Senem Kamiloglu

Bursa Uludağ Üni̇versi̇tesi̇ · Department of Food Engineering

Polyphenols and carotenoids are known for their positive effects on health, including the prevention of several chronic diseases, and many food materials have been studied so far in order to investigate the content of polyphenols and carotenoids. However, the in vivo effects of these compounds depend not only on their concentrations, but also on th...

Black carrots represent a valuable source of polyphenols, in particular anthocyanins and phenolic acids, and has attracted the attention of the scientific community especially due to the unique profile of anthocyanin compounds, which are well distinguished for their role in health promotion and prevention of chronic diseases. Black carrots are ofte...

Scope: The present study was developed to determine the ability of polyphenol-rich black carrot and its by-products, i.e., peel and pomace, to modulate the inflammatory response in tumor necrosis factor α (TNF-α) treated endothelial cells after gastrointestinal digestion and in a co-culture of intestinal Caco-2 and endothelial EA.hy926 cell model....

Phytochemicals help mitigate skin aging by scavenging free radicals, modulating key enzymatic pathways, and promoting the skin’s structural integrity. Carotenoids, vitamins, essential fatty acids, and phenolic compounds work by acting as antioxidants, inhibiting enzymes like hyaluronidase, collagenase, and elastase, which degrade skin structure, an...

Bu çalışmada çörek otu posasının iki farklı reçete ile marmelada işlenmesi sonucunda toplam fenolik madde, toplam antioksidan kapasite ve bireysel fenolik bileşenlerin biyoerişilebilirliğinde meydana gelen değişimler in vitro sindirim modeli ile incelenmiştir. UPLC-ESI-MS/MS analizi, klorojenik asit, p-salisilik asit ve o-salisilik asidin hem çörek...

Type 2 diabetes is marked by elevated blood sugar levels and linked to impaired insulin secretion and resistance to insulin. Researchers are continuously investigating different classes of phytochemicals including natural pigments for their potential direct or indirect advantages in the prevention and/or control of diabetes. In this review, clinica...

Food security and sustainability have been among the most fundamental issues throughout human history. As the Turkish Academy of Sciences (TÜBA), we present the book "Alternatif Gıda Kaynakları" (Alternative Food Sources) as an indication of our deep interest in this critical issue and our search for solutions. In this book, alternative food source...

The industrial processing of pineapples generates a substantial quantity of by-products, including shell, crown, and core. Bromelain, a proteolytic enzyme found naturally in pineapple, including its by-products, may positively influence the bioaccessibility of phenolics from milk coffee. Therefore, this study aimed to assess how the inclusion of ex...

Citrus fruits hold a significant position among the valuable commodities of the Mediterranean region. They contribute to health promotion by assisting in the prevention of chronic disease-related pathophysiological conditions. Exploration into the phytochemical composition of citrus fruits and their processed products has unveiled the existence of...

The industrial processing of pineapples generates a substantial quantity of by-products including shell, crown, and core. Bromelain, a proteolytic enzyme found naturally in pineapple including the by-products, may positively influence the bioaccessibility of phenolics from milk coffee. Therefore, this study aimed to assess how the inclusion of pine...

Butternut squash (Cucurbita moschata) is recognized as a functional food due to its abundant content of health-promoting compounds, including carotenoids and polyphenols. The aim of this study was to examine the impact of industrial freezing stages on the bioaccessibility of carotenoids and polyphenols in organic Butternut squash supplied for baby...

BACKGROUND Citrus peels, which are often discarded as waste in the food‐processing industry, are rich sources of polyphenols. The aim of the current study was to investigate the influence of an industrial freezing process along with blanching and cutting pretreatments on the in vitro gastrointestinal digestion stability of orange (Citrus sinensis L...

Amaç: Tüketicilerin doğal katkı maddeleri içeren; yağ, kolesterol ve tuz seviyeleri düşürülmüş; besin değeri yüksek ve bitkisel içerikli fonksiyonel et ürünlerine gösterdikleri ilgi her geçen gün artmaktadır. Bu çalışmada; sığır eti kaynaklı kıymaya soya unu, mercimek unu ve nohut unu baklagil proteinleri, bal kabağı unu, karabuğday unu, peynir alt...

The health-related properties attributed to berries and the subsequent interest awakened within the market of functional foods mean that these small fruits may be potential targets for food fraud. In this review, studies on berry authentication through modern analytical techniques are discussed in detail. Most of the studies reported to date are re...

