Sengul Uysal

Erciyes Üniversitesi · Halil Bayraktar Health Services Vocational College

Herbal Medicine for Autoimmune Diseases addresses the immune system's role in autoimmune conditions and introduces evidence-based herbal therapies for diseases like lupus, diabetes, rheumatoid arthritis, and more. Chapters highlight innovative approaches such as phyto-nanotechnology for enhanced drug delivery and the therapeutic benefits of berry f...

Pomegranate peel, a fruit by-product, is a rich source bioactive compound. This study evaluated the effects of shade (SD) and oven drying (OD) on the bioactive content and antioxidant properties of pomegranate peel. The antioxidant capacity was evaluated by reducing power activity, radical scavenging, and metal chelating assays. Results showed that...

This study investigated the antioxidant and enzyme inhibitory properties of Myrtus communis leaves. Three different solvents including methanol, 50%-methanol, and water were used to extract of M. communis. In addition, total bioactive compounds were evaluated by using total phenolic and total flavonoid content assays. In antioxidant assays, water e...

The aim of this chapter is to review the ethnobotanical uses, chemical composition, and biological effects of Hyoscyamus niger. The plant has been known since the ancient era and the ethnobotanical records have indicated different uses including toothache, asthma, and gastrointestinal problems, as a sedative, hallucinogenic. Observed ethnobotanical...

Pistacia terebinthus, Anacardiaceae, is used in traditional medicine and its fruits are consumed as coffee in Turkey. However, the research on the chemical and biological activity of P. terebinthus leaves is almost lack. In the present study, we aimed to evaluate the comprehensive antioxidant capacity (DPPH, ABTS, reducing power and metal chelating...

Mentha spicata is one of the most popular species in the genus, and it is of great interest as a gastrointestinal and sedative agent in the folk medicine system. In this study, different M. spicata extracts, obtained by the use of four solvents (hexane, chloroform, acetone and acetone/water) were chemically characterized using HPLC-ESI-MS n , which...

Potentilla L. species have a long history of use in folk medicine for the management of various human ailments. Despite the tremendous number of studies describing the phytochemical and pharmacological profile of a number of Potentilla species, there is a paucity of scientific data regarding the biological activity of Potentilla norvegica. Thus, th...

The chemical components, in vitro antioxidant capacities and enzyme inhibitory effects of dichloromethane (DCM), ethyl acetate (EA), methanol (MeOH) and water extracts of the medicinal plant, Sida acuta Burm. f. were evaluated. The individual phenolic components were assessed via ultra-high-performance liquid chromatography-high-resolution mass spe...

In the present study, the methanolic, hydro-methanolic, dichloromethane, hexane and aqueous extracts of Salvia ceratophylla L. (Family: Lamiaceae), a lemon-scented herb, were tested for total phenolic (TPC) and flavonoid content (TFC) and antioxidant activities were evaluated using a battery of assays (2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2-azin...

Aim of study: This study aimed to investigate the antioxidant capacity and enzyme inhibitory effect of different solvent extracts obtained from Prunus avium leaves. Material and methods: The antioxidant capacity were evaluated using in vitro assays including DPPH, ABTS, CUPRAC, FRAP, phosphomolybdenum and metal chelating activity. Enzyme inhibitory...

The present study outlines the phenolic composition and pharmacological properties of different extracts of Digitalis cariensis Boiss. ex Jaub. & Spach root and aerial parts. The metabolic profiles of the studied extracts were characterized by UHPLC-MS. The in vitro antioxidant and enzyme (acetylcholinesterase (AChE), butyrylcholinesterase (BChE),...

Species from the genus Potentilla have a long history of use in ethnomedicine as a remedy inter alia for diarrhoea, diabetes mellitus, inflammations and topical infections [1]. However, the literature does not report any phytochemical study on Potentilla norvegica L. (Rosaceae). Moreover, data concerning biological activities are also limited [2,3]...

The pharmacological properties of Asphodelus species have been advocated previously. In this respect, the present study attempts to unravel the antioxidant and enzyme inhibitory activity of root extracts of two Asphodelus species, namely, A. albus and A. aestivus. Data gathered demonstrated that the dichloromethane (25.49, 51.30, 104.31, and 81.58...

Fully ripe fruits and mature leaves of Elaeagnus angustifolia were harvested and analyzed by means of analytical and biological tests to better comprehend the chemical composition and therapeutic/nutraceutical potential of this plant. Fruits and leaves were dried and the obtained powders were analyzed to study their color character and (via headspa...

The seeds of Tamarindus indica L., classified as bio-waste, are powerful sources of bioactive compounds, especially tannins. In order to use its full potential, extraction of such bioactive constituents should be done under the optimized conditions. In the frame of this paper, central-composite experimental design and RSM (response surface methodol...

