Selvaraj Milton Prabu

Selvaraj Milton Prabu
University of Madras | UMadras · Department of Zoology

Ph.D

About

108
Publications
36,749
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
2,961
Citations
Introduction
I am working as an Associate Professor in the Department of Zoology, University of Madras,Guindy campus ,Chennai. At present, i am involving in the toxicological research about the organ toxic effects of heavy metals and their chelation by phytoconstituents. I have published more than 83 international peer-reviewed papers, 7 book chapters and 3 books with a total impact factor 142. 56 and I have organized two national conferences and workshops in environmental toxicology and completed one UGC Major research project in toxicology. I have guided 5 Ph.d's and 19 M.Phil Scholars. I have reviewed more than 250 peer referred articles in almost all the leading scientific publication services including Nature,Frontiers,wiley,blackwell,springer,elsevier,sage,rsc,acs,crs,bentham..etc.
Additional affiliations
February 2018 - June 2020
University of Madras
Position
  • Professor (Associate)
Description
  • Handling classes for M.Sc M.Phil & PhD-Life sciences certificate courses related to life sciences Research activity related to environmental toxicology and phyto-therapeutics
February 2018 - June 2020
University of Madras
Position
  • Professor (Associate)
February 2018 - June 2021
Unuiversity of Madras
Position
  • Professor (Associate)
Description
  • Handling classes for PG and research scholars in the frontier areas of life sciences
Education
November 1998 - January 2018
Annamalai University
Field of study
  • Environmental Toxicology,ethnomedicine and Pharmacotherapeutics

Publications

Publications (108)
Article
Arsenic (As) is a well-known human carcinogen and a potent hepatotoxin. Environmental exposure to arsenic imposes a serious health hazard to humans and other animals worldwide. Tetrahydrocurcumin (THC), one of the major metabolites of curcumin, exhibits many of the same physiological and pharmacological activities as curcumin and in some systems ma...
Article
Full-text available
The efficacy of diallyl trisulfide (DATS) against arsenic (As) induced dyslipidemia in the plasma and livers of rats was studied. Oral administration of As [5 mg/kg of body weight (BW)/day] for 4 weeks showed significant (p<0.05) increases in TC, LDL-C, VLDL-C, FFA, PL, and TG levels and the activity of HMG-CoA reductase in the plasma and liver, wi...
Article
Full-text available
Abstract Mitochondria are the particular target of arsenic (As) in the cell. Cell death induced by As is associated with mitochondrial membrane depolarization and release of cytochrome c from the mitochondria. This study was aimed to investigate the protective role of diallyl trisulphide against As induced oxidative stress in cardiac mitochondria....
Article
Full-text available
Arsenic ROS Dimethoxycurcumin NADPH oxidase Apoptosis Nrf2/Keap1 signaling a b s t r a c t NADPH oxidase mediated ROS generation plays a decisive role in the pathogenesis of arsenic (As) hep-atotoxicity. Antioxidant phytochemicals, like dimethoxycurcumin (DiMC) has a tremendous scope in attenuating the ROS mediated hepatic injury. Hence, the presen...
Article
The present study was undertaken to evaluate the cardioprotective role of (−)-epigallocatechin-gallate (EGCG) against Fluoride (F) induced oxidative stress mediated cardiotoxicity in rats. The animals exposed to F as sodium Fluoride (NaF) (25 mg/kg BW) for 4weeks exhibited a significant increase in the levels of cardiac troponins T and I (cTnT & I)...
Article
Full-text available
The widespread use of Benzophenone-3 (BP-3) has resulted in its release into the ecosystem, and its potential impact on the aquatic ecosystem is of rising concern. Therefore, the current investigation was conducted to analyze the effect of BP-3 at environmentally relevant concentration (44 μg/L in river) in the zebra fish liver through the biochemi...
Chapter
Background: Arsenic (As), an entrenched natural cancer-causing agent, has been found to cause oxidative pressure initiated fiery lung maladies in people upon unending introduction. The aim of our examination is to explore the ameliorative capability of garlic polysulfide, i.e., diallyl trisulfide (DATS), against As-initiated oxidative lung damage i...
Article
Background/aims: Agriculture and industrial expansion in recent years have resulted in the undue discharge of arsenic into the environment, building arsenic toxicity a major worldwide anxiety. Oxidative stress is considered as the most conspicuous effect of arsenic toxicity. The current study was designed to evaluate the protective ability of sulf...