Citrus fruits can be consumed fresh or they can be subjected to various processes including freezing to extend their shelf life. The aim of the current study was to evaluate the bioaccessibility of polyphenols in samples collected at different stages of the industrial freezing process of oranges and grapefruits. The major polyphenols were identifie...

Amaç: Bu çalışmanın amacı, taze ve donuk Klementin türü mandalinada ve mandalina kabuğunda toplam fenolik maddenin, toplam flavonoid maddenin, toplam antioksidan kapasitenin ve flavanon glikozitlerin biyoerişilebilirliklerinin in vitro sindirim modeli kullanılarak değerlendirilmesidir. Materyal ve yöntem: Mandalina polifenollerinin biyoerişilebilir...

The common medlar (Mespilus germanica L.) is one of two species within the Mespilus genus (Maloideae subfamily). Its use can be traced back almost 30 centuries, from ancient Assyrians and Babylonians to Greeks and Romans and through modern times. During the Middle Ages it was a popular fruit tree and a highly appreciated ornamental tree in gardens...

Pollen, a natural component of flowers that regulates the reproduction of plants, is in granular form and collected by bees as source of food. A wide range of nutrients including carbohydrates, amino acids, vitamins and polyphenols constitute bee pollen, the latter being responsible for its various biological activities. The aim of the current stud...

Food Traceability 4.0 refers to the application of fourth industrial revolution (or Industry 4.0) technologies to ensure food authenticity, safety, and high food quality. Growing interest in food traceability has led to the development of a wide range of chemical, biomolecular, isotopic, chromatographic, and spectroscopic methods with varied perfor...

Fig (Ficus carica) is one of the most abundant fruits in the Mediterranean diet, promoting health by preventing pathophysiological conditions related to chronic diseases. Phytochemical studies on figs revealed the presence of several bioactive compounds, including polyphenols, carotenoids, vitamins, organic acids, triterpenoids, phytosterols, and f...

Sübye; kavun çekirdekleri, şeker ve su ile hazırlanan geleneksel bir soğuk içecektir. Bu çalışmada ağız, mide ve bağırsaktaki sindirimi taklit eden in vitro bir model kullanılarak şeker ve tatlandırıcı ile hazırlanan sübye formülasyonlarında toplam fenolik madde ve toplam antioksidan kapasitedeki değişimlerin belirlenerek gıda matrisinin fenolik bi...

Emodin (1,3,8-trihydroxy-6-methylanthraquinone) is a bioactive compound, a natural anthraquinone aglycone, present mainly in herbaceous species of the families Fabaceae, Polygonaceae and Rhamnaceae, with a physiological role in protection against abiotic stress in vegetative tissues. Emodin is mainly used in traditional Chinese medicine to treat so...

Medicinal applications of turmeric-derived curcumin have been known to mankind for long ages. Its potential in managing "cystic fibrosis" has also been evaluated. This autosomal recessive genetic disease is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) which involves an impaired secretion of chloride ions and...

There has been a growing demand towards alternative protein sources due to population growth and increasing consumer awareness on sustainability and environmental issues. Proteins from various plant, marine, insect and microbial sources are considered as excellent alternatives to substitute traditional animal-based proteins due their relatively low...

BACKGROUND The potential health‐promoting effects of polyphenols depend considerably on their bioaccessibility, which is affected by the presence of other nutrients in the diet, including lipids. In this study, several salad dressing formulations were prepared using industrial broccoli by‐product powder (BBP), lemon juice (LJ), and three different...

Nowadays, consumers have become aware of different cocoa genotypes and their origins, which caused an expanding market of premium chocolates with single-origin cocoa beans. Due to the high demand for superior quality products, cocoa beans may be subjected to adulteration. For accurate discrimination of the cocoa beans, three major analytical approa...

Nowadays, the application of membrane technologies in the food industry attracted attention due to increasing interest towards environmentally friendly processing procedures as well as the production of foods with higher nutritional value. Nanofiltration, a pressure-driven membrane operation, became an economically appealing technology in the food...

The current increased industrial food production has led to a significant rise in the amount of food waste generated. These food wastes, especially fruit and vegetable byproducts, are good sources of natural pigments, such as anthocyanins, betalains, carotenoids, and chlorophylls, with both coloring and health-related properties. Therefore, recover...

