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Sepideh Arbabi Bidgoli

Sepideh Arbabi Bidgoli
Islamic Azad University Tehran Medical Sciences(IAUTMU) · Toxicology and Pharmacology

Professor
Human population studies on environmental induced diseases, Integrative health and art therapy ,Risk assessment.

About

174
Publications
41,776
Reads
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1,014
Citations
Introduction
Sepideh Arbabi Bidgoli ,Pharm.D.,Ph.D is Prof. of Toxicology,Dept. of Toxicology and Pharmacology,Faculty of Pharmacy and Pharmaceutical Sciences ,Tehran Medical Sciences ,Islamic Azad University .She is President of Iranian Environmental Mutagen Society (IrEMS), Director in charge of the Journal of Water and Environmental Nanotechnology .She served for 10 years (2008-2018) as the Secretary General of Iran NanoHealth Committee with a demonstrated history of working and consulting in the pharmaceutical industries, regulation of NanoHealth products, research in the field of cancer , women's health and education of Toxicology, Pharmacology, Ethics ,Research Methods and Scientific Writing as the official license holder of Tim Albert Method in Iran .
Additional affiliations
June 2020 - present
Bahar Toxicology Laboratory(Sam Azma)
Position
  • Responsible Toxicologist
Description
  • Bahar Toxicology Laboratory is official collaborator of Iran FDA in toxicity studies and risk assessment of Pharmaceuticals,Cosmetics and Hygienic products ,Nanomaterials,Herbal and all other health products . All tests conduct by the last versions of OECD guidelines based of GLP disciplines : Please contact us for ordering your tests or receiving our scientific consultations
March 2017 - present
Islamic Azad University Tehran Medical Sciences University(IAUTMU)
Position
  • Professor
Description
  • o Basic Toxicology o Clinical Toxicology and Poisoning Control o Pharmacology (Pharmacogenetics, Endocrine Pharmacology , Teratology ) o Pharmaceutical Ethics o Genotoxicity o Nanotoxicology o Regulatory Toxicology o Occupational Toxicology o Food Toxicology o Scientific Writing course for Academic Members o Scientific Writing course for Academic Members on the basis and concepts of Tim Albert Method(WHO certified tutor ) o Lecturer of Toxicology programs for educating pharmacists o H
June 2010 - present
Iranian Environmental Mutagen Society(IrEMS)
Position
  • CEO
Education
May 2020 - July 2020
Johns Hopkins University
Field of study
  • Evidence Based Toxicology (EBT)
May 2020 - July 2020
Johns Hopkins University
Field of study
  • Psychological First Aid
May 2020 - June 2020
University of Florida
Field of study
  • Healing with the arts

Publications

Publications (174)
Article
The efficacy and safety are two challenging factors before trusting the lipid-based Nanosystems (LBNs) for diagnostic and therapeutic purposes. The aim of this paper is to evaluate the accessible in-vitro and in-vivo studies on the contribution of major physicochemical factors of LBNs for the effective and safe delivery of drugs and anticancer agen...
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با توجه به بالارفتن میانگین سنی جوامع بشری در سطح جهان و با توجه به افزایش غیر قابل توجیه نرخ ابتلای سالانه به شایع ترین نوع بیماری زوال عقل یعنی بیماری آلزایمر ، شناسایی نقش عوامل زیست محیطی و سبک زندگی در کاهش یا افزایش خطر ابتلا به این بیماری ضرورت دارد. با این رویکرد هدف از نگارش مقاله حاضر آن بوده است که با نگاهی عمیق به مکانیسم اثر گذاری عوام...
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Initial evidence on the endocrine-disrupting effects of genetically modified (GM) food motivated us to evaluate the reproductive toxicity of GM and non-GM plant-derived edible oils in female Wistar rats. Sunflower (non-GM), maize (GM), and canola (GM) oils as popular resource dietary oils were purchased from the local market. After tracking the tar...