Natural products derived from medicinal plants provide beneficial cancer chemotherapeutic drugs. Bioactive constituents from plants are explored for their anticancer properties. Methods: Three known compounds (deacetylbaccatin III, tasumatrol B, and taxawallin J) were isolated from Taxus wallichiana. Compounds were screened against four cancer cell...

Many plants with high antioxidant activity are great of significant in the pharmaceutical and cosmetic industries. Oxidative stress plays a major part in the development of many diseases including cancer, which is known imbalance free radicals and antioxidants. Herein, new natural antioxidant compounds have great interest in the scientific research...

We endeavoured to probe into and compare the possible effect(s) of different extraction techniques (accelerated solvent extraction (ASE), microwave-assisted extraction (MAE), ultrasonication-assisted extraction (UAE), maceration, and Soxhlet extraction (SE)) on the bioactivity (antioxidant and enzyme inhibitory activities) of the aerial parts of He...

The main goals of this research were the chemical and biological characterization of the bitter melon (Momordica charantia) isolate obtained by traditional (maceration) extraction, as well as optimization of this process using response surface methodology (RSM) and artificial neural networks (ANNs). Experiments were performed using Box–Behnken expe...

Drying method is one of the most important steps in the preparation of plant materials for phytochemical analysis and biological evaluation. In this sense, this research endeavoured to evaluate the effects three drying methods (oven, freeze, and shade drying) on phytochemical component, antioxidant, and enzyme inhibitory effects of Salvia abscondit...

Objectives This study investigates into the biological effects of solvent extracts (ethyl acetate, methanol, and water) of Scutellaria orientalis L. and Scutellaria salviifolia Benth. based on its enzyme inhibitory activity and antioxidant ability together with the screening of bioactive compounds. Methods Total and individual bioactive components...

Many Potentilla species are used as traditional drugs in several countries and also studied for their possible therapeutic properties. As part of our continuous effort to shed light on the biopharmaceutical potential of such plant species, this study was aimed to establish the phytochemical fingerprinting and to evaluate biopharmaceutical potential...

The genus Rubus (Rosaceae) has great potential for and a history of use as natural agents in several traditional folk remedies. Based on this concept, this study focused on the antioxidant activities and enzyme inhibitory effects of extracts and fractions from Rubus caesius. Different chemical assays were performed to detect antioxidant capacity, n...

Tragopogon dubius and Tussilago farfara are consumed as vegetables and used in folk medicine to manage common diseases. Herein, the chemical compositions and biological activities of different leaf extracts (ethyl acetate, methanol, and water) of T. dubius and T. farfara were evaluated. The antibacterial, antifungal, and antioxidant abilities of th...

Six wild species (S. alba, S. conoidea, S. dichotoma, S. italica, S. supina, and S. vulgaris) from the Silene genera were tested for potential anti-enzymatic (acetyl cholinesterase (AChE), butyryl cholinesterase (BChE), tyrosinase, α-amylase, and α-glucosidase), antimicrobial (16 microbial strains), and antioxidant activity. An ultra-high performan...

Plants from the genus Potentilla have been traditionally used for therapeutic purposes in Turkey. Methanol root extracts from four selected Potentilla species (P. anatolica, P. argentea, P. recta, and P. reptans) were probed for their chemical composition, antioxidant properties (DPPH, ABTS, FRAP, CUPRAC, phosphomolybdenum, and metal chelating acti...

Extracts (methanol, ethyl acetate, and water) from Dianthus calocephalus Boiss. prepared by different extraction techniques (maceration, Soxhlet, and ultrasonication) were studied for possible inhibitory action against key enzymes (α-amylase, α-glucosidase, acetyl cholinesterase, butyryl cholinesterase, and tyrosinase). Antioxidant potential was es...

Traditionally used botanical remedies have attracted much interest as pharmacological targets in the management and/or treatment of several diseases. Recently, they have been probed as tyrosinase inhibitors for the management of epidermal hyperpigmentation. This study aims to investigate into the antioxidant and tyrosinase inhibitory potential of m...

Ballota macrodonta Boiss. et Balansa., is a traditionally used endemic medicinal plant used to manage a plethora of diseases in Turkey. Nonetheless, few studies have endeavoured to highlight its therapeutic potential and its phytochemical profile. We hypothesized that B. macrodonta would possess multi-pharmacological propensities and bioactive comp...

Introduction The traditional use of phyto remedies and natural products may indicate their pharmacological potential. Screening plant extracts to identify their active components has gained momentum with possible beneficial effects for public health. The aim of study was to assess and compare the biological properties of different extracts (methano...