Article
Full-text available
Abstract Background: Fluoride (Fl) exposure engenders neurodegeneration and induces oxidative stress in the brain. Therefore, the mechanism of Fl-induced neurotoxic effects needs to be determined. The aim of this study was to investigate the neuroprotective effects of EGCG (40 mg/kg) on Fl (25 mg/kg/bw)-induced oxidative stress mediated neurotoxici...
Article
Arsenic (Ar), a naturally occurring environmental toxicant, is capable of causing acute renal failure as well as renal cancer. Ar is known to exert its toxicity through oxidative stress by generating reactive oxygen species (ROS). Present study investigates the protective efficacy of sulforaphane (SFN) against arsenic induced renal damage via PI3K/...
Article
Full-text available
Background Industrial and agricultural growths in recent years has resulted in the extreme discharge of arsenic into the environment, making arsenic toxicity a major worldwide concern. Oxidative stress is considered the primary mechanism for arsenic toxicity. Purpose The main objective of this study was to evaluate sulforaphane protective ability...
Article
Full-text available
The present study aims to evaluate the protective effect of grape seed proanthocyanidins (GSP) on cadmium (Cd)-induced testicular apoptosis, inflammation, and oxidative stress in rats. A total of 24 male Wistar rats were divided into four groups, namely control, GSP (100 mg/kg BW), Cd (5 mg/kg BW), and Cd+GSP. Cd-treated rat testes exhibited a sign...
Article
Full-text available
Fluoride (Fl) is a naturally occurring electro negative compound which is classified as potent toxicant and human carcinogen. Erythrocytes are very expedient model to understand the susceptibility of oxidative stress on membrane induced by different xenobiotics. Fl administration (25mg/kg/BW) significantly increased the percentage of hemolysis, lip...
Article
Full-text available
The present study was designed to investigate the Nickel (Ni) induced biochemical and histopathological changes in gill and muscle tissues of fresh water fish grass carp. These Fish were exposed to 35mg/L of Nickel sulphate for 7 And 14 days. The activity of lipid peroxidation markers, antioxidant defense system, total protein, lipids, estimation o...
Article
Full-text available
Sulforaphane [1-isothiocyanate-(4R)-(methylsulfinyl) butane] is a natural dietary isothiocyanate produced by the enzymatic accomplishment of the myrosinase on glucopharanin, a 4-methylsulfinylbutyl glucosinolate contained in cruciferous vegetables such as broccoli, brussel sprouts, and cabbage. Exploring of this compound against various oxidative d...
Article
Background: Arsenic (As) contamination is an extremely dangerous global environmental problem as it can enter into the food chain and become bio-accumulated, endangering human health. Chronic As intoxication leads to undesirable toxic effects in various organ systems of the body, especially the kidney. Diallyl trisulfide (DATS) is an organosulfur...
Article
Full-text available
The present study was designed to investigate the neuroprotective effect of hesperetin (Hp) against cadmium (Cd)-induced neurotoxicity in rats. Cadmium (3 mg/kg body weight (b.w.), subcutaneous) administration for 3 weeks demonstrated neurotoxicity in rats by the decreased activity of acetylcholinesterase in the brain. The oxidative stress markers...
Article
Liver diseases caused by viral hepatitis infections have a negative impact on global health. Approximately 30 million people in the USA and 29 million people in the European Union suffer from chronic liver disease. There are many kinds of diseases of the liver, caused by viruses, such as hepatitis A, hepatitis B and hepatitis C, or by certain drugs...
Article
Background: Since this Nrf2-dependent cellular defense response is able to protect multi-organs, including cancer, neurodegenerative diseases, cardiovascular diseases, inflammation and chronic lung injury. The antioxidant and anti-inflammatory potential of Epigallocatechin gallate (EGCG) and Nrf2/Keap1 signaling mechanisms in pulmonary toxicity ha...
Article
Full-text available
Arsenic (As) is an environmental toxic metalloid that is present in everywhere such as air, water and soil. Generally, inorganic arsenic has a tendency to be more toxic than organic arsenic. The present study was designed to determine whether oral administration of silibinin (SB), which has been shown to have substantial antioxidant properties, whe...
Article
Full-text available
Apoptosis, also known as programmed cell death is a highly regulated and fundamental process found in all multicellular organisms. It is not only implicated in regulatory mechanisms of cells, but has been attributed to a number of diseases, like inflammation, malignancy, autoimmunity and neuro-degeneration. A variability of pollutants can persuade...