Polyphenols are plant secondary metabolites comprising of a large class of compounds, which can be broadly classified as flavonoids including flavonols, flavones, flavanones, flavanols, isoflavones, anthocyanins and non-flavonoids including phenolic acids, tannins, stilbenes, and lignans. Polyphenols have important health-promoting effects accordin...

Chronic diseases including cardiovascular diseases, diabetes, cancers, neurodegenerative diseases and chronic respiratory diseases are the major causes of global deaths. Poor diet is the main risk factor that is linked to the occurrence of degenerative diseases. Owing to their potential effects in the prevention of chronic diseases, bioactive compo...

In this study, terebinth coffee formulations were prepared with whole or skimmed milk with or without sugar/sweetener in order to study the matrix effect on the bioaccessibility of terebinth polyphenols. Quercetin glycosides and catechin were the major flavonoids identified in the terebinth formulations, whereas gallic, protocatechuic, syringic and...

https://www.frontiersin.org/research-topics/23564/the-role-of-polyphenols-and-nanopolyphenols-in-the-management-of-oxidative-stress-and-metabolic-synd

Prediction of retention times (RTs) is increasingly considered in untargeted metabolomics to complement MS/MS matching for annotation of unidentified peaks. We tested the performance of PredRet (http://predret.org/) to predict RTs for plant food bioactive metabolites in a data sharing initiative containing entry sets of 29–103 compounds (totalling...

Plants of the genus Brassica occupy the top place among vegetables in the world. This genus, which contains a group of six related species of a global economic significance, three of which are diploid: Brassica nigra (L.) K. Koch, Brassica oleracea L., and Brassica rapa L. and three are amphidiploid species: Brassica carinata A. Braun, Brassica jun...

Plants of the genus Brassica occupy the top place among vegetables in the world. This genus, which contains a group of six related species of a global economic significance, three of which are diploid: Brassica nigra (L.) K. Koch, Brassica oleracea L., and Brassica rapa L. and three are amphidiploid species: Brassica carinata A. Braun, Brassica jun...

The attention in nutraceuticals and functional foods keeps growing, driven by progressive research efforts to identify the properties and potential applications of nutraceuticals. The current population and health trends are the main reasons for the growth of the functional food market. Cardiovascular disease remains the primary leading cause of de...

Bioactive compounds including polyphenols, carotenoids, vitamins, omega–3 fatty acids, organic acids, nucleosides and nucleotides, and phytosterols have attracted great attention due to their role in prevention of several chronic diseases. Accordingly, the methods that are used to analyze these compounds are of interest. Many attempts have been mad...

Over the last decades, food safety has been a growing concern all over the world. Traceability systems are considered as the main tools for eliminating the concerns of consumers, manufacturers and legal authorities on food safety. Considering that, different types of techniques have been developed for the food industry to enable proper traceability...

Globally increased food fraud and adulteration through practices including, among the others, misrepresentation or mislabeling led to the development of laws, policies, and standards to produce authentic and traceable food products in several countries. It is critical to review the national regulations to provide a comparative evaluation of global...

Although the fate of anthocyanins along digestion has been a matter of research over the last decade, their bioaccessibility so far has been mainly assessed for single administered fruits or vegetables, which is far from the real scenario where they are co-ingested in a meal. Accordingly, the aim of this study was to evaluate the effect of simultan...

Background:Dietary flavonoids have drawn great interest owing to their potential positive effects on health, which considerably rely on their bioaccessibility, transport and further metabolism in the body. One of the key parameters that influence the flavonoid bioavailability is the interaction of these compounds with other nutrients present in the...

Analysis of the most relevant studies on the pharmacological properties and molecular mechanisms of psoralidin, a bioactive compound from the seeds of Cullen corylifolium (L.) Medik. confirmed its complex therapeutic potential. In the last years, the interest of the scientific community regarding psoralidin increased, especially after the discovery...

Recently, the interest in the application of cell viability assays has been increasing in various fields. Cell viability assays may be broadly classified as (a) dye exclusion assays, (b) colorimetric assays, (c) fluorometric assays, (d) luminometric assays, and (e) flow cytometric assays. Dye exclusion assays include trypan blue, eosin, congo red,...

BACKGROUND Spinach is well recognized as a functional food owing to its diverse nutritional composition, including polyphenols. Freezing is an efficient preservation method that is used to maintain the physical and nutritional characteristics and extend the shelf life of spinach. The aim of this study was to determine the changes in polyphenols in...

