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Senthilkumar Balakrishnan

Senthilkumar Balakrishnan

PhD

About

123
Publications
158,462
Reads
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4,499
Citations
Introduction
My research interest revolves around host - parasite interaction, molecular and microbial pathogenesis, bacterial metabolites and bioprospecting of antimicrobials.
Additional affiliations
January 2009 - September 2012
Muthayammal Institutions
Position
  • Associate Professor & Research Supervisor
October 1999 - April 2004
PGP Group of Institutions
Position
  • Lecturer
September 2012 - December 2020
Haramaya University
Position
  • Professor (Associate)
Education
October 2004 - January 2009
Periyar University
Field of study
  • Medical Microbiology & Immunology
July 1997 - May 1999
University of Madras
Field of study
  • Microbiology
June 1994 - May 1997
University of Madras
Field of study
  • Microbiology

Publications

Publications (123)
Article
Full-text available
Bacteriocins are nowadays recognized as good biopreservatives that are able to contain microbial contaminant development in several food products. In this study, the goat milk isolate Lactobacillus brevis NS01 brevicin activity on common foodborne pathogenic organisms and its characterization, stability, and statistical response surface methodology...
Article
Full-text available
Aim This study reports, for the first time, the prevalence of typhoid fever and convalescent phase asymptomatic typhoid carriers among the schoolchildren in Vellore district of Tamil Nadu state in India. Subjects and methods Blood and stool samples (n = 500) were collected from the schoolchildren, who were admitted to District Government hospitals...
Article
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Aim Typhoid fever is a serious health problem in tropical and developing countries. Although asymptomatic typhoid carriers show no clinical signs, they can spread infection to others. This study investigated the Toll like receptor 5 (TLR5) polymorphism and various clinical parameters in typhoid patients and asymptomatic typhoid carriers. Subjects a...
Article
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Purpose The aim of this study was to determine the bacterial profile of urinary tract infection (UTI) and antimicrobial susceptibility pattern among pregnant women attending at antenatal clinic in Dil Chora Referral Hospital, Dire Dawa, Eastern Ethiopia. Patients and methods An institutional-based cross-sectional study was conducted from February...
Article
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Biosynthesis of nanoparticles has received increasing attention due its effective mode of action, eco-friendly preparation methodology, and less cytotoxicity. In the present study, silver nanoparticles (AgNPs) from aqueous seed extract of Myristica fragrans (nutmeg) were characterized. Gas chromatography–mass spectrometry (GC–MS) analysis revealed...
Article
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Background Upper respiratory infections (URIs) are the leading cause of acute disease incidence worldwide and contribute to a substantial health-care burden. Although acute otitis media is a common complication of URIs, the combined global burden of URIs and otitis media has not been studied comprehensively. We used results from the Global Burden o...
Article
Full-text available
Background Upper respiratory infections (URIs) are the leading cause of acute disease incidence worldwide and contribute to a substantial health-care burden. Although acute otitis media is a common complication of URIs, the combined global burden of URIs and otitis media has not been studied comprehensively. We used results from the Global Burden o...
Article
Full-text available
The present study proves the effective green synthesis of iron oxide nanoparticles (IONPs) using Ziziphus oenoplia fruit (ZOF) extract and their application for antioxidant, antibacterial, catalytic degradation and larvicidal activity. We used UV–Visible spectroscopy, Fourier-transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), Field em...
Article
The interest in bioactives especially from botanicals to treat vancomycin-resistant enterococcal (VRE) infections is increased. Many species of Ocimum have a long history in folk medicinal and food industries. Nevertheless, their bioactive compounds remain unexplored. This study is aimed to assess the antimicrobial and antioxidant activity of basil...
Article
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Background Universal access to safe drinking water and sanitation facilities is an essential human right, recognised in the Sustainable Development Goals as crucial for preventing disease and improving human wellbeing. Comprehensive, high-resolution estimates are important to inform progress towards achieving this goal. We aimed to produce high-res...
Article
This study aims to explore novel LAB (Lactic acid bacteria) from breast-fed infants' feces towards characterizing their antimicrobial compound, bacteriocin. The LAB, Lacticaseibacillus paracasei F9-02 showed strong antimicrobial activity against clinical pathogens. Their proteinaceous nature was confirmed as the activity was completely abolished wh...
Article
Microbial synthesis of polyhydroxyalkanoates (PHA), eco-friendly biopolymers is gaining more attention towards restricting environmental pollution by substituting the conventional non-biodegradable petroleum-based plastics. The current study is aimed to economize the polyhydroxybutyrate (PHB) production by optimizing the production media using sago...
Article
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Background Previous Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) studies have reported national health estimates for Ethiopia. Substantial regional variations in socioeconomic status, population, demography, and access to health care within Ethiopia require comparable estimates at the subnational level. The GBD 2019 Ethiopia su...
