Semih Öz

Eskisehir Osmangazi University | ESOGU · Vocational School of Health Services

Purpose: Cerebral ischemia is the result of decreased or interrupted blood flow to the brain. It is the third leading cause of death after cardiovascular disease and cancer. Cerebral ischemia is reversible or irreversible in neurons in the affected area, and subsequent free radical damage can be exacerbated if reperfusion occurs. Ciproxifan is use...

Introduction: The prevalence of cerebral ischemia-related diseases, which mostly affect the brain, has become pervasive and is associated with significant societal and economic challenges. The deficiency of the organism’s antioxidant defense system results in an elevation of free radicals, which in turn contributes to the development of a range of...

Introduction: Renal ischemia (I) could develop due to decreased or ceased blood flow to the kidney in some clinical conditions such as shock, sepsis, and kidney transplantation. The re-supply of blood to the kidney is called reperfusion (R). Ischemia and reperfusion periods can cause severe kidney damage. Objectives: When we examined the I/R molecu...

Objective:Testicular torsion is one of the most common genital diseases in males in adolescence and it should be treated as soon as possible without ipsilateral testicular dysfunction. We investigated the protective effect of Capsaicin, which is an active ingredient of red-hot pepper, an antioxidant substance, on tissue damage caused by ischemia/re...

Purpose Anatomy, one of the cornerstone branches of medical education, is one of the rare areas, where the traditional method remains the most efficient education method despite technological developments. However, the COVID-19 pandemic has made it impossible for the traditional method to continue and has enabled the integration of different distan...

PurposeTraditional anatomy education (TAE) is based on teaching by seeing and touching cadavers/plastic materials that enable three-dimensional thinking, but there was no opportunity like this in distance anatomy education (DAE). Due to the COVID-19 pandemic in 2020, many trainings planned face-to-face were carried out remotely. In this study, our...

This study tested the possible protective and therapeutic effects of Viscum album extract and probiotics against carbon tetrachloride (CCl4)-induced acute/chronic liver injury. Male Wistar rats were assigned to seven groups: Control, acute CCl4, acute V. album + CCl4, acute V. album + Probiotics + CCl4, chronic CCl4, chronic CCl4 + V. album, and ch...

Lipopolysaccharide (LPS) is a component of the cell wall of Gram-negative bacteria that produces endotoxemia, which may cause septic shock. Metformin (MET) is a widely used hypoglycemic drug that exhibits anti-inflammatory properties. Fibroblast growth factor 21 (FGF21) is an endocrine polypeptide that affects glucose and lipid metabolism, and also...

Ischemia and reperfusion occur in some tissues or organs and may develop the severity of dysfunction. It causes permanent functional or structural damage and occurs many events leading to cell death. It is possible to see the damage not only in the tissues where the blood flow is stopped but also elsewhere in the body. Ciproxifan belongs to a novel...

ZET Bütün kemikler, besleyici kan damarlarının girişi için foramen nutricium (FN) olarak bilinen irili ufaklı açıklıklara sahiptirler. Bu açıklıklardan giren besleyici arterler, besleyici kanaldan geçip kemiklerin meduller boşluğuna ulaşıp kemik diafizinin beslenmesini sağlamaktadırlar. Uzun kemiklerdeki FN'ların lokalizasyonlarının bilinmesi, serb...

Kadavra, vital fonksiyonlarını tamamen yitirmiş bir insanın bedeninin eğitim ve araştırmalarda incelenmek amacıyla muhafaza edilmesidir. Bugün tıpta Anatomi eğitimde yoğun şekilde kadavra kullanılmaktadır. Lakin ülkemizde bağış sayısı yetersizliğinden dolayı toplam kadavra sayısında eksiklik bulunmakta ve bu durum da Anatomi eğitimindeki en ciddi s...

Objective: The aim of this study was to compare the effects of conivaptan, an arginine vasopressin antagonist, and mannitol, a sugar alcohol, on cerebral ischemia-induced brain injury and edema in rats. Materials and methods: Fifty-eight 8-week-old male Sprague Dawley rats were randomly divided into five groups: control, ischemia-reperfusion (I/...

This study aimed to investigate the post-ischemic effects of aquaretic conivaptan and diuretic mannitol on serum tumor necrosis factor-α (TNF-α), interleukin-15 (IL-15) and interleukin-35 (IL-35) levels in an experimental cerebral ischemia-reperfusion (I/R) rat model. Healty male Sprague-Dawley rats were randomly divided into five groups: Control (...

Metformin is a commonly used oral Type II diabetes drug around worldwide. It mainly exhibits anti- hyperglycaemic effect by suppressing hepatic gluconeogenesis. Metformin is substantially excreted by the kidney. Beyond low cost and limited side effects, metformin has also anti-aging, anti-cancer and anti-inflammatory properties. In this study, it w...

In this study, the effects of metformin on pancreatic tissue after lipopolysaccharide (LPS)-induced sepsis were investigated. 30 Sprague Dawley male rats were used in the study. Five groups were formed: control, sepsis, sepsis+1 hour before metformin, sepsis+1 hour later metformin and sepsis+3 hour later metformin as 6 animals in each group. LPS an...

In this study, it was aimed to investigate the post-ischemic effects of treatments with aquaretic conivaptan and diuretic mannitol on serum tumor necrosis factor-α (TNF-α), interleukin-15 (IL-15) and interleukin-35 (IL-35) levels following an experimental cerebral ischemia-reperfusion (I/R) rat model. Healty male Sprague-Dawley rats (n=58) were ran...

OBJECTIVES: Smoking is the main cause of many diseases today. Nicotine and some heavy metals in the cigarette cause damage to the liver, heart, lungs, etc. due to oxidative stress . Several studies have shown that L-NAME inhibits oxidative stress via NOS (nitric oxide synthase). Vitamin E(alpha-tocopherol) has been shown to be effective on oxidativ...

OBJECTIVES : Cigarette smoke causes chronic diseases , especially lung diseases which is the main source of morbidity and mortality. Many studies have shown that increased oxidant burden in smokers contributes to lung damage through many biological actions . The effect of L-NAME on oxidative stress has been shown in various studies . Vitamin -E was...

OBJECTIVES : It was aimed to investigate some blood parameter values in rats exposed to cigaratte smoke obtained from commercial cigaratte by inhalation for 42 days. It is possible that toxic substances in cigarettes and carried in blood may damage the balance between oxidant and antioxidant system.In this study, it was aimed to investigate the eff...

International tax competition has been significantly increased since 1980s as a result of liberalized financial and fiscal policies, while this leads sovereign nations faced budgetary deficit problems and public finance related considerations. This paper aims to analyze how Turkish tax system is affected by international tax competition, services s...

Many practical applications in the field of medical image processing need valid, reliable and fast image segmentation. In this study, we propose a semi-automatic segmentation approach. In this approach, an extended version of the Otsu's method for three level thresholding and a recursive connected component algorithm are combined. The segmentation...