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Background and aims: Current therapeutic regimens are not able to solve hormonal imbalance in young multiple sclerosis (MS) women and the clinical benefits of hormone therapy in MS patients remain controversial. This open labeled pilot study was aimed to find the role of Vitex agnus-castus plant supplement daily regimen in serum testosterone level...
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Abstract Background: Cadmium is ranked in the top ten environmental toxicants but its impact on Type 2 Diabetes Mellitus (T2DM) through lifestyle and diet is contradictory. Purpose: This study aimed to compare the urinary Cadmium levels (u Cd) in T2DM in an age and gender matched case control study in over 40 years volunteers and find the associati...
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Arsenic is ranked in the top ten environmental toxicants but its impact on type 2 diabetes mellitus (T2DM) and its association with other human health effects is contradictory. We aimed in this study to compare the urinary arsenic concentration (u As) in older age adults (> 40 years) and their T2DM subgroup in an age and gender-matched case control...
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Background: There is limited data on refined opium extract (Shireh) abuse, especially the magnitude of its complications and its mortality rates. To bridge such a gap, in this study, we aimed to investigate the frequency of pure refined opium extract poisoning and its consequences in a sample of our patients. Methods: This retrospective study was c...
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Background: There is limited data on refined opium extract (Shireh) abuse, especially the magnitude of its complications and its mortality rates. To bridge such a gap, in this study, we aimed to investigate the frequency of pure refined opium extract poisoning and its consequences in a sample of our patients. Methods: This retrospective study was c...
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Background: There is limited data on refined opium extract (Shireh) abuse, especially the magnitude of its complications and its mortality rates. To bridge such a gap, in this study, we aimed to investigate the frequency of pure refined opium extract poisoning and its consequences in a sample of our patients. Methods: This retrospective study was c...
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Introduction: Regarding the increasing prevalence of polycystic ovarian syndrome (PCOS) in young women and the side effects of existing medication regimens, this study was performed with aim to evaluate the antioxidants and clinical effects of oral Curcumin Nanomicell capsule with the approach to improve the women's quality of life. Methods: This c...
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بیم��اری پارکینس��ون که با تظاهرات بالین��ی قابل تمایز از جمله اخت�لاالت حرکتی و عدم تع��ادل در جابجایی، لرزش در حال استراحت، سفتی و انعطاف ناپذیری عضالت و کندی حرکات فیزیکی بدن تشخیص داده می شود، یک تا سه درصد افراد باالی 06 سال را درسراسر جهان مبتال کرده و در مردان شایع تر از زنان است. درمان اصلی آن دارودرمانی می باشد که شامل داروهای آزاد کننده د...
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Dill seed essential oil (DSEO) is a candidate for pharmaceutical and nutraceutical applications but the safety data is not available. In this study we aimed to evaluate the acute and repeated dose toxicity of DSEO in female mice via histopathological and immunohistochemical evaluations with focus on reproductive organs. After providing DSEO and cha...
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Objective: Hormonal and inflammatory mechanisms are involved in the pathogenesis of polycystic ovarian syndrome (PCOS), which is a prevalent metabolic disorder among women of reproductive age. We aimed to evaluate the comparative efficiency of short-term oral administration of Korean red ginseng extract (KRGE) and the standard treatment on PCOS by...
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Background: Current pharmacological and non-pharmacological treatment strategies for prostate cancer may control disease progression and increase the survival rates of patients but decreased quality of life is the most important concern of existing medical interventions. Erection dysfunction and fatigue are the most prevalent adverse effects of the...
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اگرچه تاریخچه استفاده از تاتو به بیش از سه هزار سال قبل از میلاد مسیح برم یگردد. تا چند دهه قبل، کاربرد اصلی تاتو عمدتا مطابق با باورهای سنتی، مذهبی و قومیتی بود و بیشتر ب هخاطر الگوهای فرقه ای و آئینی از آن استفاده می شد ولی جلوه امروزی استفاده از تاتو و خالکوبی در ایران و جهان کاملا متفاوت شده است. جوهرهای مورد استفاده در تاتو نیز مانند محصولات آ...
