Sengottuvelu Gunasekaran

Sengottuvelu Gunasekaran
Apollo Hospitals · Cardiology

MBBS,MD DM DNB FSCAI, FRCP (London), FRCP (Glasg) FACP FMMC FCSI

About

132
Publications
9,275
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226
Citations
Additional affiliations
June 2006 - August 2016
Apollo Hospitals
Position
  • Consultant
October 2003 - July 2009
Sri Ramachandra University
Position
  • Professor (Associate)
October 2003 - July 2006
Sri Ramachandra University
Position
  • Professor (Associate)
Education
August 2002 - August 2003
ICPS - Institut Cardiovasculaire Paris Sud
Field of study
  • Interventional Cardiology

Publications

Publications (132)
Article
Funding Acknowledgements Type of funding sources: None. Background Home-based cardiovascular disease (CVD) primary prevention (HBPP) and cardiac rehabilitation (HBCR) programs which occupied a small proportion of the overall Preventive Cardiology work in the past have become mainstream during the COVID-19 pandemic. Purpose This study aims to anal...
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Thrombo-embolic complications after Corona virus disease-19 (COVID-19) vaccination have been previously reported. We aimed to study the coronary thrombo-embolic complications (CTE) after COVID-19 vaccination in a single centre during the initial 3 months of vaccination drive in India. All patients admitted to our hospital between 1st March 2021 and...
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Bicuspid aortic valve (BAV) is the most common valvular congenital anomaly and is apparent in nearly 50% of candidates for AV replacement. While transcatheter aortic valve implantation (TAVI) is a recommended treatment for patients with symptomatic severe aortic stenosis (AS) at all surgical risk levels, experience with TAVI in severe bicuspid AS i...
Article
Background: Transcatheter pulmonary valve implantation (TPVI) is a surgical alternative for correcting dysfunctional right ventricular outflow tract conduits in previously operated patients. MyVal transcatheter heart valve (THV) (Meril Life Sciences, India), a new transcatheter valve designed for aortic position has not been used for TPVI. Method...
Article
Aim To evaluate healing response at strut-level and cross-section level after implanting an ultra-thin strut, everolimus-eluting stent with biodegradable polymer (Tetrilimus) using optical coherence tomography (OCT) at 3 and 6 months. Methods This was prospective, multi-centre, single-arm, and investigator-initiated study performed at seven Indian...
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The pathophysiology of acute coronary syndromes was thought to be coronary thrombosis over a plaque rupture. Autopsy studies revealed that not all cases were due to plaque rupture, even denuded endothelium or calcific nodule can beget a thrombus. Introduction of OCT made, in vivo recognition of lesion morphology clear. Plaque ruptures are most comm...
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IntroductionDosing frequency is an important factor influencing medication compliance in patients with heart failure (HF), which in turn is imperative in achieving the desired therapeutic outcome. Here we assessed the efficacy and safety of ivabradine prolonged-release (PR) once-daily (test) vs. ivabradine immediate-release (IR) twice-daily (refere...
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Background The current models to predict CAD in general population is not universally accepted. Many risk scores do not take into account factors such as south Asian ancestry, type 2 diabetes mellitus or family history of premature CAD. There is still no clarity on the position of biomarkers in addition to traditional risk factors. Purpose This st...
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Transcatheter Pulmonary Valve Implantation has become the treatment of choice in most congenital heart disease patients with degeneration and dysfunction of a previous Right ventricular outflow tract repair. It is less invasive, with a high procedural success rate. Efficacy and safety have been demonstrated for the Medtronic Melody® valve (Medtroni...
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Background Burkholderia pseudomallei is a Gram negative, soil-water saprophytic bacterium endemic in South-East Asia and Northern Australia. Melioidosis is being increasingly diagnosed in other regions like India, China, and Sri Lanka during recent years. The clinical presentation of melioidosis is extremely variable. Case summary We present a c...
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Background: Despite the increasing popularity of transcatheter aortic valve replacement (TAVR), only about 10,000 TAVR cases have been performed in Asia to date. The procedure is still in a nascent stage in India with very few centers offering this state-of-art technique. Here, we present the early results of TAVR experience at our center. Method...
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Transcatheter aortic valve implantation (TAVI) has become one of the standard care of therapy for aortic stenosis. The indications for TAVI are rapidly expanding, but there are many technical challenges faced during the procedure, like anatomical variation, vascular access and severe calcification. We hereby report two anatomically challenging case...
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Porcelain aorta is emerging as an important indication for Transcatheter aortic valve implantation (TAVI) even when the Society of Thoracic Surgeons (STS) scores are low. Good midterm results after TAVI in patients with porcelain aorta have been reported in patients with both transfemoral and transapical approach. There are unique challenges faced...
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Transcatheter aortic valve implantation (TAVI) has rapidly evolved. Patients with critical aortic stenosis (AS) are at increased risk of cardiac arrest and are particularly difficult to resuscitate. We are presenting our experience of successful TAVI after in-hospital cardiac arrest in critical AS.
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Radial access for cardiac catheterization and intervention in India has been growing steadily over the last decade with favorable clinical outcomes. However, its usage by interventional cardiologists varies greatly among Indian operators and hospitals due to large geographic disparities in health care delivery systems and practice patterns. It also...