Flavonols are the most widespread subgroup of the flavonoids. Quercetin, kaempferol, myricetin, and isorhamnetin are the major dietary flavonol aglycones, which most commonly occur as O-glycosides in dietary sources including fruits, vegetables, tea, and wine. The role of flavonols and O-glycosides in human nutrition has gained increased interest d...

Members of the Prosopis genus are native to America, Africa and Asia, and have long been used in traditional medicine. The Prosopis species most commonly used for medicinal purposes are P. africana, P. alba, P. cineraria, P. farcta, P. glandulosa, P. juliflora, P. nigra, P. ruscifolia and P. spicigera, which are highly effective in asthma, birth/po...

Taze fasulye (Phaseolus vulgaris) fenolik bileşen içeriği yüksek olan bir sebze olup, antioksidan içeriği ve aktivitesi bakımından zengin olan ve yaygın tüketilen sebzeler içerisinde sınıflandırılmaktadır. Bu çalışmada taze fasulyenin endüstriyel dondurulma işlemi sırasında çeşitli üretim basamaklardan alınan numunelerde toplam fenolik maddede, top...

Freezing is one of the most well‐established food preservation technique that is used to prolong the shelf life and maintain the quality of strawberries. The aim of the present study was (i) to investigate the changes in polyphenols from fresh and frozen strawberries during in vitro digestion and (ii) to compare effects induced by individual quick...

Cucurbita genus has received a renowned interest in the last years. This plant species, native to the Americas, has served worldwide folk medicine for treating gastrointestinal diseases and intestinal parasites, among other clinical conditions. These pharmacological effects have been increasingly correlated with their nutritional and phytochemical...

Apples can be consumed as fresh or processed into various products including frozen apples. As a result of processing, pomace which is rich in bioactive compounds, is generated. The aim of this study was to evaluate the bioaccessibility of polyphenols in fresh and frozen apples and apple pomace using an in vitro gastrointestinal digestion model. To...

Granny Smith elmalar taze olarak tüketilebildiği gibi donmuş gıda sanayinde de yaygın olarak kullanılmaktadırlar. Gıdaların üretim basamakları sırasında polifenol içeriğinde meydana gelen değişimlerin incelenmesi son ürünün besin değerini artırmak açısından önemlidir. Bu konu dikkate alınarak, bu çalışmada Granny Smith elmaların bireysel hızlı dond...

Nowadays, consumers expect to be sure that a food product complies with its label and demand further information regarding the geographical origin of the product. Beverages are among the most likely foods to be the target of food fraud. Adulteration through practices including, among the others, mixing or substituting the original material with oth...

The role of antioxidants in human nutrition has gained increased interest, especially due to their associated health benefits against a number of chronic diseases including cardiovascular and neurodegenerative diseases and certain types of cancer. To obtain any influence in a specific tissue or organ, these antioxidants must be bioavailable, that i...

Aronia phenolics are considered to be beneficial for cardiovascular health, but are not always bioavailable. In this study, we evaluated the in vitro bioavailability of Aronia juice phenolics by combination of intestinal digestion models with Caco-2 absorption models. First, intestinal luminal stability and microbial metabolism of Aronia phenolics...

Cost-efficient (bio)chemical production processes are essential to evaluate the commercial and industrial applications of promising carbohydrates and later-on also to ensure economically viable production processes. Here, the synthesis of the naturally occurring disaccharide kojibiose (2-O-α-D-glucopyranosyl-D-glucopyranoside) was evaluated using d...

This chapter reviews the current knowledge on the phenolic compounds present in olive and olive oil as well as the bioavailability of these compounds. The majority of studies regarding the bioavailability of olive and olive oil phenolics have focused on three major phenolics: hydroxytyrosol, tyrosol, and oleuropein. In general, these phenolics from...

The objectives of this PhD thesis were (i) to determine the effect of food processing and storage on black carrot polyphenols; (ii) to investigate the bioaccessibility and intestinal transport of key polyphenols in black carrots, processed products and their agronomic by-products using various in vitro gastrointestinal digestion and absorption mode...

Herbal tea is commonly consumed beverage, brewed from the leaves, flowers, seeds, fruits, stems or roots of plant species, which has been widely used for health care and disease prevention for centuries. With the increase in consumption of herbal tea, attention has been paid to their possible effects on human health and the bioactive compounds acco...