Chapter
Full-text available
Arsenic is a well known toxic metalloid which induces a broad spectrum of toxicological effects, biochemical dysfunctions and dyslipidemia, constituting serious hazard to health. DiMC is sound recognized for its antioxi-dant, anti-cancer, anti-inflammatory and anti-apoptotic actions. Hence the present study was designed to examine the antihyperlipi...
Article
Full-text available
The present study was undertaken to evaluate the possible ameliorative role of grape seed proanthocyanidins (GSP) against Cadmium (Cd) induced hepatic inflammation, apoptosis and hepatic mitochondrial toxicity in rats. Male Wistar rats were distributed in four experimental groups: control, GSP, Cd and Cd+GSP. Exposure to a hepatotoxic dose of Cd (5...
Article
Full-text available
Objective: To explore the ameliorative potential of Epigallocatechin gallate (EGCG) by evaluating markers of oxidative stress, apoptosis, and inflammation and antioxidant competence in Fl intoxicated rats. Methods: The animals were divided in to four groups that is control, EGCG alone, NaF, and EGCG with NaF. Group III animal were exposed to Fl as...
Article
Full-text available
The present study has been designed to investigate the ameliorative effect of grape seed proanthocyanidins (GSP) on cadmium (Cd)-induced oxidative damage in rat erythrocytes. Twenty four male Wistar rats were divided into four groups: control, GSP-treated group (100 mg kg(-1) body weight (BW)), Cd-treated group (cadmium chloride, 5 mg kg(-1) BW), a...
Article
Full-text available
The present study investigates the possible ameliorative effects of diallyl trisulfide (DATS) against arsenic (As)-induced hepatotoxicity and oxidative stress in rats. The four experimental groups evaluated include: (1) vehicle control; (2) As (5 mg/kg/day); (3) DATS (80 mg/kg/day) + As; and (4) DATS. Induction of As in rats caused severe hepatotox...
Article
Full-text available
Objective:To explore the ameliorative potential of Epigallocatechin gallate (EGCG) byevaluating markers of oxidative stress, apoptosis, and inflammation and antioxidantcompetence in Fl intoxicated rats.Methods:The animals were divided in to four groups that is control, EGCG alone, NaF,and EGCG with NaF. Group III animal were exposed to Fl as sodium...
Article
Full-text available
Fluoride intoxication generates free radicals, causing oxidative stress that plays a critical role in the progression of nephropathy. In the present study, we hypothesized that epigallocatechin gallate (EGCG), found in green tea, protects the kidneys of rats treated with fluoride by preventing oxidative stress, inflammation, and apoptosis. Pretreat...
Article
Full-text available
Cadmium (Cd) preferentially accumulates in the kidney, the major target for Cd-related toxicity. Cd-induced reactive oxygen species (ROS) have been considered crucial mediators for renal injury. The biologically significant ionic form of cadmium (Cd(+)) binds to many bio-molecules, and these interactions underlie the toxicity mechanisms of Cd. The...
Article
Full-text available
Due to continued anthropogenic mobilization, cadmium accumulation in the environment causes various health problems because of its diverse toxic effects, extremely lingering biological half life (20–30 years), low rate of excretion from the body and storage predominantly in soft tissue primarily liver and kidney. Cadmium is known to have numerous n...
Article
Full-text available
Background: Terminalia chebula is one of the traditional medicines used in the treatment of many diseases and possesses a wide variety of therapeutic activities. The aim of this study was to determine the antimicrobial properties of Terminalia chebula against oral pathogens related to caries. Materials and methods: In this study, Antimicrobial a...
Article
Full-text available
inflammation, and apoptosis in rats Diallyl trisulfide ameliorates arsenic-induced hepatotoxicity by abrogation of oxidative stress, Article Diallyl trisulfide ameliorates arsenic-induced hepatotoxicity by abrogation of oxidative stress, inflammation, and apoptosis in rats Abstract The present study investigates the possible ameliorative effects of...
Article
Full-text available
Abstract The efficacy of diallyl trisulfide (DATS) against arsenic (As) induced dyslipidemia in the plasma and livers of rats was studied. Oral administration of As [5 mg/kg of body weight (BW)/d] for 4 weeks showed significant (p<0.05) increases in TC, LDL-C, VLDL-C, FFA, PL, and TGs, levels and the activity of HMG-CoA reductase in the plasma and...
Article
Full-text available
Prabu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Objective: To study the ameliorative effects of grape seed proanthocyanidins (GSP) against cadmium (Cd) induced h...