Bidens tripartita L. is a traditional phyto-remedy used in several countries, yet there is still a paucity of data on its biological potential. We aimed to provide new insights on the pharmacological potential of extracts prepared from B. tripartita via highlighting its antioxidant, key enzymes inhibitory potency, and DNA protecting effects. Phytoc...

We probed into the outcome of different extraction procedures (maceration, Soxhlet extraction, and ultrasonication), on the phytochemical profile and bioactivity of the ethyl acetate, methanol, and water extracts of Dorcycinum pentapyllum subsp. haussknechtii. The antioxidant ((ABTS and DPPH), reducing power (CUPRAC and FRAP), phosphomolybdenum, me...

In the present paper, seven wheat cultivars (Ahmetaga, Bezostaya, Dagdas-94, Ekiz, Karahan-99, Konya-2002 and Tosunbey) grown in Turkey were compared for their phytochemical composition, antioxidant and enzyme inhibitory activities. Antioxidant capacities and enzyme inhibitory effects were investigated with colorimetric methods. Total phenolic cont...

In the last few years, bioactive components or theirs extraction techniques are gaining special interest in scientific areas. In this framework, orange leaves were used for preparation of extracts with high content of biologically active compounds. In order to optimize the extraction process, three levels and three variables of Box-Behnken design w...

In this work, the biological and chemical fingerprints of three extracts (ethyl acetate, methanol, and water) from two Potentilla species (Potentilla reptans and P. speciosa) were investigated. Antioxidant, enzyme inhibitory, and cytotoxic activities were performed for the biological fingerprint. For the chemical characterization, total bioactive c...

Medicinal plants have been a primary source of bioactive compounds that are finally being developed as commercial drugs. Nowadays, many phytochemicals are associated with health benefits and they are used as antioxidants, antimicrobials, anticancer and antiinflammatory agents. Phenolic compounds are the main secondary metabolites and are highly emp...

In this work, the biological and chemical fingerprints of three extracts (ethyl acetate, methanol, and water) from two Potentilla species (Potentilla reptans and P. speciosa) were investigated. Antioxidant, enzyme inhibitory, and cytotoxic activities were performed for the biological fingerprint. For the chemical characterization, total bioactive c...

The genus Potentilla is interesting for the pharmaceutical field due to its valuable medicinal properties, which have been observed in complementary and alternative medicine. In recent years, studies conducted to estimate the biological activity of several of the Potentilla species have shown a wide spectrum of therapeutic properties. In particular...

The genus Lathyrus has great importance in terms of food and agricultural areas. In this study, the in vitro antioxidant activity (phosphomolybdenum, DPPH, ABTS, FRAP, CUPRAC and metal chelating) and enzyme inhibitory activity evaluation (acetyl cholinesterase, butyryl cholinesterase, α-amylase and α-glucosidase) of L. cicera and L. digitatus were...

Members of the genus Lathyrus are used as food and as traditional medicines. In order to find new sources of biologically-active compounds, chemical and biological profiles of two Lathyrus species (L. czeczottianus and L. nissolia) were investigated. Chemical profiles were evaluated by HPLC-ESI-MSⁿ, as well as by their total phenolic and flavonoid...

Representatives of the Achillea genus are widely used as foods or nutraceuticals. Considering the increasing demand for herbal dietary supplements with health promoting effects, the objective of this research was to evaluate the biological and chemical profiles of different extracts (ethyl acetate, methanol and water) obtained from three Achillea s...

Different wild plants commonly used in folk medicine, such as different species from the genus Lathyrus, may represent new sources of biologically active compounds. Hence, a study of the composition and (bio)chemical behaviour of extracts from these plants may provide valuable information. To evaluate the phytochemical profile, and the enzyme inhib...

This study is designed to optimize the extraction of polyphenolics and antioxidant potential of loquat leaves using response surface methodology (RSM). Three levels and three variables Box-Behnken experimental design in combination with RSM was applied. Independent variables were solvent concentration (10–90%), temperature (20–60°C) and time (60–18...

The present research was performed to evaluate antioxidant activities and enzyme inhibitory potentials of two extracts (acetone and methanol) from two parts (flowers and leaves) of Mandragora autumnalis. The antioxidant properties were evaluated by using different methods. Enzyme inhibitory potentials were tested against cholinesterase (AChE and BC...

Centaurea patula is widely distributed in the Central Anatolia Region of Turkey. The essential oil of C. patula was obtained by hydrodistillation and analyzed by GC-FID and GC-MS techniques. Twenty-one components were identified representing 86.4% of the oil. Spathulenol (14.6%), n-hexadecanoic acid (13.4%), 1-pentadecene (13.1%) and phytol (12.4%)...