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Objective(s): We aimed in present study to provide solid-lipid nanoparticle (SLN) of GBE and evaluate its oral safety in the light of recent discoveries on strong inhibitory effects of Ginkgo Biloba Leaf Extract (GBE) against Covid 19 and Influenza virus. Methods: Morphology and particle sizes of nanoparticles were analyzed by Scanning Electron Mic...
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Background: We aimed in this study to evaluate the acute and repeated dose toxicity of Kelussia odoratissima Mozaff (Kelussia) identified as a rare medicinal plant species which grows in western parts of Iran with potential nutraceutical applications. Materials and Methods: To determine the clinical, hematological, biochemical, necropsy and histopa...
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Background: We aimed in this study to evaluate the acute and repeated dose toxicity of Kelussia odoratissima Mozaff (Kelussia) identified as a rare medicinal plant species which grows in western parts of Iran with potential nutraceutical applications. Materials and Methods: To determine the clinical, hematological, biochemical, necropsy and histopa...
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Background: Hyperbilirubinemia is a neonatal ubiquitous condition but the role of life style factors and endocrine disrupting chemicals (EDCs) on the incidence of this globally prevalent symptoms remained unclear. This study aimed to determine the role of EDCs and other predisposition factors in this regard. Materials and methods: At first, 120 mot...
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Superparamagnetic iron oxide nanoparticles (SPIONs) have been employed in several biomedical applications where they facilitate both diagnostic and therapeutic aims. Although the potential benefits of SPIONs with different surface chemistry and conjugated targeting ligands/proteins are considerable, complicated interactions between these nanopartic...
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This erratum is issued to amend the version of record of “Nanotechnology in Wound Healing; Semisolid Dosage Forms Containing Curcumin-Ampicillin Solid Lipid Nanoparticles, in-Vitro, Ex-Vivo and in-Vivo Characteristics” published in “Advanced Pharmaceutical Bulletin”, 2018, 8(3), 395-400. doi: 10.15171/apb.2018.046 The journal’s editorial staff intr...
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THIS study aimed to evaluate the acute and repeated dose toxicity of hydroalcoholic extract of Kelussia odoratissima Mozaff as medicinal plant which is restricted to western Iran based on its potential nutraceutical applications. To determine the clinical, hematological,biochemical, necropsy and histopathological effects of the herb’s extract, aeri...
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Gastric cancer is one of the most common cancers in the world and in the north and northwest of Iran. Given a high prevalence of polycyclic aromatic hydrocarbons (PAHs) in the environment as one of the influential factors in cancer, the present study was conducted to evaluate the relationship between tissue levels of polycyclic aromatic hydrocarbon...
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Background: Although initial studies on Elaeagnus Angustifolia L. Fruit Extract (Senjed) Nanocapsule showed its efficacy in osteoporosis in rat model as well as its significant role in elevating the serum calcium levels, there is no study on its possible genotixic potentials which is necessary for developing all nanopharmaceuticals. Objective: This...
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هر چند رابطه احتمالی بین ناباروری مردان و اختلال های سیستمیک مثل مشکلات اونکولوژیک، بیماری های قلبی ـ عروقی، اختلال های متابولیک و بیماری های اتوایمیون همواره مد نظر متخصصان درمان ناباروری قرار داشته است، لیکن کاهش شانس باروری و حتی بروز ناباوری در مردان همواره نشــانه ای از آســیب به ســلامت عمومی ایشــان و نتیجه مواجه های غیرطبیعی با عوامل آلایند...
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Background: This study aimed to evaluate the efficacy and safety of five randomly selected nanostructured products by the National Standard of No. 11070. Materials and methods: Antibacterial activities of five different nanostructured textiles were assessed on specific microorganisms to human skin and environment. The physicochemical properties wer...
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تاثیر سبک زندگی و استفاده از طب مکمل در پیشگیری و درمان ناباوری مردان :یک مطالعه مروری با رویکرد به مکانیسم های سم شناسی وداروشناسی هرچند رابطه احتمالی بین ناباروری مردان و اختلالات سیستمیک مثل مشکلات اونکولوژیک ، بیماری های قلبی عروقی ، اختلالات متابولیک و بیماری های اتوایمیون همواره مد نظر متخصصین درمان ناباروری قرارداشته است ،لیکن کاهش شانس بارو...
