Sema Ciftci

University of Health Sciences, Bakirkoy Dr. Sadi Konuk Training and Research Hospital

Objective: To evaluate the effects of the pandemic process on those with an endocrinological disease that will require close follow-up from the last visit before the pandemic. Materials and methods: Patients of 3,903 with thyroid, calcium-bone metabolism, adrenal gland, pituitary diseases, and neuroendocrine tumor (NET) were retrospectively scan...

Purpose: Forearm osteoporosis is a well-known complication of primary hyperparathyroidism (PHPT). However, measuring forearm bone mineral density (BMD) by dual-energy X-ray absorptiometry (DXA) at the distal radius is often neglected in clinical practice despite the fact that osteoporosis at any site is a criterion indicating surgery. We aimed to...

Aim Cardiac involvement in acromegaly is defined as acromegalic cardiomyopathy, an insidious and chronic disease. Previous research on acromegalic cardiomyopathy was largely focused on morphological and functional assessment of the left heart. Since the literature data regarding right heart function in acromegalic patients are limited, we aimed to...

The purpose of this study was to determine possible cut-off levels of basal DHEA-S percentile rank in the differential diagnosis of patients with Cushing’s syndrome (CS) with ACTH levels in the gray zone and normal DHEA-S levels. In this retrospective study including 623 pathologically confirmed CS, the DHEA-S percentile rank was calculated in 389...

Aim: To estimate the proportion of patients with persistent normoprolactinaemia following dopamine agonist (DA) withdrawal and to identify predictors of successful withdrawal in patients with hyperprolactinaemia. Methods: Eligible studies were identified by searching PubMed and Embase. The primary outcome was the proportion of patients with norm...

Purpose To evaluate effect of first-line dopamine agonist (DA) therapy as an alternative to surgery for visual field defect (VFD) recovery in giant and macro-prolactinoma. Methods In this retrospective study, 125 patients with giant and macro-prolactinoma, except those with a history of previous surgery or radiotherapy, were evaluated. Those who u...

Objective To evaluate the effects of the pandemic process on those with an endocrinological disease that will require close follow-up from the last visitbefore the pandemic. Design This was a retrospective study. Methods Patients of 3903 with thyroid, calcium-bone metabolism, adrenal gland, pituitary diseases, and neuroendocrine tumor (NET) were re...

Purpose: To assess depression and anxiety and their relationship with disease activity in patients with Cushing’s syndrome (CS) in the COVID-19 pandemic. Material and methods: This is a cross-sectional study including 54 patients with CS (48 female/6 male). Beck Depression Inventory-II (BDI-II), State Trait Anxiety Inventory (STAI)-State, STAI-Trai...

Aim: To examine and compare the anxiety level and stress perception of acromegaly patients with controlled and active disease in the COVID-19 pandemic. Material and Method: 49 (23 females/26 males) patients admitted to the outpatient clinic during the first month after the pandemic period were recruited in this cross-sectional study. State-Trait An...

Objective: To assess the depression and anxiety and their relationship with disease activity in patients with Cushing's syndrome (CS) in the coronavirus disease-2019 (COVID-19) pandemic. Material and Methods: This cross-sectional study included 54 patients with CS (48 females, 6 males). Beck Depression Inventory-II (BDI-II), State-Trait Anxiety Inv...

Objective: To investigate the anterior gradient 2 (AGR2) mRNA expression, which performs various cellular functions such as cell migration, differentiation, and proliferation in tissue specimens from pituitary adenomas. Material and Methods: A total of 44 pituitary adenoma specimens (20 female/24 male) from patients, and ten normal brain tissues (5...

Purpose Type 2 diabetes mellitus (T2DM) is a major risk factor for cardiovascular diseases (CVD). The plasma atherogenic index (PAI) has been suggested as a novel marker of atherosclerosis and coronary heart disease. The present study is conducted to investigate the relationship between glycated hemoglobin (HbA1c), non-HDL (high-density lipoprotein...

Purpose Type 2 diabetes mellitus (T2DM) is a major risk factor for cardiovascular diseases (CVD). The plasma atherogenic index (PAI) has been suggested as a novel marker of atherosclerosis and coronary heart disease. The present study is conducted to investigate the relationship between glycated hemoglobin (HbA1c), non-HDL (high-density lipoprote...

Aim: To determine risk factors associated with the development of insulin resistance, type 2 diabetes mellitus (T2DM), and metabolic syndrome (MetS) in gestational diabetes mellitus (GDM) patients 10 years after delivery. Methods: Medical records of patients with former GDM were screened. Eligible patients were invited to the hospital to obtain...

Case report: Adrenal pseudocysts are rare bening lesions that usually mimick solid tumors on imaging. Although they are asymptomatic and often discovered incidentally, distinguishing them from clinically important adrenocortical masses may be problematic before surgery. We report the case of a 50-years-old female who was referred to endocrinology o...

Introduction: Thyroid surgery for benign and malign diseases is one of the most common procedures performed in surgical practice. Complication rates are higher in malignant and inflammatory diseases, recurrent surgeries and in hyperthyroid patients. Hypocalcemia is one of these complications. There are many studies investigating the effect of incid...