The multicomponent pattern and biological characterization of plant material are essential for pharmaceutical field, in the food supplements quality control procedures and to all plant-based products. These nutrients often show valuable effects related to their consumption due to the occurrence of secondary metabolites that show useful properties o...

The antioxidant and enzyme inhibitory activities of two extracts [methanolic and water] of nine different fruit tree leaves were assessed. The antioxidant activity of leaves was determined by ABTS (2,2-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid)), DPPH (1,1-diphenyl-2-picrylhydrazyl radical), CUPRAC (cupric ion reducing antioxidant capacity...

Antioxidant and enzyme inhibitory effects (against cholinesterase, tyrosinase, α-amylase and α-glucosidase) of ethyl acetate, methanol, and aqueous extracts from Astragalus lagurus (Fabaceae) were investigated with spectrophotometric methods. Antioxidant capacity were evaluated by using different assay including free radical scavenging (DPPH and AB...

The multicomponent pattern and biological characterization of plant material are essential for pharmaceutical field, in the food supplements quality control procedures and to all plant-based products. These nutrients often show valuable effects related to their consumption due to the occurrence of secondary metabolites that show useful properties o...

The multicomponent pattern and biological characterization of plant material are essential for pharmaceutical field, in the food supplements quality control procedures and to all plant-based products. These nutrients often show valuable effects related to their consumption due to the occurrence of secondary metabolites that show useful properties o...

The present work focused on antioxidant and enzyme inhibitory potential of different solvent extracts (ethyl acetate, methanol and water) from Artedia squamata. Cholinesterase, tyrosinase, α-amylase and α-glucosidase inhibitory activities of the extracts were tested by microtitre plate assays. Antioxidant abilities were tested using free radical sc...

We investigated the antioxidant and enzyme inhibitory activities and chemical composition of the hydro-distilled essential oil (0.35% yield) from aerial parts of Thymus spathulifolius. Antioxidant capacity of the oil was assessed by different methods including free radical scavenging (DPPH and ABTS), reducing power (FRAP and CUPRAC) and phosphomoly...

This work reports the antioxidant, antimicrobial, and inhibitory effects of methanol and water extracts from Ganoderma applanatum (GAM: methanol extract and GAW: water extract) and G. resinaceum (GRM: methanol extract and GRW: water extract) against cholinesterase, tyrosinase, α-amylase and α-glucosidase. The total phenolics, flavonoids contents, a...

Mushrooms have been recognized as important food items due to their high nutritional and medicinal value. The present work quantifies and compares the fatty acids composition among eleven mushroom species (Auricularia auricular-judae, Collybia dryophila, Rammulina ve/utipes, Helvella lacunose, Polyporus squamosus, Rhizopogon roseolus, Russula albon...

The aim of this work was to determine antioxidant capacities, neuroprotective, skin care, antidiabetic effects, and fatty acid composition of Anchusa undulata subsp. hybrida. The antioxidant activity was screened by four different test systems including total antioxidant, antiradical, reducing power, and metal chelating activities. Neuroprotective...

In this research, the total sugar content, fatty acid compositions, and α-amylase and α-glucosidase inhibitory activity of methanolic and water extracts of nine different fruit tree leaves were determined. α-amylase and α-glycosidase inhibitory activity were determined by using Caraway-Somogyi iodine/potassium iodide and 4-nitrophenyl-α-D-glucopyra...

In this research, the total sugar content, fatty acid compositions, and α-amylase and α-glucosidase inhibitory activity of methanolic and water extracts of nine different fruit tree leaves were determined. α-amylase and α-glycosidase inhibitory activity were determined by using Caraway-Somogyi iodine/potas-sium iodide and 4-nitrophenyl-α-D-glucopyr...

This study was focused on the analysis of the phenolic content, fatty acid composition, volatile compounds and antioxidant activity of methanol extract from Centaurea urvillei subsp. stepposa. The antioxidant capacity were detected as 43.35 mg TEs/g, 52.18 mg TEs/g and 98.78 mg TEs/g for DPPH, FRAP and CUPRAC, respectively. Chlorogenic acid and api...

Giriş: Meme kanseri dünyada akciğer kanserinden sonra en sık görülen ikinci kanser türüdür ve kadınlarda kanser ölümlerinin önde gelen nedenidir. Meme kanserinde erken tanı ve tanı sonrası etkili tedavi şekillerinin belirlenmesi gelişmiş tanı ve teknik yöntemlerle mümkündür. Son yıllarda meme kanseri de dahil olmak üzere birçok kanser türünde hücre...