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Transcatheter aortic valve replacement (TAVR) is an innovative medical advancement. There is a rapid progress in the field of TAVR since its inception. As TAVR is evolving it has become refined and resullting in performinmg the procedure in less invasive approach which increses the saftey profile and helps in rapid recovery. We share our experince...
Article
Aims: The MeRes-1 trial sought to study the safety and effectiveness of a novel sirolimus-eluting bioresorbable vascular scaffold (MeRes100 BRS) in treating de novo native coronary artery lesions by clinical evaluation and using multiple imaging modalities. Methods and results: The MeRes-1 first-in-human trial was a single-arm, prospective, mult...
Article
Background & aims: Although Absorb Bioresorbable Vascular Scaffolds (A-BVS) are routinely used in the Asia-Pacific, there is little information on patient selection or deployment technique here. This document investigates the experiences of leading interventional cardiologists from the Asia-Pacific region with a focus on patient characteristics, d...
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Aim: To assess the prevalence of suboptimal bioresorbable vascular scaffold (BVS, Abbott Vascular, Santa Clara, California) deployment in real world practice with intracoronary optical coherence tomography (OCT) imaging. Methods: Consecutive patients who underwent percutaneous coronary intervention using BVS and the final optimization assessed w...
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Background: Calcific aortic stenosis and coronary artery disease share common risk factors. In some of the previous studies statins have been used to retard the progression of aortic stenosis, but the results were inconsistent. Methods: One hundred and ten patients of CAS above the age of 40 years have undergone clinical, biochemical and echocar...
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Aim: Role of PET-CT in assessment of myocardial viability in patients with LV dysfunction. Methods: This prospective study included 120 patients with LV dysfunction who underwent 99mTechnetium-Sestamibi myocardial perfusion SPECT-CT and 18FFDG cardiac PET-CT. They also underwent serial echocardiography and coronary angiography along with myocard...
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Background: Degenerative aortic stenosis (DAS) and coronary artery disease (CAD) share common risk factors. In some of the previous studies statins have been used to retard the progression of aortic stenosis, but the results are inconsistent Objective (aim): To study the risk factor profile in degenerative aortic stenosis with and without associate...
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Dabigatran is a new oral direct thrombin inhibitor and has been proposed to overcome many pitfalls of warfarin therapy. Method: In this study, we retrospectively studied 236 patients who had atrial fibrillation and were at risk of stroke who received fixed dose of Dabigatran 110 mg and adjusted-dose warfarin. Patients were followed up for a period...
Article
Major entry site complications are rare following transradial approach. Arterio-venous fistula following radial catheterization is a very rare complication. It can occur rarely and should be evaluated. This report highlights a case of radial Arterio-venous fistula following percutaneous coronary interventions by right radial approach and good outco...
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Recent technologic developments have led to the development of Absorb(TM) Bioresorbable Vascular Scaffold (BVS) [Abbott Vascular, Santa Clara, USA] for percutaneous treatment of Coronary Artery Disease by percutaneous coronary intervention (PCI). The BVS is now approved for use in many countries but experience in bifurcation lesions is limited and...
Article
Gunasekaran Sengottuvelu, MD, DM, Ravindran Rajendran, MD, DMChennai, IndiaA 58-year-old-man was referred to us after throm-bolysis for acute inferior wall myocardial infarction.A coronary angiogram showed intraluminal fillingdefects extending from the proximal to distal rightcoronary artery (RCA) suggestive of spontaneouscoronary artery dissection...
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Objectives: To study the clinical usefulness, cost benefit, and medium term outcome of fractional flow reserve (FFR) based management of coronary artery disease of intermediate severity. Background: In spite of the advantages of FFR there is paucity of data in Indian population who have frequent diffuse, small and multivessel disease where it wo...
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Despite restoration of epicardial flow during primary PCI in STEMI, microvascular obstruction may persist as a result of both atheromatous and thrombotic embolization and vasospasm. Compared with the systemic administration of IV pharmaco-therapies, highly localized administration of intracoronary pharmacotherapy may be associated with a several-hu...
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Preamble The potential risk of contrast-induced acute kidney injury (CI-AKI) has made utilization of coronary angiography in the work-up for the diagnosis of coronary artery disease in CKD quite low.1 This is in contrast to increasing prevalence and severity of CAD as the serum creatinine rises.2 In fact most CKD patients will succumb to CAD and no...
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The presence of erosion/malapposition of a Sirolimus eluting stent was clearly visualized using Optical Coherence Tomography (OCT) imaging. The presence of erosion/malapposition and the absence of neointimal hyperplasia after 10 months of sirolimus eluting stent could constitute a potential thrombogenic substrate for late stent thrombosis.
Article
Trans radial approach to cardiac catheterization and per cutaneous coronary intervention is promising, with many advantages that seemingly outweigh the relatively few limitations when employed in the appropriate patient population. This approach carries the potential to be the standard approach in the setting of elective angioplasty, with increasin...
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Radial artery perforation is a rare but important complication of the transradial approach. This report highlights two cases of radial artery perforation during percutaneous coronary intervention managed by simple strategies without resorting to an alternative route. The guiding catheter itself helps to seal the perforation, hence continuing to per...