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The etiological factors for increased risk of endocrine and reproductive disorders remain largely unclear but a huge number of data from in vitro, in vivo, and epidemiological studies, support the association of their incidence and prevalence with long term exposure to endocrine-disrupting chemicals /agrochemicals in the modern world. Engineered Na...
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Background: Curcumin ameloriates liver damages but its poor absorption, rapid metabolism, and side effects at high doses may limit its clinical applications Objective: This study aimed to evaluate the protective and regenerative effects of Curcumin Nanomicells on alcohol-induced chronic liver injuries in mice. These effects were compared with Curcu...
Conference Paper
Full-text available
During modern lifespan, people are usually exposed to a wide range of xenobiotics which mediate endocrine disrupting properties which are not limited to the first exposed generations .There are many challenges to follow both the exposure to, and effects of theses toxicants in different generations especially in their reproductive and fertility func...
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Nanosilver and nanocurcumin are popular nonmaterial with increasing public attention, but their synergistic therapeutic potentials in burns have never been considered. The present study aimed to provide a novel formulation from both nanomaterials (Ag-Curcumin NPs) and conduct their preclinical evaluation for burn healing. After evaluation of partic...
Conference Paper
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مصرف انواع لوازم آرایشی و بهداشتی و یا بهره برداری از انواع تکنیک های قدیمی و مدرن جهت حفظ جوانی ،مراقب از زیبایی های ظاهری ، افزایش جذابیت و جوانسازی پوست باعث گردیده است تا صنعت تولید فراوردهای آرایشی بهداشتی بعنوان یکی از سود آور ترین و جذاب ترین حوزه های تجاری برای سرمایه گذاران جهان محسوب گردد. به دلیل توجه ویژه کشور های شرقی به امر زیبایی و د...
Conference Paper
Telomere maintenance mechanisms (TMMs) play a crucial role in cancer with potential for targeting and as clinical markers. Human cancers are known to activate telomerase or more rarely an alternative mechanism termed alternative lengthening of telomeres (ALT) independent of telomerase activity (TA), both TMMs showing prognostic relevance. Dogs may...
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Silver nanoparticles (AgNPs) are one of the most important nanoparticles which have various biomedical applications. For example, as antifungal, antibacterial, anti-cancer and anti-inflammatory agents. Skin infection caused by Trichophyton rubrum and some opportunistic fungi such as Candida albicans and Aspergillus fumigatus are sometimes difficult...
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Introduction Nausea and vomiting is one of the most common experience that has been seen in most pregnant women. During the gestational period, nausea may be a risk factor for malnutrition of both baby and mother. Even though the underlying causes may seem unclear, supplementation containing vitamin B6 has been proven beneficial. The first line th...
Conference Paper
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Introduction Alzheimer's disease is one of the most common types of dementia. Ginkgo biloba has shown to be effective in treating Alzheimer's disease, tinnitus, inflammation, memory enhancement, and other types of disorders due to circulatory failure according to the latest research. Low bioavailability, inadequate absorption, and rapid excretion h...
Article
Streptokinase, as a thrombolytic drug, is widely used in treatment of cardiovascular disorders and deep vein thrombosis. Streptokinase is immunogenic due to its prokaryotic source, having short biological half-life (i.e. 15 to 30 min) that is not enough for an efficient therapy. In this study, nanoparticles (NPs) of chitosan/streptokinase and polye...
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Biomedical and pharmaceutical products comprising silver nanoparticles are attracting interest due to their potent antibacterial activities. For their safe use it has become imperative to test their cyto-genotoxic potential. In the present study the cytotoxicity and genotoxicity of three different sizes of AgNPs ranging from 15 to 22 nm and at conc...