Medicinal plants are sources of health-promoting substances, including phytochemicals and phytoalexins that comprise polyphenols, flavonoids, carotenoids, vitamins A, C, E and several other constituents. Many studies have indicated that medicinal plants have been used to treat human diseases for thousands of years owing to their antimicrobial and a...

Regular consumption of red wine in moderate amounts is proven to possess a positive effect on health because of the phenolic compounds and their ability to act as antioxidants. Aging is one the many factors that affects the phenolic composition of red wines. In this study, the effect of aging on total phenolics (TP), flavonoids (TF), anthocyanins (...

The number of dietary fibre enriched food products introduced to the food market has been increased due to several beneficial effects of dietary fibres, mainly on the digestive system. In recent years, there has been a trend towards finding new sources of dietary fibre, such as agronomic by-products. Dietary fibres produced from by-products of anti...

Polyphenols are a diverse group of micronutrients from plant origin that may serve as antioxidants and that contribute to human health in general. More specifically, many research groups have investigated their protective effect against cardiovascular diseases in several animal studies and human trials. Yet, because of the excessive processing of t...

Anthocyanins from different plant sources have been shown to possess health beneficial effects against a number of chronic diseases. To obtain any influence in a specific tissue or organ, these bioactive compounds must be bioavailable, i.e., effectively absorbed from the gut into the circulation and transferred to the appropriate location within th...

Plant processing by-products of black carrot represent an important disposal problem for the industry, however they are also promising sources of polyphenols, especially anthocyanins. The present study focused on the changes in polyphenols from black carrot, peel and pomace during in vitro gastrointestinal digestion. Total phenolic content (TPC), t...

The role of antioxidants in human nutrition has gained increased interest, especially due to their associated health beneficial effects for a number of chronic diseases, including cardiovascular diseases and certain types of cancer. Fruits and vegetables are perishable and difficult to preserve as fresh products. Dried fruits and vegetables can be...

Tea and herbal infusions are among the major contributors of phenolic compounds, specifically flavonoids, in our daily diet. Honey is another antioxidant-rich food that is widely used as a natural sweetener. In this work, the effects of honey addition on antioxidant properties of different herbal teas were investigated. For this purpose, 2 differen...

In order to investigate the effect of sun-drying on the health-related constituents as well as bioaccessibility of figs; total phenolics, flavonoids, proanthocyanidins, anthocyanins, antioxidant capacity and major phenolic compounds were determined for two commercial figs (Sarilop and Bursa siyahi) with different color (yellow and purple). In addit...

In order to investigate the effect of home processing on the bioaccessibility of health-related constituents of tomatoes; total lycopene, phenolics, flavonoids, and antioxidant capacity were determined from seven different tomato products using an in vitro gastrointestinal digestion model. Additionally, the changes in the contents of the major toma...

Herbs and spices have been used for many purposes including medicine, flavourings, and preservatives, etc. Constituents of herbs and spices can function as natural antioxidants and thus improve human nutrition and health. The main objective of this study was to evaluate the total phenolic and flavonoid contents of 35 different Turkish herbs and spi...

Dried fruits and nuts are considered as healthy snacks and they are often consumed together in the Turkish diet. In order to investigate the effect of codigestion of dried fruits (figs, apricots, raisins) together with nuts (almonds, walnuts, hazelnuts), total phenolics (TP) and total antioxidant capacity (TAC) have been evaluated spectrophotometri...

In this study, to evaluate the in vitro bioaccessibility of eight different pekmez and pestil samples, total phenolics, flavonoids, proanthocyanidins, anthocyanins and antioxidant capacity were determined at different phases of simulated gastrointestinal (GI) digestion. For the analysis of antioxidant activity, four different methods were used incl...

In this study, in order to evaluate the in vitro bioaccessibility of fresh and sun-dried figs, total antioxidant capacity (TAC), total proanthocyanidin content (TPA) and the major phenolic compounds were determined at different phases of simulated gastrointestinal (GI) tract digestion for Sarilop and Bursa siyahi fig varieties. Four major phenolic...

Sour cherry (Prunus cerasus L.) is rich in polyphenols, and like its processed products, is especially rich in anthocyanins. We have applied HPLC, spectrophotometric and on-line antioxidant detection methods to follow the fate of cherry antioxidants during an entire multi-step industrial-scale processing strategy. This was performed for 22 sampling...