Context Signs and symptoms of Cushing’s syndrome (CS) overlap with common diseases, such as the metabolic syndrome, obesity, osteoporosis, and depression. Therefore, it can take years to finally diagnose CS, though early diagnosis is important for prevention of complications. Objective The aim of this study was to assess the time span between firs...

The purpose of the study was to compare serum visfatin levels between patients with acromegaly and healthy controls and to evaluate the relationships between visfatin levels and epicardial fat thickness (EFT), carotid intima media thickness (cIMT), and ankle brachial index (ABI). We conducted a cross-sectional case-control study of 54 patients with...

Acromegaly is known to be associated with high incidence of malignancies probably due to the mitogenic effects of IGF-1. Differentiated thyroid cancer (DTC) is reported to be one of the most frequent malignancies associated with acromegaly. But there is no data about the clinical course of DTC in acromegalic patients. In this study, we evaluated th...

Acromegaly is known to be associated with high incidence of malignancies probably due to the mitogenic effects of IGF-1. Differentiated thyroid cancer (DTC) is reported to be one of the most frequent malignancies associated with acromegaly. But there is no data about the clinical course of DTC in acromegalic patients. In this study, we evaluated th...

Introduction: The laparoscopic adrenalectomy (LA) has become the gold standard since the transperitoneal laparoscopic approach was first reported. Aim: To evaluate the applicability, safety and short-term results of laparoscopic surgery in adrenal masses over 6 cm. Material and methods: Demographic data, hormonal activities, imaging modalities, ope...

Context Dopamine agonist (DA)-induced impulse control disorder (ICD) in prolactinomas is not sufficiently known. Objective To evaluate the prevalence of DA-induced ICDs and possible risk factors related to these disorders in patients with prolactinoma. Design, Setting and Participants This is a cross-sectional multicenter study involving 308 prol...

Purpose To investigate the nodular thyroid disease (NTD) and the natural course of thyroid nodules in patients with acromegaly. Methods 138 patients with acromegaly (73 F/65 M), whose initial thyroid ultrasonography performed in our university hospital, were included in this study. The frequencies of NTD, papillary thyroid cancer (PTC) and associa...

Amaç: Güncel rehberlere göre glikolize hemoglobin A1c (HbA1c) hedefleri hastanın yaşı ve komorbiditeleri göz önüne alınarak kişiselleştirilmelidir. Çalışmamızda, hastanemize başvuran diyabetik hastalarda cinsiyet ve yaşa göre HbA1c değerlerinin nasıl değiştiğini belirlemeyi ve bulguları literatür eşliğinde incelemeyi amaçladık. Gereç ve Yöntemler:...

Aims: Aryl hydrocarbon receptor-interacting protein (AIP) gene mutations have long been associated with apparently sporadic pituitary adenomas (PAs) with a prevalence range of 0-12%. The aim of this study was to evaluate the frequency of germline AIP variations in a large cohort of apparently sporadic PAs diagnosed before the age of 40 years, who...

Purpose: To assess baseline T2-weighted signal intensity (T2-WSI) of functional pituitary adenomas (FPA), and to investigate the relationship of baseline T2-WSI with clinical features, histopathological granulation patterns, and response to treatment in patients with acromegaly, prolactinoma and Cushing's disease (CD). Methods: Somatotroph adeno...

Background Regarding the incidence of colorectal malignancy and polyps in patients with acromegaly, studies reported different results in different populations. For this reason, the aim of this study was to determine the frequency of possible colonic pathologies, such as diverticula, polyps, and malignancies in Turkish patients with active acromega...

Objective: The granulation pattern of pituitary tumors may be important to predict tumor behavior, treatment outcomes, and recurrences. Therefore, we compared densely granulated corticotroph tumor (DGCT) and sparsely granulated corticotroph tumor (SGCT) in terms of clinicopathologic findings. Material and method: A total of 41 patients (31 femal...

Background: To evaluate the applicability, safety and short-term results of laparoscopic surgery in adrenal masses over six centimetres. Methods: Demographic data, preoperative hormonal activities, imaging modalities, surgical and medical history, operative findings, operation time, conversion to open surgery, complications, duration of hospital st...

In this study, we aimed to evaluate the presence of glucose metabolism abnormalities and their impact on IGF-1 levels in patients with acromegaly. Ninety-three patients with acromegaly (n=93; 52 males/41 females) were included in this study. Patients were separated into three groups such as; normal glucose tolerance (n=23, 25%), prediabetes (n=38,...

Objective The aim of this study was to determine the frequency of central thyroid dysfunctions in Cushing's syndrome (CS). We also aimed to evaluate the frequency of hyperthyroidism due to the syndrome of the inappropriate secretion of TSH (SITSH), which was recently defined in patients with insufficient hydrocortisone replacement after surgery. M...