Conference Paper
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Abstrct: Background: The purpose of this research was to develop a quantitative real-time PCR for CK19 (Cytokeratin 19)-mRNA and evaluate its potential for the molecular detection of breast cancer cell lines. Methods: The method is based on real-time PCR (Polymerase Chain Reaction) by fluorescent SYBR green. RNA was prepared from MCF7, MDA-MB-231,...
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Background: Ferula species have shown wide range of pharmacological properties but there is no study on oral safety profile of Ferula persica due to standard toxicology guidelines. Objective: This study aimed to evaluate the acute and subchronic oral toxicity of the alcoholic extract of the aerial parts of Ferula persica to provide its safe dose fo...
Conference Paper
Extensive research over the past several decades has identified numerous dietary and phytochemical compounds from the forests that have breast chemopreventive potentials and could represent an important source of anti-cancer lead molecules. In this regard, several natural supplements have attracted considerable attention as modifiable risk factor i...
Conference Paper
Full-text available
Preventive Activities of Korean Red Ginseng against Endocrine Disrupting Chemicals Toxicity: A New Approach for Women’s Health Sepideh Arbabi Bidgoli Prof. of Toxicology, Dept. of Pharmacology and Toxicology, Faculty of Pharmacy, Pharmaceutical Sciences Branch, Islamic Azad University BACKGROUND: Polycyclic aromatic hydrocarbons (PAHs) and most...
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Full-text available
Objective(s): In this work, Ginkgo biloba extract (GBE) loaded solid lipid nanoparticles (SLNs) were synthesized via high pressure homogenization method and their physicochemical properties, as well as cytotoxicity and antibacterial activities were evaluated. Methods: Ginkgo biloba extract SLNs (GBE-SLNs) were prepared using high pressure homogeniz...
Article
Full-text available
Although ZnO nanoparticles possess novel properties that make them available to a wide range of applications, the questions regarding their safety may arise when they come in direct contact with biological systems (such as skin, lungs, and tissues). In this study, we evaluated the possible toxic effects of different dosages of zinc oxide nanopartic...
Article
Full-text available
Purpose: Wound healing is a natural biologic process, but the duration of it may take too long. Trying to shorten this process is one of the challenges for scientists. Many technologies were applied to achieve this goal as well as nanotechnology. In this study semi solid formulations containing curcumin and ampicillin solid lipid nanoparticles (SLN...
Article
Full-text available
Multiple sclerosis is one of the most salient degenerative disorders of CNS with dysregulated immune process that resulted in axonal damage and demyelination. In the present investigation, the serum level of testosterone was assessed in women who were struggling with multiple sclerosis (MS). Also, the level of omega-3, vitamin D, and the irregular...
Article
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Background: Cumin (Cuminum cyminum L.) seeds possess many nutritional values and a wide range of dietary and therapeutic applications. Hypothesis: Long-term administration of cumin caused toxic effects and infertility in male rodents but its hormonal effects in females have been remained unclear. Purpose: We aimed in the present study to determine...
Article
Full-text available
Objective(s): In this work, Ginkgo biloba extract (GBE) loaded solid lipid nanoparticles (SLNs) were synthesized via high pressure homogenization method and their physicochemical properties, as well as cytotoxicity and antibacterial activities were evaluated. Methods: Ginkgo biloba extract SLNs (GBE-SLNs) were prepared using high pressure homogeniz...
Article
Full-text available
Waterpipe Tobacco Smoke(WTS) is an unhealthy lifestyle that may increase the risk of genotoxic responses and chronic diseases such as cancer. Micronucleus test is a successful and reliable method which is used for screening of genotoxic responses of the whole body and also for screening those people who had already exposed to genotoxic compounds. I...
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The species Asteraceae Centaurea repens (Asteraceae), known as Acroptilon repens, and Talkhe in persian is used in folk medicine as an emetic, anti-epileptic, and anti-malaria herb in many parts of the world but its toxic effects have not determined yet. This study aimed to evaluate the acute and subchronic toxicity of this extract to find its poss...
