonia can be allocated into low and high-risk mortality groups by simple clinical criteria. We studied the value of the stratification for outcome as proposed by Fine, et al. to guide the decision for in-hospital versus outpatient treatment in the emergency department. We studied demographic data, risk group str...

A 85-year-old woman was admitted to our hospital because of a presumtive diagnosis of pulmonary thromboembolism. The patient presented with a history of progressive dyspnoea and retrosternal pain. 3-4 weeks ago she had noticed a swollen left leg. On examination a 4/6-pansystolic murmur was found. An arterial blood gas analysis showed a reduced oxyg...

In a 67-year-old patient, generalised stable muscular weakness preexisting for several years became rapidly progressive within a few weeks prior to hospitalisation. He died one month after admission from acute cardiocirculatory failure. There was no history of muscular pain, clinical examination showed weak or absent tendon reflexes, hyposensibilit...

A 32-year-old immigrant from Pakistan was admitted to our hospital with cavernous pulmonary tuberculosis. He gave a history of several 1 to 2-months courses of antimycobacterial treatment administered earlier in Pakistan. We initiated combined therapy including isoniazid, rifampin, pyrazinamide, and ethambutol. Subsequently, results of susceptibili...

A 32-year-old immigrant from Pakistan was admitted to our hospital with cavernous pulmonary tuberculosis. He gave a history of several 1 to 2-months courses of antimycobacterial treatment administered earlier in Pakistan. We initiated combined therapy including isoniazid, rifampin, pyrazinamide, and ethambutol. Subsequently, results of susceptibili...

Most of angiotensin II's (Ang II) documented effects have been attributed to the interaction of this peptide with a G-protein coupled receptor termed AT1. The role and the signalling mechanisms of the more recently characterized AT2 receptor, which does not appear to interact with G-proteins, are however still unclear. We report here that this rece...

The signalling mechanism and cellular targets of the AT2 receptor are still unknown. We report that angiotensin II (Ang II) inhibits basal and atrial natriuretic peptide stimulated particulate guanylate cyclase (pGC) activity through AT2 receptors in rat adrenal glomerulosa and PC12W cells. This inhibition is blocked by the phosphotyrosine phosphat...

Der Alterungsprozess im 21. Jahrhundert ist durch zwei Faktoren gekennzeich- net: Ein Teil der sogenannten Baby Boomer, d.h. die geburtenstarken Jahrgänge 1946 bis 1964, entwickelt altersgemäss zunehmend chronische Krankheiten, während der andere Teil durch ausgeprägtes Gesundheitsbewusstsein bei relativ guter Gesundheit ein hohes Alter erreicht. D...