Article
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Importance: The Global Burden of Diseases, Injuries, and Risk Factors Study 2019 (GBD 2019) provided systematic estimates of incidence, morbidity, and mortality to inform local and international efforts toward reducing cancer burden. Objective: To estimate cancer burden and trends globally for 204 countries and territories and by Sociodemographic...
Article
The present study was emphasized to investigate the photocatalytic degradation of malachite green (MG) and antibacterial activity of zirconium oxide nanoparticles synthesized from Annona reticulata leaf extract (AR-ZrO2NPs). The biologically synthesized AR-ZrO2NPs were characterized by UV–visible spectroscopy, Fourier transform infrared spectroscop...
Article
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Breast milk is the combination of bioactive compounds and microflora that promote newborn’s proper growth, gut flora, and immunity. Thus, it is always considered the perfect food for newborns. Amongst their bioactives, probiotic communities—especially lactic acid bacteria (LAB)—are characterized from breast milk over the first month of parturition....
Article
Aquaculture is a highly productive and fast-growing agricultural sector. The occurrence of epidemic or sporadic disease outbreak is a major limiting factor in this sector, thus better alternatives are the need of the hour. Use of indigenous probiotics is a promising strategy to control infectious diseases. Thus, the present study was aimed to scree...
Chapter
The positive impact of probiotics and prebiotics on human health has been demonstrated by various preclinical and clinical experiments. Therefore, they are used as supplements in a wide range of food products, including packaged foods, drinks, pickles, etc. However, preserving their beneficial effects in functional foods during food processing and...
Article
The objective of this study is to examine the novel usage of the aqueous leaf extract of Annona reticulata (AR) to produce zinc oxide nanoparticles (AR-ZnONPs) by reducing zinc nitrate. Fourier-transform infrared (FT-IR) spectroscopy analysis revealed that phytochemical compounds in AR leaf extract was responsible for capping and effective stabiliz...
Article
Nowadays, the accumulation of non-degradable plastics and other disposed wastes leads to environmental pollution across the world. The production of eco-friendly and cost-effective poly-β-hydroxybutyrate (PHB) could be a better alternative to conventional petroleum-based plastics and prevent environmental pollution. Besides, the area in and around...
Article
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Background: Measuring routine childhood vaccination is crucial to inform global vaccine policies and programme implementation, and to track progress towards targets set by the Global Vaccine Action Plan (GVAP) and Immunization Agenda 2030. Robust estimates of routine vaccine coverage are needed to identify past successes and persistent vulnerabilit...
Article
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Background High-resolution estimates of HIV burden across space and time provide an important tool for tracking and monitoring the progress of prevention and control efforts and assist with improving the precision and efficiency of targeting efforts. We aimed to assess HIV incidence and HIV mortality for all second-level administrative units across...
Article
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L-asparaginase (ASNase), a tetrameric enzyme, holds comprehensive applications in food industries as a reducing agent and pharma industries as an anticancer agent. In this study, we aimed to screen ASNase-producing lactic acid bacteria from cow milk. The statistically designed experiment, Plackett–Burmann design, was employed to screen the most sig...
Article
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The safe, highly effective measles vaccine has been recommended globally since 1974, yet in 2017 there were more than 17 million cases of measles and 83,400 deaths in children under 5 years old, and more than 99% of both occurred in low- and middle-income countries (LMICs)1–4. Globally comparable, annual, local estimates of routine first-dose measl...
Article
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Biofilm, a consortium of microbial cells, protected by extracellular polymeric matrix, is considered a global challenge due to the inherent antibiotic resistance conferred by its lifestyle. Besides, it poses environmental threats causing huge damage in food industries, fisheries, refineries, water systems, pharmaceutical industries, medical industr...
Article
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Background In an era of shifting global agendas and expanded emphasis on non-communicable diseases and injuries along with communicable diseases, sound evidence on trends by cause at the national level is essential. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) provides a systematic scientific assessment of published, public...
Article
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p>Background: Accurate and up-to-date assessment of demographic metrics is crucial for understanding a wide range of social, economic, and public health issues that affect populations worldwide. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 produced updated and comprehensive demographic assessments of the key indicators...
Article
The present research aims to enhance the biosurfactant (BS) production using agricultural by-products as a low-cost substrate with the statistical approach. BS production from Bacillus subtilis SASCBT01 was carried out with four different variables like pH, incubation time, cassava peel waste (CPW), and palmira sprout (PS). The model expected the h...
Article
Full-text available
The present investigation reports a simple, rapid, inexpensive, and eco-friendly approach for synthesizing Amphiroa rigida-mediated silver nanoparticles (AR-AgNPs) for the first time. The biomimetic synthesized AR-AgNPs were characterized by both spectral and microscopic analysis. The UV–visible spectrum showed the surface plasmon peak at 420 nm, w...