Article
Full-text available
Conventional transdermal drug delivery systems (TDDS) have been designed for drug delivery through the skin. These systems use the permeability property of stratum corneum, the outermost surface layer of the skin. Applying polymeric micro and nanofibers in drug delivery has recently attracted great attention and the electrospinning technique is the...
Article
Full-text available
Conventional transdermal drug delivery systems (TDDS) have been designed for drug delivery through the skin. These systems use the permeability property of stratum corneum, the outermost surface layer of the skin. Applying polymeric micro and nanofibers in drug delivery has recently attracted great attention and the electrospinning technique is the...
Article
Full-text available
Objective(s): Silver nanoparticles have been widely used as new potent antimicrobial agents in cosmetic and hygienic products, as well as in new medical devices. Serious concerns have been expressed on the potential health risks of dermal applications of nanosilver containing consumer products (AgNPs), therefore regulatory health risk assessment ha...
Article
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Aims and Objectives : Other species of cleome have showed hepato protective properties but there is no study on safety profile and xenobiotic induced hepato protective activities of Cleome brachycarpa which have showed many other pharmacological properties .This study aimed to evaluate the acute and subchronic oral toxicity of the hydroalcoholic ex...
Article
Full-text available
Waterpipe smoking has become a global youth trend especially in the Middle East countries and Iran . The aim of this study was to determine the mutagenic effects of three most popular flavored tobaccos by four different salmonella typhimurium strains and compare the possible mutagenic effects of the test samples. Ames mutagenicity assessment was c...
Article
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Breast cancer affects Iranian women at least one decade younger than their counterparts in other countries and the incidence of breast fibroadenoma is growing in the last two decades in Tehran. This study aimed to compare the AhR levels in premenopausal breast cancer and breast fibroadnemo with appropriate normal groups. Possible associations of A...
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Aims of the study: Endometriosis is a prevalent gynecologic disorder in young women at reproductive age but the underlying risk factors have not identified yet in Iran and other neighboring countries. Persistent exposure to environmental endocrine disrupting chemicals (EDCs) in particular dioxins, PAHs and polychlorinated biphenyls (PCBs) with xeno...
Article
Full-text available
Aims of the study: Endometriosis is a prevalent gynecologic disorder in young women at reproductive age but the underlying risk factors have not identified yet in Iran and other neighboring countries. Persistent exposure to environmental endocrine disrupting chemicals (EDCs) in particular dioxins, PAHs and polychlorinated biphenyls (PCBs) with xeno...
Article
Full-text available
Silver Nanoparticles (AgNPs) have gained considerable interests during the last decade due to their excellent antimicrobial activities. Despite their extensive use, the potential toxicity of these nanoparticles and possible mechanisms by which they may induce adverse reactions have not received sufficient attention and no specific biomarker exist t...
Conference Paper
Full-text available
Background & Objective: The environmentally present groups of PAHs , Aryl Hydrocarbon Receptor (AhR) ligands, chemical phthalates or phthalate esters, are ubiquitous endocrine disrupting chemicals (EDCs) which have been recognized as rising threats to public health, including cancer and reproductive disorders . They are widely used in many consumer...
Article
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Background: Kermanshahi oil is one the most favorable oils in Iran especially in Kermanshah province. We aimed to evaluate the role of usual intake of Kermanshahi oil and other kinds of dietary fats as well as different meats, vegetables and fruits, carbohydrates, cereals, grains, sweets, candy and lifestyle habits in risk of breast cancer. Mater...
Article
Full-text available
Diseases related to water impurities may present as major public health burdens. The present study aimed to assess the mutagenicity of drinking water from different zones of Tehran, and evaluate possible health risks through making tea with tea bags, by Ames mutagenicity test using TA 100, TA 98 and YG1029 strains. For this purpose, 450 water sampl...
Article
Full-text available
In this study, the enzyme streptokinase (thrombolysis agent) and chitosan (Cs) nanoparticles were prepared by self-assembly. Using experimental design, chitosan concentration, solution pH and stirring time were studied as independent variables to identify their effects on size, polydispersity index (PDI) and loading efficiency of nanoparticles. Res...