Article
Full-text available
Abstract Fluoride intoxication generates free radicals, causing oxidative stress that plays a critical role in the progression of nephropathy. In the present study, we hypothesized that epigallocatechin gallate (EGCG), found in green tea, protects the kidneys of rats treated with fluoride by preventing oxidative stress, inflammation, and apoptosis...
Article
Full-text available
Abstract Background: The present study was designed to examine the ant hyperglycemic and antihyperlipidemic effect of Epigallocatechin gallate (EGCG) on fluoride induced oxidative changes in the metabolisms of rats. Methods: The control group received the vehicles only. EGCG alone treated group received the EGCG orally at a dose of 40mg/kg in 10%...
Article
Full-text available
Background: Arsenic is an emblematic heavy metal and enters the animals through intake of arsenic contaminated water and gets stored in primitive organs. Aim: The present study was designed to investigate the protective effect of diallyl trisulfide (DATS) on arsenic (As) induced testicular oxidative stress in male rats. Methods: Experimental rats w...
Article
Full-text available
Diallyl trisulfide (DATS) abrogates arsenic induced testicular oxidative stress in rats
Article
Full-text available
Grape seed proanthocyanidins (GSP) are polyphenolic compounds which exert a novel spectrum of biological, pharmacological and therapeutic properties against oxidative stress. Recent findings have shown that GSP exhibit numerous antioxidant and free radical scavenging properties. So, it was of special concern to investigate the protective efficacy o...
Article
Full-text available
Abstract The present investigation was aimed to investigate the possible protective role of Diallyl trisulfide (DATS) against Arsenic (As) induced hepatic mitochondrial toxicity in rats. Mitochondria were isolated from the liver tissue of rats from all the groups. Lipid profile, lipid peroxidation, antioxidant enzyme activities, hepatic function en...
Data
Full-text available
Fluoride (Fl) is a naturally occurring electro negative compound which is classified as potent toxicant and human carcinogen. Erythrocytes are very expedient model to understand the susceptibility of oxidative stress on membrane induced by different xenobiotics. Fl administration (25mg/kg/BW) significantly increased the percentage of hemolysis, lip...
Article
Full-text available
Background: Arsenic (As) is a naturally occurring semimetallic element that is classified as a toxicant and a human carcinogen. Diallyl trisulphide (DATS), an organosulphur compound, is an antioxidative substance that is extracted from garlic (Allium sativum). Erythrocytes are very expedient models to understand the susceptibility of membrane to o...
Data
Purpose: Arsenic (As) is a well documented human carcinogen. Conversely, its mechanisms of toxic deed and carcinogenic possible in animals have not been indisputable. So, this study was conducted to investigate the biochemical and genotoxic possessions in male wistar rats treated with As, DATS with As and As and vitamin C (positive control). Method...
Article
Full-text available
Abstract Background: The aim of this study was to investigate the possible protective role of the Mentha piperita leaf extract (MPE) on cadmium (Cd)-induced nephrotoxicity using biochemical and histopathological approaches. Methods: The control group received the vehicles only. The Cd treated group received Cdcl (5 mg/kg) orally in isotonic salin...
Article
Full-text available
Abstract Background: The aim of this study was to investigate the possible protective role of the Mentha piperita leaf extract (MPE) on cadmium (Cd)-induced nephrotoxicity using biochemical and histopathological approaches. Methods: The control group received the vehicles only. The Cd treated group received Cdcl (5 mg/kg) orally in isotonic salin...
Data
Full-text available
INTRODUCTION Cadmium is a wide spread environmental and occupational pollutant. It is a transition metal. Exposure to cadmium has been and continues to be of major health concern all over the world. Humans are exposed to cadmium from contaminated seafoods, fruits, vegetables, tobacco smoke, industrial, occupational and environmental pollution. Cadm...
Data
Full-text available
Protective efficacy of caffeic acid (CA), a non flavonoid catecholic compound was studied against cadmium (Cd) induced hepatic oxidative stress in rats. Recent findings have shown that caffeic acid possess antioxidant and free radical scavenging properties. Male wistar rats were injected with cadmium chloride (3 mg/kg.bw subcutaneously) and simulta...
Article
Full-text available
Environmental exposure to sodium fluoride (NaF) compounds is a worldwide health concern. Epigallocatechin gallate (EGCG) is a green tea catechin found in a variety of green tea preparations. The intention of this study was to investigate the hepatoprotective role of EGCG in NaF-intoxicated rats. Rats were orally treated with NaF alone (25 mg·(kg bo...