Article
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An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Article
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Background Oral rehydration solution (ORS) is a form of oral rehydration therapy (ORT) for diarrhoea that has the potential to drastically reduce child mortality; yet, according to UNICEF estimates, less than half of children younger than 5 years with diarrhoea in low-income and middle-income countries (LMICs) received ORS in 2016. A variety of rec...
Article
Full-text available
The present study demonstrates the green synthesis of copper nanoparticles (CuNPs) from Corallocarbus epigaeus rhizome extract and its antioxidant and antibacterial activity against multi-drug resistant Salmonella enterica serovar Typhi. Biogenic CuNPs were characterized by UV–Visible spectroscopy, transmission electron microscopy, Fourier transfor...
Article
Full-text available
A double burden of malnutrition occurs when individuals, household members or communities experience both undernutrition and overweight. Here, we show geospatial estimates of overweight and wasting prevalence among children under 5 years of age in 105 low- and middle-income countries (LMICs) from 2000 to 2017 and aggregate these to policy-relevant...
Article
Full-text available
Background Across low-income and middle-income countries (LMICs), one in ten deaths in children younger than 5 years is attributable to diarrhoea. The substantial between-country variation in both diarrhoea incidence and mortality is attributable to interventions that protect children, prevent infection, and treat disease. Identifying subnational r...
Article
This research aimed to explore eco-friendly green synthesis of CuONPs using Annona muricata leaf extract that investigated for their photocatalytic activity and cytotoxic property on human breast cancer cell lines (MCF-7). The morphological and structural characteristics of eco-friendly synthesized CuONPs were confirmed by UV–vis spectroscopy, X-ra...
Article
Full-text available
Abstract Background Lactobacillus spp. play a major role in the development of dental caries. Although effective methods are known for the prevention and management of dental caries, its prevalence of dental caries is increasing amongst school-age children in Ethiopia. Hence, this study is aimed to determine the association of salivary Lactobacillu...
Article
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Globally, Salmonella infection poses a major public health problem. Here, we report antibiofilm activity and quorum sensing inhibition of aqueous seeds extract of Myristica fragrans (nutmeg) and biosynthesized silver nanoparticles (AgNPs) against multidrug resistant (MDR) Salmonella enterica serovar Typhi (S. Typhi) isolated from typhoid patients a...
Article
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Background Mobile phones of health care professionals could harbor microbes which cause nosocomial infections to the patient, family members, and the community at large. Thus, the aim of this study was to determine the prevalence of bacterial contamination of the mobile phones of health professionals, identify bacterial isolates, assess their antim...
Article
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Plant rhizomes play a vital role in the green synthesis of nanoparticles essentially because of their low-cost, facile, novel and eco-friendly. This study aimed to explore eco-friendly synthesis of gold nanoparticles (AuNPs) using Corallocarpus epigaeus rhizome extracts. Gas chromatography-mass spectrometry (GC-MS) analysis of the C. epigaeus rhizo...
Article
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The study was aimed at investigating the biologically active compounds in Pleurotus sajor-caju wild edible mushroom and its potential antioxidant and antibacterial activity against multidrug-resistant (MDR) Salmonella typhi (Accession No. KT037135). Gas chromatography-mass spectrometry (GC–MS) and Fourier transform infrared spectroscopy (FT-IR) ana...
Article
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Lignocellulosic agricultural bi-products, pearl millet (PM) and finger millet (FM) husks, were used for the production of laccase using Bacillus sp. PS under solid-state fermentation (SSF). Abiotic variables such as substrate (PM, FM) concentration (1–5%), incubation time (24–96 h) and pH (5–10) were optimized using Response surface methodology (RS...
Article
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EVIDENCE REVIEW We used the GBD study estimation methods to describe cancer incidence, mortality, years lived with disability, years of life lost, and disability-adjusted life-years (DALYs). Results are presented at the national level as well as by Socio-demographic Index (SDI), a composite indicator of income, educational attainment, and total fer...
Article
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Organic molecule dithiocarbamate transition metal complexes are novel and very attractive pharmaceutical targets for the management and control of antibiotic resistant bacteria. The direct reaction has synthesized new transition metal nickel (II), copper (II) complexes of potassium morpholine dithiocarbamate (K ⁺ C 5 H 8 NOS 2⁻ ) ligands and charac...
Article
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The aim of this study was to evaluate the plus trees of cocoa for growth, flower, yield and yield contributing characters during the initial growth phase. Thirty five (35) plus trees in two different farmer's field were recorded for their growth, flower, yield and yield contributing traits. Among the 35 plus trees, first branching height was observ...