Purpose: To evaluate the gonadal functions and related factors in female patients with acromegaly at the time of diagnosis, the course of gonadal dysfunctions and pregnancies during the follow-up period, and the investigation of ovarian reserve with serum anti-Mullerian hormone (AMH) levels in patients with reproductive age. Methods: Patients wh...

Prolactinomas are the most common hormone-secreting pituitary adenomas. Prolactinomas account for nearly 30–40 percent of all the pituitary adenomas. Although it affects individuals over a wide age range, it is more common in 20– 40-year-old female patients, who are in their reproductive age. Prolactinomas may cause hypogonadism, menstrual cycle dy...

Objective: Increased frequency of nodular thyroid disease has been reported in acromegalic patients. Recent studies have also demonstrated an increased co-existence of nodular thyroid disease with Cushing’s disease and prolactinoma. In this study, we evaluated the frequency and outcomes of nodular thyroid disease in each type of functional pituitar...

In this study, we aimed to evaluate the presence of glucose metabolism abnormalities and their impact on IGF-1 levels in patients with acromegaly. Ninety-three patients with acromegaly (n=93; 52 males/41 females) were included in this study. Patients were separated into three groups such as; normal glucose tolerance (n=23, 25%), prediabetes (n=38,...

The coexistence of Cushing’s syndrome (CS) and pregnancy is uncommon due to the suppression of gonadotropin secretion in CS. Adrenocorticotropic hormone (ACTH) dependent CS in pregnancy is less frequent than adrenal causes. The diagnosis of CS during pregnancy is difficult since physiological changes in the hypothalamo-pituitary-adrenal axis may ca...

Purpose Macroprolactin, the high-molecular mass prolactin isoform, is considered to be an inactive product with extrapituitary origin. Although macroprolactinemia is considered a benign condition, there is evidence of overlapping clinical features among patients with hyperprolactinemia. Data on the prevalence of macroprolactinemia in prolactinomas...

Paget’s disease is a disorder of aging bone which occurs in the setting of accelarated bone remodelling. In the presented case we discuss the difficulties in the diagnosis of Paget’s disease in a 77 year old patient with coexisting endometrium carcinoma. The patient was initially diagnosed with metastatic bone disease due to endometrium adenocarcin...

What is known and objective: Somatostatin analogs control GH/IGF-1 excess in acromegaly. Somatostatin receptors also mediate the complex effects of somatostatin on the gastrointestinal tract and may be defensive in inflammatory bowel diseases, such as ulcerative colitis. We present a patient who showed good response to long-acting octreotide (OCT-...

Purpose: The aim of the study was to assess the effect of dopamine agonist (DA) withdrawal, the current recurrence rate of hyperprolactinemia, and possible factors that predict recurrence in patients with prolactinoma. Methods: We evaluated DA withdrawal in 67 patients with prolactinoma (50 female/17 male) who received DA treatment for at least...

Objective: Many studies have shown that prolactin (PRL) plays an important role in autoimmune diseases. The aim of this study was to compare the current frequency of autoimmune thyroid disease (ATD) in prolactinomas with another type of functional pituitary adenoma (FPA), somatotrophinoma. Another aim of the study was to evaluate possible factors...

Abstract Introduction: Hyperosmolar hyperglisemic nonketotic coma (HONKC) is a rare complication of type 2 diabetes mellitus (DM). Polyuric dehydration caused by DI can lead to HONKC. One of the reasons of central diabetes insipidus (CDI) is metastatic malignancies. Most frequently breast and lung cancer and less frequently colorectal cancer can ca...

Detection of early vascular changes prior to clinical manifestations of atherosclerosis, such as increased arterial carotid intima-media thickness (CIMT) and impaired endothelial function is of paramount importance for early identification of subjects at increased risk of accelerated atherosclerosis. The present study was designed to evaluate the r...

Distant metastasis may be the initial sign of differentiated thyroid carcinoma in rare cases. In this instance, the treatment approach is usually individualized. Unlike most other cancers, local treatment of the primary tumor (total thyroidectomy) is preferred as ablative surgery; so that radioactive iodine therapy should be more effective. Repeate...

Abstract Thyroid cancer in ovarian teratoma is reported to be rare and experiences are limited. A 26-year-old woman had undergone bilateral cystectomy and omentectomy for bilateral cystic adnexial masses. Pathological examination showed 1.5 cm follicular variant papillary thyroid carcinoma on the basis of unilateral mature cystic teratoma. Increase...

Introduction: During pregnancy, a progressive increase in serum triglyceride (TG) and cholesterol levels is observed whereas TG levels mostly remain <300 mg/dl. In women with genetic forms of hypertriglyceridemia, pregnancy may cause extremely elevated TG levels leading to potentially life-threatening pancreatitis attacks and chylomicronemia syndr...

Introduction: Isolated bone metastasis of endometrium carcinoma is rare; but if it occurs, pelvis and vertebrae are involved mostly. Co-existence of undiagnosed Paget’s disease in a patient with malignancy causes major problems in differential diagnosis. Case: A 77 year-old woman was admitted to our hospital with severe pelvic pain. She had been di...