Serge Mordon

Serge Mordon
French Institute of Health and Medical Research | Inserm · BIOTIS U1026 Laboratory for Bioenginering of tissues

PhD

About

712
Publications
102,894
Reads
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9,661
Citations
Citations since 2016
140 Research Items
4019 Citations
20162017201820192020202120220100200300400500600
20162017201820192020202120220100200300400500600
20162017201820192020202120220100200300400500600
20162017201820192020202120220100200300400500600
Introduction
Skills and Expertise
Additional affiliations
January 2008 - December 2014
French Institute of Health and Medical Research
Position
  • Research Director, Head of INSERM unit 703

Publications

Publications (712)
Article
Folate receptor α (FRα) is overexpressed on numerous tumorous cell types such as ovarian or endometrial cancer cells. Moreover, FRα is absent from most healthy tissues as it is normally expressed only on the surface of proximal tubules cells of kidneys and choroid plexus. Thus, folate-based radiopharmaceuticals have emerged this last two decades as...
Article
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Surgical treatment is standard for the treatment of small breast cancers. Due to the pain and esthetic sequelae that can follow surgery, minimally invasive treatments are under investigation. Our aim was to conduct a dosimetry study of laser interstitial thermotherapy. Turkey tissue was used as an ex vivo model, and mammary glands from ewes were us...
Article
Introduction La maladie de Paget vulvaire (MPV) est une maladie rare atteignant préférentiellement les femmes post-ménopausiques. La chirurgie est le traitement de première intention mais présente un taux élevé de récidives (12–61 %). Cela met en lumière la nécessité de traitements alternatifs, non invasifs, notamment chez des patientes âgées et fr...
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Glioblastomas (GBMs) are high-grade malignancies with a poor prognosis. The current standard of care for GBM is maximal surgical resection followed by radiotherapy and chemotherapy. Despite all these treatments, the overall survival is still limited, with a median of 15 months. For patients harboring inoperable GBM, due to the anatomical location o...
Article
Background Photodynamic therapy (PDT) using daylight as the photoactivating light source (DL-PDT) is an effective treatment for actinic keratosis (AK). Among the artificial daylight sources, the Dermaris (Surgiris, Croix, France) is specially designed for SDL-PDT (simulated daylight PDT) of AK. To perform the PDT session, a long duration (2.5 hours...
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Photodynamic Therapy (PDT) relies on local or systemic administration of a light-sensitive dye, called photosensitizer, to accumulate into the target site followed by excitation with light of appropriate wavelength and fluence. This photo-activated molecule reacts with the intracellular oxygen to induce selective cytotoxicity of targeted cells by t...
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Photodynamic therapy (PDT) appears to be a promising strategy in biomedical applications. However, the complexity of its parameters prevents wide acceptance. This work presents and characterizes a novel optical device based on knitted light-emitting fabrics and dedicated to in vitro PDT involving low irradiance over a long illumination period. Tech...
Article
Background : Interstitial photodynamic therapy (iPDT), inserting optical fibers inside brain tumors, has been proposed for more than 30 years. While a promising therapeutical option, it is still an experimental treatment, with different ways of application, depending on the team performing the technique. Objective : In this systematic review, we r...
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PurposeGlioblastoma (GBM) is the most aggressive malignant primary brain tumor. The unfavorable prognosis despite maximal therapy relates to high propensity for recurrence. Thus, overall survival (OS) is quite limited and local failure remains the fundamental problem. Here, we present a safety and feasibility trial after treating GBM intraoperative...
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The combination of photodynamic therapy and chemotherapy is a promising strategy to enhance cancer therapeutic efficacy and reduce drug resistance. In this study two zinc(II) phthalocyanine-tin(IV) conjugates linked by a triethylene glycol chain were synthesized and characterized. In these complexes, the zinc(II) phthalocyanine was used as a potent...
Article
Résumé Introduction Le sujet anatomique reste un support pédagogique essentiel pour l’apprentissage des interventions complexes de chirurgie plastique. Nous présentons ici l’expérience universitaire d’un opérateur en formation sur modèle SIMLIFE® à très haut degré de réalisme. Celui-ci consiste en des corps humains issus de don du corps à la scien...
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Photodynamic therapy (PDT) is an innovative treatment of malignant or diseased tissues. The effectiveness of PDT depends on light dosimetry, oxygen availability, and properties of the photosensitizer (PS). Depending on the medium, photophysical properties of the PS can change leading to increase or decrease in fluorescence emission and formation of...
Article
Introduction Actinic keratoses (AK) are a common precancerous skin condition in dermatology practice. Photodynamic therapy (PDT) is an effective but painful treatment of fields of cancerization. Two studies showed that textile PDT was not inferior to conventional PDT. FLUXMEDICARE® (FLX-PDT) is the first medical device marketed. We realized a real-...
Article
Riassunto La pelle è schematicamente costituita da una sovrapposizione di tre strati di spessore variabile (epidermide, derma, ipoderma) avente ciascuno una composizione molto eterogenea. L’attacco selettivo di un bersaglio situato nella profondità di quest’organo (pelo, vaso sanguigno, ecc.) è, quindi, complesso e dipende da molti fattori: i param...
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Background: Epithelial ovarian cancers (EOC) are usually diagnosed at an advanced stage and managed by complete macroscopic cytoreductive surgery (CRS) and systemic chemotherapy. Peritoneal recurrence occurs in 60% of patients and may be due to microscopic peritoneal metastases (mPM) which are neither eradicated by surgery nor controlled by system...
Article
Introduction Les patients immunodéprimés (ID) ou greffés d’organes sont à risque de développer des kératoses actiniques (KA). À 5 ans d’une transplantation, leur fréquence est majorée de 38 % par rapport à la population générale et augmente avec la durée d’immunosuppression. Ces lésions peuvent évoluer en carcinomes épidermoïdes, plus agressifs che...
Article
Introduction La MPV est une maladie rare correspondant à un adénocarcinome intra-épidermique. Elle atteint préférentiellement les femmes de plus de 70 ans. Elle se manifeste par des lésions érythémateuses souvent prurigineuses et/ou douloureuses, parfois difficilement identifiables. Le traitement de première intention est la chirurgie, qui induit s...
Article
Topical photodynamic therapy (PDT) is widely used to treat non melanoma skin cancers. It consists of topically applying on the skin lesions a cream containing a prodrug (5-aminolevulinic acid (5-ALA) or methyl aminolevulinate (MAL)) that is then metabolized to the photosensitizer protoporphyrin IX (PpIX). Light irradiation at PpIX excitation wavele...
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Full-text available
Changes in gene expression are increasingly used to evaluate the effects of exposure to environmental agents. Housekeeping genes (Hk) are essential in these analyzes as internal controls to normalize expression levels assessed in real-time PCR (RT-PCR). Ideal Hk genes (i) are constitutively expressed; (ii) do not respond to external stimuli and (ii...
Preprint
BACKGROUND Neonatal jaundice is a very common condition occurring in 60–80% of all healthy term and late preterm neonates. In the newborn and especially in premature infants, the liver, which is still immature, is unable to eliminate the full amount of bilirubin. In the majority of cases, neonatal jaundice resolves spontaneously and causes no harm;...
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Background Neonatal jaundice is a common condition occurring in 60%-80% of all healthy-term and late-preterm neonates. In the majority of cases, neonatal jaundice resolves spontaneously and causes no harm; however, in some neonates, significant hyperbilirubinemia can develop and lead to kernicterus jaundice, a serious neurological disease. Photother...
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The development of immunotherapy has recently modified the anti-tumor therapeutic arsenal; particularly, immune checkpoint inhibitors have led to a significant increase in overall survival. The current challenge is now to select good responder patients by identifying early biomarkers to propose therapeutic combinations that potentiate the efficacy...
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A homogeneous and reproducible fluence rate delivery during clinical PDT (PhotoDynamic Therapy) plays a determinant role in preventing under‐ or overtreatment. The development of a flexible light source able to generate uniform light on all its surface would considerably improve the homogeneity of light delivery. The integration of plastic optical...
Article
Photodynamic therapy induced by protoporphyrin IX (PpIX) is widely used to treat precancerous skin lesions. The penetration depth of the prodrug 5-aminolevulinic acid (5-ALA) using topical application is currently limited, which hampers the production of PpIX in deep seated lesions. To enhance 5-ALA delivery in deep skin layers, a soluble microneed...
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Nasopharyngeal carcinoma (NPC) is a malignant tumour of the head and neck affecting localised regions of the world, with the highest rates described in Southeast Asia, Northern Africa, and Greenland. Its high morbidity rate is linked to both late-stage diagnosis and unresponsiveness to conventional anti-cancer treatments. Multiple aetiological fact...
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Often discovered at an advanced stage, ovarian cancer progresses to peritoneal carcinoma, which corresponds to the invasion of the serosa by multiple tumor implants. The current treatment is based on the combination of chemotherapy and tumor cytoreduction surgery. Despite the progress and standardization of surgical techniques combined with effecti...
Article
Surgical management of peritoneal metastases raises the problem of the theoretical spread of the entire peritoneal surface. Intraperitoneal photodynamic therapy (IntraPDT) has been limited by the lack of specificity of photosensitizers (PS) and difficulties to bring light into the abdominal cavity. Recent data in ovarian cancer may give development...
Article
Full-text available
To date, pancreatic adenocarcinoma (ADKP) is a devastating disease for which the incidence rate is close to the mortality rate. The survival rate has evolved only 2–5% in 45 years, highlighting the failure of current therapies. Otherwise, the use of photodynamic therapy (PDT), based on the use of an adapted photosensitizer (PS) has already proved i...
Article
An actinic keratosis (AK) is an area (lesion) of sun‐damaged skin, mainly found on sun‐exposed parts of the body, particularly the forearms, backs of the hands, face, ears, bald scalp and the lower legs. Left untreated, there is a small risk that an AK could progress into a form of skin cancer called squamous cell carcinoma. One way of treating AK...
Article
光化性角化症 (AK) 是指主要在身体曝光部位(尤其是前臂、手背、面部、耳部、光头头皮和小腿)发现的晒伤皮肤区域。若未经治疗,AK 可能进展成为一种名为鳞状细胞癌的皮肤癌,但这一变化的风险较低。 治疗 AK 的一种方法称为光动力疗法 (PDT)。使用 PDT 治疗 AK 的常用或常规方案称为 C‐PDT。它需要在皮肤上涂抹感光的乳膏,该乳膏随后约 2.5 小时会被高强度红光激活。这会在皮肤上引发严重的炎症, 但只会破坏异常(而非正常)的皮肤组织。 C‐PDT 的主要缺陷是患者在治疗期间会经历疼痛。由于这种疼痛, 许多患者无法完成治疗。这项研究的作者来自法国和德国, 他们拟定了一项新 AK PDT 治疗方案, 称为 P‐PDT。 P‐PDT 涉及改良后的红光激活: 光强度已显著降低, 而且在分...
Article
Introduction Les kératoses actiniques (KA) sont des lésions pré-cancéreuses chroniques fréquentes chez le sujet âgé. La photothérapie dynamique (PDT) est un traitement efficace des KA ciblant des grandes surfaces cutanées telles que le cuir chevelu où de nombreuses KA forment les « champs de cancérisation ». La PDT conventionnelle (C-PDT) pose la p...
Article
Introduction La photothérapie dynamique (PDT) conventionnelle est un traitement efficace des kératoses actiniques (KA) mais douloureux, ce qui limite son utilisation. Le premier dispositif de PDT textile (Fluxmedicare®) est commercialisé depuis octobre 2018. Nous présentons une étude en vraie vie de ce dispositif en traitement des KA du scalp et de...
Article
Photodynamic therapy (PDT) using daylight as the photoactivating light source requires weather conditions and temperature to be suitable for effective treatment and for patients to stay comfortably outdoors. In order to get rid of such requirements, artificial white light sources have been proposed as photoactivating alternatives to daylight, parti...
Article
Full-text available
Aim: The aim of this article is to summarize and review the use of photodynamic therapy for the treatment of atherosclerotic plaque and the prevention of intimal hyperplasia. Different photosensitizers are discussed and more specifically the role of indocyanine green as a potential photosensitizer. Methods: Literature search with focus on the us...
Preprint
BACKGROUND Extra-Mammary Paget's disease of the Vulva (EMPV) is a rare skin disorder, which is commonly seen in postmenopausal caucasian females and appears clinically as red, eczematous, pruriginous and sometimes painful lesions. Although most cases are non- invasive, EMPV may be associated with an underlying or distant adenocarcinoma. EMPV has a...
Article
Full-text available
Background: Extramammary Paget disease of the vulva (EMPV) is a rare skin disorder commonly seen in postmenopausal Caucasian females that appears clinically as red, eczematous, pruriginous, and sometimes painful lesions. Although most cases are noninvasive, EMPV may be associated with an underlying or distant adenocarcinoma. EMPV has a chronic and...
Article
Background: Facial acne scarring is a prevalent disease with both physical and psychosocial sequelae. Aims: This study aims to evaluate an innovative solid state dual wavelength 1,319 and 589 nm laser, which does not require consumable dye, for the treatment of acne scars. Patients/methods: A total of 12 patients (11 female, 1 man - Fitzpatric...
Article
Photodynamic therapy (PDT) induced by protoporphyrin IX (PpIX) has been widely used in dermatological practices such as treatment of skin cancers. Clearance rate depends on different factors such as light irradiation, skin oxygenation and drug penetration. The poor penetration of 5-aminolevulinic acid (5-ALA) with topical application is limited and...
Article
Full-text available
Actinic keratosis (AK) is characterized by pre-invasive, cancerous lesions on sun-exposed skin that negatively affect patient quality of life and may progress to invasive squamous cell carcinoma (SCC). If untreated, AK may either regress or progress to SCC, with significant morbidity and possible lethal outcomes. The most commonly used treatments f...
Article
Full-text available
Background Topical photodynamic therapy (PDT) using methyl aminolevulinate is a non‐invasive treatment option suitable to treat clinical and subclinical actinic keratosis (AK) over a large area (field cancerization). The most widely used, conventional protocol in Europe includes illumination with a red‐light lamp. This illumination commonly causes...
Article
Full-text available
La conception de cartes à des fins de communication ou, de manière plus générale, la visualisation de données est un champ de recherches relativement ancien qui a subi de profonds changements au cours de ces dernières années. Si de nombreuses recherches y sont consacrées, très peu d’entre elles s’intéressent à une autre tendance forte du moment : l...
Article
日光性角化病 (AK) 是指主要在身体曝光部位(尤其是手和前臂背侧、面部和耳部以及光头男性头皮)发现的晒伤皮肤区域。它们通常是无害的,但可能不美观或带来不便,一些日光性角化病有进展成为鳞状细胞癌(一种皮肤癌)的极轻微风险。有若干可能的治疗,包括光动力疗法 (PDT),在此方法中,首先在受影响的皮肤区域涂敷称为光敏剂的乳膏,然后使用一种特殊光线将其激活。此疗法可杀灭皮肤中的异常细胞。欧洲批准用于 AK PDT 的光敏剂需要在施用光敏剂后 3 小时通过红光激活(称为 C‐PDT)或在施用光敏剂后 30 分钟内通过日光激活(称为 D‐PDT)。C‐PDT 的主要不足是治疗中疼痛,而 D‐PDT 由于施用光敏剂和日光激活的间隔时间短,因此几乎无痛。遗憾的是,D‐PDT 需要良好的气候条件。因此,来自...
Article
Actinic keratoses (AKs) are areas of sun‐damaged skin found mainly on sun‐exposed parts of the body, particularly the backs of the hands and forearms, the face and ears, and the scalp in balding men. They are usually harmless although they can be unsightly or inconvenient, and there is a very small risk of some actinic keratoses progressing to a fo...
Article
Full-text available
The Monte-Carlo method is the standard method for computing the dosimetry of both ionizing and non-ionizing radiation. Because this technique is highly time-consuming in conventional implementations, several improvements have recently been developed to speed-up simulations. Among the improvements, the use of graphics processing units (GPU)to parall...
Article
Photodynamic therapy has become of interest in many European countries. Since, most of national authorities and all medical journals require the registration of the clinical study on the database ClinicalTrials. gov in order to be published, information regarding clinical studies are now available. This article aims to synthetize data gathered than...
Article
Background/purpose Photodynamic therapy (PDT) is an established treatment for actinic keratosis (AK). Among the approved protocols in Europe, the most widely used involves irradiation with the Aktilite CL 128 (C‐PDT). We aimed to assess the heterogeneity of irradiance over the treatment area when using C‐PDT. We also investigated whether there is a...
Article
Full-text available
Six ans après le physicien Serge Haroche, un autre Français, qui détient aussi la nationalité américaine, reçoit le prix Nobel de physique. Gérard Mourou, né en 1944 à Albertville (France), est professeur émérite à l’École polytechnique (Palaiseau, France) et ancien professeur à l’université du Michigan (Ann Arbor, États-Unis). Il partage la moitié...
Article
Objectives The primary objective of this study was to compare a traditional green KTP laser to a new investigational yellow laser (PhotoLase) in the treatment of facial telangiectasia in terms of the treatment outcomes. The secondary objective was to assess the functionality and reliability of the PhotoLase system from the perspective of the user....
Article
Introduction La folliculite décalvante (FD) est une dermatose inflammatoire chronique du cuir chevelu menant progressivement à une alopécie cicatricielle. La PDT est rapportée dans la littérature comme alternative thérapeutique aux traitements systémiques. Il s’agit d’un traitement simple d’application mais dont l’effet principal est la douleur au...
Article
Full-text available
Background: There is currently no therapy that prevents high-grade glioma recurrence. Thus, these primary brain tumors have unfavorable outcomes. Recently, 5-ALA photodynamic therapy (PDT) has been proposed to delay relapse and is highly expected to have potential synergistic effects with the current standard of care. However, PDT treatment delive...
Preprint
Full-text available
BACKGROUND Actinic keratosis (AK) is a common precancerous skin lesion caused by long-term sun exposure and usually develops on sun-exposed skin areas. Left untreated, AK may progress to squamous cell carcinoma. In order to prevent such risk, most clinicians routinely treat AK. Therapy options for AK include cryotherapy, topical treatments, curetta...
Article
Full-text available
Background: Actinic keratosis (AK) is a common early in situ skin carcinoma caused by long-term sun exposure and usually develops on sun-exposed skin areas. Left untreated, AK may progress to squamous cell carcinoma. To prevent such risk, most clinicians routinely treat AK. Therapy options for AK include cryotherapy, topical treatments, curettage,...
Article
We report a compact high-power yellow laser system for the treatment of cutaneous vascular lesions, such as telangiectasia and port wine stains. The system is based on optically pumped vertical-external-cavity surface-emitting lasers (VECSELs), which have emerged as an attractive alternative to solid-state and dye lasers due to their enhanced funct...
Article
Full-text available
Background Photodynamic therapy is an effective treatment for actinic keratosis, particularly for patients with large areas of field cancerization. Among the approved protocols in Europe, the most widely used requires irradiation with the Aktilite CL 128 lamp. However, pain during irradiation and the suboptimal adaptability of the lamp relative to...
Article
Background: Glioblastoma (GBM) is characterized by marked proliferation, major infiltration, and poor prognosis. Despite current treatments, including surgery, radiation oncology, and chemotherapy, the overall median survival is 15 mo and the progression-free survival is 7 to 8 mo. Because of systematic relapse of the tumor, the improvement of loc...
Preprint
Full-text available
BACKGROUND Actinic Keratosis (AK) are common pre-invasive cancerous lesions in sun-exposed skin, which negatively affect the quality of life in patients and may progress to invasive squamous cell carcinoma (SCC). Studies have shown that if untreated, AK may regress, or alternatively, may progress to SCC, with significant morbidity and possible leth...