Article
Full-text available
Urinary tract infection remains a major public health problem in developing countries, where there are limited health-care services. Its prevalence is fueled by human immunodeficiency virus (HIV) infection. The emergence of antimicrobial resistance is now widespread and poses a serious clinical threat. This study investigated the prevalence, antimi...
Article
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Cocoa (Theobroma cacao L.) is an important plantation crop of Malvaceae family and its center of origin is Upper Amazon basin of South America. In India, it is grown as an intercrop in coconut and arecanut gardens especially in South India. Morpho-agronomic characters of pods and seeds can be used to evaluate the relationship between cocoa genotype...
Article
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Performance of cocoa genotypes was studied for pod and bean characters at Pollachi, Coimbatore district. Based on the continuous evaluation, ten plus trees were identified as best performers. To study the stability of these genotypes, the pod and bean characters were evaluated during 2017-2018. Five uniformly ripened pods were collected from each g...
Article
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Performance of identified cocoa clones (TNAU CC 1 to 9) was studied for morphological and yield characters at Coconut Research Station, Aliyar Nagar. As the seedling progenies show wider genetic variability, to maintain true to type, grafted plants were used. Data collected for plant height, stem girth, number of flowers per tree, number of pods pe...
Article
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Medicinal plants have been used as an excellent source for years together as an alternative medicine for treating various disorders including anticancer, cardiovascular disorders and immunological disorders. Pueraria tuberose linn (PT) commonly known as Indian Kudzu is a folklore medicine used in Ayurvedic formulations against various disorders. Th...
Article
The study is aimed to produce bioethanol and more specifically to provide a process for producing ethanol by the fermentation of macroalgal biomass. The seaweeds were evaluated for their hydrolysis process (acid and enzyme treatment). The hydrolysates obtained from acid and enzyme saccharification process were analysed for ethanol production to sho...
Article
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A total of 26 Staphylococcus aureus isolates from the respiratory infected cotton industries labours were subjected to the multiplex PCR amplification to detect Staphylococcal enterotoxins encoding gene. S. aureus isolates showed the presence of enterotoxins encoding gene i.e. See (50%), Sec (11.5%), Sea (8%) and Sed (8%). This present study also r...
Article
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AimChildhood diarrhea caused by enteric bacteria remains an important public health problem in the developing countries. Therefore, this study aimed to determine the prevalence of childhood diarrhea, etiological agents, antibiotic susceptibility patterns and associated risk factors in Eastern Ethiopia. Subjects and methodsA total of 196 children un...
Article
Chlorpyrifos (CP) is one of organophosphorus (OP) compounds used as pesticides in the agriculture field in India. The persistence of CP causes environmental pollution and act as a nervous agent that affect human and animals health. Response surface methodology (RSM) was explored to optimize the biodegradation conditions of CP using Bacillus cereus...
Article
Full-text available
Seven improved varieties of cocoa (CCRP 1, CCRP 2, CCRP 3, CCRP 4, CCRP 5, CCRP 6, CCRP 7) were planted during 2010 at Coconut Research Station, Aliyar Nagar, Coimbatore, Tamil Nadu and their performance were evaluated for growth, yield and quality characters during 2016. The results indicated that there was significant difference among the varieti...
Article
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Cocoa (Theobroma cacao), crop of humid tropics is a drought sensitive crop. Evaluation of plant's reaction for drought, screening for drought tolerant genotypes and to develop variety suited for regions with prolonged dry period has been given utmost importance to sustain the yield potential of cocoa under changing climatic scenario. A pot culture...
Article
In this present study, the 3D structure of protease from Bacillus sp. was modeled by using modeler 9v9. The generated structure was accessed for geometrical errors and energy stability using RAMPAGE, VERFIY 3D, ERRAT and PROSA. The proteolytic nature of this modeled protease was determined by docking studies using FlexX. The kertinolytic activity w...
Article
Cellulase is an enzyme that degrades the linear polysaccharide like cellulose into glucose by breaking the β-1,4- glycosidic bonds. These enzymes are the third largest enzymes with a great potential towards the ethanol production and play a vital role in degrading the biomass. The production of ethanol depends upon the ability of the cellulose to u...
Article
Full-text available
The present study reports an eco-friendly, rapid and easy method for synthesis of silver nanoparticles (AgNPs) using Tinospora cordifolia as a reducing and capping agent. The different factor such as silver nitrate (AgNO3) concentration, fresh weight of T. cordifolia leaf, incubation time, and pH affecting silver reduction was investigated using Re...
Article
Full-text available
The present investigation has been studied with the green synthesis of silver nanoparticles (AgNPs) using medicinally valued Adhatoda vasica -Nees and to evaluate the antibacterial and anticancer activity against HEP-G2 (Human epithelium cells of liver cancer) cell lines. The UV-Vis spectroscopy results show a strong resonance